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Graefe's Archive for Clinical and Experimental Ophthalmology

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01.10.2005 | Laboratory Investigation

Neuroprotective effects of cardiotrophin-like cytokine on retinal ganglion cells

verfasst von: Frank Schuettauf, David Zurakowski, Kristine Quinto, Meghana A. Varde, Dorothea Besch, Alan Laties, Ralph Anderson, Rong Wen

Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology | Ausgabe 10/2005

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Abstract

Background

Premature neuronal cell death is a feature of numerous central nervous system and eye diseases, including glaucoma. Neurons (including retinal ganglion cells, RGCs) are protected by several neurotrophic factors, among those the IL-6 family of cytokines. Lately, a novel member of the IL-6 family of cytokines has been identified and cloned. This cytokine is known as novel neurotrophin-1/B-cell-stimulating factor-3 (NNT-1/BSF-3) or cardiotrophin-like cytokine (CLC). It shows neurotrophic as well as B-cell stimulatory effects.

Methods

In this study, the neuroprotective properties of CLC on RGC loss in vivo were investigated.

Results

CLC significantly protected RGCs from degeneration in both chosen models of retinal neuronal damage: optic nerve crush (P<0.01) and N-methyl-D-aspartate (NMDA) injection (P<0.001).

Conclusions

CLC shows neuroprotective effects on RGCs in vivo and might be a treatment option for chronic neurodegenerative eye diseases such as glaucoma. Clinical feasibility for the substance requires further investigation since the immunomodulatory and possible adverse effects have not yet been thoroughly characterized.

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Titel: Neuroprotective effects of cardiotrophin-like cytokine on retinal ganglion cells
verfasst von: Frank Schuettauf
David Zurakowski
Kristine Quinto
Meghana A. Varde
Dorothea Besch
Alan Laties
Ralph Anderson
Rong Wen
Publikationsdatum: 01.10.2005
Verlag: Springer-Verlag
Erschienen in: Graefe's Archive for Clinical and Experimental Ophthalmology / Ausgabe 10/2005
Print ISSN: 0721-832X
Elektronische ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-005-1152-7

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Neuroprotective effects of cardiotrophin-like cytokine on retinal ganglion cells

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