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Current HIV/AIDS Reports
Erschienen in: Current HIV/AIDS Reports 6/2016

05.10.2016 | Behavioral-Bio-Medical Interface (JL Brown and RJ DiClemente, Section Editors)

Microvascular Function in Aging Among Women Living with HIV

verfasst von: Jean-Jacques Monsuez, Catherine Belin, Olivier Bouchaud

Erschienen in: Current HIV/AIDS Reports | Ausgabe 6/2016

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Abstract

Combined antiretroviral therapy (CART) has turned HIV-infection to a treatable chronic disease during which many patients survive to middle and older age. However, they prematurely develop non-AIDS comorbidities such as cardiovascular disease, metabolic syndrome, diabetes, and HIV-associated neurocognitive disorders (HAND). Microcirculatory changes and endothelial dysfunction occur early both in HIV-infected and in aging patients, in whom they usually precede cardiovascular and neurocognitive impairments. Also, mild cognitive involvement has been reported in women during the menopausal transition. Disruption of the blood-brain barrier, as well as microvascular and cerebral blood flow changes, has been reported in HIV patients with HAND, including postmenopausal women. However, most studies addressing this issue included women aged less than 50 years. Whether HIV-infected women growing older with CART would be subsequently exposed to an increased progression of cognitive impairment overtime remains unknown.
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Metadaten
Titel
Microvascular Function in Aging Among Women Living with HIV
verfasst von
Jean-Jacques Monsuez
Catherine Belin
Olivier Bouchaud
Publikationsdatum
05.10.2016
Verlag
Springer US
Erschienen in
Current HIV/AIDS Reports / Ausgabe 6/2016
Print ISSN: 1548-3568
Elektronische ISSN: 1548-3576
DOI
https://doi.org/10.1007/s11904-016-0339-3

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