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Current Atherosclerosis Reports

Erschienen in:

05.02.2024 | Review

Novel Therapies for Lipoprotein(a): Update in Cardiovascular Risk Estimation and Treatment

verfasst von: Anders Berg Wulff, Børge G. Nordestgaard, Anne Langsted

Erschienen in: Current Atherosclerosis Reports | Ausgabe 4/2024

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Abstract

Purpose of Review

Lipoprotein(a) is an important causal risk factor for cardiovascular disease but currently no available medication effectively reduces lipoprotein(a). This review discusses recent findings regarding lipoprotein(a) as a causal risk factor and therapeutic target in cardiovascular disease, it reviews current clinical recommendations, and summarizes new lipoprotein(a) lowering drugs.

Recent Findings

Epidemiological and genetic studies have established lipoprotein(a) as a causal risk factor for cardiovascular disease and mortality. Guidelines worldwide now recommend lipoprotein(a) to be measured once in a lifetime, to offer patients with high lipoprotein(a) lifestyle advise and initiate other cardiovascular medications. Clinical trials including antisense oligonucleotides, small interfering RNAs, and an oral lipoprotein(a) inhibitor have shown great effect on lowering lipoprotein(a) with reductions up to 106%, without any major adverse effects.

Summary

Recent clinical phase 1 and 2 trials show encouraging results and ongoing phase 3 trials will hopefully result in the introduction of specific lipoprotein(a) lowering drugs to lower the risk of cardiovascular disease.

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Titel: Novel Therapies for Lipoprotein(a): Update in Cardiovascular Risk Estimation and Treatment
verfasst von: Anders Berg Wulff
Børge G. Nordestgaard
Anne Langsted
Publikationsdatum: 05.02.2024
Verlag: Springer US
Erschienen in: Current Atherosclerosis Reports / Ausgabe 4/2024
Print ISSN: 1523-3804
Elektronische ISSN: 1534-6242
DOI: https://doi.org/10.1007/s11883-024-01192-9

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