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Osteoporosis International

Erschienen in:

01.03.2016 | Original Article

Occupation-dependent loading increases bone strength in men

verfasst von: E. Biver, G. Perréard Lopreno, M. Hars, B. van Rietbergen, J. P. Vallée, S. Ferrari, M. Besse, R. Rizzoli

Erschienen in: Osteoporosis International | Ausgabe 3/2016

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Abstract

Summary

Ex vivo analyses of humeri and radii from an anthropological collection and in vivo analyses of the distal radius of retired men indicate that occupation-dependent loading positively influences bone strength by an increase of bone size when young followed by a slowdown of the age-related endocortical and trabecular bone alteration.

Introduction

Skeleton responds to mechanical stimuli, but it is not established whether chronic loading in the context of occupational activities (OA) influences bone properties. We assessed the impact of occupation-dependent loading on upper limb bone strength.

Methods

Individuals were classified according to the intensity of physical loading associated with their OA in two models. Ex vivo, computed tomography scans of the humeri and radii of 219 male skeletons (age of death, 20–93 years) from an anthropological collection of the 20th century (Simon collection) were used to determine estimates of bone strength and cross-sectional geometry. In vivo, distal radius were analysed in 180 men enrolled in the Geneva Retirees Cohort study using high-resolution peripheral quantitative computed tomography and finite element analysis.

Results

Heavy-loading OA was associated with higher bone strength in both models. This benefit was associated with higher total area (Tt.Ar), medullary area (Me.Ar) and cortical area (Ct.Ar) in young adult skeletons, but the difference decreased in older age. In older men, the humerus supporting heavy loading had a lower Me.Ar. This effect resulted in greater asymmetries of the Me.Ar and the Ct.Ar/Tt.Ar ratio between the humeri of men with unilateral versus bilateral heavy-loading OA. In vivo, an additional benefit of heavy-loading OA was observed on the distal radius trabecular density and microstructure.

Conclusion

Repeated occupation-dependent loading positively influences bone strength by an increase of bone size when young followed by a slowdown of the age-related endocortical and trabecular bone alteration. These data supports the necessity to promote bone health in the context of sedentary occupation.

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Vehmas T, Solovieva S, Riihimaki H, Luoma K, Leino-Arjas P (2005) Hand workload and the metacarpal cortical index. A study of middle-aged teachers and dentists. Osteoporos Int 16:672–680CrossRefPubMed

Islam SS, Biswas RS, Nambiar AM, Syamlal G, Velilla AM, Ducatman AM, Doyle EJ (2001) Incidence and risk of work-related fracture injuries: experience of a state-managed workers' compensation system. J Occup Environ Med 43:140–146CrossRefPubMed

Cooper C, Wickham C, Coggon D (1990) Sedentary work in middle life and fracture of the proximal femur. Br J Ind Med 47:69–70PubMedPubMedCentral

Jaglal SB, Kreiger N, Darlington GA (1995) Lifetime occupational physical activity and risk of hip fracture in women. Ann Epidemiol 5:321–324CrossRefPubMed

Suen LK (1998) Occupation and risk of hip fracture. J Public Health Med 20:428–433CrossRefPubMed

Moayyeri A, Besson H, Luben RN, Wareham NJ, Khaw KT (2010) The association between physical activity in different domains of life and risk of osteoporotic fractures. Bone 47:693–700CrossRefPubMed

Seeman E (2002) Pathogenesis of bone fragility in women and men. Lancet 359:1841–1850CrossRefPubMed

Dennison EM, Jameson KA, Edwards MH, Denison HJ, Aihie Sayer A, Cooper C (2014) Peripheral quantitative computed tomography measures are associated with adult fracture risk: the Hertfordshire cohort study. Bone 64:13–17CrossRefPubMed

Szulc P, Seeman E, Duboeuf F, Sornay-Rendu E, Delmas PD (2006) Bone fragility: failure of periosteal apposition to compensate for increased endocortical resorption in postmenopausal women. J Bone Miner Res 21:1856–1863CrossRefPubMed

10.

Rizzoli R, Bianchi ML, Garabedian M, McKay HA, Moreno LA (2010) Maximizing bone mineral mass gain during growth for the prevention of fractures in the adolescents and the elderly. Bone 46:294–305CrossRefPubMed

11.

Wolff J (1892) The principle of transformation of bone. A Hirschwald, Berlin

12.

Warden SJ, Mantila Roosa SM, Kersh ME, Hurd AL, Fleisig GS, Pandy MG, Fuchs RK (2014) Physical activity when young provides lifelong benefits to cortical bone size and strength in men. Proc Natl Acad Sci U S A 111:5337–5342CrossRefPubMedPubMedCentral

13.

Chang G, Regatte RR, Schweitzer ME (2009) Olympic fencers: adaptations in cortical and trabecular bone determined by quantitative computed tomography. Osteoporos Int 20:779–785CrossRefPubMed

14.

Kannus P, Haapasalo H, Sankelo M, Sievanen H, Pasanen M, Heinonen A, Oja P, Vuori I (1995) Effect of starting age of physical activity on bone mass in the dominant arm of tennis and squash players. Ann Intern Med 123:27–31CrossRefPubMed

15.

Karlsson MK, Linden C, Karlsson C, Johnell O, Obrant K, Seeman E (2000) Exercise during growth and bone mineral density and fractures in old age. Lancet 355:469–470CrossRefPubMed

16.

Nilsson M, Ohlsson C, Mellstrom D, Lorentzon M (2013) Sport-specific association between exercise loading and the density, geometry, and microstructure of weight-bearing bone in young adult men. Osteoporos Int 24:1613–1622CrossRefPubMed

17.

Nilsson M, Sundh D, Ohlsson C, Karlsson M, Mellstrom D, Lorentzon M (2014) Exercise during growth and young adulthood is independently associated with cortical bone size and strength in old Swedish men. J Bone Miner Res 29:1795–1804CrossRefPubMed

18.

Ruff CB (2005) Mechanical determinants of bone form: insights from skeletal remains. J Musculoskelet Nueronal Interact 5:202–212

19.

Perréard Lopreno GES (2003) Une démarche actualiste en paléoanthropologie: la collection de squelettes de référence. In: Besse M, Stahl Gretsch LI, Curdy P (eds) ConstellaSion: hommage à Alain Gallay, vol 95. Cahiers d’archéologie romande, Lausanne, pp 463–472

20.

Gemmerich I (1999) Création d'une collection anthropologique de référence et application des caractères discrets dans le cas de généalogies connues. Geneva, p 277

21.

Perréard Lopreno G (2007) Adaptation structurelle des os du membre supérieur et de la clavicule à l’activité : analyse de l’asymétrie des propriétés géométriques de sections transverses et de mesures linéaires dans une population identifiée (collection SIMON). Université de Genève (PhD, archives ouvertes)

22.

Durosier C, van Lierop A, Ferrari S, Chevalley T, Papapoulos S, Rizzoli R (2013) Association of circulating sclerostin with bone mineral mass, microstructure, and turnover biochemical markers in healthy elderly men and women. J Clin Endocrinol Metab 98:3873–3883CrossRefPubMed

23.

Bonnet N, Biver E, Durosier C, Chevalley T, Rizzoli R, Ferrari S (2015) Additive genetic effects on circulating periostin contribute to the heritability of bone microstructure. J Clin Endocrinol Metab 100:E1014–E1021CrossRefPubMed

24.

Chevalley T, Bonjour JP, van Rietbergen B, Rizzoli R, Ferrari S (2012) Fractures in healthy females followed from childhood to early adulthood are associated with later menarcheal age and with impaired bone microstructure at peak bone mass. J Clin Endocrinol Metab 97:4174–4181CrossRefPubMed

25.

Silman AJ, O'Neill TW, Cooper C, Kanis J, Felsenberg D (1997) Influence of physical activity on vertebral deformity in men and women: results from the European vertebral osteoporosis study. J Bone Miner Res 12:813–819CrossRefPubMed

26.

Perréard Lopreno G, Alves Cardoso F, Assis S, Milella M, Speith N (2013) Categorization of occupation in documented skeletal collections: its relevance for the interpretation of activity-related osseous changes. Int J Osteoarchaeol 23:175–185CrossRef

27.

Kontulainen SA, Johnston JD, Liu D, Leung C, Oxland TR, McKay HA (2008) Strength indices from pQCT imaging predict up to 85% of variance in bone failure properties at tibial epiphysis and diaphysis. J Musculoskelet Nueronal Interact 8:401–409

28.

Weatherholt AM, Avin KG, Hurd AL, Cox JL, Marberry ST, Santoni BG, Warden SJ (2014) Peripheral quantitative computed tomography predicts humeral diaphysis torsional mechanical properties with good short-term precision. J Clin Densitom. doi:10.1016/j.jocd.2014.10.002 PubMedPubMedCentral

29.

Ruff CB (2000) Body size, body shape, and long bone strength in modern humans. J Hum Evol 38:269–290CrossRefPubMed

30.

Buie HR, Campbell GM, Klinck RJ, MacNeil JA, Boyd SK (2007) Automatic segmentation of cortical and trabecular compartments based on a dual threshold technique for in vivo micro-CT bone analysis. Bone 41:505–515CrossRefPubMed

31.

Pistoia W, van Rietbergen B, Lochmuller EM, Lill CA, Eckstein F, Ruegsegger P (2002) Estimation of distal radius failure load with micro-finite element analysis models based on three-dimensional peripheral quantitative computed tomography images. Bone 30:842–848CrossRefPubMed

32.

Shaw CN (2011) Is 'hand preference' coded in the hominin skeleton? an in-vivo study of bilateral morphological variation. J Hum Evol 61:480–487CrossRefPubMed

33.

Mays S, Steele J, Ford M (1999) Directional asymmetry in the human clavicle. Int J Osteoarchaeol 9:18–28CrossRef

34.

Steele J, Mays S (1995) Handedness and directional asymmetry in the long bones of the human upper limb. Int J Osteoarchaeol 5:39–49CrossRef

35.

Seeman E (2013) Age- and menopause-related bone loss compromise cortical and trabecular microstructure. J Gerontol A Biol Sci Med Sci 68:1218–1225CrossRefPubMed

36.

Burr DB, Ruff CB, Johnson C (1989) Structural adaptations of the femur and humerus to arboreal and terrestrial environments in three species of macaque. Am J Phys Anthropol 79:357–367CrossRefPubMed

37.

Maggiano IS, Schultz M, Kierdorf H, Sosa TS, Maggiano CM, Tiesler Blos V (2008) Cross-sectional analysis of long bones, occupational activities and long-distance trade of the classic Maya from Xcambo—archaeological and osteological evidence. Am J Phys Anthropol 136:470–477CrossRefPubMed

38.

Ogilvie MD, Hilton CE (2011) Cross-sectional geometry in the humeri of foragers and farmers from the prehispanic American Southwest: exploring patterns in the sexual division of labor. Am J Phys Anthropol 144:11–21CrossRefPubMed

39.

Rhodes JA, Knusel CJ (2005) Activity-related skeletal change in medieval humeri: cross-sectional and architectural alterations. Am J Phys Anthropol 128:536–546CrossRefPubMed

40.

Mays S (2001) Effects of age and occupation on cortical bone in a group of 18th-19th century British men. Am J Phys Anthropol 116:34–44CrossRefPubMed

41.

Schaffler MB, Kennedy OD (2012) Osteocyte signaling in bone. Curr Osteoporos Rep 10:118–125CrossRefPubMedPubMedCentral

42.

Bonnet N, Standley KN, Bianchi EN, Stadelmann V, Foti M, Conway SJ, Ferrari SL (2009) The matricellular protein periostin is required for sost inhibition and the anabolic response to mechanical loading and physical activity. J Biol Chem 284:35939–35950CrossRefPubMedPubMedCentral

43.

Rizzoli R, Stevenson JC, Bauer JM, van Loon LJ, Walrand S, Kanis JA, Cooper C, Brandi ML, Diez-Perez A, Reginster JY (2014) The role of dietary protein and vitamin D in maintaining musculoskeletal health in postmenopausal women: a consensus statement from the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO). Maturitas 79:122–132CrossRefPubMed

44.

Perneger TV (1998) What's wrong with Bonferroni adjustments. BMJ 316:1236–1238CrossRefPubMedPubMedCentral

Titel: Occupation-dependent loading increases bone strength in men
verfasst von: E. Biver
G. Perréard Lopreno
M. Hars
B. van Rietbergen
J. P. Vallée
S. Ferrari
M. Besse
R. Rizzoli
Publikationsdatum: 01.03.2016
Verlag: Springer London
Erschienen in: Osteoporosis International / Ausgabe 3/2016
Print ISSN: 0937-941X
Elektronische ISSN: 1433-2965
DOI: https://doi.org/10.1007/s00198-015-3409-2

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Occupation-dependent loading increases bone strength in men