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Erschienen in: Knee Surgery, Sports Traumatology, Arthroscopy 2/2005

01.03.2005 | Knee

Neovascularisation in chronic painful patellar tendinosis—promising results after sclerosing neovessels outside the tendon challenge the need for surgery

verfasst von: Håkan Alfredson, Lars Öhberg

Erschienen in: Knee Surgery, Sports Traumatology, Arthroscopy | Ausgabe 2/2005

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Abstract

Sclerosing injections targeting neovascularisation have been demonstrated to give promising clinical results in patients with chronic painful Achilles tendinosis. In this study, fifteen elite or recreational athletes (12 men and three women) with the diagnosis patellar tendinosis/Jumper’s knee in 15 patellar tendons were included. All the patients had a long duration of pain symptoms (mean = 23 months) from the patellar tendon, and ultra-sonography + colour doppler examination showed structural tendon changes with hypo-echoic areas and a neovascularisation, corresponding to the painful area. The patients were treated with ultrasound and colour doppler-guided injections of the sclerosing substance Polidocanol, targeting the area with neovascularisation. At follow-up (mean = 6 months) after a mean amount of three treatments, there was a good clinical result in 12/15 tendons. The patients were back to their previous (before injury) sport activity level, and the amount of pain recorded on a VAS-scale had decreased significantly (VAS from 81 to 10). Our findings indicate that treatment with sclerosing injections, targeting the area with neovessels in patellar tendinosis, has the potential to cure the pain in the tendons and also allow the patients to go back to full patellar-tendon loading activity.
Literatur
1.
Zurück zum Zitat Alfredson H, Forsgren S, Thorsen K, Lorentzon R (2001) In vivo microdialysis and immuno-histochemical analyses of tendon tissue demonstrated high amounts of free glutamate and glutamate NMDAR1 receptors, but no signs of inflammation, in Jumper’s knee. J Orthop Res 19:881–886CrossRefPubMed Alfredson H, Forsgren S, Thorsen K, Lorentzon R (2001) In vivo microdialysis and immuno-histochemical analyses of tendon tissue demonstrated high amounts of free glutamate and glutamate NMDAR1 receptors, but no signs of inflammation, in Jumper’s knee. J Orthop Res 19:881–886CrossRefPubMed
2.
Zurück zum Zitat Alfredson H, Forsgren S, Thorsen K, Fahlström M, Johansson H, Lorentzon R (2001) Glutamate NMDAR1 receptors localised to nerves in human Achilles tendons. Implications for treatment? Knee Surg Sports Traumatol Arthrosc 9:123–126CrossRefPubMed Alfredson H, Forsgren S, Thorsen K, Fahlström M, Johansson H, Lorentzon R (2001) Glutamate NMDAR1 receptors localised to nerves in human Achilles tendons. Implications for treatment? Knee Surg Sports Traumatol Arthrosc 9:123–126CrossRefPubMed
3.
Zurück zum Zitat Coleman BD, Khan KM, Maffulli N, Cook JL, Wark JD (2000) Studies of surgical outcome after patellar tendinopathy: clinical significance of methodological deficiencies and guidelines for future studies. Scand J Med Sci Sports 10:2–11CrossRefPubMed Coleman BD, Khan KM, Maffulli N, Cook JL, Wark JD (2000) Studies of surgical outcome after patellar tendinopathy: clinical significance of methodological deficiencies and guidelines for future studies. Scand J Med Sci Sports 10:2–11CrossRefPubMed
4.
Zurück zum Zitat Coleman BD, Khan KM, Kiss ZS, Bartlett J, Young DA, Wark JD (2000) Open and arthroscopic patellar tenotomy for chronic patellar tendinopathy. a retrospective outcome study. Am J Sports Med 28(2):183–190PubMed Coleman BD, Khan KM, Kiss ZS, Bartlett J, Young DA, Wark JD (2000) Open and arthroscopic patellar tenotomy for chronic patellar tendinopathy. a retrospective outcome study. Am J Sports Med 28(2):183–190PubMed
5.
Zurück zum Zitat Conrad P, Malouf GM, Stacey MC (1995) The Australian polidocanol (aethoxysklerol) study. Results at 2 years. Dermatol Surg 21(4):334–336 Conrad P, Malouf GM, Stacey MC (1995) The Australian polidocanol (aethoxysklerol) study. Results at 2 years. Dermatol Surg 21(4):334–336
6.
Zurück zum Zitat Cook JL, Khan KM, Harcourt PR, Grant M, Young DA, Bonar SF (1997) A cross sectional study of 100 athletes with jumper’s knee managed conservatively and surgically. Br J Sports Med 31:332–336PubMed Cook JL, Khan KM, Harcourt PR, Grant M, Young DA, Bonar SF (1997) A cross sectional study of 100 athletes with jumper’s knee managed conservatively and surgically. Br J Sports Med 31:332–336PubMed
7.
Zurück zum Zitat Cook JL (2001) What’s the appropriate treatment for patellar tendinopathy? Br J Sports Med 35(5):291–294CrossRefPubMed Cook JL (2001) What’s the appropriate treatment for patellar tendinopathy? Br J Sports Med 35(5):291–294CrossRefPubMed
8.
Zurück zum Zitat Dickenson AH, Chapman V, Green GM (1997) The pharmacology of excitatory and inhibitory amino acid-mediated events in the transmission and modulation of pain in the spinal cord. A review. Gen Pharmacol 28(5):633–638PubMed Dickenson AH, Chapman V, Green GM (1997) The pharmacology of excitatory and inhibitory amino acid-mediated events in the transmission and modulation of pain in the spinal cord. A review. Gen Pharmacol 28(5):633–638PubMed
9.
Zurück zum Zitat Guex JJ (1993) Indications for the sclerosing agent polidocanol. J Dermatol Surg Oncol 19(10):959–961 Guex JJ (1993) Indications for the sclerosing agent polidocanol. J Dermatol Surg Oncol 19(10):959–961
10.
Zurück zum Zitat Johnson DP (1998) Arthroscopic surgery for patellar tendonitis. Arthroscopy 14(Suppl 1):44 Johnson DP (1998) Arthroscopic surgery for patellar tendonitis. Arthroscopy 14(Suppl 1):44
11.
Zurück zum Zitat Karlsson J, Lundin O, Wigerstad Lossing I, Peterson L (1991) Partial rupture of the patellar ligament. Results after operative treatment. Am J Sports Med 19(4):403–408PubMed Karlsson J, Lundin O, Wigerstad Lossing I, Peterson L (1991) Partial rupture of the patellar ligament. Results after operative treatment. Am J Sports Med 19(4):403–408PubMed
12.
Zurück zum Zitat Karlsson J, Kälebo P, Goksör L-Å, Thomee R, Swärd L (1992) Partial rupture of the patellar ligament. Am J Sports Med 20(4):390–395PubMed Karlsson J, Kälebo P, Goksör L-Å, Thomee R, Swärd L (1992) Partial rupture of the patellar ligament. Am J Sports Med 20(4):390–395PubMed
13.
Zurück zum Zitat Kettunen JA, Kvist M, Alanen E, Kujala UM (2002) Long-term prognosis for Jumper’s knee in male athletes. A prospective follow-up study. Am J Sports Med 30(5):689–692PubMed Kettunen JA, Kvist M, Alanen E, Kujala UM (2002) Long-term prognosis for Jumper’s knee in male athletes. A prospective follow-up study. Am J Sports Med 30(5):689–692PubMed
14.
Zurück zum Zitat Khan KM, Cook JL, Kiss ZS, Visentini PJ, Fehrmann MW, Harcourt PR, Tress BW, Wark JD (1997) Patellar tendon ultrasonography and Jumper’s knee in female basketball players: a longitudinal study. Clin J Sports Med 7:199–206 Khan KM, Cook JL, Kiss ZS, Visentini PJ, Fehrmann MW, Harcourt PR, Tress BW, Wark JD (1997) Patellar tendon ultrasonography and Jumper’s knee in female basketball players: a longitudinal study. Clin J Sports Med 7:199–206
15.
Zurück zum Zitat Khan KM, Maffuli N, Coleman BD, Cook JL, Taunton JE (1998) Patellar tendinopathy: some aspects of basic science and clinical management. Br J Sports Med 32:346–355PubMed Khan KM, Maffuli N, Coleman BD, Cook JL, Taunton JE (1998) Patellar tendinopathy: some aspects of basic science and clinical management. Br J Sports Med 32:346–355PubMed
16.
Zurück zum Zitat Khan KM, Visentini PJ, Kiss ZS, Desmond PM, Coleman BD, Cook JL, Tress BM, Wark JD, Forster BB (1999) Correlation of ultrasound and magnetic resonance imaging with clinical outcome after patellar tenotomy: prospective and retrospective studies. Clin J Sports Med 9:129–137 Khan KM, Visentini PJ, Kiss ZS, Desmond PM, Coleman BD, Cook JL, Tress BM, Wark JD, Forster BB (1999) Correlation of ultrasound and magnetic resonance imaging with clinical outcome after patellar tenotomy: prospective and retrospective studies. Clin J Sports Med 9:129–137
17.
Zurück zum Zitat Khan KM, Cook JL, Maffuli N, Kannus P (2000) Where is the pain coming from in tendinopathy? It may be biochemical, not only structural, in origin. Br J Sports Med 34(2):81–83CrossRefPubMed Khan KM, Cook JL, Maffuli N, Kannus P (2000) Where is the pain coming from in tendinopathy? It may be biochemical, not only structural, in origin. Br J Sports Med 34(2):81–83CrossRefPubMed
18.
Zurück zum Zitat Lian Ö, Holen KJ, Engebretsen L, Bahr R (1996) Relationship between symptoms of Jumper’s knee and the ultrasound characteristics of the patellar tendon among high level male volleyball players. Scand J Med Sci Sports 6:291–296PubMed Lian Ö, Holen KJ, Engebretsen L, Bahr R (1996) Relationship between symptoms of Jumper’s knee and the ultrasound characteristics of the patellar tendon among high level male volleyball players. Scand J Med Sci Sports 6:291–296PubMed
19.
Zurück zum Zitat Raatikainen T, Karpakka J, Puranen J, Orava S (1994) Operative treatment of partial rupture of the patellar ligament. Int J Sports Med 15:46–49PubMed Raatikainen T, Karpakka J, Puranen J, Orava S (1994) Operative treatment of partial rupture of the patellar ligament. Int J Sports Med 15:46–49PubMed
20.
Zurück zum Zitat Saillant G, Rolland E, Garcon P, Melchior B, Benacet JP, Roy-Camille R (1991) Surgical treatment of patellar tendinitis. A series of 80 cases. J Traumatol Sport 8:114–120 Saillant G, Rolland E, Garcon P, Melchior B, Benacet JP, Roy-Camille R (1991) Surgical treatment of patellar tendinitis. A series of 80 cases. J Traumatol Sport 8:114–120
21.
Zurück zum Zitat Terslev L (2001) Ultrasound and Power Doppler findings in Jumper’s knee-preliminary observations. Eur J Ultrasound 13(3):183–189CrossRefPubMed Terslev L (2001) Ultrasound and Power Doppler findings in Jumper’s knee-preliminary observations. Eur J Ultrasound 13(3):183–189CrossRefPubMed
22.
Zurück zum Zitat Testa V, Capasso G, Maffulli N, Bifulco G (1998) Ultrasound-guided percutaneous longitudinal tenotomy for the management of patellar tendinopathy. Med Sci Sports Exerc 31(11):1509–1515 Testa V, Capasso G, Maffulli N, Bifulco G (1998) Ultrasound-guided percutaneous longitudinal tenotomy for the management of patellar tendinopathy. Med Sci Sports Exerc 31(11):1509–1515
23.
Zurück zum Zitat Weinberg EP, Adams MJ, Hollenberg GM (1998) Color doppler sonography of patellar tendinosis. AJR Am J Roentgenol 171(3):743–744PubMed Weinberg EP, Adams MJ, Hollenberg GM (1998) Color doppler sonography of patellar tendinosis. AJR Am J Roentgenol 171(3):743–744PubMed
24.
Zurück zum Zitat Öhberg L, Lorentzon R, Alfredson H (2001) Neovascularisation in Achilles tendons with painful tendinosis but not in normal tendons: an ultrasonographic investigation. Knee Surg Sports Traumatol Arthrosc 9:233–238CrossRefPubMed Öhberg L, Lorentzon R, Alfredson H (2001) Neovascularisation in Achilles tendons with painful tendinosis but not in normal tendons: an ultrasonographic investigation. Knee Surg Sports Traumatol Arthrosc 9:233–238CrossRefPubMed
25.
Zurück zum Zitat Öhberg L, Alfredson H (2002) Ultrasound guided sclerosis of neovessels in painful chronic Achilles tendinosis: pilot study of a new treatment. Br J Sports Med 36:173–177CrossRefPubMed Öhberg L, Alfredson H (2002) Ultrasound guided sclerosis of neovessels in painful chronic Achilles tendinosis: pilot study of a new treatment. Br J Sports Med 36:173–177CrossRefPubMed
Metadaten
Titel
Neovascularisation in chronic painful patellar tendinosis—promising results after sclerosing neovessels outside the tendon challenge the need for surgery
verfasst von
Håkan Alfredson
Lars Öhberg
Publikationsdatum
01.03.2005
Erschienen in
Knee Surgery, Sports Traumatology, Arthroscopy / Ausgabe 2/2005
Print ISSN: 0942-2056
Elektronische ISSN: 1433-7347
DOI
https://doi.org/10.1007/s00167-004-0549-x

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