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08.05.2023 | Original Paper

Neural Substrates of Psychomotor Speed Deficits in Cerebral Small Vessel Disease: A Brain Disconnectome Mapping Study

verfasst von: Pedro Henrique Rodrigues da Silva, Frank-Erik de Leeuw, Maria Clara Zanon Zotin, Octavio Marques Pontes Neto, Renata Ferranti Leoni, Anil M. Tuladhar

Erschienen in: Brain Topography | Ausgabe 4/2023

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Abstract

It remains unknown which factors influence how brain disconnectivity derived from White Matter Hyperintensity (WMH) lesions leads to psychomotor speed dysfunction, one of the earliest and most common cognitive manifestations in the cerebral Small Vessel Disease (cSVD) population. While the burden of WMH has been strongly linked to psychomotor speed performance, the effect that different locations and volumes of WMH may have on cSVD-related cognitive impairment remains unclear. Therefore, we aimed to explore (1) whether global WMH, deep WMH (DWMH), and periventricular (PVWMH) volumes display different psychomotor speed associations; (2) whether tract-specific WMH volume shows stronger cognitive associations compared with global measures of WMH volume; (3) whether specific patterns of WMH location lead to different degrees of disconnectivity. Using the BCBToolkit, we investigated which pattern of distribution and which locations of WMH lesion result in impaired psychomotor speed in a well-characterized sample (n = 195) of cSVD patients without dementia. Two key findings emerge from our study. First, global (and not tract-specific) measures of WMH volume were associated with psychomotor speed performance. Second, disconnection maps revealed the involvement of callosal tracts, association and projection fibers, and frontal and parietal cortical brain areas related to psychomotor speed, while the lesion location influenced such associations. In conclusion, psychomotor deficits are affected differently by WMH burden and topographic distribution through brain disconnection in non-demented cSVD patients.

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Titel: Neural Substrates of Psychomotor Speed Deficits in Cerebral Small Vessel Disease: A Brain Disconnectome Mapping Study
verfasst von: Pedro Henrique Rodrigues da Silva
Frank-Erik de Leeuw
Maria Clara Zanon Zotin
Octavio Marques Pontes Neto
Renata Ferranti Leoni
Anil M. Tuladhar
Publikationsdatum: 08.05.2023
Verlag: Springer US
Erschienen in: Brain Topography / Ausgabe 4/2023
Print ISSN: 0896-0267
Elektronische ISSN: 1573-6792
DOI: https://doi.org/10.1007/s10548-023-00961-0

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