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Erschienen in: Journal of Cancer Research and Clinical Oncology 8/2019

10.07.2019 | Review – Cancer Research

Models used to screen for the treatment of multidrug resistant cancer facilitated by transporter-based efflux

verfasst von: Clarissa Willers, Hanna Svitina, Michael J. Rossouw, Roan A. Swanepoel, Josias H. Hamman, Chrisna Gouws

Erschienen in: Journal of Cancer Research and Clinical Oncology | Ausgabe 8/2019

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Abstract

Purpose

Efflux transporters of the adenosine triphosphate-binding cassette (ABC)-superfamily play an important role in the development of multidrug resistance (multidrug resistant; MDR) in cancer. The overexpression of these transporters can directly contribute to the failure of chemotherapeutic drugs. Several in vitro and in vivo models exist to screen for the efficacy of chemotherapeutic drugs against MDR cancer, specifically facilitated by efflux transporters.

Results

This article reviews a range of efflux transporter-based MDR models used to test the efficacy of compounds to overcome MDR in cancer. These models are classified as either in vitro or in vivo and are further categorised as the most basic, conventional models or more complex and advanced systems. Each model’s origin, advantages and limitations, as well as specific efflux transporter-based MDR applications are discussed. Accordingly, future modifications to existing models or new research approaches are suggested to develop prototypes that closely resemble the true nature of multidrug resistant cancer in the human body.

Conclusions

It is evident from this review that a combination of both in vitro and in vivo preclinical models can provide a better understanding of cancer itself, than using a single model only. However, there is still a clear lack of progression of these models from basic research to high-throughput clinical practice.
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Metadaten
Titel
Models used to screen for the treatment of multidrug resistant cancer facilitated by transporter-based efflux
verfasst von
Clarissa Willers
Hanna Svitina
Michael J. Rossouw
Roan A. Swanepoel
Josias H. Hamman
Chrisna Gouws
Publikationsdatum
10.07.2019
Verlag
Springer Berlin Heidelberg
Erschienen in
Journal of Cancer Research and Clinical Oncology / Ausgabe 8/2019
Print ISSN: 0171-5216
Elektronische ISSN: 1432-1335
DOI
https://doi.org/10.1007/s00432-019-02973-5

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