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Erschienen in: Current HIV/AIDS Reports 6/2021

31.10.2021 | The Science of Prevention (R Heffron and K Ngure, Section Editors)

Multi-level Interventions to Promote Oral Pre-exposure Prophylaxis Use Among Adolescent Girls and Young Women: a Review of Recent Research

verfasst von: Elizabeth Irungu, Nomhle Khoza, Jennifer Velloza

Erschienen in: Current HIV/AIDS Reports | Ausgabe 6/2021

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Abstract

Purpose of review

This review summarizes interventions to promote HIV pre-exposure prophylaxis (PrEP) use among adolescent girls and young women (AGYW) in HIV endemic settings, while also highlighting gaps in our current measures of PrEP intervention success.

Recent findings

AGYW report challenges with PrEP use, although the field is currently grappling with defining metrics of optimal PrEP use applicable for AGYW with dynamic HIV prevention needs. Ongoing studies are exploring multilevel interventions to address barriers to PrEP use for AGYW. At the individual and interpersonal levels, mHealth, drug-level feedback, adherence counseling, peer groups, and PrEP decision-support interventions are acceptable and feasible for AGYW although limited effectiveness data are available. At the health facility and community levels, PrEP demand creation, modified PrEP refill schedules, and integrated PrEP and reproductive health services are also promising options to support PrEP use for AGYW.

Summary

As PrEP delivery continues to expand, improved metrics of success and evidence on the effectiveness of multi-level adherence support interventions are needed to maximize the impact of PrEP for AGYW in HIV endemic settings. We present case studies of these intervention approaches but limited data are currently available on the effectiveness of these approaches. We will look toward forthcoming study results on the impact of PrEP interventions, including mHealth, drug-level feedback and other enhanced counseling, peer support, decision-support tools, PrEP demand creation, modified refills, and integrated service delivery, to determine the ideal package of PrEP support approaches for AGYW.
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Zurück zum Zitat Chen Y, Ronen K, Matemo D, Unger JA, Kinuthia J, John-Stewart G, Levin C. An interactive text messaging intervention to improve adherence to Option B+ prevention of mother-to-child HIV transmission in Kenya: cost analysis. JMIR mHealth uHealth. 2020;8(10):e18351. Chen Y, Ronen K, Matemo D, Unger JA, Kinuthia J, John-Stewart G, Levin C. An interactive text messaging intervention to improve adherence to Option B+ prevention of mother-to-child HIV transmission in Kenya: cost analysis. JMIR mHealth uHealth. 2020;8(10):e18351.
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Zurück zum Zitat Colombini M, Mayhew SH, Mutemwa R, Kivunaga J, Ndwiga C, Team TI. Perceptions and experiences of integrated service delivery among women living with HIV attending reproductive health services in Kenya: a mixed methods study. AIDS Behav. 2016;20(9):2130–40.CrossRef Colombini M, Mayhew SH, Mutemwa R, Kivunaga J, Ndwiga C, Team TI. Perceptions and experiences of integrated service delivery among women living with HIV attending reproductive health services in Kenya: a mixed methods study. AIDS Behav. 2016;20(9):2130–40.CrossRef
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Zurück zum Zitat Delaney-Moretlwe S, Chersich M, Harvey S, Stangl A, Baron D, Columbini M, et al. Empowerment clubs did not increase PrEP continuation among adolescent girls and young women in South Africa and Tanzania — results from the EMPOWER randomised trial. Abstract # FRAE0108LB. Oral presentation at the 9th International AIDS Society Conference (IAS); July 23–27, 2018; Amsterdam, the Netherlands. Delaney-Moretlwe S, Chersich M, Harvey S, Stangl A, Baron D, Columbini M, et al. Empowerment clubs did not increase PrEP continuation among adolescent girls and young women in South Africa and Tanzania — results from the EMPOWER randomised trial. Abstract # FRAE0108LB. Oral presentation at the 9th International AIDS Society Conference (IAS); July 23–27, 2018; Amsterdam, the Netherlands.
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Zurück zum Zitat Coombs A, Gold E. Generating Demand for PrEP: a desk review. Arlington, VA, USA; 2019. (Strengthening High Impact Interventions for an AIDS-Free Generation Project). Coombs A, Gold E. Generating Demand for PrEP: a desk review. Arlington, VA, USA; 2019. (Strengthening High Impact Interventions for an AIDS-Free Generation Project).
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Zurück zum Zitat • Morton JF, Myers L, Gill K, Bekker L-G, Stein G, Thomas KK, et al. Evaluation of a behavior-centered design strategy for creating demand for oral PrEP among young women in Cape Town, South Africa. Gates Open Res. 2020;4:29. This manuscript describes the use of a behavior-centered design (BCD) approach to develop a PrEP social marketing campaign for adolescent girls and young women in South Africa. Participants discussed desires for a positively framed, empowering PrEP demand creation video. • Morton JF, Myers L, Gill K, Bekker L-G, Stein G, Thomas KK, et al. Evaluation of a behavior-centered design strategy for creating demand for oral PrEP among young women in Cape Town, South Africa. Gates Open Res. 2020;4:29. This manuscript describes the use of a behavior-centered design (BCD) approach to develop a PrEP social marketing campaign for adolescent girls and young women in South Africa. Participants discussed desires for a positively framed, empowering PrEP demand creation video.
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Zurück zum Zitat Agunda P, Mutisya E, Musau A, Odera C, Maikweki L, Wango B, et al. Increasing Uptake of Oral Pre-Exposure Prophylaxis among Adolescent Girls and Young Women through Youth Peer Providers in Migori County, Kenya. Abstract #44. Oral presentation at the International Workshop on HIV and Adolescence; 2019; Nairobi, Kenya. Agunda P, Mutisya E, Musau A, Odera C, Maikweki L, Wango B, et al. Increasing Uptake of Oral Pre-Exposure Prophylaxis among Adolescent Girls and Young Women through Youth Peer Providers in Migori County, Kenya. Abstract #44. Oral presentation at the International Workshop on HIV and Adolescence; 2019; Nairobi, Kenya.
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Zurück zum Zitat • Wood S, Gross R, Shea JA, Bauermeister JA, Franklin J, Petsis D, et al. Barriers and facilitators of PrEP adherence for young men and transgender women of color. AIDS Behav. 2019;23(10):2719–29. This manuscript describes findings from a qualitative study on barriers and facilitators for PrEP use among young men who have sex with men and transgender women. Barriers included stigma, health systems inaccessibility, side effects, competing stressors, and low HIV risk perception. • Wood S, Gross R, Shea JA, Bauermeister JA, Franklin J, Petsis D, et al. Barriers and facilitators of PrEP adherence for young men and transgender women of color. AIDS Behav. 2019;23(10):2719–29. This manuscript describes findings from a qualitative study on barriers and facilitators for PrEP use among young men who have sex with men and transgender women. Barriers included stigma, health systems inaccessibility, side effects, competing stressors, and low HIV risk perception.
54.
Zurück zum Zitat Pintye J, Beima-Sofie KM, Makabong’O PA, Njoroge A, Trinidad SB, Heffron RA, et al. HIV-uninfected Kenyan adolescent and young women share perspectives on using pre-exposure prophylaxis during pregnancy. AIDS Patient Care STDs. 2018;32(12):538–44. Pintye J, Beima-Sofie KM, Makabong’O PA, Njoroge A, Trinidad SB, Heffron RA, et al. HIV-uninfected Kenyan adolescent and young women share perspectives on using pre-exposure prophylaxis during pregnancy. AIDS Patient Care STDs. 2018;32(12):538–44.
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Zurück zum Zitat •• Hill BJ, Anderson B, Lock L. COVID-19 Pandemic, Pre-exposure Prophylaxis (PrEP) care, and HIV/STI testing among patients receiving care in three HIV epidemic priority states. AIDS Behav. 2021;25(5):1361–5. This manuscript provides data on the use of a telehealth/telePrEP approach to promote PrEP prescribing during the COVID pandemic. •• Hill BJ, Anderson B, Lock L. COVID-19 Pandemic, Pre-exposure Prophylaxis (PrEP) care, and HIV/STI testing among patients receiving care in three HIV epidemic priority states. AIDS Behav. 2021;25(5):1361–5. This manuscript provides data on the use of a telehealth/telePrEP approach to promote PrEP prescribing during the COVID pandemic.
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Zurück zum Zitat • Maseko B, Hill LM, Phanga T, Bhushan N, Vansia D, Kamtsendero L, et al. Perceptions of and interest in HIV pre-exposure prophylaxis use among adolescent girls and young women in Lilongwe, Malawi. PloS One. 2020;15(1):e0226062. This manuscript describes facilitators and barriers to PrEP delivery in Malawi. Adolescent girls and young women reported preferences that PrEP is delivered in youth-friendly sections of health centers with youth-friendly counseling messages. • Maseko B, Hill LM, Phanga T, Bhushan N, Vansia D, Kamtsendero L, et al. Perceptions of and interest in HIV pre-exposure prophylaxis use among adolescent girls and young women in Lilongwe, Malawi. PloS One. 2020;15(1):e0226062. This manuscript describes facilitators and barriers to PrEP delivery in Malawi. Adolescent girls and young women reported preferences that PrEP is delivered in youth-friendly sections of health centers with youth-friendly counseling messages.
60.
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Zurück zum Zitat • Coelho LE, Torres TS, Veloso VG, Landovitz RJ, Grinsztejn B. Pre-exposure prophylaxis 2.0: new drugs and technologies in the pipeline. Lancet HIV. 2019;6(11):e788–99. • Coelho LE, Torres TS, Veloso VG, Landovitz RJ, Grinsztejn B. Pre-exposure prophylaxis 2.0: new drugs and technologies in the pipeline. Lancet HIV. 2019;6(11):e788–99.
Metadaten
Titel
Multi-level Interventions to Promote Oral Pre-exposure Prophylaxis Use Among Adolescent Girls and Young Women: a Review of Recent Research
verfasst von
Elizabeth Irungu
Nomhle Khoza
Jennifer Velloza
Publikationsdatum
31.10.2021
Verlag
Springer US
Erschienen in
Current HIV/AIDS Reports / Ausgabe 6/2021
Print ISSN: 1548-3568
Elektronische ISSN: 1548-3576
DOI
https://doi.org/10.1007/s11904-021-00576-9

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