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01.11.2014 | Original Article

Oxidative stress and recurrent aphthous stomatitis

verfasst von: Jose Bagan, Guillermo Saez, Carmen Tormos, Carmen Gavalda, Jose M. Sanchis, Leticia Bagan, Crispian Scully

Erschienen in: Clinical Oral Investigations | Ausgabe 8/2014

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Abstract

Objectives

This study analyzed the oxidative stress status in patients with recurrent aphthous stomatitis (RAS) in the presence and absence of active ulceration.

Material and methods

Oxidative stress was analyzed in peripheral mononuclear cells of 28 RAS patients with active ulceration and 29 controls. A further blood sample was collected from nine subjects randomly selected from the 28 RAS cases, during the period in which the patients did not have active oral ulceration. The reduced glutathione (GSH), malondialdehyde (MDA), and oxidized glutathione (GSSG) levels were measured in these samples.

Results

The mean MDA and GSSG levels were significantly higher in patients with active RAS than in the controls, while GSH was lower in the RAS group (p < 0.01). There was a nonsignificant tendency toward higher MDA and GSSG levels in patients with major RAS compared with minor RAS. On comparing the serum findings in the nine RAS patients in the presence and absence of lesions, the presence of ulceration was associated with even higher MDA and GSSG levels and lower GSH concentrations (p < 0.05)

Conclusions

Oxidative stress was detected in our RAS patients.

Scully C, Porter S (2008) Oral mucosal disease: recurrent aphthous stomatitis. Br J Oral Maxillofac Surg 46:198–206PubMedCrossRef

Jurge S, Kuffer R, Scully C, Porter SR (2006) Mucosal disease series. Number VI. Recurrent aphthous stomatitis. Oral Dis 12:1–21PubMedCrossRef

Natah SS, Hayrinen-Immonen R, Hietanen J (2000) Increased density of lymphocytes bearing gamma/delta T-cell receptors in recurrent aphthous ulceration (RAU). Int J Oral Maxillofac Surg 29:375–380PubMedCrossRef

Savage NW, Seymour GJ, Kruger BJ (1986) Expression of class I and class II major histocompatibility complex antigens on epithelial cells in recurrent aphthous stomatitis. J Oral Pathol 15:191–195PubMedCrossRef

Sun A, Chu CT, Liu BY et al (2000) Expression of interleukin-2 receptor by activated peripheral blood lymphocytes upregulated by the plasma level of interleukin-2 in patients with recurrent aphthous ulcers. Proc Natl Sci Counc Repub China B 24:116–122PubMed

Pekiner FN, Aytugar E, Demirel GY et al (2012) Interleukin-2, interleukin-6 and T regulatory cells in peripheral blood of patients with Behçet's disease and recurrent aphthous ulcerations. J Oral Pathol Med 41:73–79PubMedCrossRef

Bachtiar EW, Cornain S, Siregar B et al (1998) Decreased CD4+/CD8+ ratio in major type of recurrent aphthous ulcers: comparing major to minor types of ulcers. Asian Pac J Allergy Immunol 16:75–79PubMed

Sistig S, Vucicevic-Boras V, Lukac J et al (2002) Salivary IgA and IgG subclasses in oral mucosal diseases. Oral Dis 8:282–286PubMedCrossRef

Baccaglini L, Lalla RV, Bruce AJ, Sartori-Valinotti JC, Latortue MC, Carrozzo M, Rogers RS 3rd (2011) Urban legends: recurrent aphthous stomatitis. Oral Dis 17:755–770PubMedCrossRefPubMedCentral

10.

Brocklehurst P, Tickle M, Glenny AM et al (2012) Systemic interventions for recurrent aphthous stomatitis (mouth ulcers). Cochrane Database Syst Rev. 12;9:CD00541111.

11.

Cimen MY, Kaya TI, Eskandari G et al (2003) Oxidant/antioxidant status in patients with recurrent aphthous stomatitis. Clin Exp Dermatol 28:647–650PubMedCrossRef

12.

Karincaoglu Y, Batcioglu K, Erdem T et al (2005) The levels of plasma and salivary antioxidants in the patient with recurrent aphthous stomatitis. J Oral Pathol Med 34:7–12PubMedCrossRef

13.

Yardim-Akaydin S, Sepici A, Ozkan Y et al (2006) Evaluation of allantoin levels as a new marker of oxidative stress in Behçet's disease. Scand J Rheumatol 35:61–64PubMedCrossRef

14.

Cağlayan F, Miloglu O, Altun O et al (2008) Oxidative stress and myeloperoxidase levels in saliva of patients with recurrent aphthous stomatitis. Oral Dis 14:700–704PubMedCrossRef

15.

Arikan S, Durusoy C, Akalin N et al (2009) Oxidant/antioxidant status in recurrent aphthous stomatitis. Oral Dis 15:512–515PubMedCrossRef

16.

Momen-Beitollahi J, Mansourian A, Momen-Heravi F et al (2010) Assessment of salivary and serum antioxidant status in patients with recurrent aphthous stomatitis. Med Oral Patol Oral Cir Bucal 15:e557–e561PubMedCrossRef

17.

Navarro J, Obrador E, Pellicer JA et al (1997) Blood glutathione as an index of radiation-induced oxidative stress in mice and humans. Free Radic Biol Med 22:1203–1209PubMedCrossRef

18.

Brigelius R, Muckel C, Akerboom TP et al (1983) Identification and quantitation of glutathione in hepatic protein mixed disulfides and its relationship to glutathione disulfide. Biochem Pharmacol 32:2529–2534PubMedCrossRef

19.

Wong SH, Knight JA, Hopfer SM et al (1987) Lipoperoxides in plasma as measured by liquid-chromatographic separation of malondialdehyde-thiobarbituric acid adduct. Clin Chem 33:214–220PubMed

20.

Collado R, Oliver I, Tormos C et al (2012) Early ROS-mediated DNA damage and oxidative stress biomarkers in monoclonal B lymphocytosis. Cancer Lett 317:144–149PubMedCrossRef

21.

Mansego ML, Redon J, Martinez-Hervas S et al (2011) Different impacts of cardiovascular risk factors on oxidative stress. Int J Mol Sci 12:6146–6163PubMedCrossRefPubMedCentral

22.

Castañer O, Fitó M, López-Sabater MC et al (2011) The effect of olive oil polyphenols on antibodies against oxidized LDL. A randomized clinical trial. Clin Nutr 30:490–493PubMedCrossRef

23.

Klaunig JE, Kamendulis LM (2004) The role of oxidative stress in carcinogenesis. Annu Rev Pharmacol Toxicol 44:239–267PubMedCrossRef

24.

Moore T, Le A, Niemi AK (2013) A new LC-MS/MS method for the clinical determination of reduced and oxidized glutathione from whole blood. J Chromatogr B Anal Technol Biomed Life Sci 929:51–55CrossRef

25.

Redón J, Oliva MR, Tormos C et al (2003) Antioxidant activities and oxidative stress by products in human hypertension. Hypertension 41:1096–1101PubMedCrossRef

26.

Chaves FJ, Corella D, Blesa S et al (2007) Xanthine oxidoreductase polymorphisms: influence in blood pressure and oxidative stress levels. Pharmacogenet Genomics 17:589–596PubMedCrossRef

27.

López-Uriarte P, Nogués R, Saez G et al (2010) Effect of nut consumption on oxidative stress and the endothelial function in metabolic syndrome. Clin Nutr 29:373–380PubMedCrossRef

28.

Mitjavila MT, Fandos M, Salas-Salvadó J et al (2012) The Mediterranean diet improves the systemic lipid and DNA oxidative damage in metabolic syndrome individuals. A randomized, controlled, trial. Clin Nutr(Aug 31)

29.

Oliva MR, Ripoll F, Muñiz P et al (1997) Genetic alterations and oxidative metabolism in sporadic colorectal tumors from a Spanish community. Mol Carcinog 18:232–243PubMedCrossRef

30.

Sanchez M, Torres JV, Tormos C et al (2006) Impairment of antioxidant enzymes, lipid peroxidation and 8-oxo-2′-deoxyguanosine in advanced epithelial ovarian carcinoma of a Spanish community. Cancer Lett 233:28–35PubMedCrossRef

31.

Oltra AM, Carbonell F, Tormos C et al (2001) Antioxidant enzyme activities and the production of MDA and 8-oxo-dG in chronic lymphocytic leukemia. Free Radic Biol Med 30:1286–1292PubMedCrossRef

32.

Kryston TB, Georgiev AB, Pissis P et al (2011) Role of oxidative stress and DNA damage in human carcinogenesis. Mutat Res 711:193–201PubMedCrossRef

33.

Baggiolini M, Wymann MP (1990) Turning on the respiratory burst. Trends Biochem Sci 15:69–72PubMedCrossRef

34.

Gloire G, Piette J (2009) Redox regulation of nuclear post-translational modifications during NF-kappaB activation. Antioxid Redox Signal 11:2209–2222PubMedCrossRef

35.

Rahman I, Biswas SK, Kirkham PA (2006) Regulation of inflammation and redox signaling by dietary polyphenols. Biochem Pharmacol 72:1439–1452PubMedCrossRef

Titel: Oxidative stress and recurrent aphthous stomatitis
verfasst von: Jose Bagan
Guillermo Saez
Carmen Tormos
Carmen Gavalda
Jose M. Sanchis
Leticia Bagan
Crispian Scully
Publikationsdatum: 01.11.2014
Verlag: Springer Berlin Heidelberg
Erschienen in: Clinical Oral Investigations / Ausgabe 8/2014
Print ISSN: 1432-6981
Elektronische ISSN: 1436-3771
DOI: https://doi.org/10.1007/s00784-013-1181-2

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Oxidative stress and recurrent aphthous stomatitis