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01.11.2008 | Biological Psychiatry - Rapid Communication

Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies

verfasst von: Klaus-Peter Lesch, Nina Timmesfeld, Tobias J. Renner, Rebecca Halperin, Christoph Röser, T. Trang Nguyen, David W. Craig, Jasmin Romanos, Monika Heine, Jobst Meyer, Christine Freitag, Andreas Warnke, Marcel Romanos, Helmut Schäfer, Susanne Walitza, Andreas Reif, Dietrich A. Stephan, Christian Jacob

Erschienen in: Journal of Neural Transmission | Ausgabe 11/2008

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Abstract

A genome-wide association (GWA) study with pooled DNA in adult attention-deficit/hyperactivity disorder (ADHD) employing ~500K SNP markers identifies novel risk genes and reveals remarkable overlap with findings from recent GWA scans in substance use disorders. Comparison with results from our previously reported high-resolution linkage scan in extended pedigrees confirms several chromosomal loci, including 16q23.1-24.3 which also reached genome-wide significance in a recent meta-analysis of seven linkage studies (Zhou et al. in Am J Med Genet Part B, 2008). The findings provide additional support for a common effect of genes coding for cell adhesion molecules (e.g., CDH13, ASTN2) and regulators of synaptic plasticity (e.g., CTNNA2, KALRN) despite the complex multifactorial etiologies of adult ADHD and addiction vulnerability.

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Titel: Molecular genetics of adult ADHD: converging evidence from genome-wide association and extended pedigree linkage studies
verfasst von: Klaus-Peter Lesch
Nina Timmesfeld
Tobias J. Renner
Rebecca Halperin
Christoph Röser
T. Trang Nguyen
David W. Craig
Jasmin Romanos
Monika Heine
Jobst Meyer
Christine Freitag
Andreas Warnke
Marcel Romanos
Helmut Schäfer
Susanne Walitza
Andreas Reif
Dietrich A. Stephan
Christian Jacob
Publikationsdatum: 01.11.2008
Verlag: Springer Vienna
Erschienen in: Journal of Neural Transmission / Ausgabe 11/2008
Print ISSN: 0300-9564
Elektronische ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-008-0119-3

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