Erschienen in:
Open Access
01.12.2012 | Oral presentation
Novel regulatory T cells controlling antibody production and systemic autoimmunity
verfasst von:
Kazuhiko Yamamoto, Tomohisa Okamura, Keishi Fujio
Erschienen in:
Arthritis Research & Therapy
|
Sonderheft 1/2012
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Excerpt
Regulatory T cells (Tregs) are engaged in the maintenance of immunological self-tolerance and immune homeostasis. IL-10 has an important role in maintaining the normal immune state. We showed that IL-10-secreting Tregs can be delineated in normal mice as CD4+CD25-Foxp3- T cells that express lymphocyte activation gene-3 (LAG-3), an MHC class II-binding CD4 homolog. CD4+CD25-LAG3+ Tregs characteristically express early growth response gene-2 (Egr-2), a key molecule for anergy induction. Retroviral gene transfer of Egr-2 converts naïve CD4+ T cells into IL-10-secreting and LAG-3-expressing Tregs. Moreover, CD4+CD25-LAG3+ Tregs show B cell-dependent development. CD4+CD25-LAG3+ Tregs, but not CD4+CD25+ Tregs, strongly suppressed the antibody production in B cells co-cultured with helper T cells. Thus, IL-10-secreting Egr-2+LAG3+CD4+ Tregs are closely related to B cells and can be exploited for the treat ment of autoimmune diseases. …
