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Journal of Bone and Mineral Metabolism

Erschienen in:

01.07.2010 | Original Article

Mineral maturity and crystallinity index are distinct characteristics of bone mineral

verfasst von: Delphine Farlay, Gérard Panczer, Christian Rey, Pierre D. Delmas, Georges Boivin

Erschienen in: Journal of Bone and Mineral Metabolism | Ausgabe 4/2010

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Abstract

The purpose of this study was to test the hypothesis that mineral maturity and crystallinity index are two different characteristics of bone mineral. To this end, Fourier transform infrared microspectroscopy (FTIRM) was used. To test our hypothesis, synthetic apatites and human bone samples were used for the validation of the two parameters using FTIRM. Iliac crest samples from seven human controls and two with skeletal fluorosis were analyzed at the bone structural unit (BSU) level by FTIRM on sections 2–4 μm thick. Mineral maturity and crystallinity index were highly correlated in synthetic apatites but poorly correlated in normal human bone. In skeletal fluorosis, crystallinity index was increased and maturity decreased, supporting the fact of separate measurement of these two parameters. Moreover, results obtained in fluorosis suggested that mineral characteristics can be modified independently of bone remodeling. In conclusion, mineral maturity and crystallinity index are two different parameters measured separately by FTIRM and offering new perspectives to assess bone mineral traits in osteoporosis.

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Titel: Mineral maturity and crystallinity index are distinct characteristics of bone mineral
verfasst von: Delphine Farlay
Gérard Panczer
Christian Rey
Pierre D. Delmas
Georges Boivin
Publikationsdatum: 01.07.2010
Verlag: Springer Japan
Erschienen in: Journal of Bone and Mineral Metabolism / Ausgabe 4/2010
Print ISSN: 0914-8779
Elektronische ISSN: 1435-5604
DOI: https://doi.org/10.1007/s00774-009-0146-7

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