Background
Methods
Study population
Statistical analysis
STS patients
STS vs. non-cancer patients
Results
Cancer | Non-cancer | |||
---|---|---|---|---|
n | % | N | % | |
Age in years | ||||
65–69 | 475 | 13.7 | 549 | 15.8 |
70–74 | 825 | 23.7 | 836 | 24.0 |
75–79 | 880 | 25.3 | 853 | 24.5 |
80–84 | 744 | 21.4 | 715 | 20.6 |
85+ | 556 | 16.0 | 527 | 15.1 |
Race | ||||
Black | 300 | 8.6 | 301 | 8.7 |
White | 2,967 | 85.3 | 2,945 | 84.6 |
Other/unknown race | 213 | 6.1 | 234 | 6.7 |
Sex | ||||
Female | 1,843 | 53.0 | 1,972 | 56.7 |
Male | 1,637 | 47.0 | 1,508 | 43.3 |
STS subtype | ||||
Sarcoma NOS | 1,422 | 40.9 | na | na |
GIST | 845 | 24.3 | na | na |
Leiomyosarcoma | 264 | 7.6 | na | na |
Maligant fibrous histiocytoma | 224 | 6.4 | na | na |
Angiosarcoma | 184 | 5.3 | na | na |
Liposaroma | 136 | 3.9 | na | na |
Nerve sheath tumor | 118 | 3.4 | na | na |
Fibrosarcoma | 64 | 1.8 | na | na |
Synovial Sarcoma | 49 | 1.4 | na | na |
Osteosarcoma | 44 | 1.3 | na | na |
Rhabdomyosarcoma | 25 | 0.7 | na | na |
Chondrosarcoma | 25 | 0.7 | na | na |
Dermatofibrosaroma | 22 | 0.6 | na | na |
Ewing sarcoma | 19 | 0.5 | na | na |
Maligant hemangiopericytoma | 15 | 0.4 | na | na |
Clear cell sarcoma | <11 | 0.3 | na | na |
Myxosarcoma | <11 | 0.2 | na | na |
Alveolar soft part | <11 | 0.1 | na | na |
Maligant granular cell tumor | <11 | 0.1 | na | na |
Maligant giant cell tumor | <11 | 0.0 | na | na |
Primary site | ||||
Connective/subcutaneous tissue | 1,217 | 35.0 | na | na |
Digestive system | 1,107 | 31.8 | na | na |
Respiratory system | 279 | 8.0 | na | na |
Breast | 178 | 7.7 | na | na |
Other non-epithelial skin | 167 | 5.1 | na | na |
Female genital system | 160 | 4.8 | na | na |
Urinary system | 105 | 4.6 | na | na |
Other and unknown | 267 | 3.0 | na | na |
Stage | ||||
Unstaged | 482 | 13.9 | na | na |
Localized | 1,482 | 42.6 | na | na |
Regional | 800 | 23.0 | na | na |
Distant | 716 | 20.5 | na | na |
STS patients
n = 3,480 STSa patients | Incidence 12 months before STS diagnosis | Incidence 12 months after STS diagnosis |
---|---|---|
DVTa
| ||
n/person-yearsb
| 137/3,418 | 367/2,468 |
Rate/1,000c
| 40.1 (33.7–164.7) | 148.7 (133.9–164.7) |
Rate ratio (after vs. before)d
| – |
3.7 (3.0–4.5) |
PEa
| ||
n/person-yearsb
| 34/3,463 | 105/2,589 |
Rate/1,000c
| 9.8 (6.8–49.1) | 40.6 (33.2–49.1) |
Rate ratio (after vs. before)
d
| – |
4.1 (2.8–6.1) |
OTEa
| ||
n/person-yearsb
| 82/3,438 | 106/2,590 |
Rate/1,000c
| 23.9 (19.0–49.5) | 40.9 (33.5–49.5) |
Rate ratio (after vs. before)d
| – |
1.7 (1.3–2.3) |
DVTa
| PEa
| OTEa
| ||||
---|---|---|---|---|---|---|
N/P-Yb
| Rate/1,000c (95% CI) | N/P-Yb
| Rate/1,000c (95% CI) | N/P-Yb
| Rate/1,000c (95% CI) | |
By major STS subtype | ||||||
Angiosarcoma (n = 184) | 14/147 | 95.4 (52.1, 160.0) | <11 | 26.5 (7.2, 68.0) | <11 | 39.8 (14.6, 86.6) |
Fibrosarcoma (n = 64) | <11 | 72.1 (19.6, 184.5) | 0 | 0 | <11 | 17.6 (0.4, 97.8) |
GIST (n = 845) | 94/683 | 137.6 (111.2, 168.4) | 33/721 | 45.7 (31.5, 64.2) | 23/730 | 31.5 (20.0, 47.3) |
Leiomyosarcoma (n = 264) | 19/210 | 90.6 (54.5, 141.4) | <11 | 28.0 (10.3, 60.8) | <11 | 32.6 (13.1, 67.1) |
Liposarcoma (n = 224) | 13/118 | 110.1 (58.6, 188.2) | <11 | 24.5 (5.1, 71.7) | <11 | 24.5 (5.0, 71.5) |
MFH (n = 184) | 20/178 | 112.2 (68.5, 173.3) | <11 | 21.9 (6.0, 55.9) | <11 | 27.3 (8.9, 63.6) |
Nerve sheath tumor (n = 118) | 15/93 | 160.8 (90.0, 265.3) | <11 | 40.7 (11.1, 104.2) | <11 | 49.8 (16.2, 116.3) |
Sarcoma, NOS (n = 1,422) | 166/812 | 204.4 (174.5, 237.9) | 41/862 | 47.5 (34.1, 64.5) | 41/858 | 47.8 (34.3, 64.8) |
By history of VTEe
| ||||||
Yes | 61/51 | 1199.2 (917.3–1540.5) | 11/14 | 785.5 (392.3–1406.0) | 30/50 | 599.2 (404.3–855.4) |
No | 306/2,417 | 126.6 (112.8–141.6) | 94/2,575 | 27.6 (24.3–31.1) | 76/2,540 | 29.9 (23.6–37.5) |
Rate ratio (yes vs. no)d
| – |
9.5 (7.2–12.5) | – |
21.5 (11.5–40.2) | – |
20.0 (13.1–30.6) |
By history of CVD eventf
| ||||||
Yes | 120/579 | 207.3 (171.9–247.9) | 29/623 | 46.6 (31.2–66.9) | 39/619 | 63.1 (44.8–86.2) |
No | 247/1,889 | 130.8 (115.0–148.1) | 76/1,966 | 38.7 (30.5–48.4) | 67/1,971 | 34.0 (26.3–43.2) |
Rate ratio (yes vs. no)d
| – |
1.6 (1.3–2.0) |
1.2 (0.8–1.8) |
1.9 (1.3–2.8) | ||
By disease stage | ||||||
Localized | 133/1,236 | 107.6 (90.1–127.5) | 38/1,290 | 29.5 (20.9–40.4) | 34/1,295 | 26.3 (18.2–36.7) |
Regional | 93/586 | 158.7 (128.1–194.4) | 26/614 | 42.3 (27.7–62.1) | 34/610 | 55.7 (38.6–77.9) |
Distant | 86/380 | 238.9 (191.1–295.0) | 25/385 | 65.0 (42.1–95.9) | 19/387 | 49.1 (29.6–76.7) |
Rate ratio (regional and distant. vs. local)d
| – |
1.5 (1.1–1.9) | – |
1.4 (0.9–2.4) | – |
2.1 (1.3–3.4) |
By chemotherapy | ||||||
Yes | 74/324 | 227.9 (178.9–286.1) | 20/348 | 57.5 (35.1–88.7) | 19/346 | 54.9 (33.0–85.7) |
No | 293/2,413 | 136.7 (121.5–153.3) | 85/2,241 | 37.9 (30.3–46.9) | 87/2,244 | 38.8 (31.1–47.8) |
Rate ratio (yes vs. no)d
| – |
1.7 (1.3–2.2) | – |
1.5 (0.9–2.5) |
1.4 (0.9–2.3) | |
By surgery of primary tumor | ||||||
Yes | 247/1,976 | 125.0 (109.9–141.6) | 72/2,065 | 34.9 (27.3–43.9) | 76/2,064 | 36.8 (29.0–46.1) |
No | 115/467 | 246.4 (203.5–295.8) | 32/498 | 64.2 (43.9–90.7) | 29/501 | 57.9 (38.8–83.1) |
Rate ratio (yes vs. no)d
| – |
0.5 (0.4–0.6) | – |
0.5 (0.4–0.8) | – |
0.6 (0.4–1.0) |
By Primary site | ||||||
Connective/subcutaneous | 136/830 | 163.9 (137.5–193.8) | 33/877 | 37.6 (25.9–52.8) | 37/875 | 42.3 (29.8–58.3) |
Digestive system | 120/832 | 144.2 (119.5–172.4) | 38/879 | 43.2 (30.6–59.4) | 29/885 | 32.8 (22.0–47.1) |
Other/unknowng
| 111/805 | 137.8 (113.3–165.9) | 34/833 | 40.8 (28.3–57.0) | 40/830 | 48.2 (34.4–65.7) |
STS subtypea
| Hazard ratio | 95% confidence interval |
---|---|---|
Angiosarcoma | 6.4 | (1.9–21.8)+
|
GIST | 20.9 | (13.6–32.2)+
|
Leiomyosarcoma | 49.3 | (22.2–109.0)+
|
Liposarcoma | 19.1 | (4.2–87.4)+
|
MFHb
| 11.9 | (3.6–39.4)+
|
NSTc
| 15.8 | (5.8–42.7)+
|
Sarcoma NOSd
| 15.4 | (10.9–21.8)+
|
STS patients compared to an age-matched, non-cancer population
STS subtypea
| Before odds ratio (95% CI) | After hazard ratio (95% CI) |
---|---|---|
Angiosarcoma | 4.0 (1.4, 11.1)+
| 9.1 (2.1, 39.5)+
|
Fibrosarcoma | 0.5 (0.1, 2.0) | 1.0 (0.1, 16.0) |
GIST | 1.0 (0.7, 1.4) | 4.0 (2.8, 5.7)+
|
Leiomyosarcoma | 1.5 (0.6, 3.5) | 5.5 (2.1, 15.0)+
|
Liposarcoma | Not estimable | 2.5 (0.9, 7.6) |
MFHb
| 1.4 (0.6, 3.3) | 19.7 (3.7, 106.0)+
|
NSTc
| 2.1 (0.8, 5.4) | 4.4 (1.1, 17.5)+
|
Sarcoma NOSd
| 1.9 (1.4, 2.6)+
| 5.2 (3.8, 6.9)+
|