Erschienen in:
29.03.2019 | Original Article
Obesity and hiatal hernia may be non-allergic risk factors for esophageal eosinophilia in Japanese adults
verfasst von:
Fumio Tanaka, Shinya Fukumoto, Tamami Morisaki, Koji Otani, Shuhei Hosomi, Yasuaki Nagami, Noriko Kamata, Koichi Taira, Akemi Nakano, Tatsuo Kimura, Hirokazu Yamagami, Tetsuya Tanigawa, Hiroyasu Morikawa, Toshio Watanabe, Norifumi Kawada, Kazuto Hirata, Yasuhiro Fujiwara
Erschienen in:
Esophagus
|
Ausgabe 3/2019
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Abstract
Background
Esophageal eosinophilia (EE) is a basal condition of eosinophilic esophageal disorders including eosinophilic esophagitis (EoE) and asymptomatic EE. EoE is considered as an allergic disorder, while it is unclear whether other non-allergic conditions are involved in the pathophysiology of EE. The aim of this study is to investigate the non-allergic risk factors for EE.
Methods
This cross-sectional study included subjects who underwent esophagogastroduodenoscopy on a medical health check-up. We compared clinical characteristics between subjects with EE (n = 27) and those without EE (n = 5937).
Results
The detection rate of EE was 0.45% (27/5964 persons). Of 27 subjects with EE, 20 subjects were symptomatic and 7 were asymptomatic. On univariate analysis, subjects with EE significantly had higher body mass index (BMI) compared to those without EE; 23.4 (4.4) vs 22.3 (4.5) kg/m2, median (interquartile range), p = 0.005. Endoscopic findings revealed that subjects with EE had significantly higher proportion of hiatal hernia (29.6% vs 14.7%; p = 0.049). Subjects with EE were significantly younger and had higher proportion of bronchial asthma; 45 (11.5) vs 51 (18) years, p = 0.013; 25.9% vs 5.2%, p < 0.001, respectively. Multivariate analysis showed that subjects with EE were positively associated with BMI [odds ratio (OR) 1.11; 95% confidence interval (CI) 1.03–1.20; p = 0.010) and hiatal hernia (OR 2.63; 95% CI 1.12–6.18; p = 0.026) compared to those without EE. On trend test, advanced BMI classification had significant trend for increased prevalence of EE (p = 0.002).
Conclusions
Obesity and hiatal hernia may be non-allergic risk factors for EE in Japanese adults.