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Zeitschrift

Arthritis Research & Therapy

Arthritis Research & Therapy 1/2018

Ausgabe 1/2018

Inhaltsverzeichnis ( 286 Artikel )

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Abatacept used in combination with non-methotrexate disease-modifying antirheumatic drugs: a descriptive analysis of data from interventional trials and the real-world setting

Rieke Alten, Harald Burkhardt, Eugen Feist, Klaus Krüger, Juergen Rech, Andrea Rubbert-Roth, Reinhard E. Voll, Yedid Elbez, Christiane Rauch

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

One-year risk of serious infection in patients treated with certolizumab pegol as compared with other TNF inhibitors in a real-world setting: data from a national U.S. rheumatoid arthritis registry

Leslie R. Harrold, Heather J. Litman, Katherine C. Saunders, Kimberly J. Dandreo, Bernice Gershenson, Jeffrey D. Greenberg, Robert Low, Jeffrey Stark, Robert Suruki, Srihari Jaganathan, Joel M. Kremer, Mohamed Yassine

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

The epidemiology of psoriatic arthritis in Israel – a population-based study

Lihi Eder, Arnon Dov Cohen, Ilan Feldhamer, Sari Greenberg-Dotan, Erez Batat, Devy Zisman

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Type I IFN signature in childhood-onset systemic lupus erythematosus: a conspiracy of DNA- and RNA-sensing receptors?

M. Javad Wahadat, Iris L. A. Bodewes, Naomi I. Maria, Cornelia G. van Helden-Meeuwsen, Annette van Dijk-Hummelman, Eline C. Steenwijk, Sylvia Kamphuis, Marjan A. Versnel

01.12.2018 | Commentary | Ausgabe 1/2018 Open Access

Are we there yet? An update on transitional care in rheumatology

Janet E. McDonagh, Albert Farre

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Urinary angiostatin, CXCL4 and VCAM-1 as biomarkers of lupus nephritis

Chi Chiu Mok, Samar Soliman, Ling Yin Ho, Fatma A. Mohamed, Faten Ismail Mohamed, Chandra Mohan

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

The predictive prognostic factors for polymyositis/dermatomyositis-associated interstitial lung disease

Yumiko Sugiyama, Ryusuke Yoshimi, Maasa Tamura, Mitsuhiro Takeno, Yosuke Kunishita, Daiga Kishimoto, Yuji Yoshioka, Kouji Kobayashi, Kaoru Takase-Minegishi, Toshiyuki Watanabe, Naoki Hamada, Hideto Nagai, Naomi Tsuchida, Yutaro Soejima, Hiroto Nakano, Reikou Kamiyama, Takeaki Uehara, Yohei Kirino, Akiko Sekiguchi, Atsushi Ihata, Shigeru Ohno, Shouhei Nagaoka, Hideaki Nakajima

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Predictors of remission with etanercept-methotrexate induction therapy and loss of remission with etanercept maintenance, reduction, or withdrawal in moderately active rheumatoid arthritis: results of the PRESERVE trial

Josef S. Smolen, Annette Szumski, Andrew S. Koenig, Thomas V. Jones, Lisa Marshall

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

BANK1 alters B cell responses and influences the interactions between B cells and induced T regulatory cells in mice with collagen-induced arthritis

Jie Yang, Jie Ren, Yiming Yang, Juan Sun, Xiaohui Zhou, Shucong Zheng, Dandan Xuan, Yu Xue, Huimin Fan, Jiong Zhang, Hejian Zou, Weiguo Wan, Ning Kong

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Highly selective inhibition of Bruton’s tyrosine kinase attenuates skin and brain disease in murine lupus

Samantha A. Chalmers, Jing Wen, Jessica Doerner, Ariel Stock, Carla M. Cuda, Hadijat M. Makinde, Harris Perlman, Todd Bosanac, Deborah Webb, Gerald Nabozny, Jay S. Fine, Elliott Klein, Meera Ramanujam, Chaim Putterman

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Ultrasonography and magnetic resonance imaging changes in patients with polymyalgia rheumatica treated by tocilizumab

Anaïs Huwart, Florent Garrigues, Sandrine Jousse-Joulin, Thierry Marhadour, Dewi Guellec, Divi Cornec, Maelenn Gouillou, Alain Saraux, Valérie Devauchelle-Pensec

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Treatment of immunoglobulin G4-related sialadenitis: outcomes of glucocorticoid therapy combined with steroid-sparing agents

Xia Hong, Yan-Yan Zhang, Wei Li, Yan-Ying Liu, Zhen Wang, Yan Chen, Yan Gao, Zhi-Peng Sun, Xin Peng, Jia-Zeng Su, Zhi-Gang Cai, Lei Zhang, Jing He, Li-Min Ren, Hong-Yu Yang, Zhan-Guo Li, Guang-Yan Yu

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Increase of MZB1 in B cells in systemic lupus erythematosus: proteomic analysis of biopsied lymph nodes

Aya Miyagawa-Hayashino, Hajime Yoshifuji, Koji Kitagori, Shinji Ito, Takuma Oku, Yoshitaka Hirayama, Adeeb Salah, Toshiki Nakajima, Kaori Kiso, Norishige Yamada, Hironori Haga, Tatsuaki Tsuruyama

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Age and fecal microbial strain-specific differences in patients with spondyloarthritis

Matthew L. Stoll, Pamela F. Weiss, Jennifer E. Weiss, Peter A. Nigrovic, Barbara S. Edelheit, S. Lou Bridges Jr, Maria I. Danila, Charles H. Spencer, Marilynn G. Punaro, Kenneth Schikler, Andreas Reiff, Ranjit Kumar, Randy Q. Cron, Casey D. Morrow, Elliot J. Lefkowitz

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Can baseline ultrasound results help to predict failure to achieve DAS28 remission after 1 year of tight control treatment in early RA patients?

D. F. Ten Cate, J. W. G. Jacobs, W. A. A. Swen, J. M. W. Hazes, M. H. de Jager, N. M. Basoski, C. J. Haagsma, J. J. Luime, A. H. Gerards

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Anti-CCP-positive patients with RA have a higher 10-year probability of fracture evaluated by FRAX®: a registry study of RA with osteoporosis/fracture

Tien-Tsai Cheng, Shan-Fu Yu, Fu-Mei Su, Yin-Chou Chen, Ben Yu-Jih Su, Wen-Chan Chiu, Chung-Yuan Hsu, Jia-Feng Chen, Chi-Hua Ko, Han-Ming Lai

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Systemic sclerosis associated interstitial lung disease - individualized immunosuppressive therapy and course of lung function: results of the EUSTAR group

Sabine Adler, Dörte Huscher, Elise Siegert, Yannick Allanore, László Czirják, Francesco DelGaldo, Christopher P. Denton, Oliver Distler, Marc Frerix, Marco Matucci-Cerinic, Ulf Mueller-Ladner, Ingo-Helmut Tarner, Gabriele Valentini, Ulrich A. Walker, Peter M. Villiger, Gabriela Riemekasten, EUSTAR co-workers on behalf of the DeSScipher project research group within the EUSTAR network

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Synovial IL-9 facilitates neutrophil survival, function and differentiation of Th17 cells in rheumatoid arthritis

Kaustav Chowdhury, Uma Kumar, Soumabha Das, Jaydeep Chaudhuri, Prabin Kumar, Maumita Kanjilal, Parashar Ghosh, Geetabali Sircar, Ravi Kiran Basyal, Uma Kanga, Santu Bandyopadhaya, Dipendra Kumar Mitra

01.12.2018 | Editorial | Ausgabe 1/2018 Open Access

The new aims and scope of Arthritis Research & Therapy

Christopher D. Buckley, Harris Perlman

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Soluble uric acid increases PDZK1 and ABCG2 expression in human intestinal cell lines via the TLR4-NLRP3 inflammasome and PI3K/Akt signaling pathway

Mo Chen, Xiaoyong Lu, Ci Lu, Ning Shen, Yujie Jiang, Menglu Chen, Huaxiang Wu

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Altered white matter microstructure in lupus patients: a diffusion tensor imaging study

Jessika Nystedt, Markus Nilsson, Andreas Jönsen, Petra Nilsson, Anders Bengtsson, Åsa Lilja, Jimmy Lätt, Peter Mannfolk, Pia C Sundgren

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Recurrent anterior uveitis and subsequent incidence of ankylosing spondylitis: a nationwide cohort study from 2002 to 2013

Baek-Lok Oh, Jeong Seok Lee, Eun Young Lee, Hee Young Lee, Hyeong Gon Yu

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Fli1-haploinsufficient dermal fibroblasts promote skin-localized transdifferentiation of Th2-like regulatory T cells

Ryosuke Saigusa, Yoshihide Asano, Takashi Taniguchi, Megumi Hirabayashi, Kouki Nakamura, Shunsuke Miura, Takashi Yamashita, Takehiro Takahashi, Yohei Ichimura, Tetsuo Toyama, Ayumi Yoshizaki, Maria Trojanowska, Shinichi Sato

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Abatacept blocks anti-citrullinated protein antibody and rheumatoid factor mediated cytokine production in human macrophages in IDO-dependent manner

Aline Bozec, Yubin Luo, Cecilia Engdahl, Camille Figueiredo, Holger Bang, Georg Schett

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Anti-CD11b antibody treatment suppresses the osteoclast generation, inflammatory cell infiltration, and autoantibody production in arthritis-prone FcγRIIB-deficient mice

Mareki Ohtsuji, Qingshun Lin, Hideki Okazaki, Kazuko Takahashi, Hirofumi Amano, Hideo Yagita, Hiroyuki Nishimura, Sachiko Hirose

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Adiponectin aggravates bone erosion by promoting osteopontin production in synovial tissue of rheumatoid arthritis

Jie Qian, Lingxiao Xu, Xiaoxuan Sun, Yani Wang, Wenhua Xuan, Qian Zhang, Pengfei Zhao, Qin Wu, Rui Liu, Nan Che, Fang Wang, Wenfeng Tan, Miaojia Zhang

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

IL-1 family cytokines and soluble receptors in systemic lupus erythematosus

Paola Italiani, Maria Laura Manca, Francesca Angelotti, Daniela Melillo, Federico Pratesi, Ilaria Puxeddu, Diana Boraschi, Paola Migliorini

01.12.2018 | Letter | Ausgabe 1/2018 Open Access

Response to: “Monosodium urate crystal deposition associated with the progress of radiographic grade at the sacroiliac joint in axial SpA: a dual-energy CT study”

Andrea S. Klauser, Johann Gruber

01.12.2018 | Review | Ausgabe 1/2018 Open Access

Thinking BIG rheumatology: how to make functional genomics data work for you

Deborah R. Winter

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Identification of a novel autoantibody against self-vimentin specific in secondary Sjögren’s syndrome

Yu-Hui Li, Ya-Ping Gao, Jie Dong, Lian-Jie Shi, Xiao-Lin Sun, Ru Li, Xue-Wu Zhang, Yu Liu, Li Long, Jing He, Qun-Jie Zhong, Eric Morand, Guang Yang, Zhan-Guo Li

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

A unique role for galectin-9 in angiogenesis and inflammatory arthritis

Martin J. O’Brien, Qiang Shu, W.Alexander Stinson, Pei-Suen Tsou, Jeffrey H. Ruth, Takeo Isozaki, Phillip L. Campbell, Ray A. Ohara, Alisa E. Koch, David A. Fox, M. Asif Amin

01.12.2018 | Correction | Ausgabe 1/2018 Open Access

Correction to: Patients and surgeons provide endorsement of core domains for total joint replacement clinical trials

Anh Hoang, Susan M. Goodman, Iris Y. Navarro-Millán, Lisa A. Mandl, Mark P. Figgie, Mathias P. Bostrom, Douglas E. Padgett, Peter K. Sculco, Alexander S. McLawhorn, Jasvinder A. Singh

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Baseline autoantibody profile in rheumatoid arthritis is associated with early treatment response but not long-term outcomes

Emma C. de Moel, Veerle F. A. M. Derksen, Gerrie Stoeken, Leendert A. Trouw, Holger Bang, Robbert J. Goekoop, Irene Speyer, Tom W. J. Huizinga, Cornelia F. Allaart, René E. M. Toes, Diane van der Woude

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

MicroRNA-302b negatively regulates IL-1β production in response to MSU crystals by targeting IRAK4 and EphA2

Teng Ma, Xiao Liu, Zhifu Cen, Chuan Xin, Mingfeng Guo, Chaoyu Zou, Wenpeng Song, Rou Xie, Kailun Wang, Hong Zhou, Jun Zhang, Zhen Wang, Ce Bian, Kaijun Cui, Jiong Li, Yu-Quan Wei, Jing Li, Xikun Zhou

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Impaired lymph node stromal cell function during the earliest phases of rheumatoid arthritis

Janine S. Hähnlein, Reza Nadafi, Tineke de Jong, Tamara H. Ramwadhdoebe, Johanna F. Semmelink, Karen I. Maijer, IJsbrand A. Zijlstra, Mario Maas, Danielle M. Gerlag, Teunis B. H. Geijtenbeek, Paul P. Tak, Reina E. Mebius, Lisa G. M. van Baarsen

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Autoimmune reactivity to malondialdehyde adducts in systemic lupus erythematosus is associated with disease activity and nephritis

Uta Hardt, Anders Larsson, Iva Gunnarsson, Robert M. Clancy, Michelle Petri, Jill P. Buyon, Gregg J. Silverman, Elisabet Svenungsson, Caroline Grönwall

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Longitudinal stability of fibromyalgia symptom clusters

Tanya L. Hoskin, Mary O. Whipple, Sanjeev Nanda, Ann Vincent

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Anti-CD74 antibodies have no diagnostic value in early axial spondyloarthritis: data from the spondyloarthritis caught early (SPACE) cohort

Janneke J. de Winter, Marleen G. van de Sande, Niklas Baerlecken, Inger Berg, Roberta Ramonda, Désirée van der Heijde, Floris A. van Gaalen, Torsten Witte, Dominique L. Baeten

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Pharmacological characterisation of CR6086, a potent prostaglandin E2 receptor 4 antagonist, as a new potential disease-modifying anti-rheumatic drug

Gianfranco Caselli, Albino Bonazzi, Marco Lanza, Flora Ferrari, Daniele Maggioni, Cristian Ferioli, Roberto Giambelli, Eleonora Comi, Silvia Zerbi, Marco Perrella, Ornella Letari, Elena Di Luccio, Milena Colovic, Stefano Persiani, Tiziano Zanelli, Laura Mennuni, Tiziana Piepoli, Lucio Claudio Rovati

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Exploring determinants predicting response to intra-articular hyaluronic acid treatment in symptomatic knee osteoarthritis: 9-year follow-up data from the Osteoarthritis Initiative

Jean-Pierre Pelletier, Jean-Pierre Raynauld, François Abram, Marc Dorais, Philippe Delorme, Johanne Martel-Pelletier

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Integrating genome-wide DNA methylation and mRNA expression profiles identified different molecular features between Kashin-Beck disease and primary osteoarthritis

Yan Wen, Ping Li, Jingcan Hao, Chen Duan, Jing Han, Awen He, Yanan Du, Li Liu, Xiao Liang, Feng Zhang, Xiong Guo

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Sirukumab in rheumatoid arthritis refractory to sulfasalazine or methotrexate: a randomized phase 3 safety and efficacy study in Japanese patients

Tsutomu Takeuchi, Hisashi Yamanaka, Masayoshi Harigai, Ryo Tamamura, Yuichi Kato, Yoshifumi Ukyo, Toshikazu Nakano, Benjamin Hsu, Yoshiya Tanaka

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Traditional Chinese medicine formula Bi-Qi capsule alleviates rheumatoid arthritis-induced inflammation, synovial hyperplasia, and cartilage destruction in rats

Kai Wang, Dongmei Zhang, Yan Liu, Xuan Wang, Jiantong Zhao, Tingting Sun, Tingting Jin, Baoli Li, Janak L. Pathak

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Hypogalactosylation of immunoglobulin G in rheumatoid arthritis: relationship to HLA-DRB1 shared epitope, anticitrullinated protein antibodies, rheumatoid factor, and correlation with inflammatory activity

Christian Schwedler, Thomas Häupl, Ulrich Kalus, Véronique Blanchard, Gerd-Rüdiger Burmester, Denis Poddubnyy, Berthold Hoppe

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Mice with miR-146a deficiency develop severe gouty arthritis via dysregulation of TRAF 6, IRAK 1 and NALP3 inflammasome

Quan-Bo Zhang, Yu-Feng Qing, Cong-Cong Yin, Li Zhou, Xian-shuang Liu, Qing-Sheng Mi, Jing-Guo Zhou

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Blockade of TGF-β/Smad signaling by the small compound HPH-15 ameliorates experimental skin fibrosis

Vu Huy Luong, Takenao Chino, Noritaka Oyama, Takashi Matsushita, Yoko Sasaki, Dai Ogura, Shin-ichiro Niwa, Tanima Biswas, Akiyuki Hamasaki, Mikako Fujita, Yoshinari Okamoto, Masami Otsuka, Hironobu Ihn, Minoru Hasegawa

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Efficacy and safety of secukinumab administration by autoinjector in patients with psoriatic arthritis: results from a randomized, placebo-controlled trial (FUTURE 3)

Peter Nash, Philip J. Mease, Iain B. McInnes, Proton Rahman, Christopher T. Ritchlin, Ricardo Blanco, Eva Dokoupilova, Mats Andersson, Radhika Kajekar, Shephard Mpofu, Luminita Pricop, on behalf of the FUTURE 3 study group

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Pain sensitivity at rest and during muscle contraction in persons with rheumatoid arthritis: a substudy within the Physical Activity in Rheumatoid Arthritis 2010 study

Monika Löfgren, Christina H. Opava, Ingrid Demmelmaier, Cecilia Fridén, Ingrid E. Lundberg, Birgitta Nordgren, Eva Kosek

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Methotrexate inhibits effects of platelet-derived growth factor and interleukin-1β on rheumatoid arthritis fibroblast-like synoviocytes

Beatrice Bergström, Hans Carlsten, Anna-Karin Hultgård Ekwall

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Risk factors for oral methotrexate failure in patients with inflammatory polyarthritis: results from a UK prospective cohort study

James Bluett, Jamie C. Sergeant, Alex J. MacGregor, Jacqueline R. Chipping, Tarnya Marshall, Deborah P. M. Symmons, Suzanne M. M. Verstappen

01.12.2018 | Letter | Ausgabe 1/2018 Open Access

Myocellular characteristics in rheumatoid arthritis and osteoarthritis patients

Sandro Manuel Mueller, David Aguayo, Daniel Aeberli, Esther Vögelin, Marco Toigo

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Antibodies against chemokine receptors CXCR3 and CXCR4 predict progressive deterioration of lung function in patients with systemic sclerosis

Florian Weigold, Jeannine Günther, Moritz Pfeiffenberger, Otavio Cabral-Marques, Elise Siegert, Duska Dragun, Aurélie Philippe, Ann-Katrin Regensburger, Andreas Recke, Xinhua Yu, Frank Petersen, Rusan Catar, Robert Biesen, Falk Hiepe, Gerd R. Burmester, Harald Heidecke, Gabriela Riemekasten

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Impact of diuretics on the urate lowering therapy in patients with gout: analysis of an inception cohort

Laura Ranieri, Carolina Contero, Maria-Luisa Peral, Irene Calabuig, Pedro Zapater, Mariano Andres

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Interleukin-37 is increased in adult-onset Still’s disease and associated with disease activity

Huihui Chi, Dongzhou Liu, Yue Sun, Qiongyi Hu, Honglei Liu, Xiaobing Cheng, Junna Ye, Hui Shi, Yufeng Yin, Mengru Liu, Xinyao Wu, Zhuochao Zhou, Jialin Teng, Chengde Yang, Yutong Su

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Methotrexate upregulates circadian transcriptional factors PAR bZIP to induce apoptosis on rheumatoid arthritis synovial fibroblasts

Kohjin Suzuki, Kohsuke Yoshida, Takeshi Ueha, Kenta Kaneshiro, Ayako Nakai, Naonori Hashimoto, Koto Uchida, Teppei Hashimoto, Yoshiko Kawasaki, Nao Shibanuma, Natsuko Nakagawa, Yoshitada Sakai, Akira Hashiramoto

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Feasibility and reliability of the Spondyloarthritis Research Consortium of Canada sacroiliac joint inflammation score in children

Pamela F. Weiss, Walter P. Maksymowych, Robert G. Lambert, Jacob L. Jaremko, David M. Biko, Joel Paschke, Timothy G. Brandon, Rui Xiao, Nancy A. Chauvin

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Effect of filgotinib, a selective JAK 1 inhibitor, with and without methotrexate in patients with rheumatoid arthritis: patient-reported outcomes

Mark Genovese, Rene Westhovens, Luc Meuleners, Annegret Van der Aa, Pille Harrison, Chantal Tasset, Arthur Kavanaugh

01.12.2018 | Commentary | Ausgabe 1/2018 Open Access

Rheumatology in East Asia

Kazuhiko Yamamoto, Yeong-Wook Song, Zhan-guo Li

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Smoking is not linked to the development of anti-peptidylarginine deiminase 4 autoantibodies in rheumatoid arthritis

Laura C. Cappelli, Maximilian F. Konig, Allan C. Gelber, Clifton O. Bingham III, Erika Darrah

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Effectiveness and safety of tofacitinib in rheumatoid arthritis: a cohort study

Marina Amaral de Ávila Machado, Cristiano Soares de Moura, Steve Ferreira Guerra, Jeffrey R. Curtis, Michal Abrahamowicz, Sasha Bernatsky

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Clinical and MRI remission in patients with nonradiographic axial spondyloarthritis who received long-term open-label adalimumab treatment: 3-year results of the ABILITY-1 trial

Désirée van der Heijde, Joachim Sieper, Walter P. Maksymowych, Robert G. Lambert, Su Chen, Maja Hojnik, Jaclyn K. Anderson, Aileen L. Pangan

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

CCL17 blockade as a therapy for osteoarthritis pain and disease

Ming-Chin Lee, Reem Saleh, Adrian Achuthan, Andrew J. Fleetwood, Irmgard Förster, John A. Hamilton, Andrew D. Cook

01.12.2018 | Letter | Ausgabe 1/2018 Open Access

Anti-CCP antibodies and bone

Giovanni Orsolini, Ombretta Viapiana, Maurizio Rossini, Giovanni Adami, Cristian Caimmi, Angelo Fassio, Davide Gatti

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Dysregulated heme oxygenase-1low M2-like macrophages augment lupus nephritis via Bach1 induced by type I interferons

Daiga Kishimoto, Yohei Kirino, Maasa Tamura, Mitsuhiro Takeno, Yosuke Kunishita, Kaoru Takase-Minegishi, Hiroto Nakano, Ikuma Kato, Kiyotaka Nagahama, Ryusuke Yoshimi, Kazuhiko Igarashi, Ichiro Aoki, Hideaki Nakajima

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Failure of remission induction by glucocorticoids alone or in combination with immunosuppressive agents in IgG4-related disease: a prospective study of 215 patients

Liwen Wang, Panpan Zhang, Mu Wang, Ruie Feng, Yamin Lai, Linyi Peng, Yunyun Fei, Xuan Zhang, Yan Zhao, Xiaofeng Zeng, Fengchun Zhang, Wen Zhang

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Identification of novel biomarker as citrullinated inter-alpha-trypsin inhibitor heavy chain 4, specifically increased in sera with experimental and rheumatoid arthritis

Hoshimi Kawaguchi, Isao Matsumoto, Atsumu Osada, Izumi Kurata, Hiroshi Ebe, Yuki Tanaka, Asuka Inoue, Naoto Umeda, Yuya Kondo, Hiroto Tsuboi, Yasuhiro Shinkai, Yoshito Kumagai, Akihito Ishigami, Takayuki Sumida

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Osteoclasts degrade bone and cartilage knee joint compartments through different resorption processes

Henrik Löfvall, Hannah Newbould, Morten A. Karsdal, Morten H. Dziegiel, Johan Richter, Kim Henriksen, Christian S. Thudium

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Does the presence of magnetic resonance imaging-detected osteitis at diagnosis with rheumatoid arthritis lower the risk for achieving disease-modifying antirheumatic drug-free sustained remission: results of a longitudinal study

L. E. Burgers, D. M. Boeters, M. Reijnierse, A. H. M. van der Helm-van Mil

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Phenome-wide association study identifies marked increased in burden of comorbidities in African Americans with systemic lupus erythematosus

April Barnado, Robert J. Carroll, Carolyn Casey, Lee Wheless, Joshua C. Denny, Leslie J. Crofford

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Comparison of the impact of Tripterygium wilfordii Hook F and Methotrexate treatment on radiological progression in active rheumatoid arthritis: 2-year follow up of a randomized, non-blinded, controlled study

Yang-zhong Zhou, Li-dan Zhao, Hua Chen, Yan Zhang, Dan-feng Wang, Lin-fang Huang, Qian-wen Lv, Bin Liu, Zhenbin Li, Wei Wei, Hongbin Li, Xiangping Liao, Hui Liu, Xiumei Liu, Hongtao Jin, Junxiang Wang, Yun-yun Fei, Qing-jun Wu, Wen Zhang, Qun Shi, Wen-jie Zheng, Feng-chun Zhang, Fu-lin Tang, Peter E. Lipsky, Xuan Zhang

01.12.2018 | Correction | Ausgabe 1/2018 Open Access

Correction to: identification of multiple cancer-associated myositis-specific autoantibodies in idiopathic inflammatory myopathies: a large longitudinal cohort study

Hanbo Yang, Qinglin Peng, Liguo Yin, Shanshan Li, Jingli Shi, Yamei Zhang, Xin Lu, Xiaoming Shu, Sigong Zhang, Guochun Wang

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Effect of combined treatment with bisphosphonate and vitamin D on atherosclerosis in patients with systemic lupus erythematosus: a propensity score-based analysis

Kazumasa Ohmura, Masaru Kato, Toshiyuki Watanabe, Kenji Oku, Toshiyuki Bohgaki, Tetsuya Horita, Shinsuke Yasuda, Yoichi M. Ito, Norihiro Sato, Tatsuya Atsumi

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Inflammatory back pain in psoriatic arthritis is significantly more responsive to corticosteroids compared to back pain in ankylosing spondylitis: a prospective, open-labelled, controlled pilot study

Muhammad Haroon, Muddassar Ahmad, Muhammad Nouman Baig, Olivia Mason, John Rice, Oliver FitzGerald

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Effect of a low-intensity, self-management lifestyle intervention on knee pain in community-based young to middle-aged rural women: a cluster randomised controlled trial

Yuanyuan Wang, Catherine Lombard, Sultana Monira Hussain, Cheryce Harrison, Samantha Kozica, Sharmayne R. E. Brady, Helena Teede, Flavia M. Cicuttini

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Characterization of inflammatory cell infiltrate of scleroderma skin: B cells and skin score progression

Silvia Bosello, Cristiana Angelucci, Gina Lama, Stefano Alivernini, Gabriella Proietti, Barbara Tolusso, Gigliola Sica, Elisa Gremese, Gianfranco Ferraccioli

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Association between general joint hypermobility and knee, hip, and lumbar spine osteoarthritis by race: a cross-sectional study

Portia P. E. Flowers, Rebecca J. Cleveland, Todd A. Schwartz, Amanda E. Nelson, Virginia B. Kraus, Howard J. Hillstrom, Adam P. Goode, Marian T. Hannan, Jordan B. Renner, Joanne M. Jordan, Yvonne M. Golightly

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Effects of selexipag and its active metabolite in contrasting the profibrotic myofibroblast activity in cultured scleroderma skin fibroblasts

Maurizio Cutolo, Barbara Ruaro, Paola Montagna, Renata Brizzolara, Emanuela Stratta, Amelia Chiara Trombetta, Stefano Scabini, Pier Paolo Tavilla, Aurora Parodi, Claudio Corallo, Nicola Giordano, Sabrina Paolino, Carmen Pizzorni, Alberto Sulli, Vanessa Smith, Stefano Soldano

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Accuracy of the HumaSensplus point-of-care uric acid meter using capillary blood obtained by fingertip puncture

Stéphanie Fabre, Pierre Clerson, Jean-Marie Launay, Jean-François Gautier, Tiphaine Vidal-Trecan, Jean-Pierre Riveline, Adam Platt, Anna Abrahamsson, Jeffrey N. Miner, Glen Hughes, Pascal Richette, Thomas Bardin

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Factors associated with physicians’ prescriptions for rheumatoid arthritis drugs not filled by patients

Hong J. Kan, Kirill Dyagilev, Peter Schulam, Suchi Saria, Hadi Kharrazi, David Bodycombe, Charles T. Molta, Jeffrey R. Curtis

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Fcγ receptor-mediated influx of S100A8/A9-producing neutrophils as inducer of bone erosion during antigen-induced arthritis

Irene Di Ceglie, Giuliana Ascone, Niels A. J. Cremers, Annet W. Sloetjes, Birgitte Walgreen, Thomas Vogl, Johannes Roth, J. Sjef Verbeek, Fons A. J. van de Loo, Marije I. Koenders, Peter M. van der Kraan, Arjen B. Blom, Martijn H. J. van den Bosch, Peter L. E. M. van Lent

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Deleterious role of hepatitis B virus infection in therapeutic response among patients with rheumatoid arthritis in a clinical practice setting: a case-control study

Yu-Lan Chen, Jian-Zi Lin, Ying-Qian Mo, Jian-Da Ma, Qian-Hua Li, Xiao-Ying Wang, Ze-Hong Yang, Tao Yan, Dong-Hui Zheng, Lie Dai

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Smoking, body mass index, disease activity, and the risk of rapid radiographic progression in patients with early rheumatoid arthritis

Emil Rydell, Kristina Forslind, Jan-Åke Nilsson, Lennart T. H. Jacobsson, Carl Turesson

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Targeted lipidomics analysis identified altered serum lipid profiles in patients with polymyositis and dermatomyositis

Joan Raouf, Helena Idborg, Petter Englund, Helene Alexanderson, Maryam Dastmalchi, Per-Johan Jakobsson, Ingrid E. Lundberg, Marina Korotkova

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Estrogen induces St6gal1 expression and increases IgG sialylation in mice and patients with rheumatoid arthritis: a potential explanation for the increased risk of rheumatoid arthritis in postmenopausal women

Cecilia Engdahl, Albert Bondt, Ulrike Harre, Jasmin Raufer, René Pfeifle, Alessandro Camponeschi, Manfred Wuhrer, Michaela Seeling, Inga-Lill Mårtensson, Falk Nimmerjahn, Gerhard Krönke, Hans U. Scherer, Helena Forsblad-d’Elia, Georg Schett

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Integrative analysis reveals CD38 as a therapeutic target for plasma cell-rich pre-disease and established rheumatoid arthritis and systemic lupus erythematosus

Suzanne Cole, Alice Walsh, Xuefeng Yin, Mihir D. Wechalekar, Malcolm D. Smith, Susanna M. Proudman, Douglas J. Veale, Ursula Fearon, Costantino Pitzalis, Frances Humby, Michele Bombardieri, Amy Axel, Homer Adams III, Christopher Chiu, Michael Sharp, John Alvarez, Ian Anderson, Loui Madakamutil, Sunil Nagpal, Yanxia Guo

01.12.2018 | Letter | Ausgabe 1/2018 Open Access

Early achievement of deep remission predicts low incidence of renal flare in lupus nephritis class III or IV

Hironari Hanaoka, Harunobu Iida, Tomofumi Kiyokawa, Yukiko Takakuwa, Kimito Kawahata

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Two independent proteomic approaches provide a comprehensive analysis of the synovial fluid proteome response to Autologous Chondrocyte Implantation

Charlotte H. Hulme, Emma L. Wilson, Heidi R. Fuller, Sally Roberts, James B. Richardson, Pete Gallacher, Mandy J. Peffers, Sally L. Shirran, Catherine H. Botting, Karina T. Wright

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Upper zone of growth plate and cartilage matrix associated protein protects cartilage during inflammatory arthritis

Fritz Seuffert, Daniela Weidner, Wolfgang Baum, Georg Schett, Michael Stock

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Inflammation functions as a key mediator in the link between ACPA and erosion development: an association study in Clinically Suspect Arthralgia

R. M. ten Brinck, R. E. M. Toes, A. H. M. van der Helm–van Mil

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Untangling the complex relationships between incident gout risk, serum urate, and its comorbidities

Mengying Sun, Ana I. Vazquez, Richard J. Reynolds, Jasvinder A. Singh, Mathew Reeves, Tony R. Merriman, Angelo L. Gaffo, Gustavo de los Campos

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Predicting unfavorable long-term outcome in juvenile idiopathic arthritis: results from the Nordic cohort study

Veronika Rypdal, Ellen Dalen Arnstad, Kristiina Aalto, Lillemor Berntson, Maria Ekelund, Anders Fasth, Mia Glerup, Troels Herlin, Susan Nielsen, Suvi Peltoniemi, Marek Zak, Marite Rygg, Martin Rypdal, Ellen Nordal, For the Nordic Study Group of Pediatric Rheumatology (NoSPeR)

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Meta-analysis of GWAS on both Chinese and European populations identifies GPR173 as a novel X chromosome susceptibility gene for SLE

Huoru Zhang, Yan Zhang, Yong-Fei Wang, David Morris, Nattiya Hirankarn, Yujun Sheng, Jiangshan Shen, Hai-Feng Pan, Jing Yang, Sen Yang, Yong Cui, Dong-Qing Ye, Timothy J. Vyse, Xuejun Zhang, Yu Lung Lau, Wanling Yang

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Does psychological stress in patients with clinically suspect arthralgia associate with subclinical inflammation and progression to inflammatory arthritis?

Aleid C. Boer, Robin M. ten Brinck, Andrea W. M. Evers, Annette H. M. van der Helm-van Mil

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Does information on novel identified autoantibodies contribute to predicting the progression from undifferentiated arthritis to rheumatoid arthritis: a study on anti-CarP antibodies as an example

Debbie M. Boeters, Leendert A. Trouw, Annette H. M. van der Helm-van Mil, Hanna W. van Steenbergen

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Oxidative stress impairs energy metabolism in primary cells and synovial tissue of patients with rheumatoid arthritis

Emese Balogh, Douglas J. Veale, Trudy McGarry, Carl Orr, Zoltan Szekanecz, Chin-Teck Ng, Ursula Fearon, Monika Biniecka

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Fatigue independently predicts different work disability dimensions in etanercept-treated rheumatoid arthritis and ankylosing spondylitis patients

Katie L. Druce, Laraine Aikman, Maria Dilleen, Annie Burden, Piotr Szczypa, Neil Basu

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

The lack of association between the burden of monosodium urate crystals assessed with dual-energy computed tomography or ultrasonography with cardiovascular risk in the commonly high-risk gout patient

Tristan Pascart, Benoist Capon, Agathe Grandjean, Julie Legrand, Nasser Namane, Vincent Ducoulombier, Marguerite Motte, Marie Vandecandelaere, Hélène Luraschi, Catherine Godart, Eric Houvenagel, Laurène Norberciak, Jean-François Budzik

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Transcription factor motif enrichment in whole transcriptome analysis identifies STAT4 and BCL6 as the most prominent binding motif in systemic juvenile idiopathic arthritis

Boris Hügle, Anastasia Schippers, Nadine Fischer, Kim Ohl, Bernd Denecke, Fabio Ticconi, Bas Vastert, Ivan G. Costa, Johannes-Peter Haas, Klaus Tenbrock

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Efficacy and safety of febuxostat extended release and immediate release in patients with gout and moderate renal impairment: phase II placebo-controlled study

Lhanoo Gunawardhana, Michael A. Becker, Andrew Whelton, Barbara Hunt, Majin Castillo, Kenneth Saag

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Genome-wide association study meta-analysis identifies five new loci for systemic lupus erythematosus

Antonio Julià, Francisco Javier López-Longo, José J. Pérez Venegas, Silvia Bonàs-Guarch, Àlex Olivé, José Luís Andreu, Mª. Ángeles Aguirre-Zamorano, Paloma Vela, Joan M. Nolla, José Luís Marenco de la Fuente, Antonio Zea, José María Pego-Reigosa, Mercedes Freire, Elvira Díez, Esther Rodríguez-Almaraz, Patricia Carreira, Ricardo Blanco, Víctor Martínez Taboada, María López-Lasanta, Mireia López Corbeto, Josep M. Mercader, David Torrents, Devin Absher, Sara Marsal, Antonio Fernández-Nebro

01.12.2018 | Commentary | Ausgabe 1/2018 Open Access

From supernatants to cytokines: a personal view on the early history of IL-1, IL-1Ra, TNF and its inhibitor in rheumatology

Jean-Michel Dayer

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Comparison of US patient, rheumatologist, and dermatologist perceptions of psoriatic disease symptoms: results from the DISCONNECT study

M. Elaine Husni, Anthony Fernandez, Brett Hauber, Rakesh Singh, Joshua Posner, Jessie Sutphin, Arijit Ganguli

01.12.2018 | Editorial | Ausgabe 1/2018 Open Access

Methotrexate: who would have predicted its importance in rheumatoid arthritis?

Michael E. Weinblatt

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Calcification of the acetabular labrum of the hip: prevalence in the general population and relation to hip articular cartilage and fibrocartilage degeneration

Thelonius Hawellek, Jan Hubert, Sandra Hischke, Matthias Krause, Jessica Bertrand, Burkhard C. Schmidt, Andreas Kronz, Klaus Püschel, Wolfgang Rüther, Andreas Niemeier

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

The course of pain hypersensitivity according to painDETECT in patients with rheumatoid arthritis initiating treatment: results from the prospective FRAME-cohort study

Signe Rifbjerg-Madsen, Anton Wulf Christensen, Mikael Boesen, Robin Christensen, Bente Danneskiold-Samsøe, Henning Bliddal, Lene Dreyer, Henning Locht, Kirstine Amris

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

The majority of patients with newly diagnosed juvenile idiopathic arthritis achieve a health-related quality of life that is similar to that of healthy peers: results of the German multicenter inception cohort (ICON)

Miriam Listing, Kirsten Mönkemöller, Ina Liedmann, Martina Niewerth, Claudia Sengler, Joachim Listing, Dirk Foell, Arnd Heiligenhaus, Ariane Klein, Gerd Horneff, Gerd Ganser, Johannes-Peter Haas, Jens Klotsche, Kirsten Minden

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Association between inflammation and systolic blood pressure in RA compared to patients without RA

Zhi Yu, Seoyoung C. Kim, Kathleen Vanni, Jie Huang, Rishi Desai, Shawn N. Murphy, Daniel H. Solomon, Katherine P. Liao

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Comorbidity in gout at the time of first diagnosis: sex differences that may have implications for dosing of urate lowering therapy

Panagiota Drivelegka, Valgerdur Sigurdardottir, Anna Svärd, Lennart T. H. Jacobsson, Mats Dehlin

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Gout and the risk of myocardial infarction in older adults: a study of Medicare recipients

Jasvinder A. Singh, John D. Cleveland

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

How patients with gout become engaged in disease management: a constructivist grounded theory study

Alyssa Howren, Susan M. Cox, Kam Shojania, Sharan K. Rai, Hyon K. Choi, Mary A. De Vera

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Metabolomics approach by 1H NMR spectroscopy of serum reveals progression axes for asymptomatic hyperuricemia and gout

Yannan Zhang, Huanzhen Zhang, Dong Chang, Fuchuan Guo, Hongzhi Pan, Yuexin Yang

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

The effects of upper and lower limb exercise on the microvascular reactivity in limited cutaneous systemic sclerosis patients

A. Mitropoulos, A. Gumber, H. Crank, M. Akil, M. Klonizakis

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Secukinumab provides rapid and sustained pain relief in psoriatic arthritis over 2 years: results from the FUTURE 2 study

Iain B. McInnes, Philip J. Mease, Georg Schett, Bruce Kirkham, Vibeke Strand, Nicole Williams, Todd Fox, Luminita Pricop, Steffen M. Jugl, Kunal K. Gandhi, on behalf of the FUTURE 2 Study Group

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Role of CXCL13 and CCL20 in the recruitment of B cells to inflammatory foci in chronic arthritis

Estefanía Armas-González, María Jesús Domínguez-Luis, Ana Díaz-Martín, Mayte Arce-Franco, Javier Castro-Hernández, Gabriela Danelon, Vanesa Hernández-Hernández, Sagrario Bustabad-Reyes, Alberto Cantabrana, Mariagrazia Uguccioni, Federico Díaz-González

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

IL-17A induces osteoblast differentiation by activating JAK2/STAT3 in ankylosing spondylitis

Sungsin Jo, Sung Eun Wang, Young Lim Lee, Suman Kang, Bitnara Lee, Jinil Han, Il-Hoon Sung, Ye-Soo Park, Sang-Cheol Bae, Tae-Hwan Kim

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

H1-antihistamines are associated with lower prevalence of radiographic knee osteoarthritis: a cross-sectional analysis of the Osteoarthritis Initiative data

Ivan Shirinsky, Valery Shirinsky

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Genetic background may contribute to the latitude-dependent prevalence of dermatomyositis and anti-TIF1-γ autoantibodies in adult patients with myositis

Joanna E. Parkes, Simon Rothwell, Alexander Oldroyd, Hector Chinoy, Janine A. Lamb, The Myositis Genetics Consortium (MYOGEN)

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

CircIBTK inhibits DNA demethylation and activation of AKT signaling pathway via miR-29b in peripheral blood mononuclear cells in systemic lupus erythematosus

Xin Wang, Chengzhong Zhang, Zhouwei Wu, Yue Chen, Weimin Shi

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Smoking-induced aggravation of experimental arthritis is dependent of aryl hydrocarbon receptor activation in Th17 cells

Jhimmy Talbot, Raphael S. Peres, Larissa G. Pinto, Rene D. R. Oliveira, Kalil A. Lima, Paula B. Donate, Jaqueline R. Silva, Bernard Ryffel, Thiago M. Cunha, José C. Alves-Filho, Foo Y. Liew, Paulo Louzada-Junior, Fernando de Queiroz Cunha

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Pannus inflammation in sacroiliitis following immune pathological injury and radiological structural damage: a study of 193 patients with spondyloarthritis

Dan min Wang, Ling Lin, Jian hua Peng, Yao Gong, Zhi duo Hou, Su biao Chen, Zheng yu Xiao

01.12.2018 | Review | Ausgabe 1/2018 Open Access

Could low birth weight and preterm birth be associated with significant burden of hip osteoarthritis? A systematic review

Sultana Monira Hussain, Ilana N. Ackerman, Yuanyuan Wang, Ella Zomer, Flavia M. Cicuttini

01.12.2018 | Letter | Ausgabe 1/2018 Open Access

Serum IL-33 level is associated with auto-antibodies but not with clinical response to biologic agents in rheumatoid arthritis

Elodie Rivière, Jérémie Sellam, Juliette Pascaud, Philippe Ravaud, Jacques-Eric Gottenberg, Xavier Mariette

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Elevated levels of plasma symmetric dimethylarginine and increased arginase activity as potential indicators of cardiovascular comorbidity in rheumatoid arthritis

Unnikrishnan M. Chandrasekharan, Zeneng Wang, Yuping Wu, W. H. Wilson Tang, Stanley L. Hazen, Sihe Wang, M. Elaine Husni

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

GWAS-identified CCR1 and IL10 loci contribute to M1 macrophage-predominant inflammation in Behçet’s disease

Hiroto Nakano, Yohei Kirino, Mitsuhiro Takeno, Kana Higashitani, Hideto Nagai, Ryusuke Yoshimi, Yukie Yamaguchi, Ikuma Kato, Ichiro Aoki, Hideaki Nakajima

01.12.2018 | Correction | Ausgabe 1/2018 Open Access

Correction to: Adiponectin aggravates bone erosion by promoting osteopontin production in synovial tissue of rheumatoid arthritis

Jie Qian, Lingxiao Xu, Xiaoxuan Sun, Yani Wang, Wenhua Xuan, Qian Zhang, Pengfei Zhao, Qin Wu, Rui Liu, Nan Che, Fang Wang, Wenfeng Tan, Miaojia Zhang

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Anti-carbamylated protein antibodies as a new biomarker of erosive joint damage in systemic lupus erythematosus

Fulvia Ceccarelli, Carlo Perricone, Tania Colasanti, Laura Massaro, Enrica Cipriano, Monica Pendolino, Francesco Natalucci, Riccardo Mancini, Francesca Romana Spinelli, Guido Valesini, Fabrizio Conti, Cristiano Alessandri

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Ten weeks of high-intensity interval walk training is associated with reduced disease activity and improved innate immune function in older adults with rheumatoid arthritis: a pilot study

David B. Bartlett, Leslie H. Willis, Cris A. Slentz, Andrew Hoselton, Leslie Kelly, Janet L. Huebner, Virginia B. Kraus, Jennifer Moss, Michael J. Muehlbauer, Guillaume Spielmann, William E. Kraus, Janet M. Lord, Kim M. Huffman

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Is local platelet-rich plasma injection clinically superior to hyaluronic acid for treatment of knee osteoarthritis? A systematic review of randomized controlled trials

Yalong Di, Changxu Han, Liang Zhao, Yizhong Ren

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Patient-reported outcomes from a randomized phase III trial of sarilumab monotherapy versus adalimumab monotherapy in patients with rheumatoid arthritis

Vibeke Strand, Laure Gossec, Clare W. J. Proudfoot, Chieh-I Chen, Matthew Reaney, Sophie Guillonneau, Toshio Kimura, Janet van Adelsberg, Yong Lin, Erin K. Mangan, Hubert van Hoogstraten, Gerd R. Burmester

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Presence of hepatitis B virus in synovium and its clinical significance in rheumatoid arthritis

Yu-Lan Chen, Jun Jing, Ying-Qian Mo, Jian-Da Ma, Li-Juan Yang, Le-Feng Chen, Xiang Zhang, Tao Yan, Dong-Hui Zheng, Frank Pessler, Lie Dai

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Glycation marker glucosepane increases with the progression of osteoarthritis and correlates with morphological and functional changes of cartilage in vivo

Catherine Legrand, Usman Ahmed, Attia Anwar, Kashif Rajpoot, Sabah Pasha, Cécile Lambert, Rose K. Davidson, Ian M. Clark, Paul J. Thornalley, Yves Henrotin, Naila Rabbani

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Chemerin 156F, generated by chymase cleavage of prochemerin, is elevated in joint fluids of arthritis patients

Lei Zhao, Yasuto Yamaguchi, Xiaomei Ge, William H. Robinson, John Morser, Lawrence L. K. Leung

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Hydroxychloroquine prescription trends and predictors for excess dosing per recent ophthalmology guidelines

April M. Jorge, Ronald B. Melles, Yuqing Zhang, Na Lu, Sharan K. Rai, Lucy H. Young, Karen H. Costenbader, Rosalind Ramsey-Goldman, S. Sam Lim, John M. Esdaile, Ann E. Clarke, M. B. Urowitz, Anca Askanase, Cynthia Aranow, Michelle Petri, Hyon Choi

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

The roles of neutrophil serine proteinases in idiopathic inflammatory myopathies

Siming Gao, Xiaoxia Zuo, Di Liu, Yizhi Xiao, Honglin Zhu, Huali Zhang, Hui Luo

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Mediation analysis to understand genetic relationships between habitual coffee intake and gout

Joseph Hutton, Tahzeeb Fatima, Tanya J. Major, Ruth Topless, Lisa K. Stamp, Tony R. Merriman, Nicola Dalbeth

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Obesity, hypertension and diuretic use as risk factors for incident gout: a systematic review and meta-analysis of cohort studies

Peter L. Evans, James A. Prior, John Belcher, Christian D. Mallen, Charles A. Hay, Edward Roddy

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Next-generation sequencing profiling of mitochondrial genomes in gout

Chia-Chun Tseng, Chung-Jen Chen, Jeng-Hsien Yen, Hsi-Yuan Huang, Jan-Gowth Chang, Shun-Jen Chang, Wei-Ting Liao

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Long noncoding RNA expression profile and association with SLEDAI score in monocyte-derived dendritic cells from patients with systematic lupus erythematosus

Yilun Wang, Shuang Chen, Sunyi Chen, Juan Du, Jinran Lin, Haihong Qin, Jie Wang, Jun Liang, Jinhua Xu

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Methods for high-dimensional analysis of cells dissociated from cryopreserved synovial tissue

Laura T. Donlin, Deepak A. Rao, Kevin Wei, Kamil Slowikowski, Mandy J. McGeachy, Jason D. Turner, Nida Meednu, Fumitaka Mizoguchi, Maria Gutierrez-Arcelus, David J. Lieb, Joshua Keegan, Kaylin Muskat, Joshua Hillman, Cristina Rozo, Edd Ricker, Thomas M. Eisenhaure, Shuqiang Li, Edward P. Browne, Adam Chicoine, Danielle Sutherby, Akiko Noma, Chad Nusbaum, Stephen Kelly, Alessandra B. Pernis, Lionel B. Ivashkiv, Susan M. Goodman, William H. Robinson, Paul J. Utz, James A. Lederer, Ellen M. Gravallese, Brendan F. Boyce, Nir Hacohen, Costantino Pitzalis, Peter K. Gregersen, Gary S. Firestein, Soumya Raychaudhuri, Larry W. Moreland, V. Michael Holers, Vivian P. Bykerk, Andrew Filer, David L. Boyle, Michael B. Brenner, Jennifer H. Anolik, Accelerating Medicines Partnership RA/SLE Network

01.12.2018 | Review | Ausgabe 1/2018 Open Access

The prevalence of depression in axial spondyloarthritis and its association with disease activity: a systematic review and meta-analysis

Sizheng Zhao, Daniel Thong, Natasha Miller, Stephen J. Duffield, David M. Hughes, Laura Chadwick, Nicola J. Goodson

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Radiographs in screening for sacroiliitis in children: what is the value?

Pamela F. Weiss, Rui Xiao, Timothy G. Brandon, David M. Biko, Walter P. Maksymowych, Robert G. Lambert, Jacob L. Jaremko, Nancy A. Chauvin

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Extravascular manifestations of Takayasu arteritis: focusing on the features shared with spondyloarthritis

Oh Chan Kwon, Sang-Won Lee, Yong-Beom Park, Ji Seon Oh, Sang Hoon Lee, Seokchan Hong, Chang-Keun Lee, Bin Yoo, Yong-Gil Kim

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Gout prevalence and predictors of urate-lowering therapy use: results from a population-based study

Huai Leng Pisaniello, Susan Lester, David Gonzalez-Chica, Nigel Stocks, Marie Longo, Greg R. Sharplin, Eleonora Dal Grande, Tiffany K. Gill, Samuel L. Whittle, Catherine L. Hill

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

miR-155 is dispensable in monosodium urate-induced gouty inflammation in mice

Qibin Yang, Quanbo Zhang, Yufeng Qing, Li Zhou, Qingsheng Mi, Jingguo Zhou

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Adipocyte-specific Repression of PPAR-gamma by NCoR Contributes to Scleroderma Skin Fibrosis

Benjamin Korman, Roberta Goncalves Marangoni, Gabriel Lord, Jerrold Olefsky, Warren Tourtellotte, John Varga

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

The role of anti-citrullinated protein antibody reactivities in an inception cohort of patients with rheumatoid arthritis receiving treat-to-target therapy

Maria Karolina Jonsson, Aase Haj Hensvold, Monika Hansson, Anna-Birgitte Aga, Joseph Sexton, Linda Mathsson-Alm, Martin Cornillet, Guy Serre, Siri Lillegraven, Bjørg-Tilde Svanes Fevang, Anca Irinel Catrina, Espen Andre Haavardsholm

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Prediction of primary non-response to methotrexate therapy using demographic, clinical and psychosocial variables: results from the UK Rheumatoid Arthritis Medication Study (RAMS)

Jamie C. Sergeant, Kimme L. Hyrich, James Anderson, Kamilla Kopec-Harding, Holly F. Hope, Deborah P. M. Symmons, Anne Barton, Suzanne M. M. Verstappen, RAMS Co-Investigators

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Control of cytokine mRNA degradation by the histone deacetylase inhibitor ITF2357 in rheumatoid arthritis fibroblast-like synoviocytes: beyond transcriptional regulation

Chiara Angiolilli, Pawel A. Kabala, Aleksander M. Grabiec, Marzia Rossato, Wi S. Lai, Gianluca Fossati, Paolo Mascagni, Christian Steinkühler, Perry J. Blackshear, Kris A. Reedquist, Dominique L. Baeten, Timothy R. D. J. Radstake

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Functional intraepithelial lymphocyte changes in inflammatory bowel disease and spondyloarthritis have disease specific correlations with intestinal microbiota

Emilie H. Regner, Neha Ohri, Andrew Stahly, Mark E. Gerich, Blair P. Fennimore, Diana Ir, Widian K. Jubair, Carsten Görg, Janet Siebert, Charles E. Robertson, Liron Caplan, Daniel N. Frank, Kristine A. Kuhn

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Sex-based differences in association between circulating T cell subsets and disease activity in untreated early rheumatoid arthritis patients

Jonathan Aldridge, Jayesh M. Pandya, Linda Meurs, Kerstin Andersson, Inger Nordström, Elke Theander, Anna-Carin Lundell, Anna Rudin

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Effect of subcutaneous tocilizumab treatment on work/housework status in biologic-naïve rheumatoid arthritis patients using inverse probability of treatment weighting: FIRST ACT-SC study

Yoshiya Tanaka, Hideto Kameda, Kazuyoshi Saito, Yuko Kaneko, Eiichi Tanaka, Shinsuke Yasuda, Naoto Tamura, Keishi Fujio, Takao Fujii, Toshihisa Kojima, Tatsuhiko Anzai, Chikuma Hamada, Yoshihisa Fujino, Shinya Matsuda, Hitoshi Kohsaka

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

The plasma biomarker soluble SIGLEC-1 is associated with the type I interferon transcriptional signature, ethnic background and renal disease in systemic lupus erythematosus

João J. Oliveira, Sarah Karrar, Daniel B. Rainbow, Christopher L. Pinder, Pamela Clarke, Arcadio Rubio García, Osama Al-Assar, Keith Burling, Sian Morris, Richard Stratton, Tim J. Vyse, Linda S. Wicker, John A. Todd, Ricardo C. Ferreira

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Resolution of synovitis and arrest of catabolic and anabolic bone changes in patients with psoriatic arthritis by IL-17A blockade with secukinumab: results from the prospective PSARTROS study

Eleni Kampylafka, Isabelle d’Oliveira, Christina Linz, Veronika Lerchen, Fabian Stemmler, David Simon, Matthias Englbrecht, Michael Sticherling, Jürgen Rech, Arnd Kleyer, Georg Schett, Axel J. Hueber

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

A bivalent compound targeting CCR5 and the mu opioid receptor treats inflammatory arthritis pain in mice without inducing pharmacologic tolerance

Raini Dutta, Mary M. Lunzer, Jennifer L. Auger, Eyup Akgün, Philip S. Portoghese, Bryce A. Binstadt

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

A randomized controlled trial comparing PF-06438179/GP1111 (an infliximab biosimilar) and infliximab reference product for treatment of moderate to severe active rheumatoid arthritis despite methotrexate therapy

Stanley B. Cohen, Rieke Alten, Hideto Kameda, Tomas Hala, Sebastiao C. Radominski, Muhammad I. Rehman, Ramesh Palaparthy, Karl Schumacher, Susanne Schmitt, Steven Y. Hua, Claudia Ianos, K. Lea Sewell

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Widespread pain in axial spondyloarthritis: clinical importance and gender differences

Thijs Willem Swinnen, René Westhovens, Wim Dankaerts, Kurt de Vlam

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Effects of CTLA4-Ig treatment on circulating fibrocytes and skin fibroblasts from the same systemic sclerosis patients: an in vitro assay

Maurizio Cutolo, Stefano Soldano, Paola Montagna, Amelia Chiara Trombetta, Paola Contini, Barbara Ruaro, Alberto Sulli, Stefano Scabini, Emanuela Stratta, Sabrina Paolino, Carmen Pizzorni, Vanessa Smith, Renata Brizzolara

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Serum levels of B-cell activating factor of the TNF family (BAFF) correlate with anti-Jo-1 autoantibodies levels and disease activity in patients with anti-Jo-1positive polymyositis and dermatomyositis

Olga Kryštůfková, Hana Hulejová, Heřman F. Mann, Ondřej Pecha, Ivana Půtová, Louise Ekholm, Ingrid E. Lundberg, Jiří Vencovský

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

ADAM-17 is expressed on rheumatoid arthritis fibroblast-like synoviocytes and regulates proinflammatory mediator expression and monocyte adhesion

Sho Ishii, Takeo Isozaki, Hidekazu Furuya, Hiroko Takeuchi, Yumi Tsubokura, Katsunori Inagaki, Tsuyoshi Kasama

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Ten years of follow-up data in psoriatic arthritis: results based on standardized monitoring of patients in an ordinary outpatient clinic in southern Norway

Glenn Haugeberg, Brigitte Michelsen, Stig Tengesdal, Inger Johanne Widding Hansen, Andreas Diamantopoulos, Arthur Kavanaugh

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

BATF regulates collagen-induced arthritis by regulating T helper cell differentiation

Sang-Heon Park, Jinseol Rhee, Seul-Ki Kim, Jung-Ah Kang, Ji-Sun Kwak, Young-Ok Son, Wan-Su Choi, Sung-Gyoo Park, Jang-Soo Chun

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

A five-year prospective study of spinal radiographic progression and its predictors in men and women with ankylosing spondylitis

Anna Deminger, Eva Klingberg, Mats Geijer, Jan Göthlin, Martin Hedberg, Eva Rehnberg, Hans Carlsten, Lennart T. Jacobsson, Helena Forsblad-d’Elia

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

GPR120 is an important inflammatory regulator in the development of osteoarthritis

Yuanfeng Chen, Dan Zhang, Ki Wai Ho, Sien Lin, Wade Chun-Wai Suen, Huantian Zhang, Zhengang Zha, Gang Li, Po Sing Leung

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Serum metabolomic profiling predicts synovial gene expression in rheumatoid arthritis

Rekha Narasimhan, Roxana Coras, Sara B. Rosenthal, Shannon R. Sweeney, Alessia Lodi, Stefano Tiziani, David Boyle, Arthur Kavanaugh, Monica Guma

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Factors associated with the achievement of biological disease-modifying antirheumatic drug-free remission in rheumatoid arthritis: the ANSWER cohort study

Motomu Hashimoto, Moritoshi Furu, Wararu Yamamoto, Takanori Fujimura, Ryota Hara, Masaki Katayama, Akira Ohnishi, Kengo Akashi, Shuzo Yoshida, Koji Nagai, Yonsu Son, Hideki Amuro, Toru Hirano, Kosuke Ebina, Ryuji Uozumi, Hiromu Ito, Masao Tanaka, Koichiro Ohmura, Takao Fujii, Tsuneyo Mimori

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Do ethnicity, degree of family relationship, and the spondyloarthritis subtype in affected relatives influence the association between a positive family history for spondyloarthritis and HLA-B27 carriership? Results from the worldwide ASAS cohort

Miranda van Lunteren, Alexandre Sepriano, Robert Landewé, Joachim Sieper, Martin Rudwaleit, Désirée van der Heijde, Floris van Gaalen

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Comparative effectiveness of allopurinol versus febuxostat for preventing incident dementia in older adults: a propensity-matched analysis

Jasvinder A. Singh, John D. Cleveland

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Expansion and activation of monocytic-myeloid-derived suppressor cell via STAT3/arginase-I signaling in patients with ankylosing spondylitis

Yu-feng Liu, Kun-hai Zhuang, Bin Chen, Pei-wu Li, Xuan Zhou, Hua Jiang, Li-mei Zhong, Feng-bin Liu

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

NLRP3 inflammasome inhibitor OLT1177 suppresses joint inflammation in murine models of acute arthritis

Carlo Marchetti, Benjamin Swartzwelter, Marije I. Koenders, Tania Azam, Isak W. Tengesdal, Nick Powers, Dennis M. de Graaf, Charles A. Dinarello, Leo A. B. Joosten

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Role of the mTOR pathway in minor salivary gland changes in Sjogren’s syndrome and systemic sclerosis

Zeki Soypaçacı, Zeynep Zehra Gümüş, Fulya Çakaloğlu, Mustafa Özmen, Dilek Solmaz, Sercan Gücenmez, Önay Gercik, Servet Akar

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Biologics and cardiovascular events in inflammatory arthritis: a prospective national cohort study

Joshua L. Lee, Premarani Sinnathurai, Rachelle Buchbinder, Catherine Hill, Marissa Lassere, Lyn March

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Impact of oral osteoarthritis therapy usage among other risk factors on knee replacement: a nested case-control study using the Osteoarthritis Initiative cohort

Marc Dorais, Johanne Martel-Pelletier, Jean-Pierre Raynauld, Philippe Delorme, Jean-Pierre Pelletier

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Cytokine profiling in active and quiescent SLE reveals distinct patient subpopulations

John A. Reynolds, Eoghan M. McCarthy, Sahena Haque, Pintip Ngamjanyaporn, Jamie C. Sergeant, Elaine Lee, Eileen Lee, Stephen A. Kilfeather, Ben Parker, Ian N. Bruce

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Induction of sustained remission in early inflammatory arthritis with the combination of infliximab plus methotrexate: the DINORA trial

Tanja Alexandra Stamm, Klaus Peter Machold, Daniel Aletaha, Farideh Alasti, Peter Lipsky, David Pisetsky, Robert Landewe, Desiree van der Heijde, Alexandre Sepriano, Martin Aringer, Dimitri Boumpas, Gerd Burmester, Maurizio Cutolo, Wolfgang Ebner, Winfried Graninger, Tom Huizinga, Georg Schett, Hendrik Schulze-Koops, Paul-Peter Tak, Emilio Martin-Mola, Ferdinand Breedveld, Josef Smolen

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Mediterranean diet and risk of rheumatoid arthritis: a population-based case-control study

Kari Johansson, Johan Askling, Lars Alfredsson, Daniela Di Giuseppe, on behalf of the EIRA study group

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Investigation of myositis and scleroderma specific autoantibodies in patients with lung cancer

Zoe E. Betteridge, Lynsey Priest, Robert G. Cooper, Neil J. McHugh, Fiona Blackhall, Janine A. Lamb

01.12.2018 | Correction | Ausgabe 1/2018 Open Access

Correction to: miR-155 is dispensable in monosodium urate-induced gouty inflammation in mice

Qibin Yang, Quanbo Zhang, Yufeng Qing, Li Zhou, Qingsheng Mi, Jingguo Zhou

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

A comparative clinical study of PF-06410293, a candidate adalimumab biosimilar, and adalimumab reference product (Humira®) in the treatment of active rheumatoid arthritis

Roy M. Fleischmann, Rieke Alten, Margarita Pileckyte, Kasia Lobello, Steven Y. Hua, Carol Cronenberger, Daniel Alvarez, Amy E. Bock, K. Lea Sewell

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

The relationship between ferritin and urate levels and risk of gout

Tahzeeb Fatima, Cushla McKinney, Tanya J. Major, Lisa K. Stamp, Nicola Dalbeth, Cory Iverson, Tony R. Merriman, Jeffrey N. Miner

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Clinical signs and symptoms in a joint model of four disease activity parameters in juvenile dermatomyositis: a prospective, longitudinal, multicenter cohort study

E. H. Pieter van Dijkhuizen, Maria De Iorio, Lucy R. Wedderburn, Claire T. Deakin, on behalf of the JDRG

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

High-frequency ultrasound of the skin in systemic sclerosis: an exploratory study to examine correlation with disease activity and to define the minimally detectable difference

Hongyan Li, Daniel E. Furst, Hongtao Jin, Chao Sun, Xiaoping Wang, Lin Yang, Jingjing He, Yanru Wang, Aijing Liu

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Aberrantly expressed messenger RNAs and long noncoding RNAs in degenerative nucleus pulposus cells co-cultured with adipose-derived mesenchymal stem cells

Zhihua Han, Jiandong Wang, Liang Gao, Qiugen Wang, Jianhong Wu

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Evaluation of 99mTc-rhAnnexin V-128 SPECT/CT as a diagnostic tool for early stages of interstitial lung disease associated with systemic sclerosis

Janine Schniering, Li Guo, Matthias Brunner, Roger Schibli, Shuang Ye, Oliver Distler, Martin Béhé, Britta Maurer

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Effects of transitional care on self-care, readmission rates, and quality of life in adult patients with systemic lupus erythematosus: a randomized controlled trial

Xia Xie, Yuqing Song, Hui Yang, Anliu Nie, Hong Chen, Ji-ping Li

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Serum biomarker for diagnostic evaluation of pulmonary arterial hypertension in systemic sclerosis

Lisa M. Rice, Julio C. Mantero, Eric A. Stratton, Rod Warburton, Kari Roberts, Nicholas Hill, Robert W. Simms, Robyn Domsic, Harrison W. Farber, Robert Layfatis

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Loss of Gαq impairs regulatory B-cell function

Yan He, Xiaoqing Yuan, Yan Li, Chunlian Zhong, Yuan Liu, Hongyan Qian, Jingxiu Xuan, Lihua Duan, Guixiu Shi

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Immune complexes containing scleroderma-specific autoantibodies induce a profibrotic and proinflammatory phenotype in skin fibroblasts

Elena Raschi, Cecilia Beatrice Chighizola, Laura Cesana, Daniela Privitera, Francesca Ingegnoli, Claudio Mastaglio, Pier Luigi Meroni, Maria Orietta Borghi

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

T-cell transcriptomics from peripheral blood highlights differences between polymyositis and dermatomyositis patients

Miranda Houtman, Louise Ekholm, Espen Hesselberg, Karine Chemin, Vivianne Malmström, Ann M. Reed, Ingrid E. Lundberg, Leonid Padyukov

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Osteogenic differentiation of fibroblast-like synovial cells in rheumatoid arthritis is induced by microRNA-218 through a ROBO/Slit pathway

Naoki Iwamoto, Shoichi Fukui, Ayuko Takatani, Toshimasa Shimizu, Masataka Umeda, Ayako Nishino, Takashi Igawa, Tomohiro Koga, Shin-ya Kawashiri, Kunihiro Ichinose, Mami Tmai, Hideki Nakamura, Tomoki Origuchi, Ko Chiba, Makoto Osaki, Astrid Jüngel, Steffen Gay, Atsushi Kawakami

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

The risk of clinically diagnosed gout by serum urate levels: results from 30 years follow-up of the Malmö Preventive Project cohort in southern Sweden

Meliha C. Kapetanovic, Peter Nilsson, Carl Turesson, Martin Englund, Nicola Dalbeth, Lennart Jacobsson

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

An explorative study on deep profiling of peripheral leukocytes to identify predictors for responsiveness to anti-tumour necrosis factor alpha therapies in ankylosing spondylitis: natural killer cells in focus

Ursula Schulte-Wrede, Till Sörensen, Joachim R. Grün, Thomas Häupl, Heike Hirseland, Marta Steinbrich-Zöllner, Peihua Wu, Andreas Radbruch, Denis Poddubnyy, Joachim Sieper, Uta Syrbe, Andreas Grützkau

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Recombinant human proteoglycan-4 reduces phagocytosis of urate crystals and downstream nuclear factor kappa B and inflammasome activation and production of cytokines and chemokines in human and murine macrophages

Marwa Qadri, Gregory D. Jay, Ling X. Zhang, Wendy Wong, Anthony M. Reginato, Changqi Sun, Tannin A. Schmidt, Khaled A. Elsaid

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Interferon-λ3/4 genetic variants and interferon-λ3 serum levels are biomarkers of lupus nephritis and disease activity in Taiwanese

Ji-Yih Chen, Chin-Man Wang, Tai-Di Chen, Yeong-Jian Jan Wu, Jing-Chi Lin, Ling Ying Lu, Jianming Wu

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

The host cellular immune response to cytomegalovirus targets the endothelium and is associated with increased arterial stiffness in ANCA-associated vasculitis

Dimitrios Chanouzas, Michael Sagmeister, Lovesh Dyall, Phoebe Sharp, Lucy Powley, Serena Johal, Jessica Bowen, Peter Nightingale, Charles J. Ferro, Matthew D. Morgan, Paul Moss, Lorraine Harper

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Detection of high cardiovascular risk patients with ankylosing spondylitis based on the assessment of abdominal aortic calcium as compared to carotid ultrasound

Javier Rueda-Gotor, Fernanda Genre, Alfonso Corrales, Ricardo Blanco, Patricia Fuentevilla, Virginia Portilla, Rosa Expósito, Cristina Mata, Trinitario Pina, Carlos González-Juanatey, Luis Rodriguez-Rodriguez, Miguel A. González-Gay

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Tofacitinib inhibits granulocyte–macrophage colony-stimulating factor-induced NLRP3 inflammasome activation in human neutrophils

Makiko Yashiro Furuya, Tomoyuki Asano, Yuya Sumichika, Shuzo Sato, Hiroko Kobayashi, Hiroshi Watanabe, Eiji Suzuki, Hideko Kozuru, Hiroshi Yatsuhashi, Tomohiro Koga, Hiromasa Ohira, Hideharu Sekine, Atsushi Kawakami, Kiyoshi Migita

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

T-cell costimulation blockade is effective in experimental digestive and lung tissue fibrosis

Gonçalo Boleto, Christophe Guignabert, Sonia Pezet, Anne Cauvet, Jérémy Sadoine, Ly Tu, Carole Nicco, Camille Gobeaux, Frédéric Batteux, Yannick Allanore, Jérôme Avouac

01.12.2018 | Letter | Ausgabe 1/2018 Open Access

Comments on the article “Effectiveness and safety of tofacitinib in rheumatoid arthritis: a cohort study”

Thuy Nhu Thai, Ghadeer K. Dawwas

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Physical activity is related to function and fatigue but not pain in women with fibromyalgia: baseline analyses from the Fibromyalgia Activity Study with TENS (FAST)

Ericka N. Merriwether, Laura A. Frey-Law, Barbara A. Rakel, Miriam B. Zimmerman, Dana L. Dailey, Carol G. T. Vance, Meenakshi Golchha, Katherine M. Geasland, Ruth Chimenti, Leslie J. Crofford, Kathleen A. Sluka

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Enhanced IL-6/phosphorylated STAT3 signaling is related to the imbalance of circulating T follicular helper/T follicular regulatory cells in patients with rheumatoid arthritis

Qian Niu, Zhuo-chun Huang, Xiao-juan Wu, Ya-xiong Jin, Yun-fei An, Ya-mei Li, Huan Xu, Bin Yang, Lan-lan Wang

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Short Link N promotes disc repair in a rabbit model of disc degeneration

Fackson Mwale, Koichi Masuda, Michael P. Grant, Laura M. Epure, Kenji Kato, Shingo Miyazaki, Kevin Cheng, Junichi Yamada, Won C. Bae, Carol Muehleman, Peter J. Roughley, John Antoniou

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Cortical bone loss is an early feature of nonradiographic axial spondyloarthritis

Anna Neumann, Judith Haschka, Arnd Kleyer, Louis Schuster, Matthias Englbrecht, Andreas Berlin, Camille P. Figueiredo, David Simon, Christian Muschitz, Roland Kocijan, Heinrich Resch, Jürgen Rech, Georg Schett

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Simultaneous quantification of bone erosions and enthesiophytes in the joints of patients with psoriasis or psoriatic arthritis - effects of age and disease duration

David Simon, Arnd Kleyer, Francesca Faustini, Matthias Englbrecht, Judith Haschka, Andreas Berlin, Sebastian Kraus, Axel J. Hueber, Roland Kocijan, Michael Sticherling, Juergen Rech, Georg Schett

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Arhalofenate acid inhibits monosodium urate crystal-induced inflammatory responses through activation of AMP-activated protein kinase (AMPK) signaling

Charles McWherter, Yun-Jung Choi, Ramon L. Serrano, Sushil K. Mahata, Robert Terkeltaub, Ru Liu-Bryan

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

The role of RORα in salivary gland lesions in patients with primary Sjögren’s syndrome

Xiuhong Weng, Yi Liu, Shun Cui, Bo Cheng

01.12.2018 | Correction | Ausgabe 1/2018 Open Access

Correction to: Comorbidity in gout at the time of first diagnosis: sex differences that may have implications for dosing of urate lowering therapy

Panagiota Drivelegka, Valgerdur Sigurdardottir, Anna Svärd, Lennart T. H. Jacobsson, Mats Dehlin

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Osteoporosis of the vertebra and osteochondral remodeling of the endplate causes intervertebral disc degeneration in ovariectomized mice

Zhi-feng Xiao, Jian-bo He, Guo-yi Su, Mei-hui Chen, Yu Hou, Shu-dong Chen, Ding-kun Lin

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Monosodium urate crystals reduce osteocyte viability and indirectly promote a shift in osteocyte function towards a proinflammatory and proresorptive state

Ashika Chhana, Bregina Pool, Karen E. Callon, Mei Lin Tay, David Musson, Dorit Naot, Geraldine McCarthy, Susan McGlashan, Jillian Cornish, Nicola Dalbeth

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

A single determination of C-reactive protein does not suffice to declare a patient with a diagnosis of axial spondyloarthritis ‘CRP-negative’

Robert Landewé, Tommi Nurminen, Owen Davies, Dominique Baeten

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Monosodium urate burden assessed with dual-energy computed tomography predicts the risk of flares in gout: a 12-month observational study

MSU burden and risk of gout flare
Tristan Pascart, Agathe Grandjean, Benoist Capon, Julie Legrand, Nasser Namane, Vincent Ducoulombier, Marguerite Motte, Marie Vandecandelaere, Hélène Luraschi, Catherine Godart, Eric Houvenagel, Laurène Norberciak, Jean-François Budzik

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Effects of a 15-month anti-TNF-α treatment on plasma levels of glycosaminoglycans in women with rheumatoid arthritis

Anna Szeremeta, Agnieszka Jura-Półtorak, Ewa Maria Koźma, Andrzej Głowacki, Eugeniusz Józef Kucharz, Magdalena Kopeć-Mędrek, Krystyna Olczyk

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

1,25(OH)2D3 and dexamethasone additively suppress synovial fibroblast activation by CCR6+ T helper memory cells and enhance the effect of tumor necrosis factor alpha blockade

Wendy Dankers, Claudia González-Leal, Nadine Davelaar, Patrick S. Asmawidjaja, Adriana M. C. Mus, Johanna M. W. Hazes, Edgar M. Colin, Erik Lubberts

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Interaction between CD177 and platelet endothelial cell adhesion molecule-1 downregulates membrane-bound proteinase-3 (PR3) expression on neutrophils and attenuates neutrophil activation induced by PR3-ANCA

Hui Deng, Nan Hu, Chen Wang, Min Chen, Ming-Hui Zhao

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Metabolomic alterations associated with Behçet’s disease

Wenjie Zheng, Xiuhua Wu, Maryam Goudarzi, Jing Shi, Wei Song, Chaoran Li, Jinjing Liu, Hua Chen, Xuan Zhang, Xiaofeng Zeng, Heng-Hong Li

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Neuropathic-like knee pain and associated risk factors: a cross-sectional study in a UK community sample

Gwen Sascha Fernandes, Ana Marie Valdes, David Andrew Walsh, Weiya Zhang, Michael Doherty

01.12.2018 | Review | Ausgabe 1/2018 Open Access

From association to mechanism in complex disease genetics: the role of the 3D genome

Yao Fu, Kandice L Tessneer, Chuang Li, Patrick M Gaffney

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

CCN family member 2/connective tissue growth factor (CCN2/CTGF) is regulated by Wnt–β-catenin signaling in nucleus pulposus cells

Akihiko Hiyama, Kosuke Morita, Daisuke Sakai, Masahiko Watanabe

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Are gender-specific approaches needed in diagnosing early axial spondyloarthritis? Data from the SPondyloArthritis Caught Early cohort

Augusta Ortolan, Miranda van Lunteren, Sofia Ramiro, Roberta Ramonda, Robert B. M. Landewé, Hanne Dagfinrud, Lennart T. H. Jacobsson, Désirée van der Heijde, Floris A. van Gaalen

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

CYLD suppression enhances the pro-inflammatory effects and hyperproliferation of rheumatoid arthritis fibroblast-like synoviocytes by enhancing NF-κB activation

Le-meng Zhang, Jing-Jing Zhou, Chun-lei Luo

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Association between brain-derived neurotrophic factor gene polymorphisms and fibromyalgia in a Korean population: a multicenter study

Dong-Jin Park, Seong-Ho Kim, Seong-Su Nah, Ji Hyun Lee, Seong-Kyu Kim, Yeon-Ah Lee, Seung-Jae Hong, Hyun-Sook Kim, Hye-Soon Lee, Hyoun Ah Kim, Chung-Il Joung, Sang-Hyon Kim, Shin-Seok Lee

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Influence of HLA-B27 on the Ankylosing Spondylitis phenotype: results from the REGISPONSER database

Marta Arévalo, Jordi Gratacós Masmitjà, Mireia Moreno, Joan Calvet, Cristobal Orellana, Desirée Ruiz, Carmen Castro, Pilar Carreto, Marta Larrosa, Eduardo Collantes, Pilar Font, REGISPONSER group

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Increase of circulating memory B cells after glucocorticoid-induced remission identifies patients at risk of IgG4-related disease relapse

Marco Lanzillotta, Emanuel Della-Torre, Raffaella Milani, Enrica Bozzolo, Emanuele Bozzalla-Cassione, Lucrezia Rovati, Paolo Giorgio Arcidiacono, Stefano Partelli, Massimo Falconi, Fabio Ciceri, Lorenzo Dagna

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Blocking CD248 molecules in perivascular stromal cells of patients with systemic sclerosis strongly inhibits their differentiation toward myofibroblasts and proliferation: a new potential target for antifibrotic therapy

Paola Di Benedetto, Vasiliki Liakouli, Piero Ruscitti, Onorina Berardicurti, Francesco Carubbi, Noemi Panzera, Salvatore Di Bartolomeo, Giuliana Guggino, Francesco Ciccia, Giovanni Triolo, Paola Cipriani, Roberto Giacomelli

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Is synovial hypertrophy without Doppler activity sensitive to change? Post-hoc analysis from a rheumatoid arthritis ultrasound study

Lene Terslev, Mikkel Østergaard, Joe Sexton, Hilde Berner Hammer

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

E2F2 directly regulates the STAT1 and PI3K/AKT/NF-κB pathways to exacerbate the inflammatory phenotype in rheumatoid arthritis synovial fibroblasts and mouse embryonic fibroblasts

Shiguan Wang, Lin Wang, Changshun Wu, Shui Sun, Ji-hong Pan

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

The frequency of ANCA-associated vasculitis in a national database of hospitalized patients in China

Jiannan Li, Zhao Cui, Jian-yan Long, Wei Huang, Jin-wei Wang, Haibo Wang, Luxia Zhang, Min Chen, Ming-hui Zhao

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Persistence and adverse events of biological treatment in adult patients with juvenile idiopathic arthritis: results from BIOBADASER

Juan José Bethencourt Baute, Carlos Sanchez-Piedra, Dolores Ruiz-Montesinos, Marta Medrano San Ildefonso, Carlos Rodriguez-Lozano, Eva Perez-Pampin, Ana Ortiz, Sara Manrique, Rosa Roselló, Victoria Hernandez, Cristina Campos, Agustí Sellas, Walter Alberto Sifuentes-Giraldo, Javier García-González, Fernando Sanchez-Alonso, Federico Díaz-González, Juan Jesús Gómez-Reino, Sagrario Bustabad Reyes, on behalf of the BIOBADASER study group

01.12.2018 | Review | Ausgabe 1/2018 Open Access

What is the value of musculoskeletal ultrasound in patients presenting with arthralgia to predict inflammatory arthritis development? A systematic literature review

Rosaline van den Berg, Sarah Ohrndorf, Marion C. Kortekaas, Annette H. M. van der Helm-van Mil

01.12.2018 | Review | Ausgabe 1/2018 Open Access

Modulation of T-cell responses by anti-tumor necrosis factor treatments in rheumatoid arthritis: a review

Jean-Luc Davignon, Benjamin Rauwel, Yannick Degboé, Arnaud Constantin, Jean-Fredéric Boyer, Andrey Kruglov, Alain Cantagrel

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Baseline metabolic profiles of early rheumatoid arthritis patients achieving sustained drug-free remission after initiating treat-to-target tocilizumab, methotrexate, or the combination: insights from systems biology

Xavier M Teitsma, Wei Yang, Johannes W G Jacobs, Attila Pethö-Schramm, Michelle E A Borm, Amy C Harms, Thomas Hankemeier, Jacob M van Laar, Johannes W J Bijlsma, Floris P J G Lafeber

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Low bone mineral density predicts the formation of new syndesmophytes in patients with axial spondyloarthritis

Hyoung Rae Kim, Yeon Sik Hong, Sung-Hwan Park, Ji Hyeon Ju, Kwi Young Kang

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Obesity alters the in vivo mechanical response and biochemical properties of cartilage as measured by MRI

Amber T Collins, Micaela L Kulvaranon, Hattie C Cutcliffe, Gangadhar M Utturkar, Wyatt A R Smith, Charles E Spritzer, Farshid Guilak, Louis E DeFrate

01.12.2018 | Letter | Ausgabe 1/2018 Open Access

Is the exposure to bisphosphonates or osteoporosis the predictor of spinal radiographic progression in ankylosing spondylitis?

Giovanni Orsolini, Giovanni Adami, Maurizio Rossini, Angelo Fassio, Alessandro Giollo, Cristian Caimmi, Luca Idolazzi, Davide Gatti, Ombretta Viapiana

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

I do not want to suppress the natural process of inflammation: new insights on factors associated with non-adherence in rheumatoid arthritis

Valentin Ritschl, Angelika Lackner, Carina Boström, Erika Mosor, Michaela Lehner, Maisa Omara, Romualdo Ramos, Paul Studenic, Josef Sebastian Smolen, Tanja Alexandra Stamm

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Prognostic profile of systemic sclerosis: analysis of the clinical EUSTAR cohort in China

Shasha Hu, Yong Hou, Qian Wang, Mengtao Li, Dong Xu, Xiaofeng Zeng

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Downregulation of miRNA17–92 cluster marks Vγ9Vδ2 T cells from patients with rheumatoid arthritis

Giuliana Guggino, Valentina Orlando, Laura Saieva, Piero Ruscitti, Paola Cipriani, Marco Pio La Manna, Roberto Giacomelli, Riccardo Alessandro, Giovanni Triolo, Francesco Ciccia, Francesco Dieli, Nadia Caccamo

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

MRI-detected osteophytes of the knee: natural history and structural correlates of change

Zhaohua Zhu, Changhai Ding, Weiyu Han, Shuang Zheng, Tania Winzenberg, Flavia Cicuttini, Graeme Jones

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Cytokine production by activated plasmacytoid dendritic cells and natural killer cells is suppressed by an IRAK4 inhibitor

Karin Hjorton, Niklas Hagberg, Elisabeth Israelsson, Lisa Jinton, Olof Berggren, Johanna K. Sandling, Kristofer Thörn, John Mo, Maija-Leena Eloranta, Lars Rönnblom, The DISSECT consortium

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Prospective evaluation of the capillaroscopic skin ulcer risk index in systemic sclerosis patients in clinical practice: a longitudinal, multicentre study

Ulrich A. Walker, Veronika K. Jaeger, Katharina M. Bruppacher, Rucsandra Dobrota, Lionel Arlettaz, Martin Banyai, Jörg Beron, Carlo Chizzolini, Ernst Groechenig, Rüdiger B. Mueller, François Spertini, Peter M. Villiger, Oliver Distler

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Relevance of interferon-gamma in pathogenesis of life-threatening rapidly progressive interstitial lung disease in patients with dermatomyositis

Yuichi Ishikawa, Shigeru Iwata, Kentaro Hanami, Aya Nawata, Mingzeng Zhang, Kaoru Yamagata, Shintaro Hirata, Kei Sakata, Yasuyuki Todoroki, Kazuhisa Nakano, Shingo Nakayamada, Minoru Satoh, Yoshiya Tanaka

01.12.2018 | Letter | Ausgabe 1/2018 Open Access

Should our approach to diuretic using in patients with gout change?

Duygu Tecer, Gozde Kubra Yardımcı, Alper Sari, Hakan Babaoglu

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Disease-specific composite measures for psoriatic arthritis are highly responsive to a Janus kinase inhibitor treatment that targets multiple domains of disease

Philip Helliwell, Laura C. Coates, Oliver FitzGerald, Peter Nash, Enrique R. Soriano, M. Elaine Husni, Ming-Ann Hsu, Keith S. Kanik, Thijs Hendrikx, Joseph Wu, Elizabeth Kudlacz

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Risk of chronic kidney disease in patients with gout and the impact of urate lowering therapy: a population-based cohort study

Matthew Roughley, Alyshah Abdul Sultan, Lorna Clarson, Sara Muller, Rebecca Whittle, John Belcher, Christian D. Mallen, Edward Roddy

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Psychometric validation of an empowerment scale for Spanish-speaking patients with rheumatoid arthritis

Irazú Contreras-Yáñez, Emmanuel Ruiz-Medrano, Luz del Carmen R. Hernández, Virginia Pascual-Ramos

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Potential therapeutic antibodies targeting specific adiponectin isoforms in rheumatoid arthritis

Yeon-Ah Lee, Dae-Hyun Hahm, Jung Yeon Kim, Bonjun Sur, Hyun Min Lee, Chun Jeih Ryu, Hyung-In Yang, Kyoung Soo Kim

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Changes in hepatitis B virus surface antibody titer and risk of hepatitis B reactivation in HBsAg-negative/HBcAb-positive patients undergoing biologic therapy for rheumatic diseases: a prospective cohort study

Ya-Chih Tien, Hsu-Heng Yen, Ching-Fang Li, Mei-Ping Liu, Yin-Tzu Hsue, Ming-Hui Hung, Ying-Ming Chiu

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

The involvement of C5a in the progression of experimental arthritis with Porphyromonas gingivalis infection in SKG mice

Syuichi Munenaga, Kazuhisa Ouhara, Yuta Hamamoto, Mikihito Kajiya, Katsuhiro Takeda, Satoshi Yamasaki, Toshihisa Kawai, Noriyoshi Mizuno, Tsuyoshi Fujita, Eiji Sugiyama, Hidemi Kurihara

01.12.2018 | Correction | Ausgabe 1/2018 Open Access

Correction to: Is the exposure to bisphosphonates or osteoporosis the predictor of spinal radiographic progression in ankylosing spondylitis?

Giovanni Orsolini, Giovanni Adami, Maurizio Rossini, Angelo Fassio, Alessandro Giollo, Cristian Caimmi, Luca Idolazzi, Davide Gatti, Ombretta Viapiana

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Intrauterine fetal deaths related to antiphospholipid syndrome: a descriptive study of 65 women

Mériem Belhocine, Laetitia Coutte, Nicolas Martin Silva, Nathalie Morel, Gaëlle Guettrot-Imbert, Romain Paule, Claire Le Jeunne, Micaela Fredi, Michel Dreyfus, Jean-Charles Piette, Odile Souchaud-Debouverie, Catherine Deneux-Tharaux, Vassilis Tsatsaris, Emmanuelle Pannier, Véronique Le Guern, Nathalie Costedoat-Chalumeau

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Knee pain as a predictor of structural progression over 4 years: data from the Osteoarthritis Initiative, a prospective cohort study

Yuanyuan Wang, Andrew J. Teichtahl, François Abram, Sultana Monira Hussain, Jean-Pierre Pelletier, Flavia M. Cicuttini, Johanne Martel-Pelletier

01.12.2018 | Review | Ausgabe 1/2018 Open Access

The inflammatory response in the regression of lumbar disc herniation

Carla Cunha, Ana J. Silva, Paulo Pereira, Rui Vaz, Raquel M. Gonçalves, Mário A. Barbosa

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

VZV-specific T-cell levels in patients with rheumatic diseases are reduced and differentially influenced by antirheumatic drugs

David Schub, Gunter Assmann, Urban Sester, Martina Sester, Tina Schmidt

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Functional consultation and exercises improve grip strength in osteoarthritis of the hand – a randomised controlled trial

Michaela A. Stoffer-Marx, Meike Klinger, Simone Luschin, Silvia Meriaux-Kratochvila, Monika Zettel-Tomenendal, Valerie Nell-Duxneuner, Jochen Zwerina, Ingvild Kjeken, Marion Hackl, Sylvia Öhlinger, Anthony Woolf, Kurt Redlich, Josef S. Smolen, Tanja A. Stamm

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Polydatin effectively attenuates disease activity in lupus-prone mouse models by blocking ROS-mediated NET formation

Pan Liao, Yi He, Fangyuan Yang, Guihu Luo, Jian Zhuang, Zeqing Zhai, Lili Zhuang, Zhuomiao Lin, Jiehuang Zheng, Erwei Sun

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

How much allopurinol does it take to get to target urate? Comparison of actual dose with creatinine clearance-based dose

Lisa K. Stamp, Peter T. Chapman, Murray L. Barclay, Anne Horne, Christopher Frampton, Paul Tan, Jill Drake, Nicola Dalbeth

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

The multi-biomarker disease activity score tracks response to rituximab treatment in rheumatoid arthritis patients: a post hoc analysis of three cohort studies

Nadia M. T. Roodenrijs, Maria J. H. de Hair, Gill Wheater, Mohsen Elshahaly, Janneke Tekstra, Y. K. Onno Teng, Floris P. J. G. Lafeber, Ching Chang Hwang, Xinyu Liu, Eric H. Sasso, Jacob M. van Laar

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Musculoskeletal manifestations occur predominantly in patients with later-onset familial Mediterranean fever: Data from a multicenter, prospective national cohort study in Japan

Yushiro Endo, Tomohiro Koga, Midori Ishida, Yuya Fujita, Sosuke Tsuji, Ayuko Takatani, Toshimasa Shimizu, Remi Sumiyoshi, Takashi Igawa, Masataka Umeda, Shoichi Fukui, Ayako Nishino, Shin-ya Kawashiri, Naoki Iwamoto, Kunihiro Ichinose, Mami Tamai, Hideki Nakamura, Tomoki Origuchi, Kazunaga Agematsu, Akihiro Yachie, Junya Masumoto, Kiyoshi Migita, Atsushi Kawakami

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Comorbidities in polymyalgia rheumatica: a systematic review

Richard Partington, Toby Helliwell, Sara Muller, Alyshah Abdul Sultan, Christian Mallen

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Aberrant expression of interleukin-23-regulated miRNAs in T cells from patients with ankylosing spondylitis

Ning-Sheng Lai, Hui-Chun Yu, Chien-Hsueh Tung, Kuang-Yung Huang, Hsien-Bin Huang, Ming-Chi Lu

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Sequence of joint tissue inflammation during rheumatoid arthritis development

R. M. ten Brinck, H. W. van Steenbergen, A. H. M. van der Helm–van Mil

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Induction of chronic destructive arthritis in SCID mice by arthritogenic fibroblast-like synoviocytes derived from mice with antigen-induced arthritis

Oliver Frey, Marion Hückel, Mieczyslaw Gajda, Peter K. Petrow, Rolf Bräuer

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Long-term, health-enhancing physical activity is associated with reduction of pain but not pain sensitivity or improved exercise-induced hypoalgesia in persons with rheumatoid arthritis

Monika Löfgren, Christina H. Opava, Ingrid Demmelmaier, Cecilia Fridén, Ingrid E. Lundberg, Birgitta Nordgren, Eva Kosek

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

The effect of the cholinergic anti-inflammatory pathway on collagen-induced arthritis involves the modulation of dendritic cell differentiation

Di Liu, Tong Li, Hui Luo, Xiaoxia Zuo, Sijia Liu, Shiyao Wu

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

The presence of anti-nuclear antibodies alone is associated with changes in B cell activation and T follicular helper cells similar to those in systemic autoimmune rheumatic disease

Yuriy Baglaenko, Nan-Hua Chang, Sindhu R. Johnson, Waleed Hafiz, Kieran Manion, Dario Ferri, Babak Noamani, Dennisse Bonilla, Sina Rusta-Sellehy, Larissa Lisnevskaia, Earl Silverman, Arthur Bookman, Carolina Landolt-Marticorena, Joan Wither

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Standardisation of synovial biopsy analyses in rheumatic diseases: a consensus of the EULAR Synovitis and OMERACT Synovial Tissue Biopsy Groups

Aurélie Najm, Benoît Le Goff, Carl Orr, Rogier Thurlings, Juan D. Cañete, Frances Humby, Stefano Alivernini, Antonio Manzo, Søren Andreas Just, Vasco C. Romão, Veit Krenn, Ulf Müller-Ladner, Olga Addimanda, Sander W. Tas, Maria Stoenoiu, Laurent Meric de Bellefon, Patrick Durez, Vibeke Strand, Mihir D. Wechalekar, Joao E. Fonseca, Bernard Lauwerys, Ursula Fearon, Douglas J. Veale, on behalf of EULAR Synovitis Study Group and OMERACT Synovial Tissue Special Interest Group

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Carotid artery volumetric measures associate with clinical ten-year cardiovascular (CV) risk scores and individual traditional CV risk factors in rheumatoid arthritis; a carotid-MRI feasibility study

Lesley-Anne Bissell, Bara Erhayiem, Graham Fent, Elizabeth M. A. Hensor, Agata Burska, Helena Donica, Sven Plein, Maya H. Buch, John P. Greenwood, Jacqueline Andrews

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Prevalence of comorbidities in systemic sclerosis versus rheumatoid arthritis: a comparative, multicenter, matched-cohort study

Stylianos Panopoulos, Maria Tektonidou, Alexandros A. Drosos, Stamatis-Nick Liossis, Theodoros Dimitroulas, Alexandros Garyfallos, Lazaros Sakkas, Dimitrios Boumpas, Paraskevi V. Voulgari, Dimitrios Daoussis, Konstantinos Thomas, Georgios Georgiopoulos, Georgios Vosvotekas, Dimitrios Vassilopoulos, Petros P. Sfikakis

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Association between autophagy and inflammation in patients with rheumatoid arthritis receiving biologic therapy

Yi-Ming Chen, Chun-Yu Chang, Hsin-Hua Chen, Chia-Wei Hsieh, Kuo-Tung Tang, Meng-Chun Yang, Joung-Liang Lan, Der-Yuan Chen

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Improved patient-reported outcomes in patients with psoriatic arthritis treated with abatacept: results from a phase 3 trial

Vibeke Strand, Evo Alemao, Thomas Lehman, Alyssa Johnsen, Subhashis Banerjee, Harris A. Ahmad, Philip J. Mease

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

The risks of cancer development in systemic lupus erythematosus (SLE) patients: a systematic review and meta-analysis

Lebin Song, Yi Wang, Jiayi Zhang, Ninghong Song, Xiaoyun Xu, Yan Lu

01.12.2018 | Correction | Ausgabe 1/2018 Open Access

Correction to: Incidence of giant cell arteritis in Western Norway 1972-2012: a retrospective cohort study

L. K. Brekke, A. P. Diamantopoulos, B.-T. Fevang, J. Aβmus, E. Esperø, C. G. Gjesdal

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Secukinumab provides sustained PASDAS-defined remission in psoriatic arthritis and improves health-related quality of life in patients achieving remission: 2-year results from the phase III FUTURE 2 study

L. C. Coates, D. D. Gladman, P. Nash, O. FitzGerald, A. Kavanaugh, T. K. Kvien, L. Gossec, V. Strand, L. Rasouliyan, L. Pricop, K. Ding, S. M. Jugl, C. Gaillez, on behalf of the FUTURE 2 study group

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

TNFα expressed on the surface of microparticles modulates endothelial cell fate in rheumatoid arthritis

Cristiana Barbati, Marta Vomero, Tania Colasanti, Marco Diociaiuti, Fulvia Ceccarelli, Sara Ferrigno, Annacarla Finucci, Francesca Miranda, Lucia Novelli, Carlo Perricone, Francesca Romana Spinelli, Simona Truglia, Fabrizio Conti, Guido Valesini, Cristiano Alessandri

01.12.2018 | Letter | Ausgabe 1/2018 Open Access

Juvenile onset autoinflammatory disease due to a novel mutation in TNFAIP3 (A20)

Shuzo Sato, Yuya Fujita, Tomonari Shigemura, Hisanori Matoba, Kazunaga Agematsu, Yuya Sumichika, Makiko Yashiro, Atsushi Ono, Yukihiko Kawasaki, Hiroko Kobayashi, Hiroshi Watanabe, Tomohiro Koga, Atsushi Kawakami, Kiyoshi Migita

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Calprotectin strongly and independently predicts relapse in rheumatoid arthritis and polyarticular psoriatic arthritis patients treated with tumor necrosis factor inhibitors: a 1-year prospective cohort study

José Inciarte-Mundo, Julio Ramirez, Maria Victoria Hernández, Virginia Ruiz-Esquide, Andrea Cuervo, Sonia Raquel Cabrera-Villalba, Mariona Pascal, Jordi Yagüe, Juan D. Cañete, Raimon Sanmarti

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Vitamin D deficiency is associated with higher disease activity and the risk for uveitis in juvenile idiopathic arthritis - data from a German inception cohort

Claudia Sengler, Julian Zink, Jens Klotsche, Martina Niewerth, Ina Liedmann, Gerd Horneff, Christoph Kessel, Gerd Ganser, Angelika Thon, Johannes-Peter Haas, Anton Hospach, Frank Weller-Heinemann, Arnd Heiligenhaus, Dirk Foell, Angela Zink, Kirsten Minden

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Association of serum levels of fibrosis-related biomarkers with disease activity in patients with IgG4-related disease

Shin-ya Kawashiri, Tomoki Origuchi, Masataka Umeda, Ayako Nishino, Toshimasa Shimizu, Shoichi Fukui, Tomohiro Koga, Naoki Iwamoto, Kunihiro Ichinose, Mami Tamai, Hideki Nakamura, Takahiro Maeda, Mitsuhiro Kawano, Motohisa Yamamoto, Yasumori Izumi, Atsushi Kawakami

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Immunosuppressive therapy influences the accelerated age-dependent T-helper cell differentiation in systemic lupus erythematosus remission patients

Matthias Schaier, Claudius Gottschalk, Lorenz Uhlmann, Claudius Speer, Florian Kälble, Volker Eckstein, Carsten Müller-Tidow, Stefan Meuer, Karsten Mahnke, Hanns-Martin Lorenz, Martin Zeier, Andrea Steinborn

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

The value of joint ultrasonography in predicting arthritis in seropositive patients with arthralgia: a prospective cohort study

Marian H. van Beers-Tas, Annelies B. Blanken, Mark M. J. Nielen, Franktien Turkstra, Conny J. van der Laken, Marlies Meursinge Reynders, Dirkjan van Schaardenburg

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Primary respiratory disease in patients with systemic lupus erythematosus: data from the Spanish rheumatology society lupus registry (RELESSER) cohort

Javier Narváez, Helena Borrell, Fernando Sánchez-Alonso, Iñigo Rúa-Figueroa, Francisco Javier López-Longo, María Galindo-Izquierdo, Jaime Calvo-Alén, Antonio Fernández-Nebro, Alejandro Olivé, José Luis Andreu, Víctor Martínez-Taboada, Joan Miquel Nolla, José María Pego-Reigosa, on behalf of the RELESSER Study Group

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Quantitative videocapillaroscopy correlates with functional respiratory parameters: a clue for vasculopathy as a pathogenic mechanism for lung injury in systemic sclerosis

Alfredo Guillén-Del-Castillo, Carmen Pilar Simeón-Aznar, Eduardo L. Callejas-Moraga, Carles Tolosa-Vilella, Serafín Alonso-Vila, Vicente Fonollosa-Pla, Albert Selva-O’Callaghan

01.12.2018 | Correction | Ausgabe 1/2018 Open Access

Correction to: Standardisation of synovial biopsy analyses in rheumatic diseases: a consensus of the EULAR Synovitis and OMERACT Synovial Tissue Biopsy Groups

Aurélie Najm, Benoît Le Goff, Carl Orr, Rogier Thurlings, Juan D. Cañete, Frances Humby, Stefano Alivernini, Antonio Manzo, Søren Andreas Just, Vasco C. Romão, Veit Krenn, Ulf Müller-Ladner, Olga Addimanda, Sander W. Tas, Maria Stoenoiu, Laurent Meric de Bellefon, Patrick Durez, Vibeke Strand, Mihir D. Wechalekar, Joao E. Fonseca, Bernard Lauwerys, Ursula Fearon, Douglas J. Veale, on behalf of EULAR Synovitis Study Group and OMERACT Synovial Tissue Special Interest Group

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Effect of high-intensity interval training on muscle remodeling in rheumatoid arthritis compared to prediabetes

Brian J. Andonian, David B. Bartlett, Janet L. Huebner, Leslie Willis, Andrew Hoselton, Virginia B. Kraus, William E. Kraus, Kim M. Huffman

01.12.2018 | Research | Ausgabe 1/2018 Open Access

Factors related to health-related quality of life in ankylosing spondylitis, overall and stratified by sex

Lucy Law, Jeanette Beckman Rehnman, Anna Deminger, Eva Klingberg, Lennart T. H. Jacobsson, Helena Forsblad-d’Elia

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Pharmacovigilance in juvenile idiopathic arthritis patients treated with biologic or synthetic drugs: combined data of more than 15,000 patients from Pharmachild and national registries

Joost Swart, Gabriella Giancane, Gerd Horneff, Bo Magnusson, Michael Hofer, Еkaterina Alexeeva, Violeta Panaviene, Brigitte Bader-Meunier, Jordi Anton, Susan Nielsen, Fabrizio De Benedetti, Sylvia Kamphuis, Valda Staņēviča, Maria Tracahana, Laura Marinela Ailioaie, Elena Tsitsami, Ariane Klein, Kirsten Minden, Ivan Foeldvari, Johannes Peter Haas, Jens Klotsche, Anna Carin Horne, Alessandro Consolaro, Francesca Bovis, Francesca Bagnasco, Angela Pistorio, Alberto Martini, Nico Wulffraat, Nicolino Ruperto, for the Paediatric Rheumatology International Trials Organisation (PRINTO), BiKeR and the board of the Swedish Registry

01.12.2018 | Research article | Ausgabe 1/2018 Open Access

Tophus resolution in patients with chronic refractory gout who have persistent urate-lowering responses to pegloticase

Brian F. Mandell, Anthony E. Yeo, Peter E. Lipsky

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