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Erschienen in: Archives of Orthopaedic and Trauma Surgery 6/2018

22.01.2018 | Arthroscopy and Sports Medicine

Mid-term outcome of arthroscopic AMIC for the treatment of articular cartilage defects in the knee joint is equivalent to mini-open procedures

verfasst von: J. Schagemann, P. Behrens, A. Paech, H. Riepenhof, B. Kienast, H. Mittelstädt, J. Gille

Erschienen in: Archives of Orthopaedic and Trauma Surgery | Ausgabe 6/2018

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Abstract

Introduction

We present the first retrospective study that compares two various autologous matrix-induced chondrogenesis (AMIC) surgical interventions to repair grade III–IV cartilage defects in the knee. Patients who underwent minimally invasive (arthroscopy) or open (mini-arthrotomy) AMIC were followed up to 2 years to investigate if minimally invasive AMIC is superior to open procedures.

Materials and methods

Overall n = 50 patients with focal and contained grade III–IV articular cartilage defects in the knee joint were followed in a consecutive cohort study. 20 patients were treated arthroscopically (female 7, male 13; age: mean 38.2 years, range 18–70 years; BMI: mean 27.0, range 18.7–34.7; defect size: mean 3.1 cm2, range 1.0–6.0 cm2), and 30 patients via mini-arthrotomy (female 13, male 17; age: mean 34.4 years, range 14–53 years, BMI: mean 23.9, range 18.4–28.7; defect size: mean 3.4 cm2, range 1.5–12.0 cm2). The primary defect localization was the medial femoral condyle.

Results

AMIC led to a significant improvement of VAS pain, KOOS and Lysholm scoring for up to 2 years compared to pre-op. Outcome analysis revealed no significant differences between the two different surgical approaches.

Conclusions

Our results suggest that mini-open AMIC is equivalent to the arthroscopic procedure. The anticipatory hypothesis that minimally invasive approaches bring greater patient benefit per se could not be confirmed. Therefore, we recommend to perform AMIC where indicated and suggest that the surgeon’s personal skills profile guide the choice of surgical approach.

Level of evidence

III.
Literatur
1.
Zurück zum Zitat Gomoll AH, Farr J, Gillogly SD, Kercher JS, Minas T (2011) Surgical management of articular cartilage defects of the knee. Instr Course Lect 60:461–483PubMed Gomoll AH, Farr J, Gillogly SD, Kercher JS, Minas T (2011) Surgical management of articular cartilage defects of the knee. Instr Course Lect 60:461–483PubMed
2.
Zurück zum Zitat Salzmann GM, Niemeyer P, Steinwachs M, Kreuz PC, Sudkamp NP, Mayr HO (2011) Cartilage repair approach and treatment characteristics across the knee joint: a European survey. Arch Orthop Trauma Surg 131(3):283–291CrossRefPubMed Salzmann GM, Niemeyer P, Steinwachs M, Kreuz PC, Sudkamp NP, Mayr HO (2011) Cartilage repair approach and treatment characteristics across the knee joint: a European survey. Arch Orthop Trauma Surg 131(3):283–291CrossRefPubMed
3.
Zurück zum Zitat Kreuz PC, Steinwachs MR, Erggelet C, Krause SJ, Konrad G, Uhl M, Sudkamp N (2006) Results after microfracture of full-thickness chondral defects in different compartments in the knee. Osteoarthr Cartil 14(11):1119–1125CrossRefPubMed Kreuz PC, Steinwachs MR, Erggelet C, Krause SJ, Konrad G, Uhl M, Sudkamp N (2006) Results after microfracture of full-thickness chondral defects in different compartments in the knee. Osteoarthr Cartil 14(11):1119–1125CrossRefPubMed
4.
Zurück zum Zitat Harris JD, Brophy RH, Siston RA, Flanigan DC (2010) Treatment of chondral defects in the athlete’s knee. Arthroscopy 6(6):841–852CrossRef Harris JD, Brophy RH, Siston RA, Flanigan DC (2010) Treatment of chondral defects in the athlete’s knee. Arthroscopy 6(6):841–852CrossRef
5.
Zurück zum Zitat Gille J, Behrens P, Volpi P, de Girolamo L, Reiss E, Zoch W, Anders S (2013) Outcome of autologous matrix induced chondrogenesis (AMIC) in cartilage knee surgery: data of the AMIC registry. Arch Orthop Trauma Surg 133(1):87–93CrossRefPubMed Gille J, Behrens P, Volpi P, de Girolamo L, Reiss E, Zoch W, Anders S (2013) Outcome of autologous matrix induced chondrogenesis (AMIC) in cartilage knee surgery: data of the AMIC registry. Arch Orthop Trauma Surg 133(1):87–93CrossRefPubMed
6.
Zurück zum Zitat Benthien JP, Behrens P (2011) The treatment of chondral and osteochondral defects of the knee with autologous matrix-induced chondrogenesis (AMIC): method description and recent developments. Knee Surg Sports Traumatol Arthrosc 19(8):1316–1319CrossRefPubMed Benthien JP, Behrens P (2011) The treatment of chondral and osteochondral defects of the knee with autologous matrix-induced chondrogenesis (AMIC): method description and recent developments. Knee Surg Sports Traumatol Arthrosc 19(8):1316–1319CrossRefPubMed
7.
Zurück zum Zitat Cuellar A, Ruiz-Iban MA, Cuellar R (2016) The use of all-arthroscopic autologous matrix-induced chondrogenesis for the management of humeral and glenoid chondral defects in the shoulder. Arthrosc Tech 5(2):223–227CrossRef Cuellar A, Ruiz-Iban MA, Cuellar R (2016) The use of all-arthroscopic autologous matrix-induced chondrogenesis for the management of humeral and glenoid chondral defects in the shoulder. Arthrosc Tech 5(2):223–227CrossRef
8.
Zurück zum Zitat Fontana A (2012) A novel technique for treating cartilage defects in the hip: a fully arthroscopic approach to using autologous matrix-induced chondrogenesis. Arthrosc Tech 1(1):63–68CrossRef Fontana A (2012) A novel technique for treating cartilage defects in the hip: a fully arthroscopic approach to using autologous matrix-induced chondrogenesis. Arthrosc Tech 1(1):63–68CrossRef
9.
Zurück zum Zitat Piontek T, Ciemniewska-Gorzela K, Szulc A, Naczk J, Slomczykowski M (2012) All-arthroscopic AMIC procedure for repair of cartilage defects of the knee. Knee Surg Sports Traumatol Arthrosc 20(5):922–925CrossRefPubMed Piontek T, Ciemniewska-Gorzela K, Szulc A, Naczk J, Slomczykowski M (2012) All-arthroscopic AMIC procedure for repair of cartilage defects of the knee. Knee Surg Sports Traumatol Arthrosc 20(5):922–925CrossRefPubMed
10.
Zurück zum Zitat Sadlik B, Wiewiorski M (2015) Implantation of a collagen matrix for an AMIC repair during dry arthroscopy. Knee Surg Sports Traumatol Arthrosc 23(8):2349–2352CrossRefPubMed Sadlik B, Wiewiorski M (2015) Implantation of a collagen matrix for an AMIC repair during dry arthroscopy. Knee Surg Sports Traumatol Arthrosc 23(8):2349–2352CrossRefPubMed
11.
Zurück zum Zitat Usuelli FG, de Girolamo L, Grassi M, D’Ambrosi R, Montrasio UA, Boga M (2015) All-arthroscopic autologous matrix-induced chondrogenesis for the treatment of osteochondral lesions of the talus. Arthrosc Tech 4(3):255–259CrossRef Usuelli FG, de Girolamo L, Grassi M, D’Ambrosi R, Montrasio UA, Boga M (2015) All-arthroscopic autologous matrix-induced chondrogenesis for the treatment of osteochondral lesions of the talus. Arthrosc Tech 4(3):255–259CrossRef
12.
Zurück zum Zitat Steadman JR, Miller BS, Karas SG, Schlegel TF, Briggs KK, Hawkins RJ (2003) The microfracture technique in the treatment of full-thickness chondral lesions of the knee in national football league players. J Knee Surg 16(2):83–86PubMed Steadman JR, Miller BS, Karas SG, Schlegel TF, Briggs KK, Hawkins RJ (2003) The microfracture technique in the treatment of full-thickness chondral lesions of the knee in national football league players. J Knee Surg 16(2):83–86PubMed
13.
Zurück zum Zitat Erggelet C, Sittinger M, Lahm A (2003) The arthroscopic implantation of autologous chondrocytes for the treatment of full-thickness cartilage defects of the knee joint. Arthroscopy 19(1):108–110CrossRefPubMed Erggelet C, Sittinger M, Lahm A (2003) The arthroscopic implantation of autologous chondrocytes for the treatment of full-thickness cartilage defects of the knee joint. Arthroscopy 19(1):108–110CrossRefPubMed
14.
Zurück zum Zitat Kreuz PC, Muller S, Ossendorf C, Kaps C, Erggelet C (2009) Treatment of focal degenerative cartilage defects with polymer-based autologous chondrocyte grafts: four-year clinical results. Arthritis Res Ther 11(2):R33CrossRefPubMedPubMedCentral Kreuz PC, Muller S, Ossendorf C, Kaps C, Erggelet C (2009) Treatment of focal degenerative cartilage defects with polymer-based autologous chondrocyte grafts: four-year clinical results. Arthritis Res Ther 11(2):R33CrossRefPubMedPubMedCentral
15.
Zurück zum Zitat Marcacci M, Zaffagnini S, Kon E, Visani A, Iacono F, Loreti I (2002) Arthroscopic autologous chondrocyte transplantation: technical note. Knee Surg Sports Traumatol Arthrosc 10(3):154–159CrossRefPubMed Marcacci M, Zaffagnini S, Kon E, Visani A, Iacono F, Loreti I (2002) Arthroscopic autologous chondrocyte transplantation: technical note. Knee Surg Sports Traumatol Arthrosc 10(3):154–159CrossRefPubMed
16.
Zurück zum Zitat Marcacci M, Kon E, Zaffagnini S, Iacono F, Neri MP, Vascellari A, Visani A, Russo A (2005) Multiple osteochondral arthroscopic grafting (mosaicplasty) for cartilage defects of the knee: prospective study results at 2-year follow-up. Arthroscopy 21(4):462–470CrossRefPubMed Marcacci M, Kon E, Zaffagnini S, Iacono F, Neri MP, Vascellari A, Visani A, Russo A (2005) Multiple osteochondral arthroscopic grafting (mosaicplasty) for cartilage defects of the knee: prospective study results at 2-year follow-up. Arthroscopy 21(4):462–470CrossRefPubMed
17.
Zurück zum Zitat Marcacci M, Marcheggiani Muccioli GM, Grassi A, Ricci M, Tsapralis K, Nanni G, Bonanzinga T, Zaffagnini S (2014) Arthroscopic meniscus allograft transplantation in male professional soccer players: a 36-month follow-up study. Am J Sports Med 42(2):382–388CrossRefPubMed Marcacci M, Marcheggiani Muccioli GM, Grassi A, Ricci M, Tsapralis K, Nanni G, Bonanzinga T, Zaffagnini S (2014) Arthroscopic meniscus allograft transplantation in male professional soccer players: a 36-month follow-up study. Am J Sports Med 42(2):382–388CrossRefPubMed
18.
Zurück zum Zitat Ebert JR, Fallon M, Ackland TR, Wood DJ, Janes GC (2012) Arthroscopic matrix-induced autologous chondrocyte implantation: 2-year outcomes. Arthroscopy 28(7):952–964 (e951–952)CrossRefPubMed Ebert JR, Fallon M, Ackland TR, Wood DJ, Janes GC (2012) Arthroscopic matrix-induced autologous chondrocyte implantation: 2-year outcomes. Arthroscopy 28(7):952–964 (e951–952)CrossRefPubMed
19.
Zurück zum Zitat Edwards PK, Ebert JR, Janes GC, Wood D, Fallon M, Ackland T (2014) Arthroscopic versus open matrix-induced autologous chondrocyte implantation: results and implications for rehabilitation. J Sports Rehabil 23(3):203–215CrossRef Edwards PK, Ebert JR, Janes GC, Wood D, Fallon M, Ackland T (2014) Arthroscopic versus open matrix-induced autologous chondrocyte implantation: results and implications for rehabilitation. J Sports Rehabil 23(3):203–215CrossRef
20.
Zurück zum Zitat Filardo G, Kon E, Di Martino A, Iacono F, Marcacci M (2011) Arthroscopic second-generation autologous chondrocyte implantation: a prospective 7-year follow-up study. Am J Sports Med 39(10):2153–2160CrossRefPubMed Filardo G, Kon E, Di Martino A, Iacono F, Marcacci M (2011) Arthroscopic second-generation autologous chondrocyte implantation: a prospective 7-year follow-up study. Am J Sports Med 39(10):2153–2160CrossRefPubMed
21.
Zurück zum Zitat Farr J, Cole BJ, Sherman S, Karas V (2012) Particulated articular cartilage: CAIS and DeNovo NT. J Knee Surg 25(1):23–29CrossRefPubMed Farr J, Cole BJ, Sherman S, Karas V (2012) Particulated articular cartilage: CAIS and DeNovo NT. J Knee Surg 25(1):23–29CrossRefPubMed
22.
Zurück zum Zitat Zantop T, Petersen W (2009) Arthroscopic implantation of a matrix to cover large chondral defect during microfracture. Arthroscopy 25(11):1354–1360CrossRefPubMed Zantop T, Petersen W (2009) Arthroscopic implantation of a matrix to cover large chondral defect during microfracture. Arthroscopy 25(11):1354–1360CrossRefPubMed
23.
Zurück zum Zitat Benthien JP, Behrens P (2015) Nanofractured autologous matrix induced chondrogenesis (NAMIC©)--Further development of collagen membrane aided chondrogenesis combined with subchondral needling: a technical note. Knee 22(5):411–415CrossRefPubMed Benthien JP, Behrens P (2015) Nanofractured autologous matrix induced chondrogenesis (NAMIC©)--Further development of collagen membrane aided chondrogenesis combined with subchondral needling: a technical note. Knee 22(5):411–415CrossRefPubMed
24.
Zurück zum Zitat Harris JD, Siston RA, Brophy RH, Lattermann C, Carey JL, Flanigan DC (2011) Failures, re-operations, and complications after autologous chondrocyte implantation—a systematic review. Osteoarthr Cartil 19(7):779–791CrossRefPubMed Harris JD, Siston RA, Brophy RH, Lattermann C, Carey JL, Flanigan DC (2011) Failures, re-operations, and complications after autologous chondrocyte implantation—a systematic review. Osteoarthr Cartil 19(7):779–791CrossRefPubMed
25.
Zurück zum Zitat Edwards PK, Ackland T, Ebert JR (2014) Clinical rehabilitation guidelines for matrix- induced autologous chondrocyte implantation on the tibiofemoral joint. J Orthop Sports Phys Ther 44(2):102–119CrossRefPubMed Edwards PK, Ackland T, Ebert JR (2014) Clinical rehabilitation guidelines for matrix- induced autologous chondrocyte implantation on the tibiofemoral joint. J Orthop Sports Phys Ther 44(2):102–119CrossRefPubMed
Metadaten
Titel
Mid-term outcome of arthroscopic AMIC for the treatment of articular cartilage defects in the knee joint is equivalent to mini-open procedures
verfasst von
J. Schagemann
P. Behrens
A. Paech
H. Riepenhof
B. Kienast
H. Mittelstädt
J. Gille
Publikationsdatum
22.01.2018
Verlag
Springer Berlin Heidelberg
Erschienen in
Archives of Orthopaedic and Trauma Surgery / Ausgabe 6/2018
Print ISSN: 0936-8051
Elektronische ISSN: 1434-3916
DOI
https://doi.org/10.1007/s00402-018-2887-z

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