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Neurogenetics
Erschienen in: neurogenetics 2/2015

01.04.2015 | Review article

Migraine genetics: current findings and future lines of research

verfasst von: A. M. Persico, M. Verdecchia, V. Pinzone, V. Guidetti

Erschienen in: Neurogenetics | Ausgabe 2/2015

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Abstract

In the last two decades, migraine research has greatly advanced our current knowledge of the genetic contributions and the pathophysiology of this common and debilitating disorder. Nonetheless, this knowledge still needs to grow further and to translate into more effective treatments. To date, several genes involved in syndromic and monogenic forms of migraine have been identified, allowing the generation of animal models which have significantly contributed to current knowledge of the mechanisms underlying these rare forms of migraine. Common forms of migraine are instead posing a greater challenge, as they may most often stem from complex interactions between multiple common genetic variants, with environmental triggers. This paper reviews our current understanding of migraine genetics, moving from syndromic and monogenic forms to oligogenic/polygenic migraines most recently addressed with some success through genome-wide association studies. Methodological issues in study design and future perspectives opened by biomarker research will also be briefly addressed.
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Metadaten
Titel
Migraine genetics: current findings and future lines of research
verfasst von
A. M. Persico
M. Verdecchia
V. Pinzone
V. Guidetti
Publikationsdatum
01.04.2015
Verlag
Springer Berlin Heidelberg
Erschienen in
Neurogenetics / Ausgabe 2/2015
Print ISSN: 1364-6745
Elektronische ISSN: 1364-6753
DOI
https://doi.org/10.1007/s10048-014-0433-x

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