Skip to main content
Erschienen in: Wiener Medizinische Wochenschrift 1-2/2019

19.09.2018 | original article

Neurological complications of systemic tumor therapy

verfasst von: Prof. Dr. Wolfgang Grisold, Wolfgang Löscher, Anna Grisold

Erschienen in: Wiener Medizinische Wochenschrift | Ausgabe 1-2/2019

Einloggen, um Zugang zu erhalten

Summary

The treatment of malignant tumors has considerably improved in recent years, and also the number of “long term cancer survivors” is increasing.
The spectrum of anti-tumoral agents is increasing at a fast pace and in addition to conventional therapies such as surgery, radiotherapy, and chemotherapy, new drugs with entirely new mechanisms are appearing. Side effects of old and new drugs can affect the central and peripheral nervous system, the neuromuscular junction, and muscle. These side effects often have to be distinguished from other causes and need neurological expertise. Although the majority of patients still receive conventional therapies, several new strategies such as immune therapies are being implemented. These drugs have also drug specific side effects, which do not always follow the classical principles of “toxicity.”
This review focuses on the well-known and described side effects of conventional cancer therapies and adds new observations on new drugs.
Literatur
1.
Zurück zum Zitat Zukas AM, Schiff D. Neurological complications of new chemotherapy agents. Neuro-oncology. 2018;20(1):24–36.PubMed Zukas AM, Schiff D. Neurological complications of new chemotherapy agents. Neuro-oncology. 2018;20(1):24–36.PubMed
4.
Zurück zum Zitat Radcliffe J, et al. Cognitive deficits in long-term survivors of childhood medulloblastoma and other noncortical tumors: age-dependent effects of whole brain radiation. Int J Dev Neurosci. 1994;12(4):327–34.PubMed Radcliffe J, et al. Cognitive deficits in long-term survivors of childhood medulloblastoma and other noncortical tumors: age-dependent effects of whole brain radiation. Int J Dev Neurosci. 1994;12(4):327–34.PubMed
5.
Zurück zum Zitat Zhao R, et al. Hippocampal-sparing whole-brain radiotherapy for lung cancer. Clin Lung Cancer. 2017;18(2):127–31.PubMed Zhao R, et al. Hippocampal-sparing whole-brain radiotherapy for lung cancer. Clin Lung Cancer. 2017;18(2):127–31.PubMed
6.
Zurück zum Zitat Mehanna R, Jimenez-Shahed J, Itin I. Three cases of Levodopa-resistant Parkinsonism after radiation therapy. Am J Case Rep. 2016;17:916–20.PubMedPubMedCentral Mehanna R, Jimenez-Shahed J, Itin I. Three cases of Levodopa-resistant Parkinsonism after radiation therapy. Am J Case Rep. 2016;17:916–20.PubMedPubMedCentral
7.
Zurück zum Zitat Pompe RS, von Bueren SO, Mynarek M, von Hoff K, Friedrich C, Kwiecien R, Treulieb W, Lindow C, Deinlein F, Fleischhack G, Kuehl J, Rutkowski S. Intraventricular methotrexate as part of primary therapy for children with infant and/or metastatic medulloblastoma: feasibility, acute toxicity and evidence for efficacy. Eur J Cancer. 2015;51(17):2634–42. https://doi.org/10.1016/j.ejca .2015.08.009.PubMed Pompe RS, von Bueren SO, Mynarek M, von Hoff K, Friedrich C, Kwiecien R, Treulieb W, Lindow C, Deinlein F, Fleischhack G, Kuehl J, Rutkowski S. Intraventricular methotrexate as part of primary therapy for children with infant and/or metastatic medulloblastoma: feasibility, acute toxicity and evidence for efficacy. Eur J Cancer. 2015;51(17):2634–42. https://​doi.​org/​10.​1016/​j.​ejca .2015.08.009.PubMed
8.
Zurück zum Zitat Song YP, Colaco RJ. Radiation necrosis—a growing problem in a case of brain metastases following whole brain radiotherapy and stereotactic radiosurgery. Cureus. 2018;10(1):e2037.PubMedPubMedCentral Song YP, Colaco RJ. Radiation necrosis—a growing problem in a case of brain metastases following whole brain radiotherapy and stereotactic radiosurgery. Cureus. 2018;10(1):e2037.PubMedPubMedCentral
9.
Zurück zum Zitat Shah AH, et al. Discriminating radiation necrosis from tumor progression in gliomas: a systematic review what is the best imaging modality? J Neurooncol. 2013;112(2):141–52.PubMed Shah AH, et al. Discriminating radiation necrosis from tumor progression in gliomas: a systematic review what is the best imaging modality? J Neurooncol. 2013;112(2):141–52.PubMed
10.
Zurück zum Zitat Gujral DM, et al. Radiation-induced carotid artery atherosclerosis. Radiother Oncol. 2014;110(1):31–8.PubMed Gujral DM, et al. Radiation-induced carotid artery atherosclerosis. Radiother Oncol. 2014;110(1):31–8.PubMed
11.
Zurück zum Zitat Bond KM, et al. Endovascular treatment of carotid blowout syndrome. J Vasc Surg. 2017;65(3):883–8.PubMed Bond KM, et al. Endovascular treatment of carotid blowout syndrome. J Vasc Surg. 2017;65(3):883–8.PubMed
12.
Zurück zum Zitat Tully CM, et al. The high incidence of vascular thromboembolic events in patients with metastatic or unresectable urothelial cancer treated with platinum chemotherapy agents. Cancer. 2016;122(5):712–21.PubMed Tully CM, et al. The high incidence of vascular thromboembolic events in patients with metastatic or unresectable urothelial cancer treated with platinum chemotherapy agents. Cancer. 2016;122(5):712–21.PubMed
13.
Zurück zum Zitat Grisold W, Oberndorfer S, Struhal W. Stroke and cancer: a review. Acta Neurol Scand. 2009;119(1):1–16.PubMed Grisold W, Oberndorfer S, Struhal W. Stroke and cancer: a review. Acta Neurol Scand. 2009;119(1):1–16.PubMed
14.
Zurück zum Zitat Sweiss KI, Beri R, Shord SS. Encephalopathy after high-dose Ifosfamide: a retrospective cohort study and review of the literature. Drug Saf. 2008;31(11):989–96.PubMed Sweiss KI, Beri R, Shord SS. Encephalopathy after high-dose Ifosfamide: a retrospective cohort study and review of the literature. Drug Saf. 2008;31(11):989–96.PubMed
15.
Zurück zum Zitat Valentine AD, et al. Mood and cognitive side effects of interferon-alpha therapy. Semin Oncol. 1998;25(1 Suppl 1):39–47.PubMed Valentine AD, et al. Mood and cognitive side effects of interferon-alpha therapy. Semin Oncol. 1998;25(1 Suppl 1):39–47.PubMed
16.
Zurück zum Zitat Newton HB. Neurological complications of chemotherapy to the central nervous system. In: Grisold W, Soffietti R, editors. Handbook of clinical neurology 3rd series. Vol. 105. 2012. pp. 903–16. Newton HB. Neurological complications of chemotherapy to the central nervous system. In: Grisold W, Soffietti R, editors. Handbook of clinical neurology 3rd series. Vol. 105. 2012. pp. 903–16.
17.
Zurück zum Zitat Simóa M, Rifà-Rosa X, Rodriguez-Fornellsa A, Brunab J, More S. Chemobrain: a systematic review of structural and functional neuroimaging studies. Neurosci Biobehav Rev. 2013;37(8):1311–21. Simóa M, Rifà-Rosa X, Rodriguez-Fornellsa A, Brunab J, More S. Chemobrain: a systematic review of structural and functional neuroimaging studies. Neurosci Biobehav Rev. 2013;37(8):1311–21.
18.
Zurück zum Zitat Gaman AM, et al. The role of oxidative stress in etiopathogenesis of chemotherapy induced cognitive impairment (CICI)-“Chemobrain”. Aging Dis. 2016;7(3):307–17.PubMedPubMedCentral Gaman AM, et al. The role of oxidative stress in etiopathogenesis of chemotherapy induced cognitive impairment (CICI)-“Chemobrain”. Aging Dis. 2016;7(3):307–17.PubMedPubMedCentral
19.
Zurück zum Zitat Simo M, et al. Performance monitoring in lung cancer patients pre- and post-chemotherapy using fine-grained electrophysiological measures. Neuroimage Clin. 2018;18:86–96.PubMed Simo M, et al. Performance monitoring in lung cancer patients pre- and post-chemotherapy using fine-grained electrophysiological measures. Neuroimage Clin. 2018;18:86–96.PubMed
20.
Zurück zum Zitat Ren X, St. Clair DK, Butterfield DA. Dysregulation of cytokine mediated chemotherapy induced cognitive impairment. Pharmacol Res. 2017;117:267–73.PubMed Ren X, St. Clair DK, Butterfield DA. Dysregulation of cytokine mediated chemotherapy induced cognitive impairment. Pharmacol Res. 2017;117:267–73.PubMed
21.
Zurück zum Zitat Kamiya-Matsuoka C, et al. Primary brain tumors and posterior reversible encephalopathy syndrome. Neurooncol Pract. 2014;1(4):184–90.PubMedPubMedCentral Kamiya-Matsuoka C, et al. Primary brain tumors and posterior reversible encephalopathy syndrome. Neurooncol Pract. 2014;1(4):184–90.PubMedPubMedCentral
23.
Zurück zum Zitat Deguchi S, et al. Posterior reversible encephalopathy syndrome (PRES) induced by pazopanib, a multi-targeting tyrosine kinase inhibitor, in a patient with soft-tissue sarcoma: case report and review of the literature. Invest New Drugs. 2018;36(2):346–9.PubMed Deguchi S, et al. Posterior reversible encephalopathy syndrome (PRES) induced by pazopanib, a multi-targeting tyrosine kinase inhibitor, in a patient with soft-tissue sarcoma: case report and review of the literature. Invest New Drugs. 2018;36(2):346–9.PubMed
24.
Zurück zum Zitat Gheith O, et al. Sirolimus-induced combined posterior reversible encephalopathy syndrome and lymphocytic pneumonitis in a renal transplant recipient: case report and review of the literature. Exp Clin Transplant. 2017;15(Suppl 1):170–4.PubMed Gheith O, et al. Sirolimus-induced combined posterior reversible encephalopathy syndrome and lymphocytic pneumonitis in a renal transplant recipient: case report and review of the literature. Exp Clin Transplant. 2017;15(Suppl 1):170–4.PubMed
25.
Zurück zum Zitat Bohra C, Sokol L, Dalia S. Progressive multifocal leukoencephalopathy and monoclonal antibodies: a review. Cancer Control. 2017;24(4):1073274817729901.PubMedPubMedCentral Bohra C, Sokol L, Dalia S. Progressive multifocal leukoencephalopathy and monoclonal antibodies: a review. Cancer Control. 2017;24(4):1073274817729901.PubMedPubMedCentral
26.
Zurück zum Zitat Spain L, Diem S, Larkin J. Management of toxicities of immune checkpoint inhibitors. Cancer Treat Rev. 2016;44:51–60.PubMed Spain L, Diem S, Larkin J. Management of toxicities of immune checkpoint inhibitors. Cancer Treat Rev. 2016;44:51–60.PubMed
27.
Zurück zum Zitat Kuru S, Khan N, Shaaban H. Acute hypophysitis secondary to nivolumab immunotherapy in a patient with metastatic melanoma. Int J Crit Illn Inj Sci. 2017;7(3):177–80.PubMedPubMedCentral Kuru S, Khan N, Shaaban H. Acute hypophysitis secondary to nivolumab immunotherapy in a patient with metastatic melanoma. Int J Crit Illn Inj Sci. 2017;7(3):177–80.PubMedPubMedCentral
28.
Zurück zum Zitat McGinnis GJ, Raber J. CNS side effects of immune checkpoint inhibitors: preclinical models, genetics and multimodality therapy. Immunotherapy. 2017;9(11):929–41.PubMedPubMedCentral McGinnis GJ, Raber J. CNS side effects of immune checkpoint inhibitors: preclinical models, genetics and multimodality therapy. Immunotherapy. 2017;9(11):929–41.PubMedPubMedCentral
29.
Zurück zum Zitat Pak D, et al. Lhermitte sign after chemo-IMRT of head-and-neck cancer: incidence, doses, and potential mechanisms. Int J Radiat Oncol Biol Phys. 2012;83(5):1528–33.PubMedPubMedCentral Pak D, et al. Lhermitte sign after chemo-IMRT of head-and-neck cancer: incidence, doses, and potential mechanisms. Int J Radiat Oncol Biol Phys. 2012;83(5):1528–33.PubMedPubMedCentral
30.
Zurück zum Zitat Leung WM, Tsang N‑M, Chang FT, et al. Lhermitte’s sign among nasopharyngeal cancer patients after radiotherapy. Head Neck. 2005;27:187–94.PubMed Leung WM, Tsang N‑M, Chang FT, et al. Lhermitte’s sign among nasopharyngeal cancer patients after radiotherapy. Head Neck. 2005;27:187–94.PubMed
31.
Zurück zum Zitat O’Reilly A, et al. Lhermitte’s phenomenon and platinum, beware of latency. Oncol Res Treat. 2014;37(10):591–4.PubMed O’Reilly A, et al. Lhermitte’s phenomenon and platinum, beware of latency. Oncol Res Treat. 2014;37(10):591–4.PubMed
32.
Zurück zum Zitat Pompili A, et al. Symptomatic spinal cord necrosis after irradiation for vertebral metastatic breast cancer. J Clin Oncol. 2011;29(3):e53–e6.PubMed Pompili A, et al. Symptomatic spinal cord necrosis after irradiation for vertebral metastatic breast cancer. J Clin Oncol. 2011;29(3):e53–e6.PubMed
33.
Zurück zum Zitat Bowen J, et al. The post-irradiation lower motor neuron syndrome neuronopathy or radiculopathy? Brain. 1996;119(5):1429–39.PubMed Bowen J, et al. The post-irradiation lower motor neuron syndrome neuronopathy or radiculopathy? Brain. 1996;119(5):1429–39.PubMed
34.
Zurück zum Zitat Cachia D, et al. Myelopathy following intrathecal chemotherapy in adults: a single institution experience. J Neurooncol. 2015;122(2):391–8.PubMedPubMedCentral Cachia D, et al. Myelopathy following intrathecal chemotherapy in adults: a single institution experience. J Neurooncol. 2015;122(2):391–8.PubMedPubMedCentral
35.
Zurück zum Zitat Resnick IB, et al. Spinal epidural lipomatosis following haploidentical allogeneic bone marrow transplantation for non-Hodgkin lymphoma. Clin Transplant. 2004;18(6):762–5.PubMed Resnick IB, et al. Spinal epidural lipomatosis following haploidentical allogeneic bone marrow transplantation for non-Hodgkin lymphoma. Clin Transplant. 2004;18(6):762–5.PubMed
36.
Zurück zum Zitat Grisold W, Grisold A, Löscher WN. Neuromuscular complications in cancer. J Neurol Sci. 2016;367:184–202.PubMed Grisold W, Grisold A, Löscher WN. Neuromuscular complications in cancer. J Neurol Sci. 2016;367:184–202.PubMed
37.
Zurück zum Zitat Grisold W, Grisold A, Löscher W. Cancer therapy and neuromuscular complications: a mini review. Neurology (ECronicon). 2017;9(1):20–6. Grisold W, Grisold A, Löscher W. Cancer therapy and neuromuscular complications: a mini review. Neurology (ECronicon). 2017;9(1):20–6.
38.
Zurück zum Zitat Vecht CJ. Arm pain in the patient with breast cancer. J Pain Symptom Manage. 1990;5(2):109–17.PubMed Vecht CJ. Arm pain in the patient with breast cancer. J Pain Symptom Manage. 1990;5(2):109–17.PubMed
39.
Zurück zum Zitat Orsolya H‑B, Coros MF, Stolnicu S, Naznean A, Georgescu R. Does the surgical management of the intercostobrachial nerve influence the postoperatory paresthesia of the upper limb and life quality in breast cancer patients? Chirurgia (Bucur). 2017;112(4):436–42. Orsolya H‑B, Coros MF, Stolnicu S, Naznean A, Georgescu R. Does the surgical management of the intercostobrachial nerve influence the postoperatory paresthesia of the upper limb and life quality in breast cancer patients? Chirurgia (Bucur). 2017;112(4):436–42.
40.
Zurück zum Zitat Kääriäinen M, Giordano S, Kauhanen S, Helminen M, Kuokkanen H. No need to cut the nerve in LD reconstruction to avoid jumping of the breast: a prospective randomized study. J Plast Reconstr Aesthet Surg. 2014;67(8):1106–10.PubMed Kääriäinen M, Giordano S, Kauhanen S, Helminen M, Kuokkanen H. No need to cut the nerve in LD reconstruction to avoid jumping of the breast: a prospective randomized study. J Plast Reconstr Aesthet Surg. 2014;67(8):1106–10.PubMed
41.
Zurück zum Zitat Gunterberg B, et al. Anorectal function after major resections of the sacrum with bilateral or unilateral sacrifice of sacral nerves. Br J Surg. 1976;63(7):546–54.PubMed Gunterberg B, et al. Anorectal function after major resections of the sacrum with bilateral or unilateral sacrifice of sacral nerves. Br J Surg. 1976;63(7):546–54.PubMed
42.
Zurück zum Zitat Brooks AD, et al. Resection of the sciatic, peroneal, or tibial nerves: assessment of functional status. Ann Surg Oncol. 2002;9(1):41–7.PubMed Brooks AD, et al. Resection of the sciatic, peroneal, or tibial nerves: assessment of functional status. Ann Surg Oncol. 2002;9(1):41–7.PubMed
43.
Zurück zum Zitat Stubblefield MD. Clinical evaluation and management of radiation fibrosis syndrome. Phys Med Rehabil Clin N Am. 2017;28(1):89–100.PubMed Stubblefield MD. Clinical evaluation and management of radiation fibrosis syndrome. Phys Med Rehabil Clin N Am. 2017;28(1):89–100.PubMed
44.
Zurück zum Zitat Sood SS, et al. Brachial plexopathy after stereotactic body radiation therapy for apical lung cancer: dosimetric analysis and preliminary clinical outcomes. Adv Radiat Oncol. 2018;3(1):81–6.PubMed Sood SS, et al. Brachial plexopathy after stereotactic body radiation therapy for apical lung cancer: dosimetric analysis and preliminary clinical outcomes. Adv Radiat Oncol. 2018;3(1):81–6.PubMed
45.
46.
Zurück zum Zitat Brejt N, et al. Pelvic radiculopathies, lumbosacral plexopathies, and neuropathies in oncologic disease: a multidisciplinary approach to a diagnostic challenge. Cancer Imaging. 2013;13(4):591–601.PubMedPubMedCentral Brejt N, et al. Pelvic radiculopathies, lumbosacral plexopathies, and neuropathies in oncologic disease: a multidisciplinary approach to a diagnostic challenge. Cancer Imaging. 2013;13(4):591–601.PubMedPubMedCentral
47.
Zurück zum Zitat Capek S, et al. Perineural spread of pelvic malignancies to the lumbosacral plexus and beyond: clinical and imaging patterns. Neurosurg Focus. 2015;39(3):E14.PubMed Capek S, et al. Perineural spread of pelvic malignancies to the lumbosacral plexus and beyond: clinical and imaging patterns. Neurosurg Focus. 2015;39(3):E14.PubMed
48.
Zurück zum Zitat Dalmau J, Graus F, Marco M. ‘Hot and dry foot’ as initial manifestation of neoplastic lumbosacral plexopathy. Neurology. 1989;39(6):871–2.PubMed Dalmau J, Graus F, Marco M. ‘Hot and dry foot’ as initial manifestation of neoplastic lumbosacral plexopathy. Neurology. 1989;39(6):871–2.PubMed
49.
50.
Zurück zum Zitat Gikas PD, et al. Post-radiation sciatic neuropathy: a case report and review of the literature. World J Surg Oncol. 2008;6:130.PubMedPubMedCentral Gikas PD, et al. Post-radiation sciatic neuropathy: a case report and review of the literature. World J Surg Oncol. 2008;6:130.PubMedPubMedCentral
52.
53.
Zurück zum Zitat Ibanez-Julia MJ, et al. Antineoplastic agents exacerbating Charcot Marie Tooth disease: red flags to avoid permanent disability. Acta Oncol. 2018;57(3):403–11.PubMed Ibanez-Julia MJ, et al. Antineoplastic agents exacerbating Charcot Marie Tooth disease: red flags to avoid permanent disability. Acta Oncol. 2018;57(3):403–11.PubMed
54.
Zurück zum Zitat Kerckhove N, et al. Long-term effects, pathophysiological mechanisms, and risk factors of chemotherapy-induced peripheral neuropathies: a comprehensive literature review. Front Pharmacol. 2017;8:86.PubMedPubMedCentral Kerckhove N, et al. Long-term effects, pathophysiological mechanisms, and risk factors of chemotherapy-induced peripheral neuropathies: a comprehensive literature review. Front Pharmacol. 2017;8:86.PubMedPubMedCentral
55.
Zurück zum Zitat Gu Y, et al. Immune mediated neuropathy following checkpoint immunotherapy. J Clin Neurosci. 2017;45:14–7.PubMed Gu Y, et al. Immune mediated neuropathy following checkpoint immunotherapy. J Clin Neurosci. 2017;45:14–7.PubMed
57.
Zurück zum Zitat Tanaka R, Maruyama H, Tomidokoro Y, Yanagiha K, Hirabayashi T, Ishii A, Okune M, Inoue S, Sekine I, Tamaoka A, Fujimoto M. Nivolumab-induced chronic inflammatory demyelinating polyradiculoneuropathy mimicking rapid-onset Guillain-Barré syndrome: a case report. Jpn J Clin Oncol. 2016;46(9):875–8. https://doi.org/10.1093/jjco/hyw090.CrossRefPubMed Tanaka R, Maruyama H, Tomidokoro Y, Yanagiha K, Hirabayashi T, Ishii A, Okune M, Inoue S, Sekine I, Tamaoka A, Fujimoto M. Nivolumab-induced chronic inflammatory demyelinating polyradiculoneuropathy mimicking rapid-onset Guillain-Barré syndrome: a case report. Jpn J Clin Oncol. 2016;46(9):875–8. https://​doi.​org/​10.​1093/​jjco/​hyw090.CrossRefPubMed
58.
Zurück zum Zitat Kao JC, et al. Neurological complications associated with anti-programmed death 1 (PD-1) antibodies. JAMA Neurol. 2017;74(10):1216–22.PubMedPubMedCentral Kao JC, et al. Neurological complications associated with anti-programmed death 1 (PD-1) antibodies. JAMA Neurol. 2017;74(10):1216–22.PubMedPubMedCentral
59.
Zurück zum Zitat Binda D, et al. Rasch-built Overall Disability Scale for patients with chemotherapy-induced peripheral neuropathy (CIPN-R-ODS). Eur J Cancer. 2013;49(13):2910–8.PubMed Binda D, et al. Rasch-built Overall Disability Scale for patients with chemotherapy-induced peripheral neuropathy (CIPN-R-ODS). Eur J Cancer. 2013;49(13):2910–8.PubMed
60.
Zurück zum Zitat Cornblath DR, et al. Total neuropathy score: validation and reliability study. Neurology. 1999;53(8):1660–4.PubMed Cornblath DR, et al. Total neuropathy score: validation and reliability study. Neurology. 1999;53(8):1660–4.PubMed
62.
Zurück zum Zitat Nayar G, et al. Leptomeningeal disease: current diagnostic and therapeutic strategies. Oncotarget. 2017;8(42):73312–28.PubMedPubMedCentral Nayar G, et al. Leptomeningeal disease: current diagnostic and therapeutic strategies. Oncotarget. 2017;8(42):73312–28.PubMedPubMedCentral
63.
Zurück zum Zitat Sun V, et al. Toxicities, complications, and clinical encounters during intraperitoneal chemotherapy in 17 women with ovarian cancer. Eur J Oncol Nurs. 2013;17(3):375–80.PubMed Sun V, et al. Toxicities, complications, and clinical encounters during intraperitoneal chemotherapy in 17 women with ovarian cancer. Eur J Oncol Nurs. 2013;17(3):375–80.PubMed
64.
Zurück zum Zitat Busse O, Aigner K, Wilimzig H. Peripheral nerve damage following isolated extremity perfusion with cis-platinum. Recent Results Cancer Res. 1983;86:264–7.PubMed Busse O, Aigner K, Wilimzig H. Peripheral nerve damage following isolated extremity perfusion with cis-platinum. Recent Results Cancer Res. 1983;86:264–7.PubMed
65.
Zurück zum Zitat Ari P, et al. Treatment of transient peripheral neuropathy during chimeric 14.18 antibody therapy in children with neuroblastoma: a case series. J Pediatr Hematol Oncol. 2018;40(2):e113–e6.PubMed Ari P, et al. Treatment of transient peripheral neuropathy during chimeric 14.18 antibody therapy in children with neuroblastoma: a case series. J Pediatr Hematol Oncol. 2018;40(2):e113–e6.PubMed
66.
Zurück zum Zitat Shaw AT, et al. Lorlatinib in non-small-cell lung cancer with ALK or ROS1 rearrangement: an international, multicentre, open-label, single-arm first-in-man phase 1 trial. Lancet Oncol. 2017;18(12):1590–9.PubMedPubMedCentral Shaw AT, et al. Lorlatinib in non-small-cell lung cancer with ALK or ROS1 rearrangement: an international, multicentre, open-label, single-arm first-in-man phase 1 trial. Lancet Oncol. 2017;18(12):1590–9.PubMedPubMedCentral
67.
Zurück zum Zitat Kanaan Z, et al. Guillain-Barre syndrome following treatment with Sunitinib Malate. Case Rep Oncol Med. 2014;2014:712040.PubMedPubMedCentral Kanaan Z, et al. Guillain-Barre syndrome following treatment with Sunitinib Malate. Case Rep Oncol Med. 2014;2014:712040.PubMedPubMedCentral
68.
Zurück zum Zitat Krop I, Winer EP. Trastuzumab emtansine: a novel antibody-drug conjugate for HER2-positive breast cancer. Clin Cancer Res. 2014;20(1):15–20.PubMed Krop I, Winer EP. Trastuzumab emtansine: a novel antibody-drug conjugate for HER2-positive breast cancer. Clin Cancer Res. 2014;20(1):15–20.PubMed
70.
Zurück zum Zitat Yamanouchi K, et al. The relationship between peripheral neuropathy induced by Docetaxel and systemic inflammation-based parameters in patients with breast cancer. Anticancer Res. 2017;37(12):6947–51.PubMed Yamanouchi K, et al. The relationship between peripheral neuropathy induced by Docetaxel and systemic inflammation-based parameters in patients with breast cancer. Anticancer Res. 2017;37(12):6947–51.PubMed
71.
Zurück zum Zitat Lees JG, et al. Immune-mediated processes implicated in chemotherapy-induced peripheral neuropathy. Eur J Cancer. 2017;73:22–9.PubMed Lees JG, et al. Immune-mediated processes implicated in chemotherapy-induced peripheral neuropathy. Eur J Cancer. 2017;73:22–9.PubMed
72.
Zurück zum Zitat Batchelor TT, et al. Steroid myopathy in cancer patients. Neurology. 1997;48(5):1234–8.PubMed Batchelor TT, et al. Steroid myopathy in cancer patients. Neurology. 1997;48(5):1234–8.PubMed
73.
Zurück zum Zitat Basualto-Alarcon C, et al. Sarcopenia and androgens: a link between pathology and treatment. Front Endocrinol (Lausanne). 2014;5:217. Basualto-Alarcon C, et al. Sarcopenia and androgens: a link between pathology and treatment. Front Endocrinol (Lausanne). 2014;5:217.
74.
Zurück zum Zitat Mieog JS, et al. Carpal tunnel syndrome and musculoskeletal symptoms in postmenopausal women with early breast cancer treated with exemestane or tamoxifen after 2–3 years of tamoxifen: a retrospective analysis of the Intergroup Exemestane Study. Lancet Oncol. 2012;13(4):420–32.PubMed Mieog JS, et al. Carpal tunnel syndrome and musculoskeletal symptoms in postmenopausal women with early breast cancer treated with exemestane or tamoxifen after 2–3 years of tamoxifen: a retrospective analysis of the Intergroup Exemestane Study. Lancet Oncol. 2012;13(4):420–32.PubMed
75.
Zurück zum Zitat Hoffmann S, et al. Glucocorticoids in myasthenia gravis—if, when, how, and how much? Acta Neurol Scand. 2014;130(4):211–21.PubMed Hoffmann S, et al. Glucocorticoids in myasthenia gravis—if, when, how, and how much? Acta Neurol Scand. 2014;130(4):211–21.PubMed
76.
Zurück zum Zitat Bhattacharyya S, Darby R, Berkowitz AL. Antibiotic-induced neurotoxicity. Curr Infect Dis Rep. 2014;16(12):448.PubMed Bhattacharyya S, Darby R, Berkowitz AL. Antibiotic-induced neurotoxicity. Curr Infect Dis Rep. 2014;16(12):448.PubMed
78.
Zurück zum Zitat Suzuki S. Nivolumab-related myasthenia gravis with myositis and myocarditis in Japan. Neurology. 2017;89:1127–34.PubMed Suzuki S. Nivolumab-related myasthenia gravis with myositis and myocarditis in Japan. Neurology. 2017;89:1127–34.PubMed
79.
Zurück zum Zitat Chen JH, et al. Coexisting myasthenia gravis, myositis, and polyneuropathy induced by ipilimumab and nivolumab in a patient with non-small-cell lung cancer: a case report and literature review. Medicine (Baltimore). 2017;96(50):e9262. Chen JH, et al. Coexisting myasthenia gravis, myositis, and polyneuropathy induced by ipilimumab and nivolumab in a patient with non-small-cell lung cancer: a case report and literature review. Medicine (Baltimore). 2017;96(50):e9262.
80.
Zurück zum Zitat Fearon K, et al. Definition and classification of cancer cachexia: an international consensus. Lancet Oncol. 2011;12(5):489–95.PubMed Fearon K, et al. Definition and classification of cancer cachexia: an international consensus. Lancet Oncol. 2011;12(5):489–95.PubMed
81.
Zurück zum Zitat Baracos VE, et al. Cancer-associated cachexia. Nat Rev Dis Primers. 2018;4:17105.PubMed Baracos VE, et al. Cancer-associated cachexia. Nat Rev Dis Primers. 2018;4:17105.PubMed
82.
Zurück zum Zitat Aussy A, Boyer O, Cordel N. Dermatomyositis and immune-mediated necrotizing myopathies: a window on autoimmunity and cancer. Front Immunol. 2017;8:992.PubMedPubMedCentral Aussy A, Boyer O, Cordel N. Dermatomyositis and immune-mediated necrotizing myopathies: a window on autoimmunity and cancer. Front Immunol. 2017;8:992.PubMedPubMedCentral
83.
Zurück zum Zitat Argiles JM, et al. Novel targeted therapies for cancer cachexia. Biochem J. 2017;474(16):2663–78.PubMed Argiles JM, et al. Novel targeted therapies for cancer cachexia. Biochem J. 2017;474(16):2663–78.PubMed
84.
Zurück zum Zitat Perel-Winkler A, et al. A case of Docetaxel induced myositis and review of the literature. Case Rep Rheumatol. 2015;2015:795242.PubMedPubMedCentral Perel-Winkler A, et al. A case of Docetaxel induced myositis and review of the literature. Case Rep Rheumatol. 2015;2015:795242.PubMedPubMedCentral
85.
Zurück zum Zitat Spielmann L, et al. Gemcitabine-induced myopathy. Semin Arthritis Rheum. 2014;43(6):784–91.PubMed Spielmann L, et al. Gemcitabine-induced myopathy. Semin Arthritis Rheum. 2014;43(6):784–91.PubMed
86.
Zurück zum Zitat Minami H, et al. Phase I, multicenter, open-label, dose-escalation study of sonidegib in Asian patients with advanced solid tumors. Cancer Sci. 2016;107(10):1477–83.PubMedPubMedCentral Minami H, et al. Phase I, multicenter, open-label, dose-escalation study of sonidegib in Asian patients with advanced solid tumors. Cancer Sci. 2016;107(10):1477–83.PubMedPubMedCentral
87.
Zurück zum Zitat Yoshidome Y, et al. A case of polymyositis complicated with myasthenic crisis. Clin Rheumatol. 2007;26(9):1569–70.PubMed Yoshidome Y, et al. A case of polymyositis complicated with myasthenic crisis. Clin Rheumatol. 2007;26(9):1569–70.PubMed
88.
Zurück zum Zitat Muto Y, et al. Success of rechallenging dabrafenib and trametinib combination therapy after trametinib-induced rhabdomyolysis: a case report. Melanoma Res. 2018;28(2):151–4.PubMed Muto Y, et al. Success of rechallenging dabrafenib and trametinib combination therapy after trametinib-induced rhabdomyolysis: a case report. Melanoma Res. 2018;28(2):151–4.PubMed
90.
Zurück zum Zitat Stephenson AL, Mackenzie IRA, Levy RD, Road J. Myositis associated graft-versus-host-disease presenting as respiratory muscle weakness. Thorax. 2001;56:82–4.PubMedPubMedCentral Stephenson AL, Mackenzie IRA, Levy RD, Road J. Myositis associated graft-versus-host-disease presenting as respiratory muscle weakness. Thorax. 2001;56:82–4.PubMedPubMedCentral
91.
Zurück zum Zitat Smith CI, et al. Myasthenia gravis after bone-marrow transplantation. Evidence for a donor origin. N Engl J Med. 1983;309(25):1565–8.PubMed Smith CI, et al. Myasthenia gravis after bone-marrow transplantation. Evidence for a donor origin. N Engl J Med. 1983;309(25):1565–8.PubMed
Metadaten
Titel
Neurological complications of systemic tumor therapy
verfasst von
Prof. Dr. Wolfgang Grisold
Wolfgang Löscher
Anna Grisold
Publikationsdatum
19.09.2018
Verlag
Springer Vienna
Erschienen in
Wiener Medizinische Wochenschrift / Ausgabe 1-2/2019
Print ISSN: 0043-5341
Elektronische ISSN: 1563-258X
DOI
https://doi.org/10.1007/s10354-018-0654-y

Weitere Artikel der Ausgabe 1-2/2019

Wiener Medizinische Wochenschrift 1-2/2019 Zur Ausgabe