Introduction
Methods
Study population
Data collection
Dietary data
Statistical analysis
Results
Study characteristics
Cases number (%) | Controls number (%) | |
---|---|---|
Total | 322 | 239 |
Sex* | ||
Men | 237 (74) | 138 (58) |
Women | 85 (26) | 101 (42) |
Age (years) [mean (SD)] | 62 (9.2) | 60.7 (10.6) |
Smoking status* | ||
Never smokers | 56 (17.4) | 95 (39.7) |
Ex-smokers | 162 (50.3) | 103 (43.1) |
Current smokers | 104 (32.3) | 41 (17.2) |
Years smoking [mean (SD)]* | 32.2 (14) | 27.4 (15) |
Cigarettes/day [mean (SD)]* | 26.7 (14.8) | 22.3 (15.6) |
Total calories kcal/day [mean (SD)] | 1962.56 (790.72) | 1887.74 (706.64) |
Total fat g/day [mean (SD)] | 71.74 (32.96) | 69.77 (31.76) |
Total alcohol g/day [mean (SD)] | 7.91 (15.84) | 8.29 (14.45) |
Total coffee g/day [mean (SD)] | 227.41 (210.13) | 216.57 (192.88) |
Tumor stage at diagnosis | ||
Carcinoma in situ (%) | 16 (5) | |
Non-invasive/low grade (%) | 190 (59) | |
Non-invasive/high grade (%) | 23 (7) | |
Invasive (%) | 93 (29) |
Total intake of minerals and vitamins and the risk of bladder cancer
Daily intake | Q1 | Q2 | Q3 | Q4 | p Trend |
---|---|---|---|---|---|
Alpha-carotene (μg) | 3.4–404 | 404.1–647.13 | 647.14–1104.70 | ≥1104.71 | 0.26 |
Cases/controls | 76/59 | 89/60 | 77/61 | 77/59 | |
ORs (95% CI) | 1.00 | 1.33 (0.77–2.30) | 1.19 (0.68–2.11) | 1.48 (0.83–2.64) | |
Beta-carotene (μg) | 292.29–2294.21 | 2294.22–3773.80 | 3773.81–5517.20 | ≥5517.21 | 0.90 |
Cases/controls | 94/59 | 78/61 | 65/60 | 79/59 | |
ORs (95% CI) | 1.00 | 0.87 (0.50–1.50) | 0.80 (0.46–1.39) | 0.99 (0.56–1.72) | |
Beta-cryptoxanthin (μg) | 0–52.60 | 52.61–125.77 | 125.78–215.71 | ≥215.72 | 0.65 |
Cases/controls | 109/59 | 76/61 | 59/58 | 78/61 | |
ORs (95% CI) | 1.00 | 0.69 (0.40–1.20) | 0.66 (0.37–1.16) | 0.87 (0.50–1.53) | |
Lycopene (μg) | 0–3092.68 | 3092.69–4827 | 4828–7746.43 | ≥7746.44 | 0.74 |
Cases/controls | 89/59 | 73/60 | 72/60 | 88/60 | |
ORs (95% CI) | 1.00 | 0.96 (0.55–1.66) | 0.70 (0.39–1.24) | 0.98 (0.55–1.73) | |
Lutein (μg) | 0.93–1261.48 | 1261.49–1942.44 | 1942.45–3134.85 | ≥3134.86 | 0.66 |
Cases/controls | 116/58 | 61/61 | 74/60 | 70/59 | |
ORs (95% CI) | 1.00 | 0.52 (0.30–0.90) | 0.76 (0.45–1.31) | 0.80 (0.46–1.40) | |
Total carotenoids (μg) | 398.26–8879.22 | 8879.23–12900.60 | 12900.61–17932.72 | ≥17932.73 | 0.47 |
Cases/controls | 107/59 | 73/60 | 52/60 | 87/60 | |
ORs (95% CI) | 1.00 | 0.70 (0.41–1.21) | 0.49 (0.27–0.86) | 0.90 (0.51–1.59) | |
Vitamin D (IU) | 15.53–171.74 | 171.75–388.90 | 388.91–641.12 | ≥641.13 | 0.22 |
Cases/controls | 89/59 | 72/60 | 100/60 | 61/60 | |
ORs (95% CI) | 1.00 | 0.78 (0.44–1.38) | 1.03 (0.60–1.76) | 0.58 (0.31–1.06) | |
Vitamin E (mg) | 1.13–7.26 | 7.27–20.94 | 20.95–193.35 | ≥193.36 | 0.09 |
Cases/controls | 77/57 | 95/58 | 81/57 | 54/57 | |
ORs (95% CI) | 1.00 | 1.19 (0.68–2.08) | 0.88 (0.49–1.56) | 0.66 (0.36–1.20) | |
Thiamin (mg) | 0.21–1.32 | 1.33–2.11 | 2.12–3.34 | ≥3.35 | 0.50 |
Cases/controls | 91/58 | 63/59 | 99/63 | 67/58 | |
ORs (95% CI) | 1.00 | 0.53 (0.29–0.96) | 0.97 (0.56–1.68) | 0.63 (0.35–1.14) | |
Riboflavin (mg) | 0.25–1.63 | 1.64–2.75 | 2.76–4.04 | ≥4.05 | 0.61 |
Cases/controls | 85/60 | 74/59 | 91/61 | 71/59 | |
ORs (95% CI) | 1.00 | 0.73 (0.41–1.29) | 1.02 (0.58–1.77) | 0.75 (0.42–1.34) | |
Niacin (B3) (mg) | 5.77–21.91 | 21.92–33.07 | 33.08–46.50 | ≥46.51 | 0.23 |
Cases/controls | 90/58 | 68/60 | 93/60 | 67/60 | |
ORs (95% CI) | 1.00 | 0.59 (0.33–1.06) | 0.94 (0.54–1.64) | 0.56 (0.31–1.02) | |
Vitamin B6 (mg) | 0.32–1.94 | 1.95–3.28 | 3.29–4.88 | ≥4.89 | 0.41 |
Cases/controls | 93/59 | 75/59 | 77/61 | 75/59 | |
ORs (95% CI) | 1.00 | 0.67 (0.38–1.18) | 0.82 (0.47–1.44) | 0.72 (0.41–1.27) | |
Vitamin B12 (μg) | 0.75–5.51 | 5.52–10.82 | 10.83–18.0 | ≥18.1 | 0.75 |
Cases/controls | 79/60 | 89/60 | 65/60 | 87/59 | |
ORs (95% CI) | 1.00 | 1.30 (0.75–2.26) | 0.84 (0.47–1.51) | 1.05 (0.60–1.84) | |
Folate (μg) | 48.41–339.03 | 339.04–579.10 | 579.11–819.50 | ≥819.51 | 0.43 |
Cases/controls | 82/59 | 82/61 | 85/59 | 71/60 | |
ORs (95% CI) | 1.00 | 0.83 (0.47–1.46) | 0.91 (0.53–1.56) | 0.74 (0.40–1.35) | |
Vitamin C (mg) | 14.61–113.03 | 113.04–190.25 | 190.26–366.10 | ≥366.11 | 0.42 |
Cases/controls | 98/58 | 78/60 | 80/61 | 62/59 | |
ORs (95% CI) | 1.00 | 0.83 (0.48–1.43) | 0.84 (0.48–1.45) | 0.78 (0.45–1.38) |
Daily intake | Q1 | Q2 | Q3 | Q4 | p Trend |
---|---|---|---|---|---|
Sodium (mg) | 344.61–1484.83 | 1484.84–1898.64 | 1898.65–2372.65 | ≥2372.66 | 0.32 |
Cases/controls | 78/58 | 64/60 | 59/60 | 119/60 | |
ORs (95% CI) | 1.00 | 1.17 (0.61–2.23) | 1.00 (0.48–2.12) | 1.66 (0.70–3.92) | |
Potassium (mg) | 535.63–2382.5 | 2382.6–2874.24 | 2874.25–3781.33 | ≥3781.34 | 0.58 |
Cases/controls | 101/59 | 45/60 | 95/61 | 80/59 | |
ORs (95% CI) | 1.00 | 0.50 (0.27–0.91) | 1.03 (0.53–2.0) | 0.65 (0.29–1.45) | |
Calcium (mg) | 86.63–600.36 | 600.37–918.23 | 918.24–1346.4 | ≥1346.5 | 0.27 |
Cases/controls | 99/59 | 73/60 | 90/59 | 60/60 | |
ORs (95% CI) | 1.00 | 0.60 (0.35–1.05) | 0.88 (0.50–1.53) | 0.60 (0.32–1.13) | |
Magnesium (mg) | 58.76–259.03 | 259.04–328.08 | 328.09–418.58 | ≥418.59 | 0.20 |
Cases/controls | 95/59 | 62/61 | 83/60 | 80/59 | |
ORs (95% CI) | 1.00 | 0.65 (0.36–1.15) | 0.79 (0.43–1.44) | 0.56 (0.27–1.16) | |
Phosphorus (mg) | 177.85–965.2 | 965.3–1195.67 | 1195.68–1556.5 | ≥1556.6 | 0.46 |
Cases/controls | 93/60 | 65/59 | 81/61 | 83/59 | |
ORs (95% CI) | 1.00 | 1.02 (0.55–1.92) | 0.93 (0.44–1.98) | 0.70 (0.28–1.75) | |
Iron (mg) | 2.12–11.25 | 11.26–15.56 | 15.57–23.20 | ≥23.21 | 0.93 |
Cases/controls | 82/59 | 75/60 | 77/60 | 86/60 | |
ORs (95% CI) | 1.00 | 1.04 (0.57–1.90) | 0.92 (0.49–1.73) | 1.06 (0.57–1.96) |
Carotenoids | Vitamin D | Vitamin E | Thiamin | Niacin | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
<12900.6 μg | ≥12900.6 μg | ORs (95% CI) | <388.91 IU | ≥388.91 IU | ORs (95% CI) | <20.7 (mg) | ≥20.7 (mg) | ORs (95% CI) | <2.12 (mg) | ≥2.12 (mg) | ORs (95% CI) | <33.08 (mg) | ≥33.08 (mg) | ORs (95% CI) | |
Cases/controls | Cases/controls | Cases/controls | Cases/controls | Cases/controls | Cases/controls | Cases/controls | Cases/controls | Cases/controls | Cases/controls | ||||||
Smoking status | |||||||||||||||
Never* | 28/43 | 28/52 | 0.66 (0.32–1.35) | 29/54 | 27/41 | 1.04 (0.50–2.15) | 33/51 | 20/42 | 0.64 (0.31–1.33) | 23/50 | 33/44 | 1.35 (0.66–2.77) | 27/53 | 29/41 | 1.10 (0.54–2.26) |
Ever* | 155/76 | 111/68 | 0.75 (0.48–1.17) | 132/65 | 134/79 | 0.82 (0.54–1.24) | 140/64 | 117/73 | 0.73 (0.48–1.13) | 134/70 | 132/74 | 0.91 (0.59–1.39) | 135/66 | 131/77 | 0.80 (0.52–1.23) |
p Interaction | 0.98 | 0.41 | 0.87 | 0.27 | 0.26 | ||||||||||
Cigarettes/day | |||||||||||||||
<20 | 25/30 | 26/23 | 1.65 (0.68–3.99) | 19/26 | 32/27 | 1.58 (0.66–3.79) | 20/27 | 31/23 | 1.57 (0.63–3.88) | 19/28 | 32/25 | 1.85 (0.78–4.41) | 20/27 | 31/25 | 1.64 (0.68–3.95) |
≥20 | 127/44 | 84/44 | 0.62 (0.36–1.09) | 111/38 | 100/50 | 0.73 (0.43–1.23) | 118/36 | 85/48 | 0.58 (0.34–0.99) | 114/41 | 97/47 | 0.78 (0.46–1.34) | 114/38 | 97/50 | 0.66 (0.39–1.14) |
p Interaction | 0.08 | 0.14 | 0.03 | 0.10 | 0.08 | ||||||||||
Years smoking | |||||||||||||||
<27 | 51/38 | 45/34 | 1.19 (0.58–2.47) | 49/32 | 47/40 | 0.78 (0.40–1.52) | 49/36 | 45/32 | 1.08 (0.54–2.16) | 46/30 | 50/42 | 0.71 (0.35–1.43) | 47/30 | 49/41 | 0.70 (0.35–1.41) |
≥27 | 101/37 | 64/33 | 0.62 (0.33–1.16) | 81/32 | 84/38 | 1.00 (0.55–1.81) | 89/27 | 70/40 | 0.61 (0.33–1.12) | 87/39 | 78/31 | 1.41 (0.76–2.59) | 87/35 | 78/35 | 1.02 (0.56–1.85) |
p Interaction | 0.20 | 0.58 | 0.24 | 0.19 | 0.51 | ||||||||||
Age | |||||||||||||||
<63 | 73/59 | 69/54 | 0.91 (0.49–1.68) | 76/69 | 66/44 | 1.55 (0.88–2.74) | 79/61 | 56/47 | 1.12 (0.62–2.01) | 69/65 | 73/47 | 2.02 (1.11–3.68) | 69/63 | 73/48 | 1.59 (0.88–2.87) |
≥63 | 110/60 | 70/66 | 0.59 (0.35–0.99) | 85/50 | 95/76 | 0.65 (0.40–1.08) | 94/54 | 81/68 | 0.61 (0.37–1.02) | 88/55 | 92/71 | 0.75 (0.45–1.24) | 93/56 | 87/70 | 0.64 (0.38–1.07) |
p Interaction | 0.18 | 0.04 | 0.18 | 0.02 | 0.03 |