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Journal of Neural Transmission

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01.10.2011 | Movement Disorders - Review Article

Neurophysiological evaluation of the pedunculopontine nucleus in humans

verfasst von: P. Profice, P. Mazzone, F. Pilato, M. Dileone, A. Insola, F. Ranieri, V. Di Lazzaro

Erschienen in: Journal of Neural Transmission | Ausgabe 10/2011

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Abstract

The pedunculopontine nucleus (PPTg) is constituted by a heterogeneous cluster of neurons located in caudal mesencephalic tegmentum which projects to the thalamus to trigger thalamocortical rhythms and the brainstem to modulate muscle tone and locomotion. It has been investigated as potential deep brain stimulation (DBS) target for treating Parkinson’s disease (PD) symptoms. Neurophysiological studies conducted in humans using DBS electrodes for exploring functional properties of PPTg in vivo, reviewed in this paper, demonstrated that the functional connections between PPTg and cortex, basal ganglia, brainstem network involved in sleep/wake control, and spinal cord can be explored in vivo and provided useful insights about the physiology of this nucleus and pathophysiology of PD.

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Titel: Neurophysiological evaluation of the pedunculopontine nucleus in humans
verfasst von: P. Profice
P. Mazzone
F. Pilato
M. Dileone
A. Insola
F. Ranieri
V. Di Lazzaro
Publikationsdatum: 01.10.2011
Verlag: Springer Vienna
Erschienen in: Journal of Neural Transmission / Ausgabe 10/2011
Print ISSN: 0300-9564
Elektronische ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-011-0644-3

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