Background
Results
Association between OTUB1 expression and clinicopathological variables in CRC
Variables | No. (%) | OTUB1 low | OTUB1 high | P value |
---|---|---|---|---|
Total cases
|
260
|
123 (47.3)
|
137 (52.7)
| |
Age (years)
| ||||
<65
|
171 (65.8)
|
79 (30.4)
|
92 (35.4)
|
0.62
|
≥65
|
89 (34.2)
|
44 (16.9 )
|
45 (17.3)
| |
Gender
| ||||
Male
|
140 (53.8)
|
63 (24.2)
|
77 (29.6)
|
0.421
|
Female
|
120 (46.2)
|
60 (23.1)
|
60 (23.1)
| |
Tumor location
| ||||
Colon
|
134 (51.5)
|
57 (21.9)
|
77 (29.6)
|
0.112
|
Rectum
|
126 (48.5)
|
66 (25.4)
|
60 (23.1)
| |
Tumor size (cm)
| ||||
<5
|
117 (45.0)
|
62 (23.8)
|
55 (21.2)
|
0.097
|
≥5
|
143 (55.0)
|
61 (23.5)
|
82 (31.5)
| |
Tumor invasive depth
†
| ||||
T1-T2
|
64 (24.6)
|
42 (16.1)
|
22 (8.5)
|
0.001*
|
T3-T4
|
196 (75.4)
|
81 (31.2)
|
115 (44.2)
| |
Lymph node status
| ||||
<1
|
140 (53.8)
|
76 (29.2)
|
64 (24.6)
|
0.015*
|
≥1
|
120 (46.2)
|
47 (18.1)
|
73 (28.1)
| |
Distant metastasis
| ||||
No metastasis
|
200 (76.9)
|
103 (39.6)
|
97 (37.3)
|
0.013*
|
metastasis
|
60 (23.1)
|
20 (7.7)
|
40 (15.4)
| |
AJCC/TNM stage
| ||||
I
|
61 (23.5)
|
40 (15.4)
|
21 (8.1)
|
0.003*
|
II
|
63 (24.2)
|
30 (11.5)
|
33 (12.7)
| |
III
|
76 (29.2)
|
34 (13.1)
|
42 (16.1)
| |
IV
|
60 (23.1)
|
19 (7.3)
|
41 (15.8)
| |
Chemotherapy
| ||||
Yes
|
141 (54.2)
|
59 (22.7)
|
82 (31.5)
|
0.055
|
No
|
119 (45.8)
|
64 (24.6)
|
55 (21.2)
| |
Preoperative CEA (ng/mL)
‡
| ||||
<=5
|
136 (55.3)
|
71 (28.9)
|
65 (26.4)
|
0.181
|
>5
|
110 (44.7)
|
48 (19.5)
|
62 (25.2)
|
OTUB1 overexpression is associated with poor prognosis in CRC
Variable | PFS | OS | ||
---|---|---|---|---|
HR (95% CI) | p value | HR (95% CI) | p value | |
Age (year,<65 vs ≥65)
|
1.29 (0.81-2.07)
|
0. 284
|
1.31 (0.82-2.10)
|
0.256
|
Gender (male vs female)
|
0.77 (0.48-1.22)
|
0.269
|
0.82 (0.50-1.27)
|
0.340
|
Tumor location (colon vs rectum)
|
1.39 (0.88-2.07)
|
0.161
|
1.36 (0.86-2.15)
|
0.184
|
Tumor size (cm, <5 vs ≥5)
|
0.83 (0.48-1.43)
|
0.498
|
0.85 (0.49-1.47)
|
0.553
|
Tumor invasive depth (T1-2 vs T3-4)
|
0.82 (0.33-2.00)
|
0.658
|
0.77 (0.31-1.90)
|
0.567
|
Lymph node status (<1 vs ≥1)
|
2.35 (1.25-4.41)
|
0.008*
|
2.43 (1.30-4.59)
|
0.006*
|
Distant metastasis (No vs Yes)
|
7.89 (4.58-13.61)
|
<0.001*
|
9.41 (5.49-16.16)
|
<0.001*
|
Preoperative CAE (ng/mL, <5 vs ≥5)
|
1.45 (0.86-2.44)
|
0.160
|
1.54 (0.92-2.56)
|
0.101
|
Chemotherapy (Yes vs no)
|
1.55 (0.94-2.56)
|
0.087
|
1.59 (0.96-2.62)
|
0.069
|
OTUB1 (low vs high)
|
1.61 (1.01-2.59)
|
0.049*
|
1.77 (1.10-2.86)
|
0.019*
|