Erschienen in:
01.12.2010 | Editorial Commentary
On the effectiveness of recombinant human TSH as a stimulating agent for 131I treatment of metastatic differentiated thyroid cancer
verfasst von:
Paolo Zanotti-Fregonara, Elif Hindié
Erschienen in:
European Journal of Nuclear Medicine and Molecular Imaging
|
Ausgabe 12/2010
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Excerpt
Radiotherapy with
131I is the most effective treatment of iodine-avid metastases of differentiated thyroid cancer. Early diagnosis of metastases and repeated treatment with high activities of
131I improve outcome and allow complete remission in a substantial percentage of metastatic patients [
1,
2]. However, treatment efficacy is subordinated to the ability of cancer cells to concentrate
131I. In patients whose metastases show no initial
131I uptake, the 10-year survival can be as low as 10% [
3]. Therefore, before
131I administration, it is necessary to achieve high serum thyroid-stimulating hormone (TSH) levels in order to induce cancer cells to overexpress the sodium-iodide symporter, and thus enhance their iodine-trapping ability. …