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Pediatric Radiology

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28.02.2024 | Review

MR insights into fetal brain development: what is normal and what is not

verfasst von: Maria Camila Cortes-Albornoz, M. Alejandra Bedoya, Jungwhan John Choi, Camilo Jaimes

Erschienen in: Pediatric Radiology | Ausgabe 4/2024

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Abstract

Fetal brain development is a complex, rapid, and multi-dimensional process that can be documented with MRI. In the second and third trimesters, there are predictable developmental changes that must be recognized and differentiated from disease. This review delves into the key biological processes that drive fetal brain development, highlights normal developmental anatomy, and provides a framework to identify pathology. We will summarize the development of the cerebral hemispheres, sulci and gyri, extra-axial and ventricular cerebrospinal fluid, and corpus callosum and illustrate the most common abnormal findings in the clinical setting.

Graphical abstract

Sarma A, Pruthi S (2023) Congenital brain malformations-update on newer classification and genetic basis. Semin Roentgenol 58:6–27CrossRefPubMed

Yang E, Chu WCW, Lee EY (2017) A practical approach to supratentorial brain malformations: what radiologists should know. Radiol Clin North Am 55:609–627CrossRefPubMed

Choi JJ, Yang E, Soul JS, Jaimes C (2020) Fetal magnetic resonance imaging: supratentorial brain malformations. Pediatr Radiol 50:1934–1947CrossRefPubMed

Riddle A, Nagaraj U, Hopkin RJ et al (2021) Fetal magnetic resonance imaging (MRI) in holoprosencephaly and associations with clinical outcome: implications for fetal counseling. J Child Neurol 36:357–364CrossRefPubMed

Kousa YA, du Plessis AJ, Vezina G (2018) Prenatal diagnosis of holoprosencephaly. Am J Med Genet C Semin Med Genet 178:206–213CrossRefPubMed

Gunny RS, Saunders DE, Argyropoulou MI Paediatric neuroradiology. In: Grainger & Allison’s Diagnostic Radiology, 7th ed. Elsevier, pp 1984–2045

Picone O, Hirt R, Suarez B et al (2006) Prenatal diagnosis of a possible new middle interhemispheric variant of holoprosencephaly using sonographic and magnetic resonance imaging. Ultrasound Obstet Gynecol off J Int Soc Ultrasound Obstet Gynecol 28:229–231CrossRef

Malinger G, Lev D, Lerman-Sagie T (2004) Abnormal sulcation as an early sign for migration disorders. Ultrasound Obstet Gynecol off J Int Soc Ultrasound Obstet Gynecol 24:704–705CrossRef

Garel C, Chantrel E, Brisse H et al (2001) Fetal cerebral cortex: normal gestational landmarks identified using prenatal MR imaging. AJNR Am J Neuroradiol 22:184–189PubMedPubMedCentral

10.

Boston Children’s, Hospital FNNDSC Fetal data: Boston Children’s Hospital, CRL. https://app.fetalmri.org/niivue

11.

Lerman-Sagie T, Pogledic I, Leibovitz Z, Malinger G (2021) A practical approach to prenatal diagnosis of malformations of cortical development. Eur J Paediatr Neurol EJPN off J Eur Paediatr Neurol Soc 34:50–61CrossRef

12.

Barkovich AJ (2010) Current concepts of polymicrogyria. Neuroradiology 52:479–487CrossRefPubMedPubMedCentral

13.

Miller E, Blaser S, Shannon P, Widjaja E (2009) Brain and bone abnormalities of thanatophoric dwarfism. AJR Am J Roentgenol 192:48–51CrossRefPubMed

14.

Manikkam SA, Chetcuti K, Howell KB et al (2018) Temporal lobe malformations in Achondroplasia: expanding the Brain Imaging phenotype Associated with FGFR3-Related skeletal dysplasias. AJNR Am J Neuroradiol 39:380–384CrossRefPubMedPubMedCentral

15.

Vasung L, Lepage C, Radoš M et al (2016) Quantitative and qualitative analysis of transient fetal compartments during prenatal human Brain Development. Front Neuroanat 10:11CrossRefPubMedPubMedCentral

16.

Priego G, Barrowman NJ, Hurteau-Miller J, Miller E (2017) Does 3T fetal MRI improve Image Resolution of normal brain structures between 20 and 24 weeks’ gestational age? AJNR Am J Neuroradiol 38:1636–1642CrossRefPubMedPubMedCentral

17.

Kolasinski J, Takahashi E, Stevens AA et al (2013) Radial and tangential neuronal migration pathways in the human fetal brain: anatomically distinct patterns of diffusion MRI coherence. NeuroImage 79:412–422CrossRefPubMed

18.

Kostović I, Judas M, Rados M, Hrabac P (2002) Laminar organization of the human fetal cerebrum revealed by histochemical markers and magnetic resonance imaging. Cereb Cortex N Y N 1991 12:536–544

19.

Natarajan N, Tully HM, Chapman T (2016) Prenatal presentation of pyruvate dehydrogenase complex deficiency. Pediatr Radiol 46:1354–1357CrossRefPubMedPubMedCentral

20.

Tamaru S, Kikuchi A, Takagi K et al (2012) A case of pyruvate dehydrogenase E1α subunit deficiency with antenatal brain dysgenesis demonstrated by prenatal sonography and magnetic resonance imaging. J Clin Ultrasound JCU 40:234–238CrossRefPubMed

21.

Khalid M, Khalid S, Zaheer S et al (2012) Hydranencephaly: a rare cause of an enlarging head size in an infant. North Am J Med Sci 4:520–522CrossRef

22.

Pavone P, Praticò AD, Vitaliti G et al (2014) Hydranencephaly: cerebral spinal fluid instead of cerebral mantles. Ital J Pediatr 40:79CrossRefPubMedPubMedCentral

23.

Thiong’o GM, Ferson SS, Albright AL (2020) Hydranencephaly treatments: retrospective case series and review of the literature. J Neurosurg Pediatr 26:228–231CrossRefPubMed

24.

Curry CJ, Lammer EJ, Nelson V, Shaw GM (2005) Schizencephaly: heterogeneous etiologies in a population of 4 million California births. Am J Med Genet A 137:181–189CrossRefPubMed

25.

Nabavizadeh SA, Zarnow D, Bilaniuk LT et al (2014) Correlation of prenatal and postnatal MRI findings in schizencephaly. AJNR Am J Neuroradiol 35:1418–1424CrossRefPubMedPubMedCentral

26.

D’Antonio F, Papageorghiou AT (2018) Ventriculomegaly. In: Obstetric imaging: fetal diagnosis and care. Elsevier, pp 230–235.e1

27.

Barzilay E, Bar-Yosef O, Dorembus S et al (2017) Fetal brain anomalies associated with ventriculomegaly or asymmetry: an MRI-based study. Am J Neuroradiol 38:371–375CrossRefPubMedPubMedCentral

28.

Alluhaybi AA, Altuhaini K, Ahmad M (2022) Fetal ventriculomegaly: a review of literature. Cureus 14:e22352PubMedPubMedCentral

29.

Mirsky DM, Stence NV, Powers AM et al (2020) Imaging of fetal ventriculomegaly. Pediatr Radiol 50:1948–1958CrossRefPubMed

30.

Lipitz S, Yagel S, Malinger G et al (1998) Outcome of fetuses with isolated borderline unilateral ventriculomegaly diagnosed at mid-gestation. Ultrasound Obstet Gynecol off J Int Soc Ultrasound Obstet Gynecol 12:23–26CrossRef

31.

Heaphy-Henault KJ, Guimaraes CV, Mehollin-Ray AR et al (2018) Congenital Aqueductal stenosis: findings at fetal MRI that accurately predict a postnatal diagnosis. AJNR Am J Neuroradiol 39:942–948CrossRefPubMedPubMedCentral

32.

Andescavage NN, DuPlessis A, McCarter R et al (2016) Cerebrospinal fluid and parenchymal brain development and growth in the healthy fetus. Dev Neurosci 38:420–429CrossRefPubMed

33.

Danzer E, Johnson MP, Bebbington M et al (2007) Fetal head biometry assessed by fetal magnetic resonance imaging following in utero myelomeningocele repair. Fetal Diagn Ther 22:1–6CrossRefPubMed

34.

Danzer E, Johnson MP, Bebbington M et al (2004) Correction of cerebrospinal fluid levels and brain growth demonstrated by serial fetal magnetic resonance imaging following. Am J Obstet Gynecol 191:S171CrossRef

35.

Muntoni F, Voit T (2004) The congenital muscular dystrophies in 2004: a century of exciting progress. Neuromuscul Disord 14:635–649CrossRefPubMed

36.

Goodyear PW, Bannister CM, Russell S, Rimmer S (2001) Outcome in prenatally diagnosed fetal agenesis of the corpus callosum. Fetal Diagn Ther 16:139–145CrossRefPubMed

37.

Glenn OA, Goldstein RB, Li KC et al (2005) Fetal magnetic resonance imaging in the evaluation of fetuses referred for sonographically suspected abnormalities of the corpus callosum. J Ultrasound Med off J Am Inst Ultrasound Med 24:791–804

38.

Hopkins B, Sutton VR, Lewis RA (2008) Neuroimaging aspects of Aicardi syndrome. Am J Med Genet A 146A:2871–2878CrossRefPubMedPubMedCentral

39.

García-Arreza A, García-Díaz L, Fajardo M (2013) Isolated absence of septum pellucidum: prenatal diagnosis and outcome. Fetal Diagn Ther 33:130–132CrossRefPubMed

Titel: MR insights into fetal brain development: what is normal and what is not
verfasst von: Maria Camila Cortes-Albornoz
M. Alejandra Bedoya
Jungwhan John Choi
Camilo Jaimes
Publikationsdatum: 28.02.2024
Verlag: Springer Berlin Heidelberg
Erschienen in: Pediatric Radiology / Ausgabe 4/2024
Print ISSN: 0301-0449
Elektronische ISSN: 1432-1998
DOI: https://doi.org/10.1007/s00247-024-05890-z

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MR insights into fetal brain development: what is normal and what is not

Abstract

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