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Translational Stroke Research
Erschienen in: Translational Stroke Research 1/2012

01.03.2012 | Review Article

MRI of Blood–Brain Barrier Permeability in Cerebral Ischemia

verfasst von: Quan Jiang, James R. Ewing, Michael Chopp

Erschienen in: Translational Stroke Research | Ausgabe 1/2012

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Abstract

Quantitative measurement of blood–brain barrier (BBB) permeability using MRI and its application to cerebral ischemia are reviewed. Measurement of BBB permeability using MRI has been employed to evaluate ischemic damage during acute and subacute phases of stroke and to predict hemorrhagic transformation. There is also an emerging interest on the development and use of MRI to monitor vascular structural changes and angiogenesis during stroke recovery. In this review, we describe MRI BBB permeability and susceptibility-weighted MRI measurements and its applications to evaluate ischemic damage during the acute and subacute phases of stroke and vascular remodeling during stroke recovery.
Literatur
1.
Ennis SR, Keep RF, Schielke GP, Betz AL. Decrease in perfusion of cerebral capillaries during incomplete ischemia and reperfusion. J Cereb Blood Flow Metab. 1990;10(2):213–20.PubMedCrossRef
2.
Martz D, Beer M, Betz AL. Dimethylthiourea reduces ischemic brain edema without affecting cerebral blood flow. J Cereb Blood Flow Metab. 1990;10(3):352–7.PubMedCrossRef
3.
Menzies SA, Betz AL, Hoff JT. Contributions of ions and albumin to the formation and resolution of ischemic brain edema. J Neurosurg. 1993;78(2):257–66.PubMedCrossRef
4.
Betz AL, Keep RF, Beer ME, Ren XD. Blood–brain barrier permeability and brain concentration of sodium, potassium, and chloride during focal ischemia. J Cereb Blood Flow Metab. 1994;14(1):29–37.PubMedCrossRef
5.
Garcia JH, Liu KF, Yoshida Y, Chen S, Lian J. Brain microvessels: factors altering their patency after the occlusion of a middle cerebral artery (Wistar rat). Am J Pathol. 1994;145(3):728–40.PubMed
6.
Knight RA, Barker PB, Fagan SC, Li Y, Jacobs MA, Welch KM. Prediction of impending hemorrhagic transformation in ischemic stroke using magnetic resonance imaging in rats. Stroke. 1998;29(1):144–51.PubMedCrossRef
7.
Jiang Q, Ewing JR, Zhang ZG, Zhang RL, Hu J, Divine GW, et al. Magnetization transfer MRI: application to treatment of middle cerebral artery occlusion in rat. J Magn Reson Imaging. 2001;13(2):178–84.PubMedCrossRef
8.
Jiang Q, Zhang RL, Zhang ZG, Knight RA, Ewing JR, Ding G, et al. Magnetic resonance imaging characterization of hemorrhagic transformation of embolic stroke in the rat. J Cereb Blood Flow Metab. 2002;22(5):559–68.PubMedCrossRef
9.
Jiang Q, Zhang ZG, Ding GL, Zhang L, Ewing JR, Wang L, et al. Investigation of neural progenitor cell induced angiogenesis after embolic stroke in rat using MRI. NeuroImage. 2005;28:698–707.PubMedCrossRef
10.
11.
Wintermark M, Albers GW, Alexandrov AV, Alger JR, Bammer R, Baron JC, et al. Acute stroke imaging research roadmap. Stroke. 2008;39(5):1621–8.PubMedCrossRef
12.
Tofts PS, Brix G, Buckley DL, Evelhoch JL, Henderson E, Knopp MV, et al. Estimating kinetic parameters from dynamic contrast-enhanced T(1)-weighted MRI of a diffusable tracer: standardized quantities and symbols. J Magn Reson Imaging. 1999;10(3):223–32.PubMedCrossRef
13.
Renkin EM. Transport of potassium-42 from blood to tissue in isolated mammalian skeletal muscles. Am J Physiol. 1959;197:1205–10.PubMed
14.
Crone C. The permeability of capillaries in various organs as determined by use of the ‘indicator diffusion’ method. Acta Physiol Scand. 1963;58:292–305.PubMedCrossRef
15.
Merten CL, Knitelius HO, Assheuer J, Bergmann-Kurz B, Hedde JP, Bewermeyer H. MRI of acute cerebral infarcts, increased contrast enhancement with continuous infusion of gadolinium. Neuroradiology. 1999;41(4):242–8.PubMedCrossRef
16.
Niendorf HP, Felix R, Laniado M, Schorner W, Claussen C, Weinmann HJ. Gadolinium-DTPA: a new contrast agent for magnetic resonance imaging. Radiat Med. 1985;3(1):7–12.PubMed
17.
Weinmann HJ, Brasch RC, Press WR, Wesbey GE. Characteristics of gadolinium-DTPA complex: a potential NMR contrast agent. AJR Am J Roentgenol. 1984;142(3):619–24.PubMed
18.
Johnson JA, Wilson TA. A model for capillary exchange. Am J Physiol. 1966;210(6):1299–303.PubMed
19.
Lassen NA, Perl W. Tracer kinetic methods in medical physiology. 1st ed. New York: Raven; 1979.
20.
Padhani AR, Hayes C, Landau S, Leach MO. Reproducibility of quantitative dynamic MRI of normal human tissues. NMR Biomed. 2002;15(2):143–53.PubMedCrossRef
21.
Larsson HB, Stubgaard M, Frederiksen JL, Jensen M, Henriksen O, Paulson OB. Quantitation of blood–brain barrier defect by magnetic resonance imaging and gadolinium-DTPA in patients with multiple sclerosis and brain tumors. Magn Reson Med. 1990;16(1):117–31.PubMedCrossRef
22.
Tofts PS, Kermode AG. Measurement of the blood–brain barrier permeability and leakage space using dynamic MR imaging. 1. Fundamental concepts. Magn Reson Med. 1991;17(2):357–67.PubMedCrossRef
23.
Gambhir SS, Huang SC, Hawkins RA, Phelps ME. A study of the single compartment tracer kinetic model for the measurement of local cerebral blood flow using 15O-water and positron emission tomography. J Cereb Blood Flow Metab. 1987;7(1):13–20.PubMedCrossRef
24.
Patlak CS, Blasberg RG, Fenstermacher JD. Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data. J Cereb Blood Flow Metab. 1983;3(1):1–7.PubMedCrossRef
25.
Patlak CS, Blasberg RG. Graphical evaluation of blood-to-brain transfer constants from multiple-time uptake data. Generalizations. J Cereb Blood Flow Metab. 1985;5(4):584–90.PubMedCrossRef
26.
Ewing JR, Knight RA, Nagaraja TN, Yee JS, Nagesh V, Whitton P, et al. Patlak plots of Gd-DTPA MRI data yield blood-brain transfer constants concordant with those of 14 C-sucrose in areas of blood–brain opening. Magn Reson Med. 2003;50(2):283–92.PubMedCrossRef
27.
Ewing JR, Brown SL, Lu M, Panda S, Ding G, Knight RA, et al. Model selection in magnetic resonance imaging measurements of vascular permeability: gadomer in a 9 L model of rat cerebral tumor. J Cereb Blood Flow Metab. 2006;26:310–20.PubMedCrossRef
28.
Quirk JD, Bretthorst GL, Duong TQ, Snyder AZ, Springer Jr CS, Ackerman JJ, et al. Equilibrium water exchange between the intra- and extracellular spaces of mammalian brain. Magn Reson Med. 2003;50(3):493–9.PubMedCrossRef
29.
Yankeelov TE, Rooney WD, Li X, Springer Jr CS. Variation of the relaxographic “shutter-speed” for transcytolemmal water exchange affects the CR bolus-tracking curve shape. Magn Reson Med. 2003;50(6):1151–69.PubMedCrossRef
30.
Landis CS, Li X, Telang FW, Molina PE, Palyka I, Vetek G, et al. Equilibrium transcytolemmal water-exchange kinetics in skeletal muscle in vivo. Magn Reson Med. 1999;42(3):467–78.PubMedCrossRef
31.
Paudyal R, Bagher-Ebadian H, Nagaraja TN, Fenstermacher JD, Ewing JR. Modeling of Look–Locker estimates of the magnetic resonance imaging estimate of longitudinal relaxation rate in tissue after contrast administration. Magn Reson Med. 2011;66(5):1432–44.PubMedCrossRef
32.
Paudyal R, Ewing JR, Nagaraja TN, Bagher-Ebadian H, Knight RA, Panda S, et al. The concordance of MRI and quantitative autoradiography estimates of the transvascular transfer rate constant of albumin in a rat brain tumor model. Magn Reson Med. 2011;66(5):1422–31.PubMedCrossRef
33.
Ewing JR, Brown SL, Nagaraja TN, Bagher-Ebadian H, Paudyal R, Panda S, et al. MRI measurement of change in vascular parameters in the 9 L rat cerebral tumor after dexamethasone administration. J Magn Reson Imaging. 2008;27(6):1430–8.PubMedCrossRef
34.
Look DC, Locker DR. Time saving in measurement of NMR and EPR relaxation times. Rev Sci Instrum. 1970;41(2):250–1.CrossRef
35.
Knight RA, Karki K, Ewing JR, Divine GW, Fenstermacher JD, Patlak CS, et al. Estimating blood and brain concentrations and blood-to-brain influx by magnetic resonance imaging with step-down infusion of Gd-DTPA in focal transient cerebral ischemia and confirmation by quantitative autoradiography with Gd-[(14)C]DTPA. J Cereb Blood Flow Metab. 2009;29(5):1048–58.PubMedCrossRef
36.
Jiang Q, Ewing J, Zhang Z, Arniego P, Zhang L, Ding G, et al. Quantitative permeability measurements of hemorrhagic transformation in embolic stroke using MRI. Proc X Annu Meet Int Soc Magn Reson Med. 2002;1224.
37.
Jiang Q, Ewing JR, Ding GL, Zhang L, Zhang ZG, Li L, et al. Quantitative evaluation of BBB permeability after embolic stroke in rat using MRI. J Cereb Blood Flow Metab. 2005;25(5):583–92.PubMedCrossRef
38.
Ding G, Jiang Q, Li L, Zhang L, Gang Zhang Z, Ledbetter KA, et al. Detection of BBB disruption and hemorrhage by Gd-DTPA enhanced MRI after embolic stroke in rat. Brain Res. 2006;1114(1):195–203.PubMedCrossRef
39.
Ding G, Jiang Q, Li L, Zhang L, Zhang ZG, Ledbetter KA, et al. Angiogenesis detected after embolic stroke in rat brain using magnetic resonance T2*WI. Stroke. 2008;39(5):1563–8.PubMedCrossRef
40.
Nagaraja TN, Knight RA, Ewing JR, Karki K, Nagesh V, Fenstermacher JD. Multiparametric magnetic resonance imaging and repeated measurements of blood–brain barrier permeability to contrast agents. Methods Mol Biol. 2010;686:193–212.CrossRef
41.
Jiang Q, Gollapalli L, Haacke EM, Ding GL, Zhang ZG, Zhang L, et al. Susceptibility weighted MRI for detection and staging of angiogenesis after stroke in rats. Proceedings of the Sixteenth Annual Meeting of the International Society for Magnetic Resonance in Medicine; 2008; Toronto, Canada; 2008. p. 304.
42.
Tong KA, Ashwal S, Holshouser BA, Shutter LA, Herigault G, Haacke EM, et al. Hemorrhagic shearing lesions in children and adolescents with posttraumatic diffuse axonal injury: improved detection and initial results. Radiology. 2003;227(2):332–9.PubMedCrossRef
43.
Sehgal V, Delproposto Z, Haacke EM, Tong KA, Wycliffe N, Kido DK, et al. Clinical applications of neuroimaging with susceptibility-weighted imaging. J Magn Reson Imaging. 2005;22(4):439–50.PubMedCrossRef
44.
Rauscher A, Sedlacik J, Barth M, Mentzel HJ, Reichenbach JR. Magnetic susceptibility-weighted MR phase imaging of the human brain. AJNR Am J Neuroradiol. 2005;26(4):736–42.PubMed
45.
Reichenbach JR, Barth M, Haacke EM, Klarhofer M, Kaiser WA, Moser E. High-resolution MR venography at 3.0 Tesla. J Comput Assist Tomogr. 2000;24(6):949–57.PubMedCrossRef
46.
Haacke ME, Herigault G, Yu Y, Kido D, Tong K, Obenaus A, et al. Observing tumor vascularity noninvasively using magnetic resonance imaging. Image Anal Stereol. 2002;21:107–13.CrossRef
47.
Yang GY, Betz AL. Reperfusion-induced injury to the blood–brain barrier after middle cerebral artery occlusion in rats. Stroke. 1994;25(8):1658–64. discussion 64–5.PubMedCrossRef
48.
Picozzi P, Todd NV, Crockard HA. Regional blood–brain barrier permeability changes after restoration of blood flow in postischemic gerbil brains: a quantitative study. J Cereb Blood Flow Metab. 1985;5(1):10–6.PubMedCrossRef
49.
Rosenberg GA, Estrada EY, Dencoff JE. Matrix metalloproteinases and TIMPs are associated with blood–brain barrier opening after reperfusion in rat brain. Stroke. 1998;29(10):2189–95.PubMedCrossRef
50.
Kuroiwa T, Ting P, Martinez H, Klatzo I. The biphasic opening of the blood–brain barrier to proteins following temporary middle cerebral artery occlusion. Acta Neuropathol. 1985;68(2):122–9.PubMedCrossRef
51.
Belayev L, Busto R, Zhao W, Ginsberg MD. Quantitative evaluation of blood–brain barrier permeability following middle cerebral artery occlusion in rats. Brain Res. 1996;739(1–2):88–96.PubMedCrossRef
52.
Preston E, Foster DO. Evidence for pore-like opening of the blood–brain barrier following forebrain ischemia in rats. Brain Res. 1997;761(1):4–10.PubMedCrossRef
53.
Yoshizumi H, Fujibayashi Y, Kikuchi H. A new approach to the integrity of dual blood–brain barrier functions of global ischemic rats. Barrier and carrier functions. Stroke. 1993;24(2):279–84. discussion 84–5.PubMedCrossRef
54.
Aronowski J, Strong R, Grotta JC. Reperfusion injury: demonstration of brain damage produced by reperfusion after transient focal ischemia in rats. J Cereb Blood Flow Metab. 1997;17(10):1048–56.PubMedCrossRef
55.
Murakami K, Kawase M, Kondo T, Chan PH. Cellular accumulation of extravasated serum protein and DNA fragmentation following vasogenic edema. J Neurotrauma. 1998;15(10):825–35.PubMedCrossRef
56.
Lodder J, Krijne-Kubat B, Broekman J. Cerebral hemorrhagic infarction at autopsy: cardiac embolic cause and the relationship to the cause of death. Stroke. 1986;17(4):626–9.PubMedCrossRef
57.
NINDS. The National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group: tissue plasminogen activator for acute ischemic stroke. N Engl J Med. 1995;333:1581–7.CrossRef
58.
Furlan A, Higashida R, Wechsler L, Gent M, Rowley H, Kase C, et al. Intra-arterial prourokinase for acute ischemic stroke. The PROACT II study: a randomized controlled trial. Prolyse in Acute Cerebral Thromboembolism. JAMA. 1999;282(21):2003–11.PubMedCrossRef
59.
Pessin MS, Teal PA, Caplan LR. Hemorrhagic infarction: guilt by association? AJNR Am J Neuroradiol. 1991;12(6):1123–6.PubMed
60.
Higashida RT, Furlan AJ. Trial design and reporting standards for intra-arterial cerebral thrombolysis for acute ischemic stroke. Stroke. 2003;34(8):e109–37.PubMedCrossRef
61.
Higer HP, Pedrosa P, Schaeben W, Bielke G, Meindl S. Intracranial hemorrhage in MRT. Radiologe. 1989;29(6):297–302.PubMed
62.
Jansen O, Heiland S, Schellinger P. Neuroradiologic diagnosis in acute arterial cerebral infarct. Current status of new methods. Nervenarzt. 1998;69(6):465–71.PubMedCrossRef
63.
NINDS. Intracerebral hemorrhage after intravenous t-PA therapy for ischemic stroke. The NINDS t-PA Stroke Study Group. Stroke. 1997;28(11):2109–18.CrossRef
64.
Hayman LA, Evans RA, Bastion FO, Hinck VC. Delayed high dose contrast CT: identifying patients at risk of massive hemorrhagic infarction. AJR. 1981;136:1151–9.PubMed
65.
Schulte-Altedorneburg G, Mayer T, Missler U, Droste DW, Bruckmann H. The relationship of hemorrhagic transformation, blood–brain barrier disturbance and neurological status in supratentorial infarction examined by MRI follow-up (abstract). Cerebrovasc Dis. 1996;6 suppl 2:151.
66.
Atlas S, Thulborn K. Intracranial hemorrhage. In: Atlas SW, editor. Magnetic resonance imaging of the brain and spine. Philadelphia: Lippincott-Raven Publishers; 2002. p. 773–832.
67.
Thulborn K, Atlas, S. Intracranial Hemorrhage. In: Atlas SW, editor. Magnetic Resonance Imaging of the Brain and Spine. Philadelphia: Lippincott-Raven Publishers; 1996. p. 265–314.
68.
Hayman LA, Taber KH, Ford JJ, Bryan RN. Mechanisms of MR signal alteration by acute intracerebral blood: old concepts and new theories. AJNR Am J Neuroradiol. 1991;12(5):899–907.PubMed
69.
Hayman LA, Pagani JJ, Kirkpatrick JB, Hinck VC. Pathophysiology of acute intracerebral and subarachnoid hemorrhage: applications to MR imaging. AJR Am J Roentgenol. 1989;153(1):135–9.PubMed
70.
Weingarten K, Zimmerman RD, Cahill PT, Deck MD. Detection of acute intracerebral hemorrhage on MR imaging: ineffectiveness of prolonged interecho interval pulse sequences. AJNR Am J Neuroradiol. 1991;12(3):475–9.PubMed
71.
Bradley Jr WG. MR appearance of hemorrhage in the brain. Radiology. 1993;189(1):15–26.PubMed
72.
Patel MR, Edelman RR, Warach S. Detection of hyperacute primary intraparenchymal hemorrhage by magnetic resonance imaging. Stroke. 1996;27(12):2321–4.PubMedCrossRef
73.
Linfante I, Llinas RH, Caplan LR, Warach S. MRI features of intracerebral hemorrhage within 2 hours from symptom onset. Stroke. 1999;30(11):2263–7.PubMedCrossRef
74.
Welch KM, Windham J, Knight RA, Nagesh V, Hugg JW, Jacobs M, et al. A model to predict the histopathology of human stroke using diffusion and T2-weighted magnetic resonance imaging [see comments]. Stroke. 1995;26(11):1983–9.PubMedCrossRef
75.
Jiang Q, Chopp M, Zhang ZG, Knight RA, Jacobs M, Windham JP, et al. The temporal evolution of MRI tissue signatures after transient middle cerebral artery occlusion in rat. J Neurol Sci. 1997;145(1):15–23.PubMedCrossRef
76.
Jacobs MA, Zhang ZG, Knight RA, Soltanian-Zadeh H, Goussev AV, Peck DJ, et al. A model for multiparametric mri tissue characterization in experimental cerebral ischemia with histological validation in rat: part 1. Stroke. 2001;32(4):943–9.PubMedCrossRef
77.
Wu O, Christensen S, Hjort N, Dijkhuizen RM, Kucinski T, Fiehler J, et al. Characterizing physiological heterogeneity of infarction risk in acute human ischaemic stroke using MRI. Brain. 2006;129(Pt 9):2384–93.PubMedCrossRef
78.
Karonen JO, Vanninen RL, Liu Y, Ostergaard L, Kuikka JT, Nuutinen J, et al. Combined diffusion and perfusion MRI with correlation to single-photon emission CT in acute ischemic stroke. Ischemic penumbra predicts infarct growth. Stroke. 1999;30(8):1583–90.PubMedCrossRef
79.
Albers GW. Expanding the window for thrombolytic therapy in acute stroke. The potential role of acute MRI for patient selection. Stroke. 1999;30(10):2230–7.PubMedCrossRef
80.
Hacke W, Kaste M, Bluhmki E, Brozman M, Davalos A, Guidetti D, et al. Thrombolysis with alteplase 3 to 4.5 hours after acute ischemic stroke. N Engl J Med. 2008;359(13):1317–29.PubMedCrossRef
81.
Chopp M, Li Y. Treatment of neural injury with marrow stromal cells. Lancet Neurol. 2002;1:92–100.PubMedCrossRef
82.
Wang L, Zhang Z, Wang Y, Zhang R, Chopp M. Treatment of stroke with erythropoietin enhances neurogenesis and angiogenesis and improves neurological function in rats. Stroke. 2004;35(7):1732–7.PubMedCrossRef
83.
Zhang R, Wang L, Zhang L, Chen J, Zhu Z, Zhang Z, et al. Nitric oxide enhances angiogenesis via the synthesis of vascular endothelial growth factor and cGMP after stroke in the rat. Circ Res. 2003;92(3):308–13.PubMedCrossRef
84.
Chen J, Zhang ZG, Li Y, Wang Y, Wang L, Jiang H, et al. Statins induce angiogenesis, neurogenesis, and synaptogenesis after stroke. Ann Neurol. 2003;53(6):743–51.PubMedCrossRef
85.
Zhang R, Wang Y, Zhang L, Zhang Z, Tsang W, Lu M, et al. Sildenafil (Viagra) induces neurogenesis and promotes functional recovery after stroke in rats. Stroke. 2002;33(11):2675–80.PubMedCrossRef
86.
Shyu WC, Lin SZ, Yang HI, Tzeng YS, Pang CY, Yen PS, et al. Functional recovery of stroke rats induced by granulocyte colony-stimulating factor-stimulated stem cells. Circulation. 2004;110(13):1847–54.PubMedCrossRef
87.
Jin K, Sun Y, Xie L, Childs J, Mao XO, Greenberg DA. Post-ischemic administration of heparin-binding epidermal growth factor-like growth factor (HB-EGF) reduces infarct size and modifies neurogenesis after focal cerebral ischemia in the rat. J Cereb Blood Flow Metab. 2004;24(4):399–408.PubMedCrossRef
88.
Zhang RL, Zhang ZG, Chopp M. Neurogenesis in the adult ischemic brain: generation, migration, survival, and restorative therapy. Neuroscientist. 2005;11(5):408–16.PubMedCrossRef
89.
Jiang Q, Zhang ZG, Ding GL, Silver B, Zhang L, Meng H, et al. MRI detects white matter reorganization after neural progenitor cell treatment of stroke. NeuroImage. 2006;32:1080–9.PubMedCrossRef
90.
Zhang ZG, Chopp M. Neurorestorative therapies for stroke: underlying mechanisms and translation to the clinic. Lancet Neurol. 2009;8(5):491–500.PubMedCrossRef
91.
Auerbach JM, Eiden MV, McKay RD. Transplanted CNS stem cells form functional synapses in vivo. Eur J Neurosci. 2000;12(5):1696–704.PubMedCrossRef
92.
Chen J, Li Y, Chopp M. Intracerebral transplantation of bone marrow with BDNF after MCAo in rat. Neuropharmacology. 2000;39(5):711–6.PubMedCrossRef
93.
Chen X, Li Y, Wang L, Katakowski M, Zhang L, Chen J, et al. Ischemic rat brain extracts induce human marrow stromal cell growth factor production. Neuropathology. 2002;22(4):275–9.PubMedCrossRef
94.
Chen X, Katakowski M, Li Y, Lu D, Wang L, Zhang L, et al. Human bone marrow stromal cell cultures conditioned by traumatic brain tissue extracts: growth factor production. J Neurosci Res. 2002;69(5):687–91.PubMedCrossRef
95.
Li Y, Chen J, Chen XG, Wang L, Gautam SC, Xu YX, et al. Human marrow stromal cell therapy for stroke in rat: neurotrophins and functional recovery. Neurology. 2002;59(4):514–23.PubMed
96.
Zhang R, Zhang L, Zhang Z, Wang Y, Lu M, Lapointe M, et al. A nitric oxide donor induces neurogenesis and reduces functional deficits after stroke in rats. Ann Neurol. 2001;50(5):602–11.PubMedCrossRef
97.
Li Y, Chen J, Wang L, Zhang L, Lu M, Chopp M. Intracerebral transplantation of bone marrow stromal cells in a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine mouse model of Parkinson’s disease. Neurosci Lett. 2001;316(2):67–70.PubMedCrossRef
98.
Chen J, Li Y, Wang L, Lu M, Zhang X, Chopp M. Therapeutic benefit of intracerebral transplantation of bone marrow stromal cells after cerebral ischemia in rats. J Neurol Sci. 2001;189(1–2):49–57.PubMedCrossRef
99.
Li Y, Chen J, Wang L, Lu M, Chopp M. Treatment of stroke in rat with intracarotid administration of marrow stromal cells. Neurology. 2001;56(12):1666–72.PubMed
100.
Chen J, Li Y, Wang L, Zhang Z, Lu D, Lu M, et al. Therapeutic benefit of intravenous administration of bone marrow stromal cells after cerebral ischemia in rats. Stroke. 2001;32(4):1005–11.PubMedCrossRef
101.
Li Y, Chopp M, Chen J, Wang L, Gautam SC, Xu YX, et al. Intrastriatal transplantation of bone marrow nonhematopoietic cells improves functional recovery after stroke in adult mice. J Cereb Blood Flow Metab. 2000;20(9):1311–9.PubMedCrossRef
102.
Zhang L, Chen J, Li Y, Zhang ZG, Chopp M. Quantitative measurement of motor and somatosensory impairments after mild (30 min) and severe (2 h) transient middle cerebral artery occlusion in rats. J Neurol Sci. 2000;174(2):141–6.PubMedCrossRef
103.
Johansen-Berg H. Functional imaging of stroke recovery: what have we learnt and where do we go from here? Int J Stroke. 2007;2(1):7–16.PubMedCrossRef
104.
Krupinski J, Kaluza J, Kumar P, Kumar S, Wang JM. Role of angiogenesis in patients with cerebral ischemic stroke. Stroke. 1994;25(9):1794–8.PubMedCrossRef
105.
Cramer SC, Nelles G, Benson RR, Kaplan JD, Parker RA, Kwong KK, et al. A functional MRI study of subjects recovered from hemiparetic stroke. Stroke. 1997;28(12):2518–27.PubMedCrossRef
106.
Weiller C, Ramsay SC, Wise RJ, Friston KJ, Frackowiak RS. Individual patterns of functional reorganization in the human cerebral cortex after capsular infarction. Ann Neurol. 1993;33(2):181–9.PubMedCrossRef
107.
Slevin M, Krupinski J, Slowik A, Kumar P, Szczudlik A, Gaffney J. Serial measurement of vascular endothelial growth factor and transforming growth factor-beta1 in serum of patients with acute ischemic stroke. Stroke. 2000;31(8):1863–70.PubMedCrossRef
108.
Chen J, Zhang ZG, Li Y, Wang L, Xu YX, Gautam SC, et al. Intravenous administration of human bone marrow stromal cells induces angiogenesis in the ischemic boundary zone after stroke in rats. Circ Res. 2003;92(6):692–9.PubMedCrossRef
109.
Zhang ZG, Zhang L, Tsang W, Soltanian-Zadeh H, Morris D, Zhang R, et al. Correlation of VEGF and angiopoietin expression with disruption of blood–brain barrier and angiogenesis after focal cerebral ischemia. J Cereb Blood Flow Metab. 2002;22(4):379–92.PubMedCrossRef
110.
Zhang Z, Chopp M. Vascular endothelial growth factor and angiopoietins in focal cerebral ischemia. Trends Cardiovasc Med. 2002;12(2):62–6.PubMedCrossRef
111.
Zhang ZG, Zhang L, Jiang Q, Zhang R, Davies K, Powers C, et al. VEGF enhances angiogenesis and promotes blood–brain barrier leakage in the ischemic brain. J Clin Invest. 2000;106(7):829–38.PubMedCrossRef
112.
Chopp M, Zhang ZG, Jiang Q. Neurogenesis, angiogenesis, and MRI indices of functional recovery from stroke. Stroke. 2007;38(2 Suppl):827–31.PubMedCrossRef
113.
Teng H, Zhang ZG, Wang L, Zhang RL, Zhang L, Morris D, et al. Coupling of angiogenesis and neurogenesis in cultured endothelial cells and neural progenitor cells after stroke. J Cereb Blood Flow Metab. 2008;28(4):764–71.PubMedCrossRef
114.
Wang L, Zhang ZG, Zhang RL, Gregg SR, Hozeska-Solgot A, LeTourneau Y, et al. Matrix metalloproteinase 2 (MMP2) and MMP9 secreted by erythropoietin-activated endothelial cells promote neural progenitor cell migration. J Neurosci. 2006;26(22):5996–6003.PubMedCrossRef
115.
116.
Risau W. Molecular biology of blood–brain barrier ontogenesis and function. Acta Neurochir Suppl. 1994;60:109–12.
117.
Hawighorst H, Knapstein PG, Knopp MV, Weikel W, Brix G, Zuna I, et al. Uterine cervical carcinoma: comparison of standard and pharmacokinetic analysis of time-intensity curves for assessment of tumor angiogenesis and patient survival. Cancer Res. 1998;58(16):3598–602.PubMed
118.
Hawighorst H, Weikel W, Knapstein PG, Knopp MV, Zuna I, Schonberg SO, et al. Angiogenic activity of cervical carcinoma: assessment by functional magnetic resonance imaging-based parameters and a histomorphological approach in correlation with disease outcome. Clin Cancer Res. 1998;4(10):2305–12.PubMed
119.
Brasch R, Turetschek K. MRI characterization of tumors and grading angiogenesis using macromolecular contrast media: status report. Eur J Radiol. 2000;34(3):148–55.PubMedCrossRef
120.
Pathak AP, Schmainda KM, Ward BD, Linderman JR, Rebro KJ, Greene AS. MR-derived cerebral blood volume maps: issues regarding histological validation and assessment of tumor angiogenesis. Magn Reson Med. 2001;46(4):735–47.PubMedCrossRef
121.
Neeman M. Functional and molecular MR imaging of angiogenesis: seeing the target, seeing it work. J Cell Biochem Suppl. 2002;39:11–7.PubMedCrossRef
122.
Dvorak HF, Nagy JA, Feng D, Brown LF, Dvorak AM. Vascular permeability factor/vascular endothelial growth factor and the significance of microvascular hyperpermeability in angiogenesis. Curr Top Microbiol Immunol. 1999;237:97–132.PubMedCrossRef
123.
Jackson A, Jayson GC, Li KL, Zhu XP, Checkley DR, Tessier JJ, et al. Reproducibility of quantitative dynamic contrast-enhanced MRI in newly presenting glioma. Br J Radiol. 2003;76(903):153–62.PubMedCrossRef
124.
Zhang ZG, Zhang L, Jiang Q, Chopp M. Bone marrow-derived endothelial progenitor cells participate in cerebral neovascularization after focal cerebral ischemia in the adult mouse. Circ Res. 2002;90(3):284–8.PubMedCrossRef
125.
Marti HJ, Bernaudin M, Bellail A, Schoch H, Euler M, Petit E, et al. Hypoxia-induced vascular endothelial growth factor expression precedes neovascularization after cerebral ischemia. Am J Pathol. 2000;156(3):965–76.PubMedCrossRef
126.
Hayashi T, Noshita N, Sugawara T, Chan PH. Temporal profile of angiogenesis and expression of related genes in the brain after ischemia. J Cereb Blood Flow Metab. 2003;23(2):166–80.PubMedCrossRef
127.
Slevin M, Kumar P, Gaffney J, Kumar S, Krupinski J. Can angiogenesis be exploited to improve stroke outcome? Mechanisms and therapeutic potential. Clin Sci (Lond). 2006;111(3):171–83.CrossRef
128.
Yano A, Shingo T, Takeuchi A, Yasuhara T, Kobayashi K, Takahashi K, et al. Encapsulated vascular endothelial growth factor-secreting cell grafts have neuroprotective and angiogenic effects on focal cerebral ischemia. J Neurosurg. 2005;103(1):104–14.PubMedCrossRef
129.
Li L, Jiang Q, Zhang L, Ding G, Wang L, Zhang R, et al. Ischemic cerebral tissue response to subventricular zone cell transplantation measured by iterative self-organizing data analysis technique algorithm. J Cereb Blood Flow Metab. 2006;26:1366–77.PubMedCrossRef
130.
Kemper EM, Boogerd W, Thuis I, Beijnen JH, van Tellingen O. Modulation of the blood–brain barrier in oncology: therapeutic opportunities for the treatment of brain tumours? Cancer Treat Rev. 2004;30(5):415–23.PubMedCrossRef
131.
Vidarsson L, Thornhill RE, Liu F, Mikulis DJ, Kassner A. Quantitative permeability magnetic resonance imaging in acute ischemic stroke: how long do we need to scan? Magn Reson Imaging. 2009;27(9):1216–22.PubMedCrossRef
132.
Bang OY, Saver JL, Alger JR, Shah SH, Buck BH, Starkman S, et al. Patterns and predictors of blood–brain barrier permeability derangements in acute ischemic stroke. Stroke. 2009;40(2):454–61.PubMedCrossRef
133.
Laking GR, West C, Buckley DL, Matthews J, Price PM. Imaging vascular physiology to monitor cancer treatment. Crit Rev Oncol/Hematol. 2006;58(2):95–113.CrossRef
Metadaten
Titel
MRI of Blood–Brain Barrier Permeability in Cerebral Ischemia
verfasst von
Quan Jiang
James R. Ewing
Michael Chopp
Publikationsdatum
01.03.2012
Verlag
Springer-Verlag
Erschienen in
Translational Stroke Research / Ausgabe 1/2012
Print ISSN: 1868-4483
Elektronische ISSN: 1868-601X
DOI
https://doi.org/10.1007/s12975-011-0133-x

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