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Erschienen in: Clinical Reviews in Allergy & Immunology 2-3/2010

01.04.2010

Mold and Human Health: Separating the Wheat from the Chaff

verfasst von: H. David Pettigrew, Carlo F. Selmi, Suzanne S. Teuber, M. Eric Gershwin

Erschienen in: Clinical Reviews in Allergy & Immunology | Ausgabe 2-3/2010

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Abstract

The term “mold” is utilized to define the ubiquitous fungal species commonly found in household dust and observed as visible multicellular filaments. Several well-defined human diseases are known to be caused or exacerbated by mold or by exposure to their byproducts. Among these, a solid connection has been established with infections, allergic bronchopulmonary aspergillosis, allergic fungal rhinosinusitis, hypersensitivity pneumonitis, and asthma. In the past decades, other less-defined and generally false conditions have also been ascribed to mold. We will herein review and critically discuss the available evidence on the influence of mold on human health.
Literatur
1.
Zurück zum Zitat Richard JL (2007) Some major mycotoxins and their mycotoxicoses—an overview. Int J Food Microbiol 119:3–10CrossRefPubMed Richard JL (2007) Some major mycotoxins and their mycotoxicoses—an overview. Int J Food Microbiol 119:3–10CrossRefPubMed
2.
Zurück zum Zitat Boermans HJ, Leung MC (2007) Mycotoxins and the pet food industry: toxicological evidence and risk assessment. Int J Food Microbiol 119:95–102CrossRefPubMed Boermans HJ, Leung MC (2007) Mycotoxins and the pet food industry: toxicological evidence and risk assessment. Int J Food Microbiol 119:95–102CrossRefPubMed
3.
Zurück zum Zitat Stenske KA, Smith JR, Newman SJ, Newman LB, Kirk CA (2006) Aflatoxicosis in dogs and dealing with suspected contaminated commercial foods. J Am Vet Med Assoc 228:1686–1691CrossRefPubMed Stenske KA, Smith JR, Newman SJ, Newman LB, Kirk CA (2006) Aflatoxicosis in dogs and dealing with suspected contaminated commercial foods. J Am Vet Med Assoc 228:1686–1691CrossRefPubMed
4.
Zurück zum Zitat Henghold WB 2nd (2004) Other biologic toxin bioweapons: ricin, staphylococcal enterotoxin B, and trichothecene mycotoxins. Dermatol Clin 22:257–262 vCrossRefPubMed Henghold WB 2nd (2004) Other biologic toxin bioweapons: ricin, staphylococcal enterotoxin B, and trichothecene mycotoxins. Dermatol Clin 22:257–262 vCrossRefPubMed
5.
Zurück zum Zitat Roponen M, Seuri M, Nevalainen A, Hirvonen MR (2002) Fungal spores as such do not cause nasal inflammation in mold exposure. Inhal Toxicol 14:541–549CrossRefPubMed Roponen M, Seuri M, Nevalainen A, Hirvonen MR (2002) Fungal spores as such do not cause nasal inflammation in mold exposure. Inhal Toxicol 14:541–549CrossRefPubMed
6.
Zurück zum Zitat Schleibinger H, Laussmann D, Bornehag CG, Eis D, Rueden H (2008) Microbial volatile organic compounds in the air of moldy and mold-free indoor environments. Indoor Air 18:113–124CrossRefPubMed Schleibinger H, Laussmann D, Bornehag CG, Eis D, Rueden H (2008) Microbial volatile organic compounds in the air of moldy and mold-free indoor environments. Indoor Air 18:113–124CrossRefPubMed
7.
Zurück zum Zitat Hamill R (2001) Infectious Diseases: Mycotic. In: Tierney L, McPhee S, Papadakis M (eds) Current Medical Diagnosis and Treatment 2001. Lange Medical Books/McGraw-Hill, New York, pp 1481–1493 Hamill R (2001) Infectious Diseases: Mycotic. In: Tierney L, McPhee S, Papadakis M (eds) Current Medical Diagnosis and Treatment 2001. Lange Medical Books/McGraw-Hill, New York, pp 1481–1493
8.
Zurück zum Zitat Bush RK, Portnoy JM, Saxon A, Terr AI, Wood RA (2006) The medical effects of mold exposure. J Allergy Clin Immunol 117:326–333CrossRefPubMed Bush RK, Portnoy JM, Saxon A, Terr AI, Wood RA (2006) The medical effects of mold exposure. J Allergy Clin Immunol 117:326–333CrossRefPubMed
10.
Zurück zum Zitat Greenberger PA (2002) Allergic bronchopulmonary aspergillosis. J Allergy Clin Immunol 110:685–692CrossRefPubMed Greenberger PA (2002) Allergic bronchopulmonary aspergillosis. J Allergy Clin Immunol 110:685–692CrossRefPubMed
11.
Zurück zum Zitat Greenberger PA, Patterson R (1988) Allergic bronchopulmonary aspergillosis and the evaluation of the patient with asthma. J Allergy Clin Immunol 81:646–650CrossRefPubMed Greenberger PA, Patterson R (1988) Allergic bronchopulmonary aspergillosis and the evaluation of the patient with asthma. J Allergy Clin Immunol 81:646–650CrossRefPubMed
12.
Zurück zum Zitat Seltzer JM, Fedoruk MJ (2007) Health effects of mold in children. Pediatr Clin North Am 54:309–333 viii-ixCrossRefPubMed Seltzer JM, Fedoruk MJ (2007) Health effects of mold in children. Pediatr Clin North Am 54:309–333 viii-ixCrossRefPubMed
13.
Zurück zum Zitat Rosenberg M, Patterson R, Mintzer R, Cooper BJ, Roberts M, Harris KE (1977) Clinical and immunologic criteria for the diagnosis of allergic bronchopulmonary aspergillosis. Ann Intern Med 86:405–414PubMed Rosenberg M, Patterson R, Mintzer R, Cooper BJ, Roberts M, Harris KE (1977) Clinical and immunologic criteria for the diagnosis of allergic bronchopulmonary aspergillosis. Ann Intern Med 86:405–414PubMed
14.
Zurück zum Zitat Luong A, Marple B (2005) The role of fungi in chronic rhinosinusitis. Otolaryngol Clin North Am 38:1203–1213CrossRefPubMed Luong A, Marple B (2005) The role of fungi in chronic rhinosinusitis. Otolaryngol Clin North Am 38:1203–1213CrossRefPubMed
15.
Zurück zum Zitat Luong A, Marple BF (2004) Allergic fungal rhinosinusitis. Curr Allergy Asthma Rep 4:465–470CrossRefPubMed Luong A, Marple BF (2004) Allergic fungal rhinosinusitis. Curr Allergy Asthma Rep 4:465–470CrossRefPubMed
16.
Zurück zum Zitat Ryan MW, Marple BF (2007) Allergic fungal rhinosinusitis: diagnosis and management. Curr Opin Otolaryngol Head Neck Surg 15:18–22CrossRefPubMed Ryan MW, Marple BF (2007) Allergic fungal rhinosinusitis: diagnosis and management. Curr Opin Otolaryngol Head Neck Surg 15:18–22CrossRefPubMed
17.
Zurück zum Zitat Manning SC, Holman M (1998) Further evidence for allergic pathophysiology in allergic fungal sinusitis. Laryngoscope 108:1485–1496CrossRefPubMed Manning SC, Holman M (1998) Further evidence for allergic pathophysiology in allergic fungal sinusitis. Laryngoscope 108:1485–1496CrossRefPubMed
18.
Zurück zum Zitat Bent JP 3rd, Kuhn FA (1994) Diagnosis of allergic fungal sinusitis. Otolaryngol Head Neck Surg 111:580–588CrossRefPubMed Bent JP 3rd, Kuhn FA (1994) Diagnosis of allergic fungal sinusitis. Otolaryngol Head Neck Surg 111:580–588CrossRefPubMed
19.
Zurück zum Zitat Ebbens FA, Fokkens WJ (2008) The mold conundrum in chronic rhinosinusitis: where do we stand today? Curr Allergy Asthma Rep 8:93–101CrossRefPubMed Ebbens FA, Fokkens WJ (2008) The mold conundrum in chronic rhinosinusitis: where do we stand today? Curr Allergy Asthma Rep 8:93–101CrossRefPubMed
20.
Zurück zum Zitat Ebbens FA, Georgalas C, Fokkens WJ (2009) Fungus as the cause of chronic rhinosinusitis: the case remains unproven. Curr Opin Otolaryngol Head Neck Surg 17:43–49CrossRefPubMed Ebbens FA, Georgalas C, Fokkens WJ (2009) Fungus as the cause of chronic rhinosinusitis: the case remains unproven. Curr Opin Otolaryngol Head Neck Surg 17:43–49CrossRefPubMed
21.
Zurück zum Zitat Ebbens FA, Scadding GK, Badia L, Hellings PW, Jorissen M, Mullol J, Cardesin A, Bachert C, van Zele TP, Dijkgraaf MG, Lund V, Fokkens WJ (2006) Amphotericin B nasal lavages: not a solution for patients with chronic rhinosinusitis. J Allergy Clin Immunol 118:1149–1156CrossRefPubMed Ebbens FA, Scadding GK, Badia L, Hellings PW, Jorissen M, Mullol J, Cardesin A, Bachert C, van Zele TP, Dijkgraaf MG, Lund V, Fokkens WJ (2006) Amphotericin B nasal lavages: not a solution for patients with chronic rhinosinusitis. J Allergy Clin Immunol 118:1149–1156CrossRefPubMed
22.
Zurück zum Zitat Kennedy DW, Kuhn FA, Hamilos DL, Zinreich SJ, Butler D, Warsi G, Pfister PJ, Tavakkol A (2005) Treatment of chronic rhinosinusitis with high-dose oral terbinafine: a double blind, placebo-controlled study. Laryngoscope 115:1793–1799CrossRefPubMed Kennedy DW, Kuhn FA, Hamilos DL, Zinreich SJ, Butler D, Warsi G, Pfister PJ, Tavakkol A (2005) Treatment of chronic rhinosinusitis with high-dose oral terbinafine: a double blind, placebo-controlled study. Laryngoscope 115:1793–1799CrossRefPubMed
23.
Zurück zum Zitat Weschta M, Rimek D, Formanek M, Polzehl D, Podbielski A, Riechelmann H (2004) Topical antifungal treatment of chronic rhinosinusitis with nasal polyps: a randomized, double-blind clinical trial. J Allergy Clin Immunol 113:1122–1128CrossRefPubMed Weschta M, Rimek D, Formanek M, Polzehl D, Podbielski A, Riechelmann H (2004) Topical antifungal treatment of chronic rhinosinusitis with nasal polyps: a randomized, double-blind clinical trial. J Allergy Clin Immunol 113:1122–1128CrossRefPubMed
24.
25.
Zurück zum Zitat Kurup VP, Zacharisen MC, Fink JN (2006) Hypersensitivity pneumonitis. Indian J Chest Dis Allied Sci 48:115–128PubMed Kurup VP, Zacharisen MC, Fink JN (2006) Hypersensitivity pneumonitis. Indian J Chest Dis Allied Sci 48:115–128PubMed
26.
Zurück zum Zitat Baur X (1995) Hypersensitivity pneumonitis (extrinsic allergic alveolitis) induced by isocyanates. J Allergy Clin Immunol 95:1004–1010CrossRefPubMed Baur X (1995) Hypersensitivity pneumonitis (extrinsic allergic alveolitis) induced by isocyanates. J Allergy Clin Immunol 95:1004–1010CrossRefPubMed
27.
Zurück zum Zitat Yoshizawa Y, Ohtsuka M, Noguchi K, Uchida Y, Suko M, Hasegawa S (1989) Hypersensitivity pneumonitis induced by toluene diisocyanate: sequelae of continuous exposure. Ann Intern Med 110:31–34PubMed Yoshizawa Y, Ohtsuka M, Noguchi K, Uchida Y, Suko M, Hasegawa S (1989) Hypersensitivity pneumonitis induced by toluene diisocyanate: sequelae of continuous exposure. Ann Intern Med 110:31–34PubMed
28.
Zurück zum Zitat Harrison LC, Honeyman MC, Morahan G, Wentworth JM, Elkassaby S, Colman PG, Fourlanos S (2008) Type 1 diabetes: lessons for other autoimmune diseases? J Autoimmun 31:306–310CrossRefPubMed Harrison LC, Honeyman MC, Morahan G, Wentworth JM, Elkassaby S, Colman PG, Fourlanos S (2008) Type 1 diabetes: lessons for other autoimmune diseases? J Autoimmun 31:306–310CrossRefPubMed
29.
Zurück zum Zitat Rieger R, Gershwin ME (2007) The X and why of xenobiotics in primary biliary cirrhosis. J Autoimmun 28:76–84CrossRefPubMed Rieger R, Gershwin ME (2007) The X and why of xenobiotics in primary biliary cirrhosis. J Autoimmun 28:76–84CrossRefPubMed
30.
Zurück zum Zitat Richerson HB, Bernstein IL, Fink JN, Hunninghake GW, Novey HS, Reed CE, Salvaggio JE, Schuyler MR, Schwartz HJ, Schwartz HJ, Stechschulte DJ (1989) Guidelines for the clinical evaluation of hypersensitivity pneumonitis. Report of the Subcommittee on Hypersensitivity Pneumonitis. J Allergy Clin Immunol 84:839–844CrossRefPubMed Richerson HB, Bernstein IL, Fink JN, Hunninghake GW, Novey HS, Reed CE, Salvaggio JE, Schuyler MR, Schwartz HJ, Schwartz HJ, Stechschulte DJ (1989) Guidelines for the clinical evaluation of hypersensitivity pneumonitis. Report of the Subcommittee on Hypersensitivity Pneumonitis. J Allergy Clin Immunol 84:839–844CrossRefPubMed
31.
Zurück zum Zitat Monkare S, Haahtela T (1987) Farmer’s lung—a 5-year follow-up of eighty-six patients. Clin Allergy 17:143–151CrossRefPubMed Monkare S, Haahtela T (1987) Farmer’s lung—a 5-year follow-up of eighty-six patients. Clin Allergy 17:143–151CrossRefPubMed
32.
Zurück zum Zitat Delfino RJ, Zeiger RS, Seltzer JM, Street DH, Matteucci RM, Anderson PR, Koutrakis P (1997) The effect of outdoor fungal spore concentrations on daily asthma severity. Environ Health Perspect 105:622–635CrossRefPubMed Delfino RJ, Zeiger RS, Seltzer JM, Street DH, Matteucci RM, Anderson PR, Koutrakis P (1997) The effect of outdoor fungal spore concentrations on daily asthma severity. Environ Health Perspect 105:622–635CrossRefPubMed
33.
Zurück zum Zitat Black PN, Udy AA, Brodie SM (2000) Sensitivity to fungal allergens is a risk factor for life-threatening asthma. Allergy 55:501–504CrossRefPubMed Black PN, Udy AA, Brodie SM (2000) Sensitivity to fungal allergens is a risk factor for life-threatening asthma. Allergy 55:501–504CrossRefPubMed
34.
35.
Zurück zum Zitat O’Driscoll BR, Hopkinson LC, Denning DW (2005) Mold sensitization is common amongst patients with severe asthma requiring multiple hospital admissions. BMC Pulm Med 5:4CrossRefPubMed O’Driscoll BR, Hopkinson LC, Denning DW (2005) Mold sensitization is common amongst patients with severe asthma requiring multiple hospital admissions. BMC Pulm Med 5:4CrossRefPubMed
36.
Zurück zum Zitat Pulimood TB, Corden JM, Bryden C, Sharples L, Nasser SM (2007) Epidemic asthma and the role of the fungal mold Alternaria alternata. J Allergy Clin Immunol 120:610–617CrossRefPubMed Pulimood TB, Corden JM, Bryden C, Sharples L, Nasser SM (2007) Epidemic asthma and the role of the fungal mold Alternaria alternata. J Allergy Clin Immunol 120:610–617CrossRefPubMed
37.
Zurück zum Zitat Denning DW, O’Driscoll BR, Hogaboam CM, Bowyer P, Niven RM (2006) The link between fungi and severe asthma: a summary of the evidence. Eur Respir J 27:615–626CrossRefPubMed Denning DW, O’Driscoll BR, Hogaboam CM, Bowyer P, Niven RM (2006) The link between fungi and severe asthma: a summary of the evidence. Eur Respir J 27:615–626CrossRefPubMed
38.
Zurück zum Zitat Neukirch C, Henry C, Leynaert B, Liard R, Bousquet J, Neukirch F (1999) Is sensitization to Alternaria alternata a risk factor for severe asthma? A population-based study. J Allergy Clin Immunol 103:709–711CrossRefPubMed Neukirch C, Henry C, Leynaert B, Liard R, Bousquet J, Neukirch F (1999) Is sensitization to Alternaria alternata a risk factor for severe asthma? A population-based study. J Allergy Clin Immunol 103:709–711CrossRefPubMed
39.
Zurück zum Zitat Niedoszytko M, Chelminska M, Jassem E, Czestochowska E (2007) Association between sensitization to Aureobasidium pullulans (Pullularia sp) and severity of asthma. Ann Allergy Asthma Immunol 98:153–156CrossRefPubMed Niedoszytko M, Chelminska M, Jassem E, Czestochowska E (2007) Association between sensitization to Aureobasidium pullulans (Pullularia sp) and severity of asthma. Ann Allergy Asthma Immunol 98:153–156CrossRefPubMed
40.
Zurück zum Zitat Simon-Nobbe B, Denk U, Poll V, Rid R, Breitenbach M (2008) The spectrum of fungal allergy. Int Arch Allergy Immunol 145:58–86CrossRefPubMed Simon-Nobbe B, Denk U, Poll V, Rid R, Breitenbach M (2008) The spectrum of fungal allergy. Int Arch Allergy Immunol 145:58–86CrossRefPubMed
41.
Zurück zum Zitat Dales RE, Cakmak S, Judek S, Dann T, Coates F, Brook JR, Burnett RT (2003) The role of fungal spores in thunderstorm asthma. Chest 123:745–750CrossRefPubMed Dales RE, Cakmak S, Judek S, Dann T, Coates F, Brook JR, Burnett RT (2003) The role of fungal spores in thunderstorm asthma. Chest 123:745–750CrossRefPubMed
42.
Zurück zum Zitat Belanger K, Beckett W, Triche E, Bracken MB, Holford T, Ren P, McSharry JE, Gold DR, Platts-Mills TA, Leaderer BP (2003) Symptoms of wheeze and persistent cough in the first year of life: associations with indoor allergens, air contaminants, and maternal history of asthma. Am J Epidemiol 158:195–202CrossRefPubMed Belanger K, Beckett W, Triche E, Bracken MB, Holford T, Ren P, McSharry JE, Gold DR, Platts-Mills TA, Leaderer BP (2003) Symptoms of wheeze and persistent cough in the first year of life: associations with indoor allergens, air contaminants, and maternal history of asthma. Am J Epidemiol 158:195–202CrossRefPubMed
43.
Zurück zum Zitat Gent JF, Ren P, Belanger K, Triche E, Bracken MB, Holford TR, Leaderer BP (2002) Levels of household mold associated with respiratory symptoms in the first year of life in a cohort at risk for asthma. Environ Health Perspect 110:A781–786PubMed Gent JF, Ren P, Belanger K, Triche E, Bracken MB, Holford TR, Leaderer BP (2002) Levels of household mold associated with respiratory symptoms in the first year of life in a cohort at risk for asthma. Environ Health Perspect 110:A781–786PubMed
44.
Zurück zum Zitat Andersson M, Downs S, Mitakakis T, Leuppi J, Marks G (2003) Natural exposure to Alternaria spores induces allergic rhinitis symptoms in sensitized children. Pediatr Allergy Immunol 14:100–105CrossRefPubMed Andersson M, Downs S, Mitakakis T, Leuppi J, Marks G (2003) Natural exposure to Alternaria spores induces allergic rhinitis symptoms in sensitized children. Pediatr Allergy Immunol 14:100–105CrossRefPubMed
45.
Zurück zum Zitat Gergen PJ, Turkeltaub PC (1992) The association of individual allergen reactivity with respiratory disease in a national sample: data from the second National Health and Nutrition Examination Survey, 1976–80 (NHANES II). J Allergy Clin Immunol 90:579–588CrossRefPubMed Gergen PJ, Turkeltaub PC (1992) The association of individual allergen reactivity with respiratory disease in a national sample: data from the second National Health and Nutrition Examination Survey, 1976–80 (NHANES II). J Allergy Clin Immunol 90:579–588CrossRefPubMed
46.
Zurück zum Zitat Helbling A, Gayer F, Pichler WJ, Brander KA (1998) Mushroom (Basidiomycete) allergy: diagnosis established by skin test and nasal challenge. J Allergy Clin Immunol 102:853–858CrossRefPubMed Helbling A, Gayer F, Pichler WJ, Brander KA (1998) Mushroom (Basidiomycete) allergy: diagnosis established by skin test and nasal challenge. J Allergy Clin Immunol 102:853–858CrossRefPubMed
47.
Zurück zum Zitat Rowe MS, Bailey J, Ownby DR (1986) Evaluation of the cause of nasal and ocular symptoms associated with lawn mowing. J Allergy Clin Immunol 77:714–719CrossRefPubMed Rowe MS, Bailey J, Ownby DR (1986) Evaluation of the cause of nasal and ocular symptoms associated with lawn mowing. J Allergy Clin Immunol 77:714–719CrossRefPubMed
48.
Zurück zum Zitat Katz Y, Verleger H, Barr J, Rachmiel M, Kiviti S, Kuttin ES (1999) Indoor survey of moulds and prevalence of mould atopy in Israel. Clin Exp Allergy 29:186–192CrossRefPubMed Katz Y, Verleger H, Barr J, Rachmiel M, Kiviti S, Kuttin ES (1999) Indoor survey of moulds and prevalence of mould atopy in Israel. Clin Exp Allergy 29:186–192CrossRefPubMed
49.
Zurück zum Zitat Lander F, Meyer HW, Norn S (2001) Serum IgE specific to indoor moulds, measured by basophil histamine release, is associated with building-related symptoms in damp buildings. Inflamm Res 50:227–231CrossRefPubMed Lander F, Meyer HW, Norn S (2001) Serum IgE specific to indoor moulds, measured by basophil histamine release, is associated with building-related symptoms in damp buildings. Inflamm Res 50:227–231CrossRefPubMed
50.
Zurück zum Zitat Montealegre F, Meyer B, Chardon D, Vargas W, Zavala D, Hart B, Bayona M (2004) Comparative prevalence of sensitization to common animal, plant and mould allergens in subjects with asthma, or atopic dermatitis and/or allergic rhinitis living in a tropical environment. Clin Exp Allergy 34:51–58CrossRefPubMed Montealegre F, Meyer B, Chardon D, Vargas W, Zavala D, Hart B, Bayona M (2004) Comparative prevalence of sensitization to common animal, plant and mould allergens in subjects with asthma, or atopic dermatitis and/or allergic rhinitis living in a tropical environment. Clin Exp Allergy 34:51–58CrossRefPubMed
51.
Zurück zum Zitat Reijula K, Leino M, Mussalo-Rauhamaa H, Nikulin M, Alenius H, Mikkola J, Elg P, Kari O, Makinen-Kiljunen S, Haahtela T (2003) IgE-mediated allergy to fungal allergens in Finland with special reference to Alternaria alternata and Cladosporium herbarum. Ann Allergy Asthma Immunol 91:280–287CrossRefPubMed Reijula K, Leino M, Mussalo-Rauhamaa H, Nikulin M, Alenius H, Mikkola J, Elg P, Kari O, Makinen-Kiljunen S, Haahtela T (2003) IgE-mediated allergy to fungal allergens in Finland with special reference to Alternaria alternata and Cladosporium herbarum. Ann Allergy Asthma Immunol 91:280–287CrossRefPubMed
52.
Zurück zum Zitat Scalabrin DM, Bavbek S, Perzanowski MS, Wilson BB, Platts-Mills TA, Wheatley LM (1999) Use of specific IgE in assessing the relevance of fungal and dust mite allergens to atopic dermatitis: a comparison with asthmatic and nonasthmatic control subjects. J Allergy Clin Immunol 104:1273–1279CrossRefPubMed Scalabrin DM, Bavbek S, Perzanowski MS, Wilson BB, Platts-Mills TA, Wheatley LM (1999) Use of specific IgE in assessing the relevance of fungal and dust mite allergens to atopic dermatitis: a comparison with asthmatic and nonasthmatic control subjects. J Allergy Clin Immunol 104:1273–1279CrossRefPubMed
53.
Zurück zum Zitat Boguniewicz M, Schmid-Grendelmeier P, Leung DY (2006) Atopic dermatitis. J Allergy Clin Immunol 118:40–43CrossRefPubMed Boguniewicz M, Schmid-Grendelmeier P, Leung DY (2006) Atopic dermatitis. J Allergy Clin Immunol 118:40–43CrossRefPubMed
54.
Zurück zum Zitat Leung DY (2000) Atopic dermatitis: new insights and opportunities for therapeutic intervention. J Allergy Clin Immunol 105:860–876CrossRefPubMed Leung DY (2000) Atopic dermatitis: new insights and opportunities for therapeutic intervention. J Allergy Clin Immunol 105:860–876CrossRefPubMed
55.
Zurück zum Zitat Casagrande BF, Fluckiger S, Linder MT, Johansson C, Scheynius A, Crameri R, Schmid-Grendelmeier P (2006) Sensitization to the yeast Malassezia sympodialis is specific for extrinsic and intrinsic atopic eczema. J Invest Dermatol 126:2414–2421CrossRefPubMed Casagrande BF, Fluckiger S, Linder MT, Johansson C, Scheynius A, Crameri R, Schmid-Grendelmeier P (2006) Sensitization to the yeast Malassezia sympodialis is specific for extrinsic and intrinsic atopic eczema. J Invest Dermatol 126:2414–2421CrossRefPubMed
56.
Zurück zum Zitat Johansson C, Sandstrom MH, Bartosik J, Sarnhult T, Christiansen J, Zargari A, Back O, Wahlgren CF, Faergemann J, Scheynius A, Tengvall Linder M (2003) Atopy patch test reactions to Malassezia allergens differentiate subgroups of atopic dermatitis patients. Br J Dermatol 148:479–488CrossRefPubMed Johansson C, Sandstrom MH, Bartosik J, Sarnhult T, Christiansen J, Zargari A, Back O, Wahlgren CF, Faergemann J, Scheynius A, Tengvall Linder M (2003) Atopy patch test reactions to Malassezia allergens differentiate subgroups of atopic dermatitis patients. Br J Dermatol 148:479–488CrossRefPubMed
57.
Zurück zum Zitat Zargari A, Eshaghi H, Back O, Johansson S, Scheynius A (2001) Serum IgE reactivity to Malassezia furfur extract and recombinant M. furfur allergens in patients with atopic dermatitis. Acta Derm Venereol 81:418–422CrossRefPubMed Zargari A, Eshaghi H, Back O, Johansson S, Scheynius A (2001) Serum IgE reactivity to Malassezia furfur extract and recombinant M. furfur allergens in patients with atopic dermatitis. Acta Derm Venereol 81:418–422CrossRefPubMed
58.
Zurück zum Zitat Elagin RB, Balijepalli S, Diacovo MJ, Baekkeskov S, Jaume JC (2009) Homing of GAD65 specific autoimmunity and development of insulitis requires expression of both DQ8 and human GAD65 in transgenic mice. J Autoimmun 33:50–57CrossRefPubMed Elagin RB, Balijepalli S, Diacovo MJ, Baekkeskov S, Jaume JC (2009) Homing of GAD65 specific autoimmunity and development of insulitis requires expression of both DQ8 and human GAD65 in transgenic mice. J Autoimmun 33:50–57CrossRefPubMed
59.
Zurück zum Zitat Gebe JA, Unrath KA, Yue BB, Miyake T, Falk BA, Nepom GT (2008) Autoreactive human T-cell receptor initiates insulitis and impaired glucose tolerance in HLA DR4 transgenic mice. J Autoimmun 30:197–206CrossRefPubMed Gebe JA, Unrath KA, Yue BB, Miyake T, Falk BA, Nepom GT (2008) Autoreactive human T-cell receptor initiates insulitis and impaired glucose tolerance in HLA DR4 transgenic mice. J Autoimmun 30:197–206CrossRefPubMed
60.
Zurück zum Zitat Hogan TV, Ang DK, Gleeson PA, van Driel IR (2008) Extrathymic mechanisms of T cell tolerance: lessons from autoimmune gastritis. J Autoimmun 31:268–273CrossRefPubMed Hogan TV, Ang DK, Gleeson PA, van Driel IR (2008) Extrathymic mechanisms of T cell tolerance: lessons from autoimmune gastritis. J Autoimmun 31:268–273CrossRefPubMed
61.
Zurück zum Zitat Jordan MA, Baxter AG (2008) The genetics of immunoregulatory T cells. J Autoimmun 31:237–244CrossRefPubMed Jordan MA, Baxter AG (2008) The genetics of immunoregulatory T cells. J Autoimmun 31:237–244CrossRefPubMed
62.
Zurück zum Zitat Maverakis E, Beech JT, Schneider S, Sercarz EE (2008) Presentation of a determinant by MHC class II can be prevented through competitive capture by a flanking determinant on a multideterminant peptide. J Autoimmun 31:59–65CrossRefPubMed Maverakis E, Beech JT, Schneider S, Sercarz EE (2008) Presentation of a determinant by MHC class II can be prevented through competitive capture by a flanking determinant on a multideterminant peptide. J Autoimmun 31:59–65CrossRefPubMed
63.
Zurück zum Zitat Morahan G, Peeva V, Mehta M, Williams R (2008) Systems genetics can provide new insights in to immune regulation and autoimmunity. J Autoimmun 31:233–236CrossRefPubMed Morahan G, Peeva V, Mehta M, Williams R (2008) Systems genetics can provide new insights in to immune regulation and autoimmunity. J Autoimmun 31:233–236CrossRefPubMed
64.
Zurück zum Zitat Pai S, Thomas R (2008) Immune deficiency or hyperactivity-Nf-kappab illuminates autoimmunity. J Autoimmun 31:245–251CrossRefPubMed Pai S, Thomas R (2008) Immune deficiency or hyperactivity-Nf-kappab illuminates autoimmunity. J Autoimmun 31:245–251CrossRefPubMed
65.
Zurück zum Zitat Papadimitraki ED, Bertsias GK, Boumpas DT (2007) Toll like receptors and autoimmunity: a critical appraisal. J Autoimmun 29:310–318PubMed Papadimitraki ED, Bertsias GK, Boumpas DT (2007) Toll like receptors and autoimmunity: a critical appraisal. J Autoimmun 29:310–318PubMed
66.
Zurück zum Zitat Poletaev AB, Stepanyuk VL, Gershwin ME (2008) Integrating immunity: the immunculus and self-reactivity. J Autoimmun 30:68–73CrossRefPubMed Poletaev AB, Stepanyuk VL, Gershwin ME (2008) Integrating immunity: the immunculus and self-reactivity. J Autoimmun 30:68–73CrossRefPubMed
67.
Zurück zum Zitat Sanchez-Pernaute O, Ospelt C, Neidhart M, Gay S (2008) Epigenetic clues to rheumatoid arthritis. J Autoimmun 30:12–20CrossRefPubMed Sanchez-Pernaute O, Ospelt C, Neidhart M, Gay S (2008) Epigenetic clues to rheumatoid arthritis. J Autoimmun 30:12–20CrossRefPubMed
68.
Zurück zum Zitat Youinou P, Jamin C (2009) The weight of interleukin-6 in B cell-related autoimmune disorders. J Autoimmun 32:206–210CrossRefPubMed Youinou P, Jamin C (2009) The weight of interleukin-6 in B cell-related autoimmune disorders. J Autoimmun 32:206–210CrossRefPubMed
69.
70.
71.
Zurück zum Zitat Tsai YJ, Gershwin ME (2002) The sick building syndrome: what is it when it is? Compr Ther 28:140–144CrossRefPubMed Tsai YJ, Gershwin ME (2002) The sick building syndrome: what is it when it is? Compr Ther 28:140–144CrossRefPubMed
72.
73.
Zurück zum Zitat Terr AI (2001) Stachybotrys: relevance to human disease. Ann Allergy Asthma Immunol 87:57–63CrossRefPubMed Terr AI (2001) Stachybotrys: relevance to human disease. Ann Allergy Asthma Immunol 87:57–63CrossRefPubMed
74.
Zurück zum Zitat Fatal fungus. (1998), Environ Health Perspect 106, A11-12. Fatal fungus. (1998), Environ Health Perspect 106, A11-12.
75.
Zurück zum Zitat Pestka JJ, Yike I, Dearborn DG, Ward MD, Harkema JR (2008) Stachybotrys chartarum, trichothecene mycotoxins, and damp building-related illness: new insights into a public health enigma. Toxicol Sci 104:4–26CrossRefPubMed Pestka JJ, Yike I, Dearborn DG, Ward MD, Harkema JR (2008) Stachybotrys chartarum, trichothecene mycotoxins, and damp building-related illness: new insights into a public health enigma. Toxicol Sci 104:4–26CrossRefPubMed
76.
Zurück zum Zitat Johanning E, Biagini R, Hull D, Morey P, Jarvis B, Landsbergis P (1996) Health and immunology study following exposure to toxigenic fungi (Stachybotrys chartarum) in a water-damaged office environment. Int Arch Occup Environ Health 68:207–218PubMed Johanning E, Biagini R, Hull D, Morey P, Jarvis B, Landsbergis P (1996) Health and immunology study following exposure to toxigenic fungi (Stachybotrys chartarum) in a water-damaged office environment. Int Arch Occup Environ Health 68:207–218PubMed
77.
Zurück zum Zitat Hodgson MJ, Morey P, Leung WY, Morrow L, Miller D, Jarvis BB, Robbins H, Halsey JF, Storey E (1998) Building-associated pulmonary disease from exposure to Stachybotrys chartarum and Aspergillus versicolor. J Occup Environ Med 40:241–249CrossRefPubMed Hodgson MJ, Morey P, Leung WY, Morrow L, Miller D, Jarvis BB, Robbins H, Halsey JF, Storey E (1998) Building-associated pulmonary disease from exposure to Stachybotrys chartarum and Aspergillus versicolor. J Occup Environ Med 40:241–249CrossRefPubMed
78.
Zurück zum Zitat Nordness ME, Zacharisen MC, Fink JN (2003) Toxic and other non-IgE-mediated effects of fungal exposures. Curr Allergy Asthma Rep 3:438–446CrossRefPubMed Nordness ME, Zacharisen MC, Fink JN (2003) Toxic and other non-IgE-mediated effects of fungal exposures. Curr Allergy Asthma Rep 3:438–446CrossRefPubMed
79.
Zurück zum Zitat Edmondson DA, Nordness ME, Zacharisen MC, Kurup VP, Fink JN (2005) Allergy and “toxic mold syndrome”. Ann Allergy Asthma Immunol 94:234–239CrossRefPubMed Edmondson DA, Nordness ME, Zacharisen MC, Kurup VP, Fink JN (2005) Allergy and “toxic mold syndrome”. Ann Allergy Asthma Immunol 94:234–239CrossRefPubMed
80.
Zurück zum Zitat Borchers AT, Chang C, Keen CL, Gershwin ME (2006) Airborne environmental injuries and human health. Clin Rev Allergy Immunol 31:1–101CrossRefPubMed Borchers AT, Chang C, Keen CL, Gershwin ME (2006) Airborne environmental injuries and human health. Clin Rev Allergy Immunol 31:1–101CrossRefPubMed
81.
Zurück zum Zitat Acute pulmonary hemorrhage/hemosiderosis among infants—Cleveland, January 1993-November 1994. (1994), MMWR Morb Mortal Wkly Rep 43, 881-883 Acute pulmonary hemorrhage/hemosiderosis among infants—Cleveland, January 1993-November 1994. (1994), MMWR Morb Mortal Wkly Rep 43, 881-883
82.
Zurück zum Zitat Update: pulmonary hemorrhage/hemosiderosis among infants—Cleveland, Ohio, 1993-1996. (1997), MMWR Morb Mortal Wkly Rep 46, 33-35 Update: pulmonary hemorrhage/hemosiderosis among infants—Cleveland, Ohio, 1993-1996. (1997), MMWR Morb Mortal Wkly Rep 46, 33-35
83.
Zurück zum Zitat Etzel RA, Montana E, Sorenson WG, Kullman GJ, Allan TM, Dearborn DG, Olson DR, Jarvis BB, Miller JD (1998) Acute pulmonary hemorrhage in infants associated with exposure to Stachybotrys atra and other fungi. Arch Pediatr Adolesc Med 152:757–762PubMed Etzel RA, Montana E, Sorenson WG, Kullman GJ, Allan TM, Dearborn DG, Olson DR, Jarvis BB, Miller JD (1998) Acute pulmonary hemorrhage in infants associated with exposure to Stachybotrys atra and other fungi. Arch Pediatr Adolesc Med 152:757–762PubMed
84.
Zurück zum Zitat Dearborn DG, Yike I, Sorenson WG, Miller MJ, Etzel RA (1999) Overview of investigations into pulmonary hemorrhage among infants in Cleveland, Ohio. Environ Health Perspect 107(Suppl 3):495–499PubMed Dearborn DG, Yike I, Sorenson WG, Miller MJ, Etzel RA (1999) Overview of investigations into pulmonary hemorrhage among infants in Cleveland, Ohio. Environ Health Perspect 107(Suppl 3):495–499PubMed
85.
Zurück zum Zitat From the Centers for Disease Control and Prevention. Update: pulmonary hemorrhage/hemosiderosis among infants—Cleveland, Ohio, 1993–1996. (2000), JAMA 283, 1951–1953 From the Centers for Disease Control and Prevention. Update: pulmonary hemorrhage/hemosiderosis among infants—Cleveland, Ohio, 1993–1996. (2000), JAMA 283, 1951–1953
86.
Zurück zum Zitat Chapman JA, Terr AI, Jacobs RL, Charlesworth EN, Bardana EJ Jr (2003) Toxic mold: phantom risk vs science. Ann Allergy Asthma Immunol 91:222–232CrossRefPubMed Chapman JA, Terr AI, Jacobs RL, Charlesworth EN, Bardana EJ Jr (2003) Toxic mold: phantom risk vs science. Ann Allergy Asthma Immunol 91:222–232CrossRefPubMed
87.
Zurück zum Zitat Babcock DW (2006) The legal implications of “toxic” mold exposure. J Environ Health 68:50–51PubMed Babcock DW (2006) The legal implications of “toxic” mold exposure. J Environ Health 68:50–51PubMed
Metadaten
Titel
Mold and Human Health: Separating the Wheat from the Chaff
verfasst von
H. David Pettigrew
Carlo F. Selmi
Suzanne S. Teuber
M. Eric Gershwin
Publikationsdatum
01.04.2010
Verlag
Humana Press Inc
Erschienen in
Clinical Reviews in Allergy & Immunology / Ausgabe 2-3/2010
Print ISSN: 1080-0549
Elektronische ISSN: 1559-0267
DOI
https://doi.org/10.1007/s12016-009-8175-5

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