Skip to main content
Erschienen in: Arthritis Research & Therapy 1/2003

01.02.2003 | Review

Natural killer cells and autoimmunity

verfasst von: Anthony R French, Wayne M Yokoyama

Erschienen in: Arthritis Research & Therapy | Ausgabe 1/2003

Einloggen, um Zugang zu erhalten

Abstract

Autoimmune diseases are often characterized as clinical syndromes caused by the inappropriate activation of T or B cells resulting in systemic or organ-specific damage. However, studies support a role for the innate immune system, and in particular natural killer (NK) cells, in stimulating or suppressing autoimmunity. This review focuses on recent research elucidating a potential immunoregulatory role for NK cells in modulating T and B cell-mediated autoimmunity.
Anhänge
Nur mit Berechtigung zugänglich
Literatur
1.
Zurück zum Zitat Yokoyama WM: Natural killer cell receptors. Curr Opin Immunol. 1998, 10: 298-305. 10.1016/S0952-7915(98)80168-4.CrossRefPubMed Yokoyama WM: Natural killer cell receptors. Curr Opin Immunol. 1998, 10: 298-305. 10.1016/S0952-7915(98)80168-4.CrossRefPubMed
2.
Zurück zum Zitat Seaman WE: Natural killer cells and natural killer T cells. Arthritis Rheum. 2000, 43: 1204-1217. 10.1002/1529-0131(200006)43:6<1204::AID-ANR3>3.0.CO;2-I.CrossRefPubMed Seaman WE: Natural killer cells and natural killer T cells. Arthritis Rheum. 2000, 43: 1204-1217. 10.1002/1529-0131(200006)43:6<1204::AID-ANR3>3.0.CO;2-I.CrossRefPubMed
3.
Zurück zum Zitat Biron CA, Nguyen KB, Pien GC, Cousens LP, Salazar-Mather TP: Natural killer cells in antiviral defense: function and regulation by innate cytokines. Annu Rev Immunol. 1999, 17: 189-220. 10.1146/annurev.immunol.17.1.189.CrossRefPubMed Biron CA, Nguyen KB, Pien GC, Cousens LP, Salazar-Mather TP: Natural killer cells in antiviral defense: function and regulation by innate cytokines. Annu Rev Immunol. 1999, 17: 189-220. 10.1146/annurev.immunol.17.1.189.CrossRefPubMed
4.
Zurück zum Zitat French AR, Yokoyama WM: Natural killer cells and viral infections. Curr Opin Immunol. 2003, 15: 45-51. 10.1016/S095279150200002X.CrossRefPubMed French AR, Yokoyama WM: Natural killer cells and viral infections. Curr Opin Immunol. 2003, 15: 45-51. 10.1016/S095279150200002X.CrossRefPubMed
5.
Zurück zum Zitat Horwitz DA, Gray JD, Ohtsuka K, Hirokawa M, Takahashi T: The immunoregulatory effects of NK cells – the role of TGF-β and implications for autoimmunity. Immunol Today. 1997, 18: 538-542. 10.1016/S0167-5699(97)01149-3.CrossRefPubMed Horwitz DA, Gray JD, Ohtsuka K, Hirokawa M, Takahashi T: The immunoregulatory effects of NK cells – the role of TGF-β and implications for autoimmunity. Immunol Today. 1997, 18: 538-542. 10.1016/S0167-5699(97)01149-3.CrossRefPubMed
6.
Zurück zum Zitat Fearon DT, Locksley RM: The instructive role of innate immunity in the acquired immune response. Science. 1996, 272: 50-53.CrossRefPubMed Fearon DT, Locksley RM: The instructive role of innate immunity in the acquired immune response. Science. 1996, 272: 50-53.CrossRefPubMed
7.
Zurück zum Zitat Kos FJ: Regulation of adaptive immunity by natural killer cells. Immunol Res. 1998, 17: 303-312.CrossRefPubMed Kos FJ: Regulation of adaptive immunity by natural killer cells. Immunol Res. 1998, 17: 303-312.CrossRefPubMed
8.
Zurück zum Zitat Su HC, Nguyen KB, Salazar-Mather TP, Ruzek MC, Dalod MY, Biron CA: NK cell functions restrain T cell responses during viral infections. Eur J Immunol. 2001, 31: 3048-3055. 10.1002/1521-4141(2001010)31:10<3048::AID-IMMU3048>3.0.CO;2-1.CrossRefPubMed Su HC, Nguyen KB, Salazar-Mather TP, Ruzek MC, Dalod MY, Biron CA: NK cell functions restrain T cell responses during viral infections. Eur J Immunol. 2001, 31: 3048-3055. 10.1002/1521-4141(2001010)31:10<3048::AID-IMMU3048>3.0.CO;2-1.CrossRefPubMed
9.
Zurück zum Zitat Zitvogel L: Dendritic and natural killer cells cooperate in the control/switch of innate immunity. J Exp Med. 2002, 195: F9-F14. 10.1084/jem.20012040.PubMedCentralCrossRefPubMed Zitvogel L: Dendritic and natural killer cells cooperate in the control/switch of innate immunity. J Exp Med. 2002, 195: F9-F14. 10.1084/jem.20012040.PubMedCentralCrossRefPubMed
10.
Zurück zum Zitat Lanier LL: NK cell receptors. Annu Rev Immunol. 1998, 16: 359-393. 10.1146/annurev.immunol.16.1.359.CrossRefPubMed Lanier LL: NK cell receptors. Annu Rev Immunol. 1998, 16: 359-393. 10.1146/annurev.immunol.16.1.359.CrossRefPubMed
11.
Zurück zum Zitat Campbell KS, Colonna M: Human natural killer cell receptors and signal transduction. Int Rev Immunol. 2001, 20: 333-370.CrossRefPubMed Campbell KS, Colonna M: Human natural killer cell receptors and signal transduction. Int Rev Immunol. 2001, 20: 333-370.CrossRefPubMed
12.
Zurück zum Zitat Moretta L, Biassoni R, Bottino C, Cantoni C, Pende D, Mingari MC, Moretta A: Human NK cells and their receptors. Microbes Infect. 2002, 4: 1539-1544. 10.1016/S1286-4579(02)00037-0.CrossRefPubMed Moretta L, Biassoni R, Bottino C, Cantoni C, Pende D, Mingari MC, Moretta A: Human NK cells and their receptors. Microbes Infect. 2002, 4: 1539-1544. 10.1016/S1286-4579(02)00037-0.CrossRefPubMed
13.
Zurück zum Zitat Yokoyama WM, Plougastel BF: Immune functions encoded by the natural killer gene complex. Nat Rev Immunol. 2003, 3: 304-316. 10.1038/nri1055.CrossRefPubMed Yokoyama WM, Plougastel BF: Immune functions encoded by the natural killer gene complex. Nat Rev Immunol. 2003, 3: 304-316. 10.1038/nri1055.CrossRefPubMed
14.
Zurück zum Zitat Ljunggren HG, Karre K: In search of the 'missing self': MHC molecules and NK cell recognition. Immunol Today. 1990, 11: 237-244. 10.1016/0167-5699(90)90097-S.CrossRefPubMed Ljunggren HG, Karre K: In search of the 'missing self': MHC molecules and NK cell recognition. Immunol Today. 1990, 11: 237-244. 10.1016/0167-5699(90)90097-S.CrossRefPubMed
15.
Zurück zum Zitat Raulet DH: Development and tolerance of natural killer cells. Curr Opin Immunol. 1999, 11: 129-134. 10.1016/S0952-7915(99)80023-5.CrossRefPubMed Raulet DH: Development and tolerance of natural killer cells. Curr Opin Immunol. 1999, 11: 129-134. 10.1016/S0952-7915(99)80023-5.CrossRefPubMed
16.
Zurück zum Zitat Raulet DH, Vance RE, McMahon CW: Regulation of the natural killer cell receptor repertoire. Annu Rev Immunol. 2001, 19: 291-330. 10.1146/annurev.immunol.19.1.291.CrossRefPubMed Raulet DH, Vance RE, McMahon CW: Regulation of the natural killer cell receptor repertoire. Annu Rev Immunol. 2001, 19: 291-330. 10.1146/annurev.immunol.19.1.291.CrossRefPubMed
17.
Zurück zum Zitat Lanier LL: On guard – activating NK cell receptors. Nat Immunol. 2001, 2: 23-27. 10.1038/83130.CrossRefPubMed Lanier LL: On guard – activating NK cell receptors. Nat Immunol. 2001, 2: 23-27. 10.1038/83130.CrossRefPubMed
18.
Zurück zum Zitat Diefenbach A, Raulet DH: Strategies for target cell recognition by natural killer cells. Immunol Rev. 2001, 181: 170-184. 10.1034/j.1600-065X.2001.1810114.x.CrossRefPubMed Diefenbach A, Raulet DH: Strategies for target cell recognition by natural killer cells. Immunol Rev. 2001, 181: 170-184. 10.1034/j.1600-065X.2001.1810114.x.CrossRefPubMed
19.
Zurück zum Zitat Moretta A, Bottino C, Vitale M, Pende D, Cantoni C, Mingari MC, Biassoni R, Moretta L: Activating receptors and coreceptors involved in human natural killer cell-mediated cytolysis. Annu Rev Immunol. 2001, 19: 197-223. 10.1146/annurev.immunol.19.1.197.CrossRefPubMed Moretta A, Bottino C, Vitale M, Pende D, Cantoni C, Mingari MC, Biassoni R, Moretta L: Activating receptors and coreceptors involved in human natural killer cell-mediated cytolysis. Annu Rev Immunol. 2001, 19: 197-223. 10.1146/annurev.immunol.19.1.197.CrossRefPubMed
20.
Zurück zum Zitat Smith HR, Idris AH, Yokoyama WM: Murine natural killer cell activation receptors. Immunol Rev. 2001, 181: 115-125. 10.1034/j.1600-065X.2001.1810109.x.CrossRefPubMed Smith HR, Idris AH, Yokoyama WM: Murine natural killer cell activation receptors. Immunol Rev. 2001, 181: 115-125. 10.1034/j.1600-065X.2001.1810109.x.CrossRefPubMed
21.
Zurück zum Zitat Groh V, Rhinehart R, Randolph-Habecker J, Topp MS, Riddell SR, Spies T: Costimulation of CD8αβ T cells by NKG2D via engagement by MIC induced on virus-infected cells. Nat Immunol. 2001, 2: 255-260. 10.1038/85321.CrossRefPubMed Groh V, Rhinehart R, Randolph-Habecker J, Topp MS, Riddell SR, Spies T: Costimulation of CD8αβ T cells by NKG2D via engagement by MIC induced on virus-infected cells. Nat Immunol. 2001, 2: 255-260. 10.1038/85321.CrossRefPubMed
22.
Zurück zum Zitat Das H, Groh V, Kuijl C, Sugita M, Morita CT, Spies T, Bukowski JF: MICA engagement by human Vγ2Vδ2 T cells enhances their antigen-dependent effector function. Immunity. 2001, 15: 83-93. 10.1016/S1074-7613(01)00168-6.CrossRefPubMed Das H, Groh V, Kuijl C, Sugita M, Morita CT, Spies T, Bukowski JF: MICA engagement by human Vγ2Vδ2 T cells enhances their antigen-dependent effector function. Immunity. 2001, 15: 83-93. 10.1016/S1074-7613(01)00168-6.CrossRefPubMed
23.
Zurück zum Zitat Tieng V, Le Bouguenec C, du Merle L, Bertheau P, Desreumaux P, Janin A, Charron D, Toubert A: Binding of Escherichia coli adhesin AfaE to CD55 triggers cell-surface expression of the MHC class I-related molecule MICA. Proc Natl Acad Sci USA. 2002, 99: 2977-2982. 10.1073/pnas.032668099.PubMedCentralCrossRefPubMed Tieng V, Le Bouguenec C, du Merle L, Bertheau P, Desreumaux P, Janin A, Charron D, Toubert A: Binding of Escherichia coli adhesin AfaE to CD55 triggers cell-surface expression of the MHC class I-related molecule MICA. Proc Natl Acad Sci USA. 2002, 99: 2977-2982. 10.1073/pnas.032668099.PubMedCentralCrossRefPubMed
24.
Zurück zum Zitat Grunebaum E, Malatzky-Goshen E, Shoenfeld Y: Natural killer cells and autoimmunity. Immunol Res. 1989, 8: 292-304.CrossRefPubMed Grunebaum E, Malatzky-Goshen E, Shoenfeld Y: Natural killer cells and autoimmunity. Immunol Res. 1989, 8: 292-304.CrossRefPubMed
25.
Zurück zum Zitat Flodstrom M, Shi FD, Sarvetnick N, Ljunggren HG: The natural killer cell – friend or foe in autoimmune disease?. Scand J Immunol. 2002, 55: 432-441. 10.1046/j.1365-3083.2002.01084.x.CrossRefPubMed Flodstrom M, Shi FD, Sarvetnick N, Ljunggren HG: The natural killer cell – friend or foe in autoimmune disease?. Scand J Immunol. 2002, 55: 432-441. 10.1046/j.1365-3083.2002.01084.x.CrossRefPubMed
26.
Zurück zum Zitat Baxter AG, Smyth MJ: The role of NK cells in autoimmune disease. Autoimmunity. 2002, 35: 1-14. 10.1080/08916930290005864.CrossRefPubMed Baxter AG, Smyth MJ: The role of NK cells in autoimmune disease. Autoimmunity. 2002, 35: 1-14. 10.1080/08916930290005864.CrossRefPubMed
27.
Zurück zum Zitat Yanagihara Y, Shiozawa K, Takai M, Kyogoku M, Shiozawa S: Natural killer (NK) T cells are significantly decreased in the peripheral blood of patients with rheumatoid arthritis (RA). Clin Exp Immunol. 1999, 118: 131-136. 10.1046/j.1365-2249.1999.01018.x.PubMedCentralCrossRefPubMed Yanagihara Y, Shiozawa K, Takai M, Kyogoku M, Shiozawa S: Natural killer (NK) T cells are significantly decreased in the peripheral blood of patients with rheumatoid arthritis (RA). Clin Exp Immunol. 1999, 118: 131-136. 10.1046/j.1365-2249.1999.01018.x.PubMedCentralCrossRefPubMed
28.
Zurück zum Zitat Koreck A, Suranyi A, Szony BJ, Farkas A, Bata-Csorgo Z, Kemeny L, Dobozy A: CD3+CD56+ NK T cells are significantly decreased in the peripheral blood of patients with psoriasis. Clin Exp Immunol. 2002, 127: 176-182. 10.1046/j.1365-2249.2002.01721.x.PubMedCentralCrossRefPubMed Koreck A, Suranyi A, Szony BJ, Farkas A, Bata-Csorgo Z, Kemeny L, Dobozy A: CD3+CD56+ NK T cells are significantly decreased in the peripheral blood of patients with psoriasis. Clin Exp Immunol. 2002, 127: 176-182. 10.1046/j.1365-2249.2002.01721.x.PubMedCentralCrossRefPubMed
29.
Zurück zum Zitat Bossowski A, Urban M, Stasiak-Barmuta A: Analysis of circulating T gamma/delta lymphocytes and CD16/56 cell populations in children and adolescents with Graves' disease. Pediatr Res. 2003, 54: 425-429. 10.1203/01.PDR.0000076663.94850.44.CrossRefPubMed Bossowski A, Urban M, Stasiak-Barmuta A: Analysis of circulating T gamma/delta lymphocytes and CD16/56 cell populations in children and adolescents with Graves' disease. Pediatr Res. 2003, 54: 425-429. 10.1203/01.PDR.0000076663.94850.44.CrossRefPubMed
30.
Zurück zum Zitat Ciampolillo A, Guastamacchia E, Amati L, Magrone T, Munno I, Jirillo E, Triggiani V, Fallacara R, Tafaro E: Modifications of the immune responsiveness in patients with autoimmune thyroiditis: evidence for a systemic immune alteration. Curr Pharm Des. 2003, 9: 1946-1950. 10.2174/1381612033454270.CrossRefPubMed Ciampolillo A, Guastamacchia E, Amati L, Magrone T, Munno I, Jirillo E, Triggiani V, Fallacara R, Tafaro E: Modifications of the immune responsiveness in patients with autoimmune thyroiditis: evidence for a systemic immune alteration. Curr Pharm Des. 2003, 9: 1946-1950. 10.2174/1381612033454270.CrossRefPubMed
31.
Zurück zum Zitat Cameron AL, Kirby B, Griffiths CE: Circulating natural killer cells in psoriasis. Br J Dermatol. 2003, 149: 160-164. 10.1046/j.1365-2133.2003.05319.x.CrossRefPubMed Cameron AL, Kirby B, Griffiths CE: Circulating natural killer cells in psoriasis. Br J Dermatol. 2003, 149: 160-164. 10.1046/j.1365-2133.2003.05319.x.CrossRefPubMed
32.
Zurück zum Zitat O'Gorman M, Smith R, Garrison A, Shamiyeh E, Pachman L: Lymphocyte subsets in peripheral blood from newly diagnosed, untreated patients with juvenile dermatomyositis (JDM) are associated with disease activity scores (DAS). Arthritis Rheum. 2002, 46 (suppl 9): S490- O'Gorman M, Smith R, Garrison A, Shamiyeh E, Pachman L: Lymphocyte subsets in peripheral blood from newly diagnosed, untreated patients with juvenile dermatomyositis (JDM) are associated with disease activity scores (DAS). Arthritis Rheum. 2002, 46 (suppl 9): S490-
33.
Zurück zum Zitat Yabuhara A, Yang FC, Nakazawa T, Iwasaki Y, Mori T, Koike K, Kawai H, Komiyama A: A killing defect of natural killer cells as an underlying immunologic abnormality in childhood systemic lupus erythematosus. J Rheumatol. 1996, 23: 171-177.PubMed Yabuhara A, Yang FC, Nakazawa T, Iwasaki Y, Mori T, Koike K, Kawai H, Komiyama A: A killing defect of natural killer cells as an underlying immunologic abnormality in childhood systemic lupus erythematosus. J Rheumatol. 1996, 23: 171-177.PubMed
34.
Zurück zum Zitat Wouters CH, Ceuppens JL, Stevens EA: Different circulating lymphocyte profiles in patients with different subtypes of juvenile idiopathic arthritis. Clin Exp Rheumatol. 2002, 20: 239-248.PubMed Wouters CH, Ceuppens JL, Stevens EA: Different circulating lymphocyte profiles in patients with different subtypes of juvenile idiopathic arthritis. Clin Exp Rheumatol. 2002, 20: 239-248.PubMed
35.
Zurück zum Zitat Wulffraat NM, Rijkers GT, Elst E, Brooimans R, Kuis W: Reduced perforin expression in systemic juvenile idiopathic arthritis is restored by autologous stem-cell transplantation. Rheumatology (Oxford). 2003, 42: 375-379. 10.1093/rheumatology/keg074.CrossRef Wulffraat NM, Rijkers GT, Elst E, Brooimans R, Kuis W: Reduced perforin expression in systemic juvenile idiopathic arthritis is restored by autologous stem-cell transplantation. Rheumatology (Oxford). 2003, 42: 375-379. 10.1093/rheumatology/keg074.CrossRef
36.
Zurück zum Zitat Imashuku S, Hyakuna N, Funabiki T, Ikuta K, Sako M, Iwai A, Fukushima T, Kataoka S, Yabe M, Muramatsu K, Kohdera U, Nakadate H, Kitazawa K, Toyoda Y, Ishii E: Low natural killer activity and central nervous system disease as a high-risk prognostic indicator in young patients with hemophagocytic lymphohistiocytosis. Cancer. 2002, 94: 3023-3031. 10.1002/cncr.10515.CrossRefPubMed Imashuku S, Hyakuna N, Funabiki T, Ikuta K, Sako M, Iwai A, Fukushima T, Kataoka S, Yabe M, Muramatsu K, Kohdera U, Nakadate H, Kitazawa K, Toyoda Y, Ishii E: Low natural killer activity and central nervous system disease as a high-risk prognostic indicator in young patients with hemophagocytic lymphohistiocytosis. Cancer. 2002, 94: 3023-3031. 10.1002/cncr.10515.CrossRefPubMed
37.
Zurück zum Zitat Grom AA, Villanueva J, Lee S, Goldmuntz EA, Passo MH, Filipovich A: Natural killer cell dysfunction in patients with systemic-onset juvenile rheumatoid arthritis and macrophage activation syndrome. J Pediatr. 2003, 142: 292-296. 10.1067/mpd.2003.110.CrossRefPubMed Grom AA, Villanueva J, Lee S, Goldmuntz EA, Passo MH, Filipovich A: Natural killer cell dysfunction in patients with systemic-onset juvenile rheumatoid arthritis and macrophage activation syndrome. J Pediatr. 2003, 142: 292-296. 10.1067/mpd.2003.110.CrossRefPubMed
38.
Zurück zum Zitat Erkeller-Yusel F, Hulstaart F, Hannet I, Isenberg D, Lydyard P: Lymphocyte subsets in a large cohort of patients with systemic lupus erythematosus. Lupus. 1993, 2: 227-231.CrossRefPubMed Erkeller-Yusel F, Hulstaart F, Hannet I, Isenberg D, Lydyard P: Lymphocyte subsets in a large cohort of patients with systemic lupus erythematosus. Lupus. 1993, 2: 227-231.CrossRefPubMed
39.
Zurück zum Zitat Erkeller-Yuksel FM, Lydyard PM, Isenberg DA: Lack of NK cells in lupus patients with renal involvement. Lupus. 1997, 6: 708-712.CrossRefPubMed Erkeller-Yuksel FM, Lydyard PM, Isenberg DA: Lack of NK cells in lupus patients with renal involvement. Lupus. 1997, 6: 708-712.CrossRefPubMed
40.
Zurück zum Zitat Munschauer FE, Hartrich LA, Stewart CC, Jacobs L: Circulating natural killer cells but not cytotoxic T lymphocytes are reduced in patients with active relapsing multiple sclerosis and little clinical disability as compared to controls. J Neuroimmunol. 1995, 62: 177-181. 10.1016/0165-5728(95)00115-9.CrossRefPubMed Munschauer FE, Hartrich LA, Stewart CC, Jacobs L: Circulating natural killer cells but not cytotoxic T lymphocytes are reduced in patients with active relapsing multiple sclerosis and little clinical disability as compared to controls. J Neuroimmunol. 1995, 62: 177-181. 10.1016/0165-5728(95)00115-9.CrossRefPubMed
41.
Zurück zum Zitat Kastrukoff LF, Morgan NG, Zecchini D, White R, Petkau AJ, Satoh J, Paty DW: A role for natural killer cells in the immunopathogenesis of multiple sclerosis. J Neuroimmunol. 1998, 86: 123-133. 10.1016/S0165-5728(98)00014-9.CrossRefPubMed Kastrukoff LF, Morgan NG, Zecchini D, White R, Petkau AJ, Satoh J, Paty DW: A role for natural killer cells in the immunopathogenesis of multiple sclerosis. J Neuroimmunol. 1998, 86: 123-133. 10.1016/S0165-5728(98)00014-9.CrossRefPubMed
42.
Zurück zum Zitat Riccieri V, Spadaro A, Parisi G, Taccari E, Moretti T, Bernardini G, Favaroni M, Strom R: Down-regulation of natural killer cells and of gamma/delta T cells in systemic lupus erythematosus. Does it correlate to autoimmunity and to laboratory indices of disease activity?. Lupus. 2000, 9: 333-337. 10.1191/096120300678828460.CrossRefPubMed Riccieri V, Spadaro A, Parisi G, Taccari E, Moretti T, Bernardini G, Favaroni M, Strom R: Down-regulation of natural killer cells and of gamma/delta T cells in systemic lupus erythematosus. Does it correlate to autoimmunity and to laboratory indices of disease activity?. Lupus. 2000, 9: 333-337. 10.1191/096120300678828460.CrossRefPubMed
43.
Zurück zum Zitat Takahashi K, Miyake S, Kondo T, Terao K, Hatakenaka M, Hashimoto S, Yamamura T: Natural killer type 2 bias in remission of multiple sclerosis. J Clin Invest. 2001, 107: R23-R29.PubMedCentralCrossRefPubMed Takahashi K, Miyake S, Kondo T, Terao K, Hatakenaka M, Hashimoto S, Yamamura T: Natural killer type 2 bias in remission of multiple sclerosis. J Clin Invest. 2001, 107: R23-R29.PubMedCentralCrossRefPubMed
44.
Zurück zum Zitat Biron CA, Byron KS, Sullivan JL: Severe herpesvirus infections in an adolescent without natural killer cells. N Engl J Med. 1989, 320: 1731-1735.CrossRefPubMed Biron CA, Byron KS, Sullivan JL: Severe herpesvirus infections in an adolescent without natural killer cells. N Engl J Med. 1989, 320: 1731-1735.CrossRefPubMed
45.
Zurück zum Zitat Jawahar S, Moody C, Chan M, Finberg R, Geha R, Chatila T: Natural Killer (NK) cell deficiency associated with an epitope-deficient Fc receptor type IIIA (CD16-II). Clin Exp Immunol. 1996, 103: 408-413.PubMedCentralCrossRefPubMed Jawahar S, Moody C, Chan M, Finberg R, Geha R, Chatila T: Natural Killer (NK) cell deficiency associated with an epitope-deficient Fc receptor type IIIA (CD16-II). Clin Exp Immunol. 1996, 103: 408-413.PubMedCentralCrossRefPubMed
46.
Zurück zum Zitat Orange JS: Human natural killer cell deficiencies and susceptibility to infection. Microbes Infect. 2002, 4: 1545-1558. 10.1016/S1286-4579(02)00038-2.CrossRefPubMed Orange JS: Human natural killer cell deficiencies and susceptibility to infection. Microbes Infect. 2002, 4: 1545-1558. 10.1016/S1286-4579(02)00038-2.CrossRefPubMed
47.
Zurück zum Zitat Lamy T, Loughran TP: Clinical features of large granular lymphocyte leukemia. Semin Hematol. 2003, 40: 185-195. 10.1016/S0037-1963(03)00133-1.CrossRefPubMed Lamy T, Loughran TP: Clinical features of large granular lymphocyte leukemia. Semin Hematol. 2003, 40: 185-195. 10.1016/S0037-1963(03)00133-1.CrossRefPubMed
48.
Zurück zum Zitat Tefferi A, Li CY, Witzig TE, Dhodapkar MV, Okuno SH, Phyliky RL: Chronic natural killer cell lymphocytosis: a descriptive clinical study. Blood. 1994, 84: 2721-2725.PubMed Tefferi A, Li CY, Witzig TE, Dhodapkar MV, Okuno SH, Phyliky RL: Chronic natural killer cell lymphocytosis: a descriptive clinical study. Blood. 1994, 84: 2721-2725.PubMed
49.
Zurück zum Zitat Rabbani GR, Phyliky RL, Tefferi A: A long-term study of patients with chronic natural killer cell lymphocytosis. Br J Haematol. 1999, 106: 960-966. 10.1046/j.1365-2141.1999.01624.x.CrossRefPubMed Rabbani GR, Phyliky RL, Tefferi A: A long-term study of patients with chronic natural killer cell lymphocytosis. Br J Haematol. 1999, 106: 960-966. 10.1046/j.1365-2141.1999.01624.x.CrossRefPubMed
50.
Zurück zum Zitat Martin MP, Nelson G, Lee JH, Pellett F, Gao X, Wade J, Wilson MJ, Trowsdale J, Gladman D, Carrington M: Cutting edge: susceptibility to psoriatic arthritis: influence of activating killer Ig-like receptor genes in the absence of specific HLA-C alleles. J Immunol. 2002, 169: 2818-2822.CrossRefPubMed Martin MP, Nelson G, Lee JH, Pellett F, Gao X, Wade J, Wilson MJ, Trowsdale J, Gladman D, Carrington M: Cutting edge: susceptibility to psoriatic arthritis: influence of activating killer Ig-like receptor genes in the absence of specific HLA-C alleles. J Immunol. 2002, 169: 2818-2822.CrossRefPubMed
51.
Zurück zum Zitat van der Slik AR, Koeleman BP, Verduijn W, Bruining GJ, Roep BO, Giphart MJ: KIR in type 1 diabetes: disparate distribution of activating and inhibitory natural killer cell receptors in patients versus HLA-matched control subjects. Diabetes. 2003, 52: 2639-2642.CrossRefPubMed van der Slik AR, Koeleman BP, Verduijn W, Bruining GJ, Roep BO, Giphart MJ: KIR in type 1 diabetes: disparate distribution of activating and inhibitory natural killer cell receptors in patients versus HLA-matched control subjects. Diabetes. 2003, 52: 2639-2642.CrossRefPubMed
52.
Zurück zum Zitat Takeno M, Shimoyama Y, Kashiwakura JI, Nagafuchi H, Sakane T, Suzuki N: Abnormal killer inhibitory receptor expression on natural killer cells in patients with Behcet's disease. Rheumatol Int. 2003, [epub ahead of print] Takeno M, Shimoyama Y, Kashiwakura JI, Nagafuchi H, Sakane T, Suzuki N: Abnormal killer inhibitory receptor expression on natural killer cells in patients with Behcet's disease. Rheumatol Int. 2003, [epub ahead of print]
53.
Zurück zum Zitat Namekawa T, Snyder MR, Yen JH, Goehring BE, Leibson PJ, Weyand CM, Goronzy JJ: Killer cell activating receptors function as costimulatory molecules on CD4+CD28null T cells clonally expanded in rheumatoid arthritis. J Immunol. 2000, 165: 1138-1145.CrossRefPubMed Namekawa T, Snyder MR, Yen JH, Goehring BE, Leibson PJ, Weyand CM, Goronzy JJ: Killer cell activating receptors function as costimulatory molecules on CD4+CD28null T cells clonally expanded in rheumatoid arthritis. J Immunol. 2000, 165: 1138-1145.CrossRefPubMed
54.
Zurück zum Zitat Warrington KJ, Takemura S, Goronzy JJ, Weyand CM: CD4+, CD28- T cells in rheumatoid arthritis patients combine features of the innate and adaptive immune systems. Arthritis Rheum. 2001, 44: 13-20. 10.1002/1529-0131(200101)44:1<13::AID-ANR3>3.0.CO;2-6.CrossRefPubMed Warrington KJ, Takemura S, Goronzy JJ, Weyand CM: CD4+, CD28- T cells in rheumatoid arthritis patients combine features of the innate and adaptive immune systems. Arthritis Rheum. 2001, 44: 13-20. 10.1002/1529-0131(200101)44:1<13::AID-ANR3>3.0.CO;2-6.CrossRefPubMed
55.
Zurück zum Zitat Yen JH, Moore BE, Nakajima T, Scholl D, Schaid DJ, Weyand CM, Goronzy JJ: Major histocompatibility complex class I-recognizing receptors are disease risk genes in rheumatoid arthritis. J Exp Med. 2001, 193: 1159-1168. 10.1084/jem.193.10.1159.PubMedCentralCrossRefPubMed Yen JH, Moore BE, Nakajima T, Scholl D, Schaid DJ, Weyand CM, Goronzy JJ: Major histocompatibility complex class I-recognizing receptors are disease risk genes in rheumatoid arthritis. J Exp Med. 2001, 193: 1159-1168. 10.1084/jem.193.10.1159.PubMedCentralCrossRefPubMed
56.
Zurück zum Zitat Snyder MR, Lucas M, Vivier E, Weyand CM, Goronzy JJ: Selective activation of the c-Jun NH2-terminal protein kinase signaling pathway by stimulatory KIR in the absence of KARAP/ DAP12 in CD4+ T cells. J Exp Med. 2003, 197: 437-449. 10.1084/jem.20020383.PubMedCentralCrossRefPubMed Snyder MR, Lucas M, Vivier E, Weyand CM, Goronzy JJ: Selective activation of the c-Jun NH2-terminal protein kinase signaling pathway by stimulatory KIR in the absence of KARAP/ DAP12 in CD4+ T cells. J Exp Med. 2003, 197: 437-449. 10.1084/jem.20020383.PubMedCentralCrossRefPubMed
57.
Zurück zum Zitat Groh V, Bruhl A, El-Gabalawy H, Nelson JL, Spies T: Stimulation of T cell autoreactivity by anomalous expression of NKG2D and its MIC ligands in rheumatoid arthritis. Proc Natl Acad Sci USA. 2003, 100: 9452-9457. 10.1073/pnas.1632807100.PubMedCentralCrossRefPubMed Groh V, Bruhl A, El-Gabalawy H, Nelson JL, Spies T: Stimulation of T cell autoreactivity by anomalous expression of NKG2D and its MIC ligands in rheumatoid arthritis. Proc Natl Acad Sci USA. 2003, 100: 9452-9457. 10.1073/pnas.1632807100.PubMedCentralCrossRefPubMed
58.
Zurück zum Zitat Bauer S, Groh V, Wu J, Steinle A, Phillips JH, Lanier LL, Spies T: Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA. Science. 1999, 285: 727-729. 10.1126/science.285.5428.727.CrossRefPubMed Bauer S, Groh V, Wu J, Steinle A, Phillips JH, Lanier LL, Spies T: Activation of NK cells and T cells by NKG2D, a receptor for stress-inducible MICA. Science. 1999, 285: 727-729. 10.1126/science.285.5428.727.CrossRefPubMed
59.
Zurück zum Zitat Tak PP, Kummer JA, Hack CE, Daha MR, Smeets TJ, Erkelens GW, Meinders AE, Kluin PM, Breedveld FC: Granzyme-positive cytotoxic cells are specifically increased in early rheumatoid synovial tissue. Arthritis Rheum. 1994, 37: 1735-1743.CrossRefPubMed Tak PP, Kummer JA, Hack CE, Daha MR, Smeets TJ, Erkelens GW, Meinders AE, Kluin PM, Breedveld FC: Granzyme-positive cytotoxic cells are specifically increased in early rheumatoid synovial tissue. Arthritis Rheum. 1994, 37: 1735-1743.CrossRefPubMed
60.
Zurück zum Zitat Dalbeth N, Callan MF: A subset of natural killer cells is greatly expanded within inflamed joints. Arthritis Rheum. 2002, 46: 1763-1772. 10.1002/art.10410.CrossRefPubMed Dalbeth N, Callan MF: A subset of natural killer cells is greatly expanded within inflamed joints. Arthritis Rheum. 2002, 46: 1763-1772. 10.1002/art.10410.CrossRefPubMed
61.
Zurück zum Zitat Pridgeon C, Lennon GP, Pazmany L, Thompson RN, Christmas SE, Moots RJ: Natural killer cells in the synovial fluid of rheumatoid arthritis patients exhibit a CD56bright, CD94bright, CD158negative phenotype. Rheumatology (Oxford). 2003, 42: 870-878. 10.1093/rheumatology/keg240.CrossRef Pridgeon C, Lennon GP, Pazmany L, Thompson RN, Christmas SE, Moots RJ: Natural killer cells in the synovial fluid of rheumatoid arthritis patients exhibit a CD56bright, CD94bright, CD158negative phenotype. Rheumatology (Oxford). 2003, 42: 870-878. 10.1093/rheumatology/keg240.CrossRef
62.
Zurück zum Zitat Cooper MA, Fehniger TA, Turner SC, Chen KS, Ghaheri BA, Ghayur T, Carson WE, Caligiuri MA: Human natural killer cells: a unique innate immunoregulatory role for the CD56bright subset. Blood. 2001, 97: 3146-3151. 10.1182/blood.V97.10.3146.CrossRefPubMed Cooper MA, Fehniger TA, Turner SC, Chen KS, Ghaheri BA, Ghayur T, Carson WE, Caligiuri MA: Human natural killer cells: a unique innate immunoregulatory role for the CD56bright subset. Blood. 2001, 97: 3146-3151. 10.1182/blood.V97.10.3146.CrossRefPubMed
63.
Zurück zum Zitat Farag SS, VanDeusen JB, Fehniger TA, Caligiuri MA: Biology and clinical impact of human natural killer cells. Int J Hematol. 2003, 78: 7-17.CrossRefPubMed Farag SS, VanDeusen JB, Fehniger TA, Caligiuri MA: Biology and clinical impact of human natural killer cells. Int J Hematol. 2003, 78: 7-17.CrossRefPubMed
64.
Zurück zum Zitat Fujinami RS: Can virus infections trigger autoimmune disease?. J Autoimmun. 2001, 16: 229-234. 10.1006/jaut.2000.0484.CrossRefPubMed Fujinami RS: Can virus infections trigger autoimmune disease?. J Autoimmun. 2001, 16: 229-234. 10.1006/jaut.2000.0484.CrossRefPubMed
65.
Zurück zum Zitat Paya CV, Patick AK, Leibson PJ, Rodriguez M: Role of natural killer cells as immune effectors in encephalitis and demyelination induced by Theiler's virus. J Immunol. 1989, 143: 95-102.PubMed Paya CV, Patick AK, Leibson PJ, Rodriguez M: Role of natural killer cells as immune effectors in encephalitis and demyelination induced by Theiler's virus. J Immunol. 1989, 143: 95-102.PubMed
66.
Zurück zum Zitat Fairweather D, Kaya Z, Shellam GR, Lawson CM, Rose NR: From infection to autoimmunity. J Autoimmun. 2001, 16: 175-186. 10.1006/jaut.2000.0492.CrossRefPubMed Fairweather D, Kaya Z, Shellam GR, Lawson CM, Rose NR: From infection to autoimmunity. J Autoimmun. 2001, 16: 175-186. 10.1006/jaut.2000.0492.CrossRefPubMed
67.
Zurück zum Zitat Takeda K, Dennert G: The development of autoimmunity in C57BL/6 lpr mice correlates with the disappearance of natural killer type 1-positive cells: evidence for their suppressive action on bone marrow stem cell proliferation, B cell immunoglobulin secretion, and autoimmune symptoms. J Exp Med. 1993, 177: 155-164. 10.1084/jem.177.1.155.CrossRefPubMed Takeda K, Dennert G: The development of autoimmunity in C57BL/6 lpr mice correlates with the disappearance of natural killer type 1-positive cells: evidence for their suppressive action on bone marrow stem cell proliferation, B cell immunoglobulin secretion, and autoimmune symptoms. J Exp Med. 1993, 177: 155-164. 10.1084/jem.177.1.155.CrossRefPubMed
68.
Zurück zum Zitat Smeltz RB, Wolf NA, Swanborg RH: Inhibition of autoimmune T cell responses in the DA rat by bone marrow-derived NK cells in vitro: implications for autoimmunity. J Immunol. 1999, 163: 1390-1397.PubMed Smeltz RB, Wolf NA, Swanborg RH: Inhibition of autoimmune T cell responses in the DA rat by bone marrow-derived NK cells in vitro: implications for autoimmunity. J Immunol. 1999, 163: 1390-1397.PubMed
69.
Zurück zum Zitat Fort MM, Leach MW, Rennick DM: A role for NK cells as regulators of CD4+ T cells in a transfer model of colitis. J Immunol. 1998, 161: 3256-3261.PubMed Fort MM, Leach MW, Rennick DM: A role for NK cells as regulators of CD4+ T cells in a transfer model of colitis. J Immunol. 1998, 161: 3256-3261.PubMed
70.
Zurück zum Zitat Zhang B, Yamamura T, Kondo T, Fujiwara M, Tabira T: Regulation of experimental autoimmune encephalomyelitis by natural killer (NK) cells. J Exp Med. 1997, 186: 1677-1687. 10.1084/jem.186.10.1677.PubMedCentralCrossRefPubMed Zhang B, Yamamura T, Kondo T, Fujiwara M, Tabira T: Regulation of experimental autoimmune encephalomyelitis by natural killer (NK) cells. J Exp Med. 1997, 186: 1677-1687. 10.1084/jem.186.10.1677.PubMedCentralCrossRefPubMed
71.
Zurück zum Zitat Matsumoto Y, Kohyama K, Aikawa Y, Shin T, Kawazoe Y, Suzuki Y, Tanuma N: Role of natural killer cells and TCR gamma delta T cells in acute autoimmune encephalomyelitis. Eur J Immunol. 1998, 28: 1681-1688. 10.1002/(SICI)1521-4141(199805)28:05<1681::AID-IMMU1681>3.0.CO;2-T.CrossRefPubMed Matsumoto Y, Kohyama K, Aikawa Y, Shin T, Kawazoe Y, Suzuki Y, Tanuma N: Role of natural killer cells and TCR gamma delta T cells in acute autoimmune encephalomyelitis. Eur J Immunol. 1998, 28: 1681-1688. 10.1002/(SICI)1521-4141(199805)28:05<1681::AID-IMMU1681>3.0.CO;2-T.CrossRefPubMed
72.
Zurück zum Zitat Shi FD, Takeda K, Akira S, Sarvetnick N, Ljunggren HG: IL-18 directs autoreactive T cells and promotes autodestruction in the central nervous system via induction of IFN-gamma by NK cells. J Immunol. 2000, 165: 3099-3104.CrossRefPubMed Shi FD, Takeda K, Akira S, Sarvetnick N, Ljunggren HG: IL-18 directs autoreactive T cells and promotes autodestruction in the central nervous system via induction of IFN-gamma by NK cells. J Immunol. 2000, 165: 3099-3104.CrossRefPubMed
73.
Zurück zum Zitat Carnaud C, Lee D, Donnars O, Park SH, Beavis A, Koezuka Y, Bendelac A: Cutting edge: cross-talk between cells of the innate immune system: NKT cells rapidly activate NK cells. J Immunol. 1999, 163: 4647-4650.PubMed Carnaud C, Lee D, Donnars O, Park SH, Beavis A, Koezuka Y, Bendelac A: Cutting edge: cross-talk between cells of the innate immune system: NKT cells rapidly activate NK cells. J Immunol. 1999, 163: 4647-4650.PubMed
74.
Zurück zum Zitat Gerosa F, Baldani-Guerra B, Nisii C, Marchesini V, Carra G, Trinchieri G: Reciprocal activating interaction between natural killer cells and dendritic cells. J Exp Med. 2002, 195: 327-333. 10.1084/jem.20010938.PubMedCentralCrossRefPubMed Gerosa F, Baldani-Guerra B, Nisii C, Marchesini V, Carra G, Trinchieri G: Reciprocal activating interaction between natural killer cells and dendritic cells. J Exp Med. 2002, 195: 327-333. 10.1084/jem.20010938.PubMedCentralCrossRefPubMed
75.
Zurück zum Zitat Piccioli D, Sbrana S, Melandri E, Valiante NM: Contact-dependent stimulation and inhibition of dendritic cells by natural killer cells. J Exp Med. 2002, 195: 335-341. 10.1084/jem.20010934.PubMedCentralCrossRefPubMed Piccioli D, Sbrana S, Melandri E, Valiante NM: Contact-dependent stimulation and inhibition of dendritic cells by natural killer cells. J Exp Med. 2002, 195: 335-341. 10.1084/jem.20010934.PubMedCentralCrossRefPubMed
76.
Zurück zum Zitat Moretta A: Natural killer cells and dendritic cells: rendezvous in abused tissues. Nat Rev Immunol. 2002, 2: 957-964. 10.1038/nri956.CrossRefPubMed Moretta A: Natural killer cells and dendritic cells: rendezvous in abused tissues. Nat Rev Immunol. 2002, 2: 957-964. 10.1038/nri956.CrossRefPubMed
77.
Zurück zum Zitat Schott E, Bonasio R, Ploegh HL: Elimination in vivo of developing T cells by natural killer cells. J Exp Med. 2003, 198: 1213-1224. 10.1084/jem.20030918.PubMedCentralCrossRefPubMed Schott E, Bonasio R, Ploegh HL: Elimination in vivo of developing T cells by natural killer cells. J Exp Med. 2003, 198: 1213-1224. 10.1084/jem.20030918.PubMedCentralCrossRefPubMed
78.
Zurück zum Zitat Shi FD, Wang HB, Li H, Hong S, Taniguchi M, Link H, Van Kaer L, Ljunggren HG: Natural killer cells determine the outcome of B cell-mediated autoimmunity. Nat Immunol. 2000, 1: 245-251. 10.1038/79792.CrossRefPubMed Shi FD, Wang HB, Li H, Hong S, Taniguchi M, Link H, Van Kaer L, Ljunggren HG: Natural killer cells determine the outcome of B cell-mediated autoimmunity. Nat Immunol. 2000, 1: 245-251. 10.1038/79792.CrossRefPubMed
79.
Zurück zum Zitat Korsgren M, Persson CG, Sundler F, Bjerke T, Hansson T, Chambers BJ, Hong S, Van Kaer L, Ljunggren HG, Korsgren O: Natural killer cells determine the development of allergen-induced eosinophilic airway inflammation in mice. J Exp Med. 1999, 189: 553-562. 10.1084/jem.189.3.553.PubMedCentralCrossRefPubMed Korsgren M, Persson CG, Sundler F, Bjerke T, Hansson T, Chambers BJ, Hong S, Van Kaer L, Ljunggren HG, Korsgren O: Natural killer cells determine the development of allergen-induced eosinophilic airway inflammation in mice. J Exp Med. 1999, 189: 553-562. 10.1084/jem.189.3.553.PubMedCentralCrossRefPubMed
80.
Zurück zum Zitat Backstrom E, Chambers BJ, Kristensson K, Ljunggren HG: Direct NK cell-mediated lysis of syngenic dorsal root ganglia neurons in vitro. J Immunol. 2000, 165: 4895-4900.CrossRefPubMed Backstrom E, Chambers BJ, Kristensson K, Ljunggren HG: Direct NK cell-mediated lysis of syngenic dorsal root ganglia neurons in vitro. J Immunol. 2000, 165: 4895-4900.CrossRefPubMed
81.
Zurück zum Zitat Morse RH, Seguin R, McCrea EL, Antel JP: NK cell-mediated lysis of autologous human oligodendrocytes. J Neuroimmunol. 2001, 116: 107-115. 10.1016/S0165-5728(01)00289-2.CrossRefPubMed Morse RH, Seguin R, McCrea EL, Antel JP: NK cell-mediated lysis of autologous human oligodendrocytes. J Neuroimmunol. 2001, 116: 107-115. 10.1016/S0165-5728(01)00289-2.CrossRefPubMed
82.
Zurück zum Zitat Hickey WF, Ueno K, Hiserodt JC, Schmidt RE: Exogenously-induced, natural killer cell-mediated neuronal killing: a novel pathogenetic mechanism. J Exp Med. 1992, 176: 811-817. 10.1084/jem.176.3.811.CrossRefPubMed Hickey WF, Ueno K, Hiserodt JC, Schmidt RE: Exogenously-induced, natural killer cell-mediated neuronal killing: a novel pathogenetic mechanism. J Exp Med. 1992, 176: 811-817. 10.1084/jem.176.3.811.CrossRefPubMed
83.
Zurück zum Zitat Backstrom E, Chambers BJ, Ho EL, Naidenko OV, Mariotti R, Fremont DH, Yokoyama WM, Kristensson K, Ljunggren HG: Natural killer cell-mediated lysis of dorsal root ganglia neurons via RAE1/NKG2D interactions. Eur J Immunol. 2003, 33: 92-100. 10.1002/immu.200390012.CrossRefPubMed Backstrom E, Chambers BJ, Ho EL, Naidenko OV, Mariotti R, Fremont DH, Yokoyama WM, Kristensson K, Ljunggren HG: Natural killer cell-mediated lysis of dorsal root ganglia neurons via RAE1/NKG2D interactions. Eur J Immunol. 2003, 33: 92-100. 10.1002/immu.200390012.CrossRefPubMed
84.
Zurück zum Zitat Kitaichi N, Kotake S, Morohashi T, Onoe K, Ohno S, Taylor AW: Diminution of experimental autoimmune uveoretinitis (EAU) in mice depleted of NK cells. J Leukoc Biol. 2002, 72: 1117-1121.PubMed Kitaichi N, Kotake S, Morohashi T, Onoe K, Ohno S, Taylor AW: Diminution of experimental autoimmune uveoretinitis (EAU) in mice depleted of NK cells. J Leukoc Biol. 2002, 72: 1117-1121.PubMed
85.
Zurück zum Zitat Flodstrom M, Maday A, Balakrishna D, Cleary MM, Yoshimura A, Sarvetnick N: Target cell defense prevents the development of diabetes after viral infection. Nat Immunol. 2002, 3: 373-382. 10.1038/ni771.CrossRefPubMed Flodstrom M, Maday A, Balakrishna D, Cleary MM, Yoshimura A, Sarvetnick N: Target cell defense prevents the development of diabetes after viral infection. Nat Immunol. 2002, 3: 373-382. 10.1038/ni771.CrossRefPubMed
Metadaten
Titel
Natural killer cells and autoimmunity
verfasst von
Anthony R French
Wayne M Yokoyama
Publikationsdatum
01.02.2003
Verlag
BioMed Central
Erschienen in
Arthritis Research & Therapy / Ausgabe 1/2003
Elektronische ISSN: 1478-6362
DOI
https://doi.org/10.1186/ar1034

Weitere Artikel der Ausgabe 1/2003

Arthritis Research & Therapy 1/2003 Zur Ausgabe

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Mehr Lebenszeit mit Abemaciclib bei fortgeschrittenem Brustkrebs?

24.05.2024 Mammakarzinom Nachrichten

In der MONARCHE-3-Studie lebten Frauen mit fortgeschrittenem Hormonrezeptor-positivem, HER2-negativem Brustkrebs länger, wenn sie zusätzlich zu einem nicht steroidalen Aromatasehemmer mit Abemaciclib behandelt wurden; allerdings verfehlte der numerische Zugewinn die statistische Signifikanz.

ADT zur Radiatio nach Prostatektomie: Wenn, dann wohl länger

24.05.2024 Prostatakarzinom Nachrichten

Welchen Nutzen es trägt, wenn die Strahlentherapie nach radikaler Prostatektomie um eine Androgendeprivation ergänzt wird, hat die RADICALS-HD-Studie untersucht. Nun liegen die Ergebnisse vor. Sie sprechen für länger dauernden Hormonentzug.

„Überwältigende“ Evidenz für Tripeltherapie beim metastasierten Prostata-Ca.

22.05.2024 Prostatakarzinom Nachrichten

Patienten mit metastasiertem hormonsensitivem Prostatakarzinom sollten nicht mehr mit einer alleinigen Androgendeprivationstherapie (ADT) behandelt werden, mahnt ein US-Team nach Sichtung der aktuellen Datenlage. Mit einer Tripeltherapie haben die Betroffenen offenbar die besten Überlebenschancen.

So sicher sind Tattoos: Neue Daten zur Risikobewertung

22.05.2024 Melanom Nachrichten

Das größte medizinische Problem bei Tattoos bleiben allergische Reaktionen. Melanome werden dadurch offensichtlich nicht gefördert, die Farbpigmente könnten aber andere Tumoren begünstigen.

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.