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Erschienen in: Journal of Neural Transmission 8/2011

01.08.2011 | Basic Neurosciences, Genetics and Immunology - Rapid Communication

Naloxone decreases the inhibitory effect of somatostatin on GH release induced by cigarette smoking in man

verfasst von: Vittorio Coiro, Riccardo Volpi, Adriano Stella, Simona Cataldo, Claudio Giumelli, Francesco Maccanelli, Anna Araldi, Paolo Chiodera

Erschienen in: Journal of Neural Transmission | Ausgabe 8/2011

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Abstract

To establish whether somatostatin (SRIH) exerts its inhibitory effect on the nicotine-induced release of GH by interacting with an opioid pathway, normal volunteers were treated with naloxone during (2 no-filter) cigarettes smoking and with SRIH. Nicotine significantly increased serum GH levels about 3.5 fold. Naloxone alone did not change GH rise induced by cigarette smoking. The stimulatory effect of GH by nicotine was completely blocked by SRIH. In the presence of both SRIH and naloxone, GH levels rose 1.5 fold in response to nicotine. Since naloxone only partially reversed the inhibiting action of SRIH, only a partial involvement of opioid peptides in SRIH action might be supposed. Alternatively, SRIH and naloxone-sensitive opiates might produce this inhibiting effect on GH rise in response to cigarette smoking through independent pathways.
Literatur
Zurück zum Zitat Beauvillain JC, Tramu G, Garaud JC (1984) Coexistence of substances related to enkephalin and somatostatin in granules of the guinea-pig median eminence: demonstration by use of colloidal gold immunocytochemical methods. Brain Res 30:389–393CrossRef Beauvillain JC, Tramu G, Garaud JC (1984) Coexistence of substances related to enkephalin and somatostatin in granules of the guinea-pig median eminence: demonstration by use of colloidal gold immunocytochemical methods. Brain Res 30:389–393CrossRef
Zurück zum Zitat Chiodera P, Gnudi A, Bianconi L, Capretti L, Fagnoni F, Volpi R, Coiro V (1989) Naloxone abolishes the inhibiting effect of somatostatin on the release of oxytocin evoked by insulin-induced hypoglycemia in humans. Metabolism 38:709–711PubMedCrossRef Chiodera P, Gnudi A, Bianconi L, Capretti L, Fagnoni F, Volpi R, Coiro V (1989) Naloxone abolishes the inhibiting effect of somatostatin on the release of oxytocin evoked by insulin-induced hypoglycemia in humans. Metabolism 38:709–711PubMedCrossRef
Zurück zum Zitat Chiodera P, Coiro V (1991) Endogenous opioid mediation of somatostatin inhibition of arginine vasopressin release evoked by insulin-induced hypoglycemia in man. J Neural Transm Gen Sect 83:121–126PubMedCrossRef Chiodera P, Coiro V (1991) Endogenous opioid mediation of somatostatin inhibition of arginine vasopressin release evoked by insulin-induced hypoglycemia in man. J Neural Transm Gen Sect 83:121–126PubMedCrossRef
Zurück zum Zitat Coiro V, Casti A, Rubino P, Manfredi G, Maffei ML, Volta E, Cataldo S, Melani A, Saccani Jotti G, Chiodera P (2008) Effect of naloxone on somatostatin inhibition of arginine vasopressin response to physical exercise in normal men. J Neural Transm 115:803–807PubMedCrossRef Coiro V, Casti A, Rubino P, Manfredi G, Maffei ML, Volta E, Cataldo S, Melani A, Saccani Jotti G, Chiodera P (2008) Effect of naloxone on somatostatin inhibition of arginine vasopressin response to physical exercise in normal men. J Neural Transm 115:803–807PubMedCrossRef
Zurück zum Zitat Delitala G, Tomasi P, Palermo M, Ross RJM, Grossman A, Besser GM (1989) Opioids stimulate growth hormone (GH) release in man independently of GH-releasing hormone. J Clin Endocrinol Metab 69:356–358PubMedCrossRef Delitala G, Tomasi P, Palermo M, Ross RJM, Grossman A, Besser GM (1989) Opioids stimulate growth hormone (GH) release in man independently of GH-releasing hormone. J Clin Endocrinol Metab 69:356–358PubMedCrossRef
Zurück zum Zitat Dupont A, Cusan L, Ferland L, Coy H, Labrie F (1979) Stimulatory effects of endorphins and their analogs on prolactin and growth hormone secretion. In: Tolis G, Martin JB (eds) Clinical neuroendocrinology. Raven Press, New York, pp 161–172 Dupont A, Cusan L, Ferland L, Coy H, Labrie F (1979) Stimulatory effects of endorphins and their analogs on prolactin and growth hormone secretion. In: Tolis G, Martin JB (eds) Clinical neuroendocrinology. Raven Press, New York, pp 161–172
Zurück zum Zitat Fodor M, Csaba SZ, Kordon C, Epelbaun J (1994) POMC neurons innervate somatostatin cells in the hypothalamus periventricular nucleus. Neuroendocrinology 60(Suppl 1):76 Fodor M, Csaba SZ, Kordon C, Epelbaun J (1994) POMC neurons innervate somatostatin cells in the hypothalamus periventricular nucleus. Neuroendocrinology 60(Suppl 1):76
Zurück zum Zitat Grossman A (1983) Brain opiates and neuroendocrine function. Clin Endocrinol Metab 12:725–746PubMedCrossRef Grossman A (1983) Brain opiates and neuroendocrine function. Clin Endocrinol Metab 12:725–746PubMedCrossRef
Zurück zum Zitat Grossman A, Rees LH (1983) The neuroendocrinology of opioid peptides. Br Med Bull 39:83–88PubMed Grossman A, Rees LH (1983) The neuroendocrinology of opioid peptides. Br Med Bull 39:83–88PubMed
Zurück zum Zitat Miki N, Ono M, Shizume K (1984) Evidence that opiatergic and alpha-adrenergic mechanisms stimulate rat growth hormone release via growth hormone releasing factor (GRF). Endocrinology 114:1950–1952PubMedCrossRef Miki N, Ono M, Shizume K (1984) Evidence that opiatergic and alpha-adrenergic mechanisms stimulate rat growth hormone release via growth hormone releasing factor (GRF). Endocrinology 114:1950–1952PubMedCrossRef
Zurück zum Zitat Muller EE, Locatelli V, Cocchi D (1999) Neuroendocrine control of growth hormone secretion. Physiol Rev 79:511–607PubMed Muller EE, Locatelli V, Cocchi D (1999) Neuroendocrine control of growth hormone secretion. Physiol Rev 79:511–607PubMed
Zurück zum Zitat Sandeberg H, Roman L, Zavodnik J (1973) The effect of smoking on serum somatotropin, immunoreactive insulin and blood glucose levels in young adult males. J Pharmacol Exp Ther 184:787–791 Sandeberg H, Roman L, Zavodnik J (1973) The effect of smoking on serum somatotropin, immunoreactive insulin and blood glucose levels in young adult males. J Pharmacol Exp Ther 184:787–791
Zurück zum Zitat Wilkins JN, Carlson HE, Van Vunakis H, Hill MA, Gritz E, Jarvik ME (1982) Nicotine from cigarette smoking increases circulating levels of cortisol, growth hormone, and prolactin in male chronic smokers. Psychopharmacology 78:305–308PubMedCrossRef Wilkins JN, Carlson HE, Van Vunakis H, Hill MA, Gritz E, Jarvik ME (1982) Nicotine from cigarette smoking increases circulating levels of cortisol, growth hormone, and prolactin in male chronic smokers. Psychopharmacology 78:305–308PubMedCrossRef
Metadaten
Titel
Naloxone decreases the inhibitory effect of somatostatin on GH release induced by cigarette smoking in man
verfasst von
Vittorio Coiro
Riccardo Volpi
Adriano Stella
Simona Cataldo
Claudio Giumelli
Francesco Maccanelli
Anna Araldi
Paolo Chiodera
Publikationsdatum
01.08.2011
Verlag
Springer Vienna
Erschienen in
Journal of Neural Transmission / Ausgabe 8/2011
Print ISSN: 0300-9564
Elektronische ISSN: 1435-1463
DOI
https://doi.org/10.1007/s00702-011-0610-0

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