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Current Bladder Dysfunction Reports
Erschienen in: Current Bladder Dysfunction Reports 4/2023

30.11.2023

Our Knowledge of the Relationship of the Urinary Microbiome and Overactive Bladder: Past, Present, Future

verfasst von: Gillian E. Jacobsen, Katherine Amin

Erschienen in: Current Bladder Dysfunction Reports | Ausgabe 4/2023

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Abstract

Purpose of Review

This review covers the latest research on the urinary microbiome and its relationship to overactive bladder. We sought to understand what urinary microbiome characteristics may be associated with overactive bladder and what research has been done to come to these conclusions.

Recent Findings

The latest research has gone beyond simply characterizing the microbial environment of urine and has transcended deeper into relationships between microbes and lower urinary tract disorders, specifically overactive bladder. Advances in next-generation sequencing technologies have largely made this possible. Multiple studies have found alterations in the urinary microbiome in patients with overactive bladder and/or urgency urinary incontinence.

Summary

Early research indicates a lack of Lactobacillus species as well as an increase in Gardnerella and Staphylococcus species may be linked to overactive bladder. Certain uropathogens such as Escherichia coli and Gardnerella vaginalis may produce neuroexcitatory molecules that induce bladder contraction. However, more research is needed to confirm these findings and find targetable mechanistic links between these microbes and disease.
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Metadaten
Titel
Our Knowledge of the Relationship of the Urinary Microbiome and Overactive Bladder: Past, Present, Future
verfasst von
Gillian E. Jacobsen
Katherine Amin
Publikationsdatum
30.11.2023
Verlag
Springer US
Erschienen in
Current Bladder Dysfunction Reports / Ausgabe 4/2023
Print ISSN: 1931-7212
Elektronische ISSN: 1931-7220
DOI
https://doi.org/10.1007/s11884-023-00726-2

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