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Erschienen in: Current Heart Failure Reports 5/2015

01.10.2015 | Biomarkers of Heart Failure (W.H.W. Tang, Section Editor

Novel Biomarker Approaches for Managing Patients With Cardiac Transplantation

verfasst von: Peter J. Kennel, P. Christian Schulze

Erschienen in: Current Heart Failure Reports | Ausgabe 5/2015

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Abstract

Despite major advances in the medical care of patients following heart transplantation (HTx) and a steady increase in long-term survival, allograft surveillance is still based on endomyocardial biopsy, the gold standard since the 1970s. This invasive procedure calls for less burdening and more cost-effective approaches. In recent years, impressive progress has been made in utilizing blood-based biomarkers for the diagnosis and management of diseases in a variety of fields. Hence, a number of trials have been performed testing the usefulness of circulating molecules or other technical methods to overcome the need for surveillance myocardial biopsy in HTx patients. Here, we review current approaches and the state of research on novel biomarkers for the management of patients following heart transplantation.
Literatur
1.
Zurück zum Zitat Adhyaru BB, Jacobson TA. New cholesterol guidelines for the management of atherosclerotic cardiovascular disease risk: a comparison of the 2013 American College of Cardiology/American Heart Association Cholesterol Guidelines with the 2014 National Lipid Association Recommendations for Patient-Centered Management of Dyslipidemia. Cardiol Clin. 2015;33:181–96.CrossRefPubMed Adhyaru BB, Jacobson TA. New cholesterol guidelines for the management of atherosclerotic cardiovascular disease risk: a comparison of the 2013 American College of Cardiology/American Heart Association Cholesterol Guidelines with the 2014 National Lipid Association Recommendations for Patient-Centered Management of Dyslipidemia. Cardiol Clin. 2015;33:181–96.CrossRefPubMed
2.
Zurück zum Zitat Akat KM, Moore-McGriff D, Morozov P, Brown M, Gogakos T, Correa Da Rosa J, et al. Comparative RNA-sequencing analysis of myocardial and circulating small RNAs in human heart failure and their utility as biomarkers. Proc Natl Acad Sci U S A. 2014;111:11151–6.PubMedCentralCrossRefPubMed Akat KM, Moore-McGriff D, Morozov P, Brown M, Gogakos T, Correa Da Rosa J, et al. Comparative RNA-sequencing analysis of myocardial and circulating small RNAs in human heart failure and their utility as biomarkers. Proc Natl Acad Sci U S A. 2014;111:11151–6.PubMedCentralCrossRefPubMed
3.
Zurück zum Zitat Arnau-Vives MA, Almenar L, Hervas I, Osa A, Martinez-Dolz L, Rueda J, et al. Predictive value of brain natriuretic peptide in the diagnosis of heart transplant rejection. J Heart Lung Transplant. 2004;23:850–6.CrossRefPubMed Arnau-Vives MA, Almenar L, Hervas I, Osa A, Martinez-Dolz L, Rueda J, et al. Predictive value of brain natriuretic peptide in the diagnosis of heart transplant rejection. J Heart Lung Transplant. 2004;23:850–6.CrossRefPubMed
4.
Zurück zum Zitat Battes LC, Caliskan K, Rizopoulos D, Constantinescu AA, Robertus JL, Akkerhuis M, et al. Repeated measurements of NT-pro-B-type natriuretic peptide, troponin T or C-reactive protein do not predict future allograft rejection in heart transplant recipients. Transplantation. 2015;99:580–5.CrossRefPubMed Battes LC, Caliskan K, Rizopoulos D, Constantinescu AA, Robertus JL, Akkerhuis M, et al. Repeated measurements of NT-pro-B-type natriuretic peptide, troponin T or C-reactive protein do not predict future allograft rejection in heart transplant recipients. Transplantation. 2015;99:580–5.CrossRefPubMed
5.
Zurück zum Zitat Borozdenkova S, Westbrook JA, Patel V, Wait R, Bolad I, Burke MM, et al. Use of proteomics to discover novel markers of cardiac allograft rejection. J Proteome Res. 2004;3:282–8.CrossRefPubMed Borozdenkova S, Westbrook JA, Patel V, Wait R, Bolad I, Burke MM, et al. Use of proteomics to discover novel markers of cardiac allograft rejection. J Proteome Res. 2004;3:282–8.CrossRefPubMed
6.
Zurück zum Zitat Chance JJ, Segal JB, Wallerson G, Kasper E, Hruban RH, Kickler TS, et al. Cardiac troponin T and C-reactive protein as markers of acute cardiac allograft rejection. Clin Chim Acta. 2001;312:31–9.CrossRefPubMed Chance JJ, Segal JB, Wallerson G, Kasper E, Hruban RH, Kickler TS, et al. Cardiac troponin T and C-reactive protein as markers of acute cardiac allograft rejection. Clin Chim Acta. 2001;312:31–9.CrossRefPubMed
7.
Zurück zum Zitat Chen W, Peng W, Huang J, Yu X, Tan K, Chen Y, et al. Microarray analysis of long non-coding RNA expression in human acute rejection biopsy samples following renal transplantation. Mol Med Rep. 2014;10:2210–6.PubMed Chen W, Peng W, Huang J, Yu X, Tan K, Chen Y, et al. Microarray analysis of long non-coding RNA expression in human acute rejection biopsy samples following renal transplantation. Mol Med Rep. 2014;10:2210–6.PubMed
8.•
Zurück zum Zitat Cohen Freue GV, Meredith A, Smith D, Bergman A, Sasaki M, Lam KK, et al. Computational biomarker pipeline from discovery to clinical implementation: plasma proteomic biomarkers for cardiac transplantation. PLoS Comput Biol. 2013;9, e1002963. Bioinformatic approach to discover valid biomarkers.PubMedCentralCrossRefPubMed Cohen Freue GV, Meredith A, Smith D, Bergman A, Sasaki M, Lam KK, et al. Computational biomarker pipeline from discovery to clinical implementation: plasma proteomic biomarkers for cardiac transplantation. PLoS Comput Biol. 2013;9, e1002963. Bioinformatic approach to discover valid biomarkers.PubMedCentralCrossRefPubMed
9.
Zurück zum Zitat Costanzo MR, Dipchand A, Starling R, Anderson A, Chan M, Desai S, et al. The International Society of Heart and Lung Transplantation Guidelines for the care of heart transplant recipients. J Heart Lung Transplant. 2010;29:914–56.CrossRefPubMed Costanzo MR, Dipchand A, Starling R, Anderson A, Chan M, Desai S, et al. The International Society of Heart and Lung Transplantation Guidelines for the care of heart transplant recipients. J Heart Lung Transplant. 2010;29:914–56.CrossRefPubMed
10.
Zurück zum Zitat Crespo-Leiro MG, Stypmann J, Vanhaecke J. Utility of Gene Expression Profiling Test (GEP) score instability to predict future clinical outcomes in heart transplant: results from the CARGO 2 European-Based Multicenter Trial. J Heart Lung Transplant. 2013;32(4):S113–4.CrossRef Crespo-Leiro MG, Stypmann J, Vanhaecke J. Utility of Gene Expression Profiling Test (GEP) score instability to predict future clinical outcomes in heart transplant: results from the CARGO 2 European-Based Multicenter Trial. J Heart Lung Transplant. 2013;32(4):S113–4.CrossRef
11.•
Zurück zum Zitat Daly KP. Circulating donor-derived cell-free DNA: a true biomarker for cardiac allograft rejection? Ann Transl Med. 2015;3:47. Introduces the concept of dscfDNA.PubMedCentralPubMed Daly KP. Circulating donor-derived cell-free DNA: a true biomarker for cardiac allograft rejection? Ann Transl Med. 2015;3:47. Introduces the concept of dscfDNA.PubMedCentralPubMed
12.•
Zurück zum Zitat De Vlaminck I, Valantine HA, Snyder TM, Strehl C, Cohen G, Luikart H, et al. Circulating cell-free DNA enables noninvasive diagnosis of heart transplant rejection. Sci Transl Med. 2014;6, 241ra277. dscfDNA trial.CrossRef De Vlaminck I, Valantine HA, Snyder TM, Strehl C, Cohen G, Luikart H, et al. Circulating cell-free DNA enables noninvasive diagnosis of heart transplant rejection. Sci Transl Med. 2014;6, 241ra277. dscfDNA trial.CrossRef
13.•
Zurück zum Zitat Deng MC, Eisen HJ, Mehra MR, Billingham M, Marboe CC, Berry G, et al. Noninvasive discrimination of rejection in cardiac allograft recipients using gene expression profiling. Am J Transplant. 2006;6:150–60. Allomap key trial.CrossRefPubMed Deng MC, Eisen HJ, Mehra MR, Billingham M, Marboe CC, Berry G, et al. Noninvasive discrimination of rejection in cardiac allograft recipients using gene expression profiling. Am J Transplant. 2006;6:150–60. Allomap key trial.CrossRefPubMed
14.
Zurück zum Zitat Deng MC, Elashoff B, Pham MX, Teuteberg JJ, Kfoury AG, Starling RC, et al. Utility of gene expression profiling score variability to predict clinical events in heart transplant recipients. Transplantation. 2014. Deng MC, Elashoff B, Pham MX, Teuteberg JJ, Kfoury AG, Starling RC, et al. Utility of gene expression profiling score variability to predict clinical events in heart transplant recipients. Transplantation. 2014.
15.
Zurück zum Zitat Dengler TJ, Zimmermann R, Braun K, Muller-Bardorff M, Zehelein J, Sack FU, et al. Elevated serum concentrations of cardiac troponin T in acute allograft rejection after human heart transplantation. J Am Coll Cardiol. 1998;32:405–12.CrossRefPubMed Dengler TJ, Zimmermann R, Braun K, Muller-Bardorff M, Zehelein J, Sack FU, et al. Elevated serum concentrations of cardiac troponin T in acute allograft rejection after human heart transplantation. J Am Coll Cardiol. 1998;32:405–12.CrossRefPubMed
16.•
Zurück zum Zitat Duong Van Huyen JP, Tible M, Gay A, Guillemain R, Aubert O, Varnous S, et al. MicroRNAs as non-invasive biomarkers of heart transplant rejection. Eur Heart J. 2014;35:3194–202. miRNA trial.CrossRefPubMed Duong Van Huyen JP, Tible M, Gay A, Guillemain R, Aubert O, Varnous S, et al. MicroRNAs as non-invasive biomarkers of heart transplant rejection. Eur Heart J. 2014;35:3194–202. miRNA trial.CrossRefPubMed
18.
Zurück zum Zitat Garrido IP, Pascual-Figal DA, Nicolas F, Gonzalez-Carrillo MJ, Manzano-Fernandez S, Sanchez-Mas J, et al. Usefulness of serial monitoring of B-type natriuretic peptide for the detection of acute rejection after heart transplantation. Am J Cardiol. 2009;103:1149–53.CrossRefPubMed Garrido IP, Pascual-Figal DA, Nicolas F, Gonzalez-Carrillo MJ, Manzano-Fernandez S, Sanchez-Mas J, et al. Usefulness of serial monitoring of B-type natriuretic peptide for the detection of acute rejection after heart transplantation. Am J Cardiol. 2009;103:1149–53.CrossRefPubMed
19.•
Zurück zum Zitat Hidestrand M, Tomita-Mitchell A, Hidestrand PM, Oliphant A, Goetsch M, Stamm K, et al. Highly sensitive noninvasive cardiac transplant rejection monitoring using targeted quantification of donor-specific cell-free deoxyribonucleic acid. J Am Coll Cardiol. 2014;63:1224–6. dscfDNA trial.CrossRefPubMed Hidestrand M, Tomita-Mitchell A, Hidestrand PM, Oliphant A, Goetsch M, Stamm K, et al. Highly sensitive noninvasive cardiac transplant rejection monitoring using targeted quantification of donor-specific cell-free deoxyribonucleic acid. J Am Coll Cardiol. 2014;63:1224–6. dscfDNA trial.CrossRefPubMed
20.
Zurück zum Zitat Kienzl K, Sarg B, Golderer G, Obrist P, Werner ER, Werner-Felmayer G, et al. Proteomic profiling of acute cardiac allograft rejection. Transplantation. 2009;88:553–60.CrossRefPubMed Kienzl K, Sarg B, Golderer G, Obrist P, Werner ER, Werner-Felmayer G, et al. Proteomic profiling of acute cardiac allograft rejection. Transplantation. 2009;88:553–60.CrossRefPubMed
21.
Zurück zum Zitat Kirchhoff W, Gradaus R, Stypmann J, Deng MC, Tian TD, Scheld HH, et al. Vasoactive peptides during long-term follow-up of patients after cardiac transplantation. J Heart Lung Transplant. 2004;23:284–8.CrossRefPubMed Kirchhoff W, Gradaus R, Stypmann J, Deng MC, Tian TD, Scheld HH, et al. Vasoactive peptides during long-term follow-up of patients after cardiac transplantation. J Heart Lung Transplant. 2004;23:284–8.CrossRefPubMed
22.
Zurück zum Zitat Kumarswamy R, Bauters C, Volkmann I, Maury F, Fetisch J, Holzmann A, et al. Circulating long noncoding RNA, LIPCAR, predicts survival in patients with heart failure. Circ Res. 2014;114:1569–75.CrossRefPubMed Kumarswamy R, Bauters C, Volkmann I, Maury F, Fetisch J, Holzmann A, et al. Circulating long noncoding RNA, LIPCAR, predicts survival in patients with heart failure. Circ Res. 2014;114:1569–75.CrossRefPubMed
23.
Zurück zum Zitat Lampert BC, Teuteberg JJ, Shullo MA, Holtz J, Smith KJ. Cost-effectiveness of routine surveillance endomyocardial biopsy after 12 months post-heart transplantation. Circ Heart Fail. 2014;7:807–13.CrossRefPubMed Lampert BC, Teuteberg JJ, Shullo MA, Holtz J, Smith KJ. Cost-effectiveness of routine surveillance endomyocardial biopsy after 12 months post-heart transplantation. Circ Heart Fail. 2014;7:807–13.CrossRefPubMed
24.••
Zurück zum Zitat Lund LH, Edwards LB, Kucheryavaya AY, Benden C, Christie JD, Dipchand AI, et al. The registry of the International Society for Heart and Lung Transplantation: thirty-first official adult heart transplant report—2014; focus theme: retransplantation. J Heart Lung Transplant. 2014;33:996–1008. Statistics for cardiac allograft survival and incidence of rejection episodes.CrossRefPubMed Lund LH, Edwards LB, Kucheryavaya AY, Benden C, Christie JD, Dipchand AI, et al. The registry of the International Society for Heart and Lung Transplantation: thirty-first official adult heart transplant report—2014; focus theme: retransplantation. J Heart Lung Transplant. 2014;33:996–1008. Statistics for cardiac allograft survival and incidence of rejection episodes.CrossRefPubMed
25.
Zurück zum Zitat Maisel A, Mueller C, Adams Jr K, Anker SD, Aspromonte N, Cleland JG, et al. State of the art: using natriuretic peptide levels in clinical practice. Eur J Heart Fail. 2008;10:824–39.CrossRefPubMed Maisel A, Mueller C, Adams Jr K, Anker SD, Aspromonte N, Cleland JG, et al. State of the art: using natriuretic peptide levels in clinical practice. Eur J Heart Fail. 2008;10:824–39.CrossRefPubMed
26.
Zurück zum Zitat Mullen JC, Bentley MJ, Scherr KD, Chorney SG, Burton NI, Tymchak WJ, et al. Troponin T and I are not reliable markers of cardiac transplant rejection. Eur J Cardiothorac Surg. 2002;22:233–7.CrossRefPubMed Mullen JC, Bentley MJ, Scherr KD, Chorney SG, Burton NI, Tymchak WJ, et al. Troponin T and I are not reliable markers of cardiac transplant rejection. Eur J Cardiothorac Surg. 2002;22:233–7.CrossRefPubMed
28.
Zurück zum Zitat Patel PC, Hill DA, Ayers CR, Lavingia B, Kaiser P, Dyer AK, et al. High-sensitivity cardiac troponin I assay to screen for acute rejection in patients with heart transplant. Circ Heart Fail. 2014;7:463–9.CrossRefPubMed Patel PC, Hill DA, Ayers CR, Lavingia B, Kaiser P, Dyer AK, et al. High-sensitivity cardiac troponin I assay to screen for acute rejection in patients with heart transplant. Circ Heart Fail. 2014;7:463–9.CrossRefPubMed
29.•
Zurück zum Zitat Pham MX, Teuteberg JJ, Kfoury AG, Starling RC, Deng MC, Cappola TP, et al. Gene-expression profiling for rejection surveillance after cardiac transplantation. N Engl J Med. 2010;362:1890–900. Allomap key trial.CrossRefPubMed Pham MX, Teuteberg JJ, Kfoury AG, Starling RC, Deng MC, Cappola TP, et al. Gene-expression profiling for rejection surveillance after cardiac transplantation. N Engl J Med. 2010;362:1890–900. Allomap key trial.CrossRefPubMed
30.••
Zurück zum Zitat Qian WJ, Jacobs JM, Liu T, Camp 2nd DG, Smith RD. Advances and challenges in liquid chromatography-mass spectrometry-based proteomics profiling for clinical applications. Mol Cell Proteomics. 2006;5:1727–44. Illustrates challenges and pitfalls in the development for protein biomarkers.PubMedCentralCrossRefPubMed Qian WJ, Jacobs JM, Liu T, Camp 2nd DG, Smith RD. Advances and challenges in liquid chromatography-mass spectrometry-based proteomics profiling for clinical applications. Mol Cell Proteomics. 2006;5:1727–44. Illustrates challenges and pitfalls in the development for protein biomarkers.PubMedCentralCrossRefPubMed
31.
Zurück zum Zitat Strimbu KandTavel JA. What are biomarkers? Curr Opin HIV AIDS. 2010;5:463–6.CrossRef Strimbu KandTavel JA. What are biomarkers? Curr Opin HIV AIDS. 2010;5:463–6.CrossRef
32.
Zurück zum Zitat Subherwal S, Kobashigawa JA, Cogert G, Patel J, Espejo M, Oeser B. Incidence of acute cellular rejection and non-cellular rejection in cardiac transplantation. Transplant Proc. 2004;36:3171–2.CrossRefPubMed Subherwal S, Kobashigawa JA, Cogert G, Patel J, Espejo M, Oeser B. Incidence of acute cellular rejection and non-cellular rejection in cardiac transplantation. Transplant Proc. 2004;36:3171–2.CrossRefPubMed
33.
Zurück zum Zitat Sukma Dewi I, Torngren K, Gidlof O, Kornhall B, Ohman J. Altered serum miRNA profiles during acute rejection after heart transplantation: potential for non-invasive allograft surveillance. J Heart Lung Transplant. 2013;32:463–6.CrossRefPubMed Sukma Dewi I, Torngren K, Gidlof O, Kornhall B, Ohman J. Altered serum miRNA profiles during acute rejection after heart transplantation: potential for non-invasive allograft surveillance. J Heart Lung Transplant. 2013;32:463–6.CrossRefPubMed
34.
Zurück zum Zitat Wang K, Liu F, Zhou LY, Long B, Yuan SM, Wang Y, et al. The long noncoding RNA CHRF regulates cardiac hypertrophy by targeting miR-489. Circ Res. 2014;114:1377–88.CrossRefPubMed Wang K, Liu F, Zhou LY, Long B, Yuan SM, Wang Y, et al. The long noncoding RNA CHRF regulates cardiac hypertrophy by targeting miR-489. Circ Res. 2014;114:1377–88.CrossRefPubMed
35.
Zurück zum Zitat Wu AH, Johnson ML, Aaronson KD, Gordon D, Dyke DB, Koelling TM. Brain natriuretic peptide predicts serious cardiac allograft rejection independent of hemodynamic measurements. J Heart Lung Transplant. 2005;24:52–7.CrossRefPubMed Wu AH, Johnson ML, Aaronson KD, Gordon D, Dyke DB, Koelling TM. Brain natriuretic peptide predicts serious cardiac allograft rejection independent of hemodynamic measurements. J Heart Lung Transplant. 2005;24:52–7.CrossRefPubMed
Metadaten
Titel
Novel Biomarker Approaches for Managing Patients With Cardiac Transplantation
verfasst von
Peter J. Kennel
P. Christian Schulze
Publikationsdatum
01.10.2015
Verlag
Springer US
Erschienen in
Current Heart Failure Reports / Ausgabe 5/2015
Print ISSN: 1546-9530
Elektronische ISSN: 1546-9549
DOI
https://doi.org/10.1007/s11897-015-0269-1

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