Skip to main content
Erschienen in: AIDS and Behavior 3/2016

01.03.2016 | Original Paper

Number of Drinks to “Feel a Buzz” by HIV Status and Viral Load in Men

verfasst von: Kathleen A. McGinnis, David A. Fiellin, Janet P. Tate, Robert L. Cook, R. Scott Braithwaite, Kendall J. Bryant, E. Jennifer Edelman, Adam J. Gordon, Kevin L. Kraemer, Stephen A. Maisto, Amy C. Justice, The Veterans Aging Cohort Study

Erschienen in: AIDS and Behavior | Ausgabe 3/2016

Einloggen, um Zugang zu erhalten

Abstract

The impact of HIV and its treatment on the effects of alcohol remain unclear. Blood alcohol concentrations have been noted to be higher in HIV infected individuals prior to antiretroviral initiation. Our goal was to compare number of drinks to “feel a buzz or high” among HIV infected and uninfected men, stratified by viral load (VL) suppression. Data includes 1478 HIV infected and 1170 uninfected men in the veterans aging cohort study who endorsed current drinking. Mean (SD) number of drinks to feel a buzz was 3.1 (1.7) overall. In multivariable analyses, HIV infected men reported a lower mean number of drinks to feel a buzz compared to uninfected men (coef = −14 for VL < 500; −34 for VL ≥ 500; p ≤ .05). Men with HIV, especially those with a detectable VL, reported fewer drinks to feel a buzz. Future research on the relationship between alcohol and HIV should consider the role of VL suppression.
Literatur
1.
2.
Zurück zum Zitat Justice AC, Lasky E, McGinnis KA, Skanderson M, Conigliaro J, Fultz SL, et al. Medical disease and alcohol use among veterans with human immunodeficiency infection: a comparison of disease measurement strategies. Med Care. 2006;44(8 Suppl 2):S52–60.CrossRefPubMed Justice AC, Lasky E, McGinnis KA, Skanderson M, Conigliaro J, Fultz SL, et al. Medical disease and alcohol use among veterans with human immunodeficiency infection: a comparison of disease measurement strategies. Med Care. 2006;44(8 Suppl 2):S52–60.CrossRefPubMed
3.
Zurück zum Zitat Braithwaite RS, Justice AC, Chang CC, Fusco JS, Raffanti SR, Wong JB, et al. Estimating the proportion of patients infected with HIV who will die of comorbid diseases. Am J Med. 2005;118(8):890–8.CrossRefPubMed Braithwaite RS, Justice AC, Chang CC, Fusco JS, Raffanti SR, Wong JB, et al. Estimating the proportion of patients infected with HIV who will die of comorbid diseases. Am J Med. 2005;118(8):890–8.CrossRefPubMed
4.
Zurück zum Zitat Braithwaite RS, Conigliaro J, Roberts MS, Shechter S, Schaefer A, McGinnis K, et al. Estimating the impact of alcohol consumption on survival for HIV+ individuals. AIDS Care. 2007;19(4):459–66.CrossRefPubMedPubMedCentral Braithwaite RS, Conigliaro J, Roberts MS, Shechter S, Schaefer A, McGinnis K, et al. Estimating the impact of alcohol consumption on survival for HIV+ individuals. AIDS Care. 2007;19(4):459–66.CrossRefPubMedPubMedCentral
5.
Zurück zum Zitat Samet JH, Horton NJ, Traphagen ET, Lyon SM, Freedberg KA. Alcohol consumption and HIV disease progression: are they related? Alcohol Clin Exp Res. 2003;27(5):862–7.CrossRefPubMed Samet JH, Horton NJ, Traphagen ET, Lyon SM, Freedberg KA. Alcohol consumption and HIV disease progression: are they related? Alcohol Clin Exp Res. 2003;27(5):862–7.CrossRefPubMed
6.
Zurück zum Zitat Samet JH, Horton NJ, Meli S, Freedberg KA, Palepu A. Alcohol consumption and antiretroviral adherence among HIV-infected persons with alcohol problems. Alcohol Clin Exp Res. 2004;28(4):572–7.CrossRefPubMed Samet JH, Horton NJ, Meli S, Freedberg KA, Palepu A. Alcohol consumption and antiretroviral adherence among HIV-infected persons with alcohol problems. Alcohol Clin Exp Res. 2004;28(4):572–7.CrossRefPubMed
7.
Zurück zum Zitat Braithwaite RS, McGinnis KA, Conigliaro J, Maisto SA, Crystal S, Day N, et al. A temporal and dose-response association between alcohol consumption and medication adherence among veterans in care. Alcohol Clin Exp Res. 2005;29(7):1190–7.CrossRefPubMed Braithwaite RS, McGinnis KA, Conigliaro J, Maisto SA, Crystal S, Day N, et al. A temporal and dose-response association between alcohol consumption and medication adherence among veterans in care. Alcohol Clin Exp Res. 2005;29(7):1190–7.CrossRefPubMed
8.
Zurück zum Zitat Lim JK, Tate JP, Fultz SL, Goulet JL, Conigliaro J, Bryant KJ, et al. Relationship between alcohol use categories and noninvasive markers of advanced hepatic fibrosis in HIV-infected, chronic hepatitis C virus-infected, and uninfected patients. Clin Infect Dis. 2014;58(10):1449–58.CrossRefPubMedPubMedCentral Lim JK, Tate JP, Fultz SL, Goulet JL, Conigliaro J, Bryant KJ, et al. Relationship between alcohol use categories and noninvasive markers of advanced hepatic fibrosis in HIV-infected, chronic hepatitis C virus-infected, and uninfected patients. Clin Infect Dis. 2014;58(10):1449–58.CrossRefPubMedPubMedCentral
9.
Zurück zum Zitat Cook RL, McGinnis KA, Kraemer KL, Gordon AJ, Conigliaro J, Maisto SA, et al. Intoxication before intercourse and risky sexual behavior in male veterans with and without human immunodeficiency virus infection. Med Care. 2006;44(8 Suppl 2):S31–6.CrossRefPubMed Cook RL, McGinnis KA, Kraemer KL, Gordon AJ, Conigliaro J, Maisto SA, et al. Intoxication before intercourse and risky sexual behavior in male veterans with and without human immunodeficiency virus infection. Med Care. 2006;44(8 Suppl 2):S31–6.CrossRefPubMed
10.
Zurück zum Zitat McCance-Katz EF, Lum PJ, Beatty G, Gruber VA, Peters M, Rainey PM. Untreated HIV infection is associated with higher blood alcohol levels. J Acquir Immune Defic Syndr. 2012;60(3):282–8.CrossRefPubMedPubMedCentral McCance-Katz EF, Lum PJ, Beatty G, Gruber VA, Peters M, Rainey PM. Untreated HIV infection is associated with higher blood alcohol levels. J Acquir Immune Defic Syndr. 2012;60(3):282–8.CrossRefPubMedPubMedCentral
11.
Zurück zum Zitat McCance-Katz EF, Gruber VA, Beatty G, Lum PJ, Rainey PM. Interactions between alcohol and the antiretroviral medications ritonavir or efavirenz. J Addict Med. 2013;7(4):264–70.CrossRefPubMedPubMedCentral McCance-Katz EF, Gruber VA, Beatty G, Lum PJ, Rainey PM. Interactions between alcohol and the antiretroviral medications ritonavir or efavirenz. J Addict Med. 2013;7(4):264–70.CrossRefPubMedPubMedCentral
12.
Zurück zum Zitat Midanik LT. Drunkenness, feeling the effects and 5+ measures. Addiction. 1999;94(6):887–97.CrossRefPubMed Midanik LT. Drunkenness, feeling the effects and 5+ measures. Addiction. 1999;94(6):887–97.CrossRefPubMed
13.
Zurück zum Zitat Levitt A, Sher KJ, Bartholow BD. The language of intoxication: preliminary investigations. Alcohol Clin Exp Res. 2009;33(3):448–54.CrossRefPubMed Levitt A, Sher KJ, Bartholow BD. The language of intoxication: preliminary investigations. Alcohol Clin Exp Res. 2009;33(3):448–54.CrossRefPubMed
14.
Zurück zum Zitat Weathermon R, Crabb DW. Alcohol and medication interactions. Alcohol Res Health. 1999;23(1):40–54.PubMed Weathermon R, Crabb DW. Alcohol and medication interactions. Alcohol Res Health. 1999;23(1):40–54.PubMed
15.
Zurück zum Zitat Justice AC, Dombrowski E, Conigliaro J, Fultz SL, Gibson D, Madenwald T, et al. Veterans aging cohort study (VACS): overview and description. Med Care. 2006;44(8 Suppl 2):S13–24.CrossRefPubMedPubMedCentral Justice AC, Dombrowski E, Conigliaro J, Fultz SL, Gibson D, Madenwald T, et al. Veterans aging cohort study (VACS): overview and description. Med Care. 2006;44(8 Suppl 2):S13–24.CrossRefPubMedPubMedCentral
16.
Zurück zum Zitat Conigliaro J, Madenwald T, Bryant K, Braithwaite S, Gordon A, Fultz SL, et al. The Veterans Aging Cohort Study: observational studies of alcohol use, abuse, and outcomes among human immunodeficiency virus-infected veterans. Alcohol Clin Exp Res. 2004;28(2):313–21.CrossRefPubMed Conigliaro J, Madenwald T, Bryant K, Braithwaite S, Gordon A, Fultz SL, et al. The Veterans Aging Cohort Study: observational studies of alcohol use, abuse, and outcomes among human immunodeficiency virus-infected veterans. Alcohol Clin Exp Res. 2004;28(2):313–21.CrossRefPubMed
17.
Zurück zum Zitat Greenfield TK, Midanik LT, Rogers JD. A 10-year national trend study of alcohol consumption, 1984–1995: is the period of declining drinking over? Am J Public Health. 2000;90(1):47–52.CrossRefPubMedPubMedCentral Greenfield TK, Midanik LT, Rogers JD. A 10-year national trend study of alcohol consumption, 1984–1995: is the period of declining drinking over? Am J Public Health. 2000;90(1):47–52.CrossRefPubMedPubMedCentral
19.
Zurück zum Zitat Bush K, Kivlahan DR, McDonell MB, Fihn SD, Bradley KA. The AUDIT alcohol consumption questions (AUDIT-C): an effective brief screening test for problem drinking. Ambulatory care quality improvement project (ACQUIP). Alcohol use disorders identification test. Arch Intern Med. 1998;158(16):1789–95.CrossRefPubMed Bush K, Kivlahan DR, McDonell MB, Fihn SD, Bradley KA. The AUDIT alcohol consumption questions (AUDIT-C): an effective brief screening test for problem drinking. Ambulatory care quality improvement project (ACQUIP). Alcohol use disorders identification test. Arch Intern Med. 1998;158(16):1789–95.CrossRefPubMed
20.
Zurück zum Zitat McGinnis KA, Justice AC, Kraemer KL, Saitz R, Bryant KJ, Fiellin DA. Comparing alcohol screening measures among HIV-infected and -uninfected men. Alcohol Clin Exp Res. 2013;37(3):435–42.CrossRefPubMedPubMedCentral McGinnis KA, Justice AC, Kraemer KL, Saitz R, Bryant KJ, Fiellin DA. Comparing alcohol screening measures among HIV-infected and -uninfected men. Alcohol Clin Exp Res. 2013;37(3):435–42.CrossRefPubMedPubMedCentral
21.
Zurück zum Zitat Justice AC, McGinnis KA, Skanderson M, Chang CC, Gibert CL, Goetz MB, et al. Towards a combined prognostic index for survival in HIV infection: the role of ‘non-HIV’ biomarkers. HIV Med. 2010;11(2):143–51.CrossRefPubMedPubMedCentral Justice AC, McGinnis KA, Skanderson M, Chang CC, Gibert CL, Goetz MB, et al. Towards a combined prognostic index for survival in HIV infection: the role of ‘non-HIV’ biomarkers. HIV Med. 2010;11(2):143–51.CrossRefPubMedPubMedCentral
22.
Zurück zum Zitat Tate JP, Justice AC, Hughes MD, Bonnet F, Reiss P, Mocroft A, et al. An internationally generalizable risk index for mortality after one year of antiretroviral therapy. AIDS. 2013;27(4):563–72.CrossRefPubMedPubMedCentral Tate JP, Justice AC, Hughes MD, Bonnet F, Reiss P, Mocroft A, et al. An internationally generalizable risk index for mortality after one year of antiretroviral therapy. AIDS. 2013;27(4):563–72.CrossRefPubMedPubMedCentral
23.
Zurück zum Zitat Justice AC, Freiberg MS, Tracy R, Kuller L, Tate JP, Goetz MB, et al. Does an index composed of clinical data reflect effects of inflammation, coagulation, and monocyte activation on mortality among those aging with HIV? Clin Infect Dis. 2012;54(7):984–94.CrossRefPubMedPubMedCentral Justice AC, Freiberg MS, Tracy R, Kuller L, Tate JP, Goetz MB, et al. Does an index composed of clinical data reflect effects of inflammation, coagulation, and monocyte activation on mortality among those aging with HIV? Clin Infect Dis. 2012;54(7):984–94.CrossRefPubMedPubMedCentral
24.
Zurück zum Zitat Wagner JH, Justice AC, Chesney M, Sinclair G, Weissman S, Rodriguez-Barradas M. Patient- and provider-reported adherence: toward a clinically useful approach to measuring antiretroviral adherence. J Clin Epidemiol. 2001;54(Suppl 1):S91–8.CrossRefPubMed Wagner JH, Justice AC, Chesney M, Sinclair G, Weissman S, Rodriguez-Barradas M. Patient- and provider-reported adherence: toward a clinically useful approach to measuring antiretroviral adherence. J Clin Epidemiol. 2001;54(Suppl 1):S91–8.CrossRefPubMed
25.
Zurück zum Zitat Butt AA, McGinnis K, Rodriguez-Barradas MC, Crystal S, Simberkoff M, Goetz MB, et al. HIV infection and the risk of diabetes mellitus. AIDS. 2009;23(10):1227–34.CrossRefPubMedPubMedCentral Butt AA, McGinnis K, Rodriguez-Barradas MC, Crystal S, Simberkoff M, Goetz MB, et al. HIV infection and the risk of diabetes mellitus. AIDS. 2009;23(10):1227–34.CrossRefPubMedPubMedCentral
26.
Zurück zum Zitat Maudens KE, Patteet L, van Nuijs AL, Van BC, Covaci A, Neels H. The influence of the body mass index (BMI) on the volume of distribution of ethanol. Forensic Sci Int. 2014;243C:74–8.CrossRef Maudens KE, Patteet L, van Nuijs AL, Van BC, Covaci A, Neels H. The influence of the body mass index (BMI) on the volume of distribution of ethanol. Forensic Sci Int. 2014;243C:74–8.CrossRef
27.
Zurück zum Zitat William G. Linear splines and piecewise linear functions. Stata Technical Bulletin 15. Stata Technical Bulletin Reprints. 3. College Station, TX: Stata Corporation; 1993. p. 13–7. William G. Linear splines and piecewise linear functions. Stata Technical Bulletin 15. Stata Technical Bulletin Reprints. 3. College Station, TX: Stata Corporation; 1993. p. 13–7.
28.
Zurück zum Zitat StataCorp. Stata Statistical Software: release 13.0. College Station: Stata Corporation; 2013. StataCorp. Stata Statistical Software: release 13.0. College Station: Stata Corporation; 2013.
29.
Zurück zum Zitat Assimakopoulos SF, Dimitropoulou D, Marangos M, Gogos CA. Intestinal barrier dysfunction in HIV infection: pathophysiology, clinical implications and potential therapies. Infection. 2014;42:951–9.CrossRefPubMed Assimakopoulos SF, Dimitropoulou D, Marangos M, Gogos CA. Intestinal barrier dysfunction in HIV infection: pathophysiology, clinical implications and potential therapies. Infection. 2014;42:951–9.CrossRefPubMed
30.
Zurück zum Zitat Baron RM, Kenny DA. The moderator-mediator variable distinction in social psychological research: conceptual, strategic, an statistical considerations. J Pers Soc Psychol. 1986;51(6):1173–82.CrossRefPubMed Baron RM, Kenny DA. The moderator-mediator variable distinction in social psychological research: conceptual, strategic, an statistical considerations. J Pers Soc Psychol. 1986;51(6):1173–82.CrossRefPubMed
31.
Zurück zum Zitat Me S. Asymptotic confidence intervals for indirect effects in structural equation models. Sociol Methodol. 1982;13:290–312.CrossRef Me S. Asymptotic confidence intervals for indirect effects in structural equation models. Sociol Methodol. 1982;13:290–312.CrossRef
32.
Zurück zum Zitat Me S. Some new results on indirect effects and their standard errors in covariance structure models. Sociol Methodol. 1986;16:159–86.CrossRef Me S. Some new results on indirect effects and their standard errors in covariance structure models. Sociol Methodol. 1986;16:159–86.CrossRef
33.
Zurück zum Zitat Hesselbrock M, Babor TF, Hesselbrock V, Meyer RE, Workman K. “Never believe an alcoholic”? On the validity of self-report measures of alcohol dependence and related constructs. Subst Use Misuse. 1983;18(5):593–609. Hesselbrock M, Babor TF, Hesselbrock V, Meyer RE, Workman K. “Never believe an alcoholic”? On the validity of self-report measures of alcohol dependence and related constructs. Subst Use Misuse. 1983;18(5):593–609.
34.
Zurück zum Zitat Del Boca FK, Darkes J. The validity of self-reports of alcohol consumption: state of the science and challenges for research. Addiction. 2003;98(Suppl 2):1–12.CrossRefPubMed Del Boca FK, Darkes J. The validity of self-reports of alcohol consumption: state of the science and challenges for research. Addiction. 2003;98(Suppl 2):1–12.CrossRefPubMed
35.
Zurück zum Zitat Litten RZ, Fertig J. Self-report and biochemical measures of alcohol consumption. Addiction. 2003;98(Suppl 2):3–4.CrossRef Litten RZ, Fertig J. Self-report and biochemical measures of alcohol consumption. Addiction. 2003;98(Suppl 2):3–4.CrossRef
36.
Zurück zum Zitat Litten RZ, Bradley AM, Moss HB. Alcohol biomarkers in applied settings: recent advances and future research opportunities. Alcohol Clin Exp Res. 2010;34(6):955–67.CrossRefPubMed Litten RZ, Bradley AM, Moss HB. Alcohol biomarkers in applied settings: recent advances and future research opportunities. Alcohol Clin Exp Res. 2010;34(6):955–67.CrossRefPubMed
37.
Zurück zum Zitat Kerr WC, Greenfield TK, Midanik LT. How many drinks does it take you to feel drunk? Trends and predictors for subjective drunkenness. Addiction. 2006;101(10):1428–37.CrossRefPubMed Kerr WC, Greenfield TK, Midanik LT. How many drinks does it take you to feel drunk? Trends and predictors for subjective drunkenness. Addiction. 2006;101(10):1428–37.CrossRefPubMed
Metadaten
Titel
Number of Drinks to “Feel a Buzz” by HIV Status and Viral Load in Men
verfasst von
Kathleen A. McGinnis
David A. Fiellin
Janet P. Tate
Robert L. Cook
R. Scott Braithwaite
Kendall J. Bryant
E. Jennifer Edelman
Adam J. Gordon
Kevin L. Kraemer
Stephen A. Maisto
Amy C. Justice
The Veterans Aging Cohort Study
Publikationsdatum
01.03.2016
Verlag
Springer US
Erschienen in
AIDS and Behavior / Ausgabe 3/2016
Print ISSN: 1090-7165
Elektronische ISSN: 1573-3254
DOI
https://doi.org/10.1007/s10461-015-1053-7

Weitere Artikel der Ausgabe 3/2016

AIDS and Behavior 3/2016 Zur Ausgabe

Leitlinien kompakt für die Innere Medizin

Mit medbee Pocketcards sicher entscheiden.

Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag

Echinokokkose medikamentös behandeln oder operieren?

06.05.2024 DCK 2024 Kongressbericht

Die Therapie von Echinokokkosen sollte immer in spezialisierten Zentren erfolgen. Eine symptomlose Echinokokkose kann – egal ob von Hunde- oder Fuchsbandwurm ausgelöst – konservativ erfolgen. Wenn eine Op. nötig ist, kann es sinnvoll sein, vorher Zysten zu leeren und zu desinfizieren. 

Umsetzung der POMGAT-Leitlinie läuft

03.05.2024 DCK 2024 Kongressbericht

Seit November 2023 gibt es evidenzbasierte Empfehlungen zum perioperativen Management bei gastrointestinalen Tumoren (POMGAT) auf S3-Niveau. Vieles wird schon entsprechend der Empfehlungen durchgeführt. Wo es im Alltag noch hapert, zeigt eine Umfrage in einem Klinikverbund.

Proximale Humerusfraktur: Auch 100-Jährige operieren?

01.05.2024 DCK 2024 Kongressbericht

Mit dem demographischen Wandel versorgt auch die Chirurgie immer mehr betagte Menschen. Von Entwicklungen wie Fast-Track können auch ältere Menschen profitieren und bei proximaler Humerusfraktur können selbst manche 100-Jährige noch sicher operiert werden.

Die „Zehn Gebote“ des Endokarditis-Managements

30.04.2024 Endokarditis Leitlinie kompakt

Worauf kommt es beim Management von Personen mit infektiöser Endokarditis an? Eine Kardiologin und ein Kardiologe fassen die zehn wichtigsten Punkte der neuen ESC-Leitlinie zusammen.

Update Innere Medizin

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.