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International Urology and Nephrology

Erschienen in:

07.04.2016 | Nephrology - Original Paper

Naloxone pretreatment prevents kidney injury after liver ischemia reperfusion injury

verfasst von: Mohammad Ashrafzadeh Takhtfooladi, Mehran Shahzamani, Ahmad Asghari, Aris Fakouri

Erschienen in: International Urology and Nephrology | Ausgabe 7/2016

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Abstract

Purpose

The aim of this study was to assess the effects of naloxone, an opioid receptor antagonist, on the renal injury as a remote organ after hepatic ischemia reperfusion (IR) in rats.

Materials and methods

Forty male Wistar rats were randomly allocated into four groups as follows: sham, sham + naloxone, IR and IR + naloxone. In anesthetized rats, hepatic ischemia was applied for 30 min in IR and IR + naloxone groups. Sham + naloxone and IR + naloxone groups were given naloxone (3.0 mg/kg, iv) 30 min before ischemia. After 24 h, blood and tissue samples were obtained for histopathological, tissue malondialdehyde (MDA) and biochemical analyses.

Results

Histopathological study of liver in IR group showed enlarged sinusoids, sinusoidal congestion, cellular degenerative changes and necrosis. The kidney of the rats with hepatic IR showed pathological changes in tubular cell swelling, tubular dilatation, moderate to severe necrosis, glomerular fibrosis and hemorrhage. Histological examination confirmed the extent of hepatic and renal changes in IR group was higher (P < 0.05) than in other groups. Rats that underwent hepatic IR exhibited significant increase in serum concentrations of urea and creatinine levels (P < 0.05). The serum alanine aminotransferase and aminotransferase values were significantly higher in IR group compared to the other groups (P < 0.05). Liver IR produced a significant increase in hepatic and renal tissue MDA levels, while pretreatment with naloxone was associated with a significantly lower MDA levels (P < 0.05).

Conclusion

The results of this study showed that naloxone pretreatment protected the renal injury from hepatic IR.

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Titel: Naloxone pretreatment prevents kidney injury after liver ischemia reperfusion injury
verfasst von: Mohammad Ashrafzadeh Takhtfooladi
Mehran Shahzamani
Ahmad Asghari
Aris Fakouri
Publikationsdatum: 07.04.2016
Verlag: Springer Netherlands
Erschienen in: International Urology and Nephrology / Ausgabe 7/2016
Print ISSN: 0301-1623
Elektronische ISSN: 1573-2584
DOI: https://doi.org/10.1007/s11255-016-1280-5

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Abstract

Purpose

Materials and methods

Results

Conclusion

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