nach oben

Breast Cancer Research

Erschienen in:

01.12.2000 | Review

Molecular biology of breast cancer metastasis Clinical implications of experimental studies on metastatic inefficiency

verfasst von: Ann F Chambers, George N Naumov, Sharon A Vantyghem, Alan B Tuck

Erschienen in: Breast Cancer Research | Ausgabe 6/2000

Einloggen, um Zugang zu erhalten

Abstract

Recent technological advances have led to an increasing ability to detect isolated tumour cells and groups of tumour cells in patients' blood, lymph nodes or bone marrow. However, the clinical significance of these cells is unclear. Should they be considered as evidence of metastasis, necessitating aggressive treatment, or are they in some cases unrelated to clinical outcome? Quantitative experimental studies on the basic biology of metastatic inefficiency are providing clues that may help in understanding the significance of these cells. This understanding will be of use in guiding clinical studies to assess the significance of isolated tumour cells and micrometastases in cancer patients.

Pisani P, Parkin DM, Bray F, Ferlay J: Estimates of the worldwide mortality from 25 cancers in 1990. Int J Cancer. 1999, 83: 18-29. 10.1002/(SICI)1097-0215(1999)83:12+<18::AID-IJC5>3.0.CO;2-L.CrossRefPubMed

Pisani P, Parkin DM, Bray F, Ferlay J: Erratum: estimates of the worldwide mortality from 25 cancers in 1990. Int J Cancer. 1999, 83: 870-873. 10.1002/(SICI)1097-0215(19991210)83:6<870::AID-IJC35>3.0.CO;2-9.CrossRefPubMed

Funke I, Schraut W: Meta-analyses of studies on bone marrow micrometastases: an independent prognostic impact remains to be substantiated. J Clin Oncol. 1998, 16: 557-566., This is an important meta-analysis of the literature to date on the prognostic significance of isolated tumour cells in bone marrowPubMed

Page DL, Anderson TJ, Carter BA: Minimal solid tumor involvement of regional and distant sites: when is a metastasis not a metastasis? [editorial]. Cancer. 1999, 86: 2589-2592. 10.1002/(SICI)1097-0142(19991215)86:12<2589::AID-CNCR1>3.3.CO;2-Z., This is an excellent editorial, which comments on [34] and discusses the clinical significance of micrometastases and isolated tumour cells.CrossRefPubMed

Weiss L: Metastatic inefficiency. Adv Cancer Res. 1990, 54: 159-211.CrossRefPubMed

Tarin D, Vass AC, Kettlewell MG, Price JE: Absence of metastatic sequelae during long-term treatment of malignant ascites by peritoneo-venous shunting. A clinico-pathological report. Invasion Metastasis. 1984, 4: 1-12.PubMed

Tarin D, Price JE, Kettlewell MG, Souter RG, Vass AC, Crossley B: Mechanisms of human tumor metastasis studied in patients with peritoneovenous shunts. Cancer Res. 1984, 44: 3584-3592.PubMed

Fidler IJ: Metastasis: quantitative analysis of distribution and fate of tumor emboli labeled with ¹²⁵I-5-iodo-2'-deoxyuridine. J Natl Cancer Inst. 1970, 45: 773-782.PubMed

Butler TP, Gullino PM: Quantitation of cell shedding into efferent blood of mammary adenocarcinoma. Cancer Res. 1975, 35: 512-516.PubMed

10.

Liotta LA, Kleinerman J, Saidel GM: Quantitative relationships of intravascular tumor cells, tumor vessels, and pulmonary metastases following tumor implantation. Cancer Res. 1974, 34: 997-1004.PubMed

11.

Chambers AF, MacDonald IC, Schmidt EE, Koop S, Morris VL, Khokha R, Groom AC: Steps in tumor metastasis: new concepts from intravital videomicroscopy. Cancer Metastasis Rev. 1995, 14: 279-301.CrossRefPubMed

12.

MacDonald IC, Schmidt EE, Morris V, Groom AC, Chambers AF: In vivo videomicroscopy of experimental hematogenous metastasis: cancer cell arrest, extravasation and migration. In: Motion Analysis of Living Cells. Edited by Soll DR, Wessels D. New York: John Wiley and Sons,. 1998, 263-287., This is a review of IVVM and cell ‘accounting’ procedures, with an especially technical focus

13.

Chambers AF, MacDonald IC, Schmidt EE, Morris VL, Groom AC: Pre-clinical assessment of anti-cancer therapeutic strategies using in vivo videomicroscopy. Cancer Metastasis Rev. 1999, 17: 263-269. 10.1023/A:1006136428254.CrossRef

14.

Chambers AF: The metastatic process: basic research and clinical implications. Oncol Res. 1999, 11: 161-168.PubMed

15.

Chambers AF, MacDonald IC, Schmidt EE, Morris VL, Groom AC: Clinical targets for anti-metastasis therapy. Adv Cancer Res. 2000, 79: 91-121., This is an extensive review of findings to date using IVVM and cell ‘accounting’ procedures to clarify the metastatic processCrossRefPubMed

16.

Koop S, MacDonald IC, Luzzi K, Schmidt EE, Morris VL, Grattan M, Khokha R, Chambers AF, Groom AC: Fate of melanoma cells entering the microcirculation: over 80% survive and extravasate. Cancer Res . 1995, 55: 2520-2523.PubMed

17.

Luzzi KJ, MacDonald IC, Schmidt EE, Kerkvliet N, Morris VL, Chambers AC, Groom AC: Multistep nature of metastatic inefficiency: dormancy of solitary cells after successful extravasation, and limited survival of early micrometastases. Am J Pathol. 1998, 153: 865-873.CrossRefPubMedPubMedCentral

18.

Morris VL, MacDonald IC, Koop S, Schmidt EE, Chambers AF, Groom AC: Early interactions of cancer cells with the microvasculature in mouse liver and muscle during hematogenous metastasis: videomicroscopic analysis. Clin Exptl Metastasis. 1993, 11: 377-390.CrossRef

19.

Morris VL, Koop S, MacDonald IC, Schmidt EE, Grattan M, Percy D, Chambers AF, Groom AC: Mammary carcinoma cell lines of high and low metastatic potential differ not in extravasation but in subsequent migration and growth. Clin Exptl Metastasis. 1994, 12: 357-367.CrossRef

20.

Naumov GN, Wilson SM, MacDonald IC, Schmidt EE, Morris VL, Groom AC, Hoffman RM, Chambers AF: Cellular expression of green fluorescent protein, coupled with high-resolution in vivo videomicroscopy, to monitor steps in tumor metastasis. J Cell Sci. 1999, 112: 1835-1842.PubMed

21.

Farina KL, Wyckoff JB, Rivera J, Lee H, Segall JE, Condeelis JS, Jones JG: Cell motility of tumor cells visualized in living intact primary tumors using green fluorescent protein. Cancer Res. 1998, 58: 2528-2532.PubMed

22.

Sckell A, Safabakhsh N, Dellian M, Jain RK: Primary tumor size-dependent inhibition of angiogenesis at a secondary site: an intravital microscopic study in mice. Cancer Res. 1998, 58: 5866-5869.PubMed

23.

Scherbarth S, Orr FW: Intravital videomicroscopic evidence for regulation of metastasis by the hepatic microvasculature: effects of interleukin-1α on metastasis and the location of B16F1 melanoma cell arrest. Cancer Res. 1997, 57: 4105-4110.PubMed

24.

Talmadge JE, Wolman SR, Fidler IJ: Evidence for the clonal origin of spontaneous metastases. Science. 1982, 217: 361-363.CrossRefPubMed

25.

Chambers AF, Wilson S: Use of Neo^R B16F1 murine melanoma cells to assess clonality of experimental metastases in the immune-deficient chick embryo. Clin Exptl Metastasis. 1982, 6: 171-182.CrossRef

26.

Koop S, Schmidt EE, MacDonald IC, Morris VL, Khokha R, Grattan M, Leone J, Chambers AF, Groom AC: Independence of metastatic ability and extravasation: metastatic ras-transformed and control fibroblasts extravasate equally well. Proc Natl Acad Sci USA. 1996, 93: 11080-11084. 10.1073/pnas.93.20.11080.CrossRefPubMedPubMedCentral

27.

Welch DR: Technical considerations for studying cancer metastasis in vivo. Clin Exp Metastasis . 1997, 15: 272-301. 10.1023/A:1018477516367., This is an excellent and comprehensive review on experimental methods used to study tumour metastasisCrossRefPubMed

28.

Cameron MD, Schmidt EE, Kerkvliet N, Nadkarni KV, Morris VL, Groom AC, Chambers AF, MacDonald IC: Temporal progression of metastasis in lung: cell survival, dormancy, and location dependence of metastatic inefficiency. Cancer Res. 2000, 60: 2541-2546.PubMed

29.

Welch DR, Steeg PS, Rinker-Schaeffer CW: Molecular biology of breast cancer metastasis: genetic regulation of human breast carcinoma metastasis. Breast Cancer Res. 2000, 2:

30.

Chekmareva MA, Kadkhodaian MM, Hollowell CM, Kim H, Yoshida BA, Luu HH, Stadler WM, Rinker-Schaeffer CW: Chromosome 17-mediated dormancy of AT6.1 prostate cancer micrometastases. Cancer Res . 1998, 58: 4963-4969., This is an important study that demonstrates that a metastasis-suppressor gene functions by blocking growth of cells that successfully arrive at a secondary site.PubMed

31.

Goldberg SF, Harms JF, Quon K, Welch DR: Metastasis-suppressed C8161 melanoma cell arrest in lung but fail to proliferate. Clin Exp Metastasis. 1999, 17: 601-617. 10.1023/A:1006718800891., This paper shows that a second, unrelated metastasis-suppressor gene also functions by blocking growth of cells that successfully arrive at a secondary site (see also [30])CrossRefPubMed

32.

Wyckoff JB, Jones JG, Condeelis JS, Segall JE: A critical step in metastasis: in vivo analysis of intravasation at the primary tumor. Cancer Res. 2000, 60: 2504-2511.PubMed

33.

Swartz MA, Kristensen CA, Melder RJ, Roberge S, Calautti E, Fukumura D, Jain RK: Cells shed from tumours show reduced clonogenicity, resistance to apoptosis, and in vivo tumorigenicity. Br J Cancer. 1999, 81: 756-759. 10.1038/sj.bjc.6690760.CrossRefPubMedPubMedCentral

34.

Dowlatshahi K, Fan M, Bloom KJ, Spitz DJ, Patel S, Snider HC: Occult metastases in the sentinel lymph nodes of patients with early stage breast carcinoma: a preliminary study. Cancer. 1999, 86: 990-996. 10.1002/(SICI)1097-0142(19990915)86:6<990::AID-CNCR14>3.0.CO;2-D.CrossRefPubMed

35.

Allred DC, Elledge RM: Caution concerning micrometastatic breast carcinoma in sentinel lymph nodes [editorial]. Cancer. 1999, 86: 905-907. 10.1002/(SICI)1097-0142(19990915)86:6<905::AID-CNCR1>3.0.CO;2-K., A good editorial is presented, which comments on the significance of [34]CrossRefPubMed

36.

Hermanek P, Hutter RV, Sobin LH, Wittekind C: Classification of isolated tumor cells and micrometastasis. Cancer. 1999, 86: 2668-2673. 10.1002/(SICI)1097-0142(19991215)86:12<2668::AID-CNCR11>3.0.CO;2-R., This paper identifies the need to consider isolated tumour cells separately from micrometastases, and establishes a working definition of a ‘micrometastasis’CrossRefPubMed

37.

Racila E, Euhus D, Weiss AJ, Rao C, McConnell J, Terstappen LW, Uhr JW: Detection and characterization of carcinoma cells in the blood. Proc Natl Acad Sci USA. 1998, 95: 4589-4594. 10.1073/pnas.95.8.4589.CrossRefPubMedPubMedCentral

38.

Brown DC, Purushotham AD, Birnie GD, George WD: Detection of intraoperative tumor cell dissemination in patients with breast cancer by use of reverse transcription and polymerase chain reaction. Surgery . 1995, 117: 95-101.CrossRefPubMed

39.

Choy A, McCulloch P: Induction of tumour cell shedding into effluent venous blood breast cancer surgery. Br J Cancer. 1996, 73: 79-82.CrossRefPubMedPubMedCentral

40.

Mori M, Mimori K, Ueo H, Karimine N, Barnard GF, Sugimachi K, Akiyoshi T: Molecular detection of circulating solid carcinoma cells in the peripheral blood: the concept of early systemic disease. Int J Cancer. 1996, 68: 739-743. 10.1002/(SICI)1097-0215(19961211)68:6<739::AID-IJC8>3.3.CO;2-Q.CrossRefPubMed

41.

Mori M, Mimori K, Ueo H, Tsuji K, Shiraishi T, Barnard GF, Sugimachi K, Akiyoshi T: Clinical significance of molecular detection of carcinoma cells in lymph nodes and peripheral blood by reverse transcription-polymerase chain reaction in patients with gastrointestinal or breast carcinomas. J Clin Oncol. 1998, 16: 128-132.PubMed

42.

Golinger RC, Gregorio RM, Fisher ER: Tumor cells in venous blood draining mammary carcinomas. Arch Surg. 1977, 112: 707-708.CrossRefPubMed

43.

Cady B: Lymph node metastases. Indicators, but not governors of survival. Arch Surg. 1984, 119: 1067-1072.CrossRefPubMed

44.

Jatoi I: Breast cancer: a systemic or local disease?. Am J Clin Oncol. 1997, 20: 536-539. 10.1097/00000421-199710000-00022.CrossRefPubMed

Titel: Molecular biology of breast cancer metastasis Clinical implications of experimental studies on metastatic inefficiency
verfasst von: Ann F Chambers
George N Naumov
Sharon A Vantyghem
Alan B Tuck
Publikationsdatum: 01.12.2000
Verlag: BioMed Central
Erschienen in: Breast Cancer Research / Ausgabe 6/2000
Elektronische ISSN: 1465-542X
DOI: https://doi.org/10.1186/bcr86

Springer Medizin

Molecular biology of breast cancer metastasis Clinical implications of experimental studies on metastatic inefficiency

Abstract

Neu im Fachgebiet Onkologie

Adjuvante Immuntherapie verlängert Leben bei RCC

Alectinib verbessert krankheitsfreies Überleben bei ALK-positivem NSCLC

Bei Senioren mit Prostatakarzinom auf Anämie achten!

ICI-Therapie in der Schwangerschaft wird gut toleriert

Update Onkologie

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 6/2000

P53 autoantibodies in 1006 patients followed up for breast cancer

Molecular biology of breast metastasis The use of mathematical models to determine relapse and to predict response to chemotherapy in breast cancer

Molecular biology of breast cancer metastasis Inflammatory breast cancer: clinical syndrome and molecular determinants

Molecular biology of breast cancer metastasis ‘Has it spread?’: Disarming one of the most terrifying questions

Molecular biology of breast cancer metastasis Molecular expression of vascular markers by aggressive breast cancer cells

Computer-assisted mammographic imaging

Neu im Fachgebiet Onkologie

Adjuvante Immuntherapie verlängert Leben bei RCC

Alectinib verbessert krankheitsfreies Überleben bei ALK-positivem NSCLC

Bei Senioren mit Prostatakarzinom auf Anämie achten!

ICI-Therapie in der Schwangerschaft wird gut toleriert

Update Onkologie