Background
Methods
Participants
Anthropometrics
Magnetic resonance imaging
MRI-detected osteophytes
Cartilage defects
Cartilage volume
Bone marrow lesions
Meniscal extrusion
Infrapatellar fat pad
Effusion-synovitis
Statistical analysis
Results
Characteristics of the study population
Stable or decreased OPs | Increased OPs |
p
| |
---|---|---|---|
N = 222 | N = 191 | ||
Age (years) | 62.2 ± 7.3 | 62.9 ± 7.0 | 0.30 |
Female (%) | 53 | 47 | 0.22 |
BMI (kg/m2) |
26.9 ± 3.9
|
28.5 ± 4.9
|
< 0.01
|
Baseline total cartilage defect score (0–4) |
1.48 ± 0.73
|
2.13 ± 1.03
|
< 0.01
|
Baseline total BML score (0–3) |
0.33 ± 0.56
|
0.59 ± 0.78
|
< 0.01
|
Baseline total tibial CV (ml) | 5.11 ± 1.22 | 5.08 ± 1.13 | 0.80 |
Baseline meniscal extrusion score (0–2) |
0.13 ± 0.36
|
0.27 ± 0.51
|
< 0.01
|
Total effusion-synovitis score (0–3) |
1.90 ± 0.67
|
2.08 ± 0.81
|
0.01
|
Suprapatellar effusion-synovitis score (0–3) |
1.53 ± 0.64
|
1.76 ± 0.84
|
0.01
|
Central portion effusion-synovitis score (0–3) | 1.56 ± 0.71 | 1.65 ± 0.77 | 0.19 |
Posterior femoral recess effusion-synovitis score (0–3) | 0.66 ± 0.79 | 0.76 ± 0.78 | 0.14 |
Subpopliteal recess effusion-synovitis score (0–3) |
0.60 ± 0.79
|
0.78 ± 0.94
|
0.04
|
IPFP area (cm2) | 7.6 ± 1.2 | 7.7 ± 1.3 | 0.18 |
Presence of IPFP abnormality (%) | 75% | 82% | 0.10 |
IPFP quality score (0–6) |
1.45 ± 1.21
|
2.12 ± 1.64
|
< 0.01
|
Baseline total OP score (0–36) |
2.80 ± 3.45
|
7.62 ± 7.70
|
< 0.01
|
Natural history of MRI-detected OPs
Factors associated with an increase in MRI-detected OPs
Multivariable* | Multivariable** | |
---|---|---|
RR (95% CI) | RR (95% CI) | |
Increase in MRI-detected OPs (yes or no) | ||
Medial BMLs |
1.37 (1.19, 1.58)
|
1.17 (1.02, 1.35)
|
Lateral BMLs |
1.81 (1.11, 2.97)
| 1.11 (0.84, 2.40) |
Patellar BMLs |
1.16 (1.02, 1.33)
| 1.14 (0.94, 1.37) |
Total BMLs |
1.30 (1.19, 1.42)
|
1.16 (1.03, 1.31)
|
Medial cartilage defects |
1.39 (1.25, 1.54)
|
1.30 (1.16, 1.45)
|
Lateral cartilage defects |
1.42 (1.26, 1.61)
|
1.35 (1.21, 1.51)
|
Patellar cartilage defects |
1.34 (1.22, 1.47)
|
1.25 (1.13, 1.38)
|
Total cartilage defects |
2.19 (1.71, 2.80)
|
1.33 (1.20, 1.46)
|
Medial meniscal extrusion |
1.39 (1.12, 1.71)
|
1.24 (1.00, 1.55)
|
Lateral meniscal extrusion |
1.50 (1.27, 1.79)
|
1.33 (1.14, 1.56)
|
Total meniscal extrusion |
1.40 (1.17, 1.69)
|
1.22 (1.01, 1.47)
|
Multivariable* | Multivariable** | |
---|---|---|
RR (95% CI) | RR (95% CI) | |
Increased total MRI-detected OP (yes or no) | ||
Total effusion-synovitis |
1.23 (1.05, 1.45)
| 1.08 (0.94, 1.24) |
Suprapatellar effusion-synovitis |
1.25 (1.09, 1.45)
| 1.08 (0.92, 1.64) |
Central portion effusion-synovitis | 1.11 (0.96, 1.29) | 1.06 (0.94, 1.20) |
Posterior femoral recess effusion-synovitis | 1.14 (0.97, 1.33) | 1.05 (0.93, 1.19) |
Subpopliteal recess effusion-synovitis |
1.15 (1.03, 1.29)
| 1.07 (0.97, 1.18) |
IPFP quality score (0–6) |
1.17 (1.10, 1.24)
|
1.08 (1.01, 1.15)
|
IPFP maximum area (cm2) | 1.04 (0.93, 1.16) | 1.03 (0.93, 1.14) |
IPFP abnormal change (yes/no) | 1.21 (0.91, 1.60) | 0.91 (0.69, 1.22) |
Increased medial MRI-detected OP (yes or no) | ||
Total effusion-synovitis | 1.25 (0.91, 1.73) | 1.13 (0.84, 1.51) |
Suprapatellar effusion-synovitis | 1.31 (0.96, 1.80) | 1.15 (0.89, 1.48) |
Central portion effusion-synovitis | 1.14 (0.83, 1.58) | 1.02 (0.75, 1.39) |
Posterior femoral recess effusion-synovitis | 1.10 (0.83, 1.46) | 1.01 (0.76, 1.33) |
Subpopliteal recess effusion-synovitis | 1.22 (0.99, 1.52) | 1.09 (0.88, 1.34) |
IPFP quality score (0–6) |
1.40 (1.24, 1.57)
|
1.20 (1.06, 1.37)
|
IPFP maximum area (cm2) | 0.96 (0.77, 1.20) | 0.96 (0.78, 1.19) |
IPFP abnormal change (yes/no) |
3.17 (1.31, 7.65)
| 1.87 (0.73, 4.79) |
Increased lateral MRI-detected OP (yes or no) | ||
Total effusion-synovitis |
1.40 (1.13, 1.75)
|
1.27 (1.03, 1.57)
|
Suprapatellar effusion-synovitis |
1.37 (1.22, 1.68)
|
1.22 (1.01, 1.47)
|
Central portion effusion-synovitis |
1.24 (1.00, 1.53)
| 1.16 (0.97, 1.40) |
Posterior femoral recess effusion-synovitis | 1.18 (0.97, 1.43) | 1.08 (0.91, 1.28) |
Subpopliteal recess effusion-synovitis | 1.12 (0.96, 1.31) | 1.08 (0.94, 1.25) |
IPFP quality score (0–6) |
1.29 (1.19, 1.40)
|
1.19 (1.08, 1.30)
|
IPFP maximum area (cm2) | 1.02 (0.89, 1.18) | 1.05 (0.91, 1.21) |
IPFP abnormal change (yes/no) |
1.87 (1.15, 3.03)
| 1.40 (0.87, 2.25) |