Skip to main content
main-content

11.11.2017 | Original Article | Ausgabe 2/2018

International Journal of Public Health 2/2018

Moderate physical activity reduces 10-year diabetes incidence: the mediating role of oxidative stress biomarkers

Zeitschrift:
International Journal of Public Health > Ausgabe 2/2018
Autoren:
Efi Koloverou, Konstantinos Tambalis, Demosthenes B. Panagiotakos, Ekavi Georgousopoulou, Christina Chrysohoou, Ioannis Skoumas, Dimitrios Tousoulis, Christodoulos Stefanadis, Christos Pitsavos, The ATTICA study group
Wichtige Hinweise
Efi Koloverou and Konstantinos Tampalis contributed equally to the manuscript.

Abstract

Objectives

To evaluate the effect of physical activity levels on 10-year diabetes incidence and investigate the potential mechanism.

Methods

In 2001–2002, a random sample of apparently healthy 3042 men and women (18–89 years) was selected to participate in the ATTICA study. Several socio-demographic, clinical and lifestyle characteristics were recorded. Physical activity level was recorded through a translated, validated, version of International Physical Activity Questionnaire (IPAQ); MET min/week was calculated and quartiles constructed. Diabetes diagnosis was defined according to the ADA criteria. During 2011–2012, a 10-year follow-up was performed.

Results

n = 191 cases were recorded, yielding an incidence of 12.9%. In multivariable analysis, moderate physical activity level (331–1484 MET min/week) was found to decrease 10-year diabetes incidence by 53% compared to very low physical activity (< 150 MET min/week) (OR = 0.47; 95% CI 0.24, 0.93). For high physical activity level (> 1484 MET min/week), the results were not significant. The antidiabetic effect was found to be mediated by oxidized LDL and total antioxidant capacity.

Conclusions

The current work revealed the significant beneficial role of moderate physical activity against diabetes development, potentially through attenuating oxidative stress.

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

★ PREMIUM-INHALT
e.Med Interdisziplinär

Mit e.Med Interdisziplinär erhalten Sie Zugang zu allen CME-Fortbildungen und Fachzeitschriften auf SpringerMedizin.de. Zusätzlich können Sie eine Zeitschrift Ihrer Wahl in gedruckter Form beziehen – ohne Aufpreis.

Literatur
Über diesen Artikel

Weitere Artikel der Ausgabe 2/2018

International Journal of Public Health 2/2018 Zur Ausgabe