nach oben

Journal of Neural Transmission

Erschienen in:

01.05.2012 | Basic Neurosciences, Genetics and Immunology - Original Article

On the origin of the triplet puzzle of homologies in receptor heteromers: toll-like receptor triplets in different types of receptors

verfasst von: Alexander O. Tarakanov, Kjell G. Fuxe, Dasiel O. Borroto-Escuela

Erschienen in: Journal of Neural Transmission | Ausgabe 5/2012

Einloggen, um Zugang zu erhalten

Abstract

Based on our theory, we have discovered main triplets of amino acid residues in the GABAB1 receptor and several other neural receptors, which seem to originate from toll-like receptors and appear also as homologies in receptor heteromers. The obtained results strengthen our hypothesis that these triplets may ‘guide-and-clasp’ receptor–receptor interactions.

Nur mit Berechtigung zugänglich

Agnati RF, Guidolin D, Leo G, Guescini M, Pizzi M, Stocchi V, Spano PF, Ghidoni R, Ciruela F, Genedani S, Fuxe K (2011) Possible new targets for GPCR modulation: allosteric integrations, plasma membrane domains, intercellular transfer and epigenetic mechanisms. J Recept Signal Transduct Res 31:315–331PubMedCrossRef

Akira S, Uematsu S, Takeuchi O (2006) Pathogen recognition and innate immunity. Cell 124:783–801PubMedCrossRef

Allen JA, Halverson-Tamboli RA, Rasenick MM (2007) Lipid raft microdomains and neurotransmitter signalling. Nat Rev Neurosci 8:128–140PubMedCrossRef

Block ML, Zecca L, Hong J-S (2007) Microglia-mediated neurotoxicity: uncovering the molecular mechanisms. Nat Rev Neurosci 8:57–59PubMedCrossRef

Borroto-Escuela DO, Tarakanov AO, Guidolin D, Ciruela F, Agnati LF, Fuxe K (2011a) Moonlight characteristics of G protein-coupled receptors: focus on receptor heteromers and relevance for neurodegeneration. IUBMB Life 63:463–472PubMedCrossRef

Borroto-Escuela DO, Romero-Fernandez W, Mudo G et al (2011b) FGFR1-5-HT1A heteroreceptor complexes and their enhancement of hippocampal plasticity. Biol Psych (in press)

Bulenger S, Marullo S, Bouvier M (2005) Emerging role of homo- and heterodimerization in G-protein-coupled receptor biosynthesis and maturation. Trends Pharmacol Sci 26:131–137PubMedCrossRef

Buljan M, Bateman A (2009) The evolution of protein domain families. Biochem Soc Trans 37:751–755PubMedCrossRef

Canals M, Marcellino D, Fanelli F, Ciruela F, de Benedetti P, Goldberg SR, Neve K, Fuxe K, Agnati LF, Woods AS, Ferré S, Lluis C, Bouvier M, Franco R (2003) Adenosine A2A-dopamine D2 receptor–receptor heteromerization: qualitative and quantitative assessment by fluorescence and bioluminescence energy transfer. J Biol Chem 278:46741–46749PubMedCrossRef

Charo IF, Ransohoff RM (2006) The many roles of chemokines and chemokine receptors in inflammation. N Engl J Med 354:610–621PubMedCrossRef

Couve A, Fillipov AK, Connolly CN, Bettler B, Brown DA, Moss SJ (1998) Intracellular retention of recombinant GABAB receptors. J Biol Chem 273:26361–26367PubMedCrossRef

Dzik JM (2010) The ancestry and cumulative evolution of immune reactions. Acta Biochim Pol 57:443–466PubMed

Ernst AM, Contreas FX, Brügger B, Wieland F (2010) Determinants of specificity at the protein-lipid interface in membranes. FEBS Lett 584:1713–1720PubMedCrossRef

Fallahi-Sichani M, Linderman JJ (2009) Lipid raft-mediated refulation of G-protein coupled receptor signaling by ligands which influence receptor dimerization: a computational study. PloS One 4:e6604PubMedCrossRef

Faraone D, Aguzzi MS, Ragone G, Russo K, Capogrossi MC, Facchiano A (2006) Heterodimerization of FGF-receptor 1 and PDGF-receptor-alpha: a novel mechanism underlying the inhibitory effect of PDGF-BB on FGF2 in human cells. Blood 107:1896–1902PubMedCrossRef

Fuxe KG, Tarakanov AO, Goncharova LB, Agnati LF (2008) A new road to neuroinflammation in Parkinson’s disease? Brain Res Rev 58:453–458PubMedCrossRef

Gamulin V, Rinkevich B, Schäcke H, Kruse M, Müller IM, Müller WE (1994) Cell adhesion receptors and nuclear receptors are highly conserved from the lowest metazoa (marine sponges) to vertebrates. Biol Chem Hoppe Seyler 375:583–588PubMedCrossRef

Goncharova LB, Tarakanov AO (2008) Why chemokines are cytokines while their receptors are not cytokine ones? Curr Med Chem 15:1297–1304PubMedCrossRef

Gonzalez-Maeso J et al (2008) Identification of a serotonin/glutamate receptor complex implicated in psychosis. Nature 452:93–97PubMedCrossRef

Guyon A, Nahon JL (2007) Multiple actions of the chemokine stromal cell-derived factor-1a on neuronal activity. J Mol Endocrinol 38:365–376PubMedCrossRef

Hague C, Lee SE, Chen Z, Prinster SC, Hall RA, Minneman KP (2006) Heterodimers of alpha1B- and alpha1D-adrenergic receptors form a single functional entity. Mol Pharmacol 69:45–55PubMed

He J, Xu J, Castleberry AM, Lau AG, Hall RA (2002) Glycosylation of beta(1)-adrenergic receptors refulates receptor surface expression and dimerization. Biochem Biophys Res Commun 297:565–572PubMedCrossRef

Hirono M, Yoshioka T, Konishi S (2001) GABA(B) receptor activation enhances mGluR-mediated responses at cerebellar excitatory synapses. Nat Neurosci 4:1207–1216PubMedCrossRef

Jin MS, Kim SE, Heo JY et al (2007) Crystal structure of the TL1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide. Cell 130:1071–1082PubMedCrossRef

Kammerer RA, Frank S, Schulthess T, Landwehr R, Lustig A, Engel J (1999) Heterodimerization of a functional GABAB receptor is mediated by parallel coiled-coil α-helices. Biochemistry 38:13263–13269PubMedCrossRef

Kanzok SM et al (2004) Origin of toll-like receptor-mediated innate immunity. J Mol Evol 58:442–448PubMedCrossRef

Marshall FH, Jones KA, Kaupmann K, Bettler B (2001) GABAB receptors—the first 7TM heterodimers. Trends Pharmacol Sci 20:396–399CrossRef

Pagano A, Rovelli G, Mosbacher J, Lohmann T, Duthey B, Stauffer D, Ristig D, Schuler V, Meigel I, Lampert C, Stein T, Prezeau L, Blahos J, Pin J-P, Froestl W, Kuhn R, Heid J, Kaupmann K, Bettler B (2001) C-terminal interaction is essential for surface trafficking but not for heterotrimeric assembly of GABAB receptors. J Neurosci 21:1189–1202PubMed

Pin JP, Kniazeff J, Binet V, Liu J, Maure D, Galvez T, Duthey B, Havlickova M, Blahos J, Prezeau L, Rondard P (2004) Activation mechanism of the heterodimeric GABAB receptor. Biochem Pharmacol 68:1565–1572PubMedCrossRef

Romero-Fernandez W, Borroto-Escuela DO, Tarakanov AO et al (2011) Agonist-induced formation of FGFR1 homodimers and signaling differ among members of the FGF family. Biochem Biophys Res Commun 409:764–768PubMedCrossRef

Savi P, Zachayus J-L, Delesque-Touchard N, Labouret C, Hervé C, Uzabiaga M-F, Pereillo J-M, Culouscou J-M, Bono F, Ferrara P, Herbert J-M (2006) The active metabolite of Clopidogrel disrupts P2Y12 receptor oligomers and partitions them out of lipid rafts. Proc Natl Acad Sci USA 103:11069–11074PubMedCrossRef

Tansky MF, Pothoulakis C, Leeman SE (2007) Functional consequences of alteration of N-linked glycosylation sites on the neurokinin 1 receptor. Proc Natl Acad Sci USA 104:10691–10696PubMedCrossRef

Tarakanov AO, Fuxe KG, Agnati LF, Goncharova LB (2009) Possible role of receptor heteromers in multiple sclerosis. J Neural Transm 116:989–994PubMedCrossRef

Tarakanov AO, Fuxe KG (2010) Triplet puzzle: homologies of receptor heteromers. J Mol Neurosci 41:294–303PubMedCrossRef

Tarakanov AO, Fuxe KG (2011) The triplet puzzle of homologies in receptor heteromers exists also in other types of protein–protein interactions. J Mol Neurosci 44:173–177PubMedCrossRef

Wellendorph P, Bräuner-Osborne H (2009) Molecular basis for amino acid sensing by family C G-protein-coupled receptors. Br J Pharmacol 156:869–884PubMedCrossRef

Wheatley M, Hawtin SR (1999) Glycosylation of G-protein-coupled receptors for hormones central to normal reproductive functioning: its occurrence and role. Hum Reprod Update 5:356–364PubMedCrossRef

Titel: On the origin of the triplet puzzle of homologies in receptor heteromers: toll-like receptor triplets in different types of receptors
verfasst von: Alexander O. Tarakanov
Kjell G. Fuxe
Dasiel O. Borroto-Escuela
Publikationsdatum: 01.05.2012
Verlag: Springer Vienna
Erschienen in: Journal of Neural Transmission / Ausgabe 5/2012
Print ISSN: 0300-9564
Elektronische ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-011-0734-2

Leitlinien kompakt für die Neurologie

Mit medbee Pocketcards sicher entscheiden.

^{Seit 2022 gehört die medbee GmbH zum Springer Medizin Verlag}

Kostenlos registrieren

Neu im Fachgebiet Neurologie

Akuter Schwindel: Wann lohnt sich eine MRT?

28.04.2024 Schwindel Nachrichten

Akuter Schwindel stellt oft eine diagnostische Herausforderung dar. Wie nützlich dabei eine MRT ist, hat eine Studie aus Finnland untersucht. Immerhin einer von sechs Patienten wurde mit akutem ischämischem Schlaganfall diagnostiziert.

Niedriger diastolischer Blutdruck erhöht Risiko für schwere kardiovaskuläre Komplikationen

25.04.2024 Hypotonie Nachrichten

Wenn unter einer medikamentösen Hochdrucktherapie der diastolische Blutdruck in den Keller geht, steigt das Risiko für schwere kardiovaskuläre Ereignisse: Darauf deutet eine Sekundäranalyse der SPRINT-Studie hin.

Frühe Alzheimertherapie lohnt sich

25.04.2024 AAN-Jahrestagung 2024 Nachrichten

Ist die Tau-Last noch gering, scheint der Vorteil von Lecanemab besonders groß zu sein. Und beginnen Erkrankte verzögert mit der Behandlung, erreichen sie nicht mehr die kognitive Leistung wie bei einem früheren Start. Darauf deuten neue Analysen der Phase-3-Studie Clarity AD.

Viel Bewegung in der Parkinsonforschung

25.04.2024 Parkinson-Krankheit Nachrichten

Neue arznei- und zellbasierte Ansätze, Frühdiagnose mit Bewegungssensoren, Rückenmarkstimulation gegen Gehblockaden – in der Parkinsonforschung tut sich einiges. Auf dem Deutschen Parkinsonkongress ging es auch viel um technische Innovationen.

Update Neurologie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.

Newsletter bestellen

Springer Medizin

Abstract

Bitte loggen Sie sich ein, um Zugang zu diesem Inhalt zu erhalten

Weitere Artikel der Ausgabe 5/2012

Should magnesium be given to every migraineur? No

Neuropsychology, neuroimaging or motor phenotype in diagnosis of Parkinson’s disease-dementia: which matters most?

Why all migraine patients should be treated with magnesium

Involvement of immunologic and biochemical mechanisms in the pathogenesis of Tourette’s syndrome

Reversal of stress-induced dendritic atrophy in the prefrontal cortex by intracranial self-stimulation

Intra- and inter-cortical motor excitability in Alzheimer’s disease