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Current Osteoporosis Reports
Erschienen in: Current Osteoporosis Reports 1/2023

13.12.2022 | Biomechanics (JS Nyman and V Ferguson, Section Editors)

Osteocyte Remodeling of the Lacunar-Canalicular System: What’s in a Name?

verfasst von: C. M. Heveran, J. D. Boerckel

Erschienen in: Current Osteoporosis Reports | Ausgabe 1/2023

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Abstract

Purpose of Review

Osteocytes directly modify the bone surrounding the expansive lacunar-canalicular system (LCS) through both resorption and deposition. The existence of this phenomenon is now widely accepted, but is referred to as “osteocyte osteolysis,” “LCS remodeling,” and “perilacunar remodeling,” among other names. The uncertainty in naming this physiological process reflects the many persistent questions about why and how osteocytes interact with local bone matrix. The goal of this review is to examine the purpose and nature of LCS remodeling and its impacts on multiscale bone quality.

Recent Findings

While LCS remodeling is clearly important for systemic calcium mobilization, this process may have additional potential drivers and may impact the ability of bone to resist fracture. There is abundant evidence that the osteocyte can resorb and replace bone mineral and does so outside of extreme challenges to mineral homeostasis. The impacts of the osteocyte on organic matrix are less certain, especially regarding whether osteocytes produce osteoid. Though multiple lines of evidence point towards osteocyte production of organic matrix, definitive work is needed. Recent high-resolution imaging studies demonstrate that LCS remodeling influences local material properties. The role of LCS remodeling in the maintenance and deterioration of bone matrix quality in aging and disease are active areas of research.

Summary

In this review, we highlight current progress in understanding why and how the osteocyte removes and replaces bone tissue and the consequences of these activities to bone quality. We posit that answering these questions is essential for evaluating whether, how, when, and why LCS remodeling may be manipulated for therapeutic benefit in managing bone fragility.
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Metadaten
Titel
Osteocyte Remodeling of the Lacunar-Canalicular System: What’s in a Name?
verfasst von
C. M. Heveran
J. D. Boerckel
Publikationsdatum
13.12.2022
Verlag
Springer US
Erschienen in
Current Osteoporosis Reports / Ausgabe 1/2023
Print ISSN: 1544-1873
Elektronische ISSN: 1544-2241
DOI
https://doi.org/10.1007/s11914-022-00766-3

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