Background
Methods
Results
Demographic and clinical characteristics of participants
Variables | N=330 | % |
---|---|---|
Age (Days)
| ||
0 – 6 | 253 | 76.7 |
7 – 28 | 77 | 23.3 |
Sex
| ||
Male | 170 | 51.5 |
Female | 160 | 48.5 |
Weight (gm)
| ||
≤ 2500 | 109 | 33 |
> 2500 | 221 | 67 |
Maturity
| ||
Preterm | 77 | 23.3 |
Term | 253 | 76.7 |
Clinical features (signs & symptoms)
| ||
Fever | 302 | 91.5 |
Hypothermia | 8 | 2.4 |
Inability to feed | 206 | 62.4 |
Bulging fontanelle | 33 | 10.0 |
Difficulty in breathing | 73 | 22.1 |
Lower chest wall in drawing | 89 | 27.0 |
Convulsions | 10 | 3.0 |
Umbilical pus discharge with hyperaemia | 317 | 96.1 |
Skin rash with pus spots | 31 | 9.4 |
Jaundice | 44 | 13.3 |
Bacterial isolation
Organism | Early and late infection (days) (N=74) | Total N(%) | p value | |
---|---|---|---|---|
0 – 6 n(%) | 7 – 28 n(%) | |||
Staphylococcus aureus
| 15 (55.6) | 12 (44.4) | 27 (36.5) | 0.721* |
Klebsiella species
| 17 (77.3) | 5 (22.7) | 22 (29.7) | |
Escherichia coli
| 10 (71.4) | 4 (28.6) | 14 (18.9) | |
Staphylococcus epidermidis
| 6 (100) | 0 (0) | 6 (8.1) | |
Group B Streptococci
| 1 (100) | 0 (0) | 1 (1.4) | |
Pseudomonas spp
| 1 (50.0) | 1 (50.0) | 2 (2.7) | |
Other streptococcus species
| 2 (100) | 0 (0) | 2 (2.7) | |
Total
|
52 (70.3)
|
22 (29.7)
|
74 (100)
|
Organism | Early and late infection (days) (N=297) | Total n (%) | p value | |
---|---|---|---|---|
0 – 6 n (%) | 7 – 28 n (%) | |||
Staphylococcus aureus
| 98 (74.2) | 34 (25.8) | 132(44.4) | 0.616* |
Klebsiella species
| 61 (79.2) | 16 (20.8) | 77 (25.9) | |
Escherichia coli
| 57 (80.3) | 14 (19.7) | 71 (23.9) | |
Staphylococcus epidermidis
| 3 (100) | 0 (0) | 3 (1.0) | |
Pseudomonas species
| 6 (85.7) | 1 (14.3) | 7 (2.4) | |
Proteus species
| 7 (100) | 0 (0) | 7 (2.4) | |
Total
|
232(78.1)
|
65 (21.9)
|
297 (100)
|
Antimicrobial susceptibility of isolated bacteria
Organism | Antibacterial agent | |||||
---|---|---|---|---|---|---|
Amp R n (%) | Clox R n (%) | Gent R n (%) | Amik R n (%) | Cefur R n (%) | Ceft R n(%) | |
Staphy. aureus
| 23 (85.2) | 22 (81.5) | 15 (55.6) | 0 (0) | 4 (14.8) | 4 (14.8) |
Klebsiella species
| 22 (100) | 21 (95.5) | 17 (77.3) | 1 (4.5) | 8 (36.4) | 4 (18.2) |
E. coli
| 13 (92.9) | 14 (100) | 6 (42.9) | 0 (0) | 1 (7.1) | 2 (14.3) |
Group B Streptococci
| 0 (0) | 1 (100) | 1 (100) | 0 (0) | 0 (0) | 0 (0) |
Pseudomonas spp
| 1 (50) | 0 (0) | 0 (0) | 0 (0) | 1 (50) | 1 (50) |
Other Strept. species
| 1 (50) | 0 (0) | 1 (50) | 0 (0) | 0 (0) | 0 (0) |
Total
|
60 (88.2)
|
58 (85.3)
|
40 (58.8)
|
1 (1.5)
|
14 (20.6)
|
11 (16.2)
|
Organism | Antibacterial agent | |||||
---|---|---|---|---|---|---|
Amp R n (%) | Clox R n (%) | Gent R n (%) | Amik R n (%) | Cefur R n (%) | Ceft R n (%) | |
Staphy aureus
| 116 (87.9) | 106 (80.3) | 69 (52.3) | 7 (5.3) | 45 (34.1) | 55 (41.7) |
Kleb species
| 75 (97.4) | 75 (97.4) | 47 (61) | 2 (2.6) | 34 (44.2) | 31 (40.3) |
E. coli
| 63 (88.7) | 60 (84.5) | 28 (39.4) | 5 (7) | 24 (33.8) | 19 (26.8) |
Pseudomonas spp
| 7 (100) | 7 (100) | 4 (57.1) | 0 (0) | 4 (57.1) | 6 (85.7) |
Proteus species
| 6 (85.7) | 5 (71.4) | 2 (28.6) | 0 (0) | 0 (0) | 2 (28.6) |
Total
|
267(90.8)
|
253 (86.1)
|
150 (51.0)
|
14 (4.8)
|
107(36.4)
|
113 (38.4)
|