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Erschienen in: Hepatology International 1/2013

01.03.2013 | Review Article

Paradigms in the management of hepatic hydrothorax: past, present, and future

verfasst von: Sachin Kumar, Shiv Kumar Sarin

Erschienen in: Hepatology International | Ausgabe 1/2013

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Abstract

Hepatic hydrothorax (HH) is an infrequent but a well-known complication of portal hypertension in patients with end-stage liver disease. The estimated prevalence of HH is around 4–6 % in cirrhotics. Thoracentesis and pleural fluid analysis is a must for establishing the diagnosis of this transudative effusion in the absence of primary cardiopulmonary disease. Management strategies include sodium restriction, diuretics, thoracentesis, transjugular intrahepatic portosystemic shunt, pleurodesis, and video assisted thoracic surgery in selected patients. Liver transplantation remains the ultimate definitive management paradigm. Refractory HH thus warrants prompt consideration of liver transplantation.
Literatur
1.
2.
Zurück zum Zitat Roussos A, Philippou N, Mantzaris GJ, et al. Hepatic hydrothorax: pathophysiology diagnosis and management. J Gastroenterol Hepatol. 2007;22(9):1388–93.PubMedCrossRef Roussos A, Philippou N, Mantzaris GJ, et al. Hepatic hydrothorax: pathophysiology diagnosis and management. J Gastroenterol Hepatol. 2007;22(9):1388–93.PubMedCrossRef
3.
Zurück zum Zitat Cardenas A, Kelleher T, Chopra S. Review article: hepatic hydrothorax. Aliment Pharmacol Ther. 2004;20(3):271–9.PubMedCrossRef Cardenas A, Kelleher T, Chopra S. Review article: hepatic hydrothorax. Aliment Pharmacol Ther. 2004;20(3):271–9.PubMedCrossRef
4.
Zurück zum Zitat Chen TA, Lo GH, Lai KH. Risk factors for spontaneous bacterial empyema in cirrhotic patients with hydrothorax. J Chin Med Assoc. 2003;66(10):579–86.PubMed Chen TA, Lo GH, Lai KH. Risk factors for spontaneous bacterial empyema in cirrhotic patients with hydrothorax. J Chin Med Assoc. 2003;66(10):579–86.PubMed
5.
Zurück zum Zitat Ladero JM. Recurring hepatic hydrothorax: a difficult therapeutic challenge. Rev Esp Enferm Dig. 2001;93(9):561–5.PubMed Ladero JM. Recurring hepatic hydrothorax: a difficult therapeutic challenge. Rev Esp Enferm Dig. 2001;93(9):561–5.PubMed
6.
Zurück zum Zitat Gur C, Ilan Y, Shibolet O. Hepatic hydrothorax—pathophysiology, diagnosis and treatment—review of the literature. Liver Int. 2004;24(4):281–4.PubMedCrossRef Gur C, Ilan Y, Shibolet O. Hepatic hydrothorax—pathophysiology, diagnosis and treatment—review of the literature. Liver Int. 2004;24(4):281–4.PubMedCrossRef
7.
Zurück zum Zitat Garcia N Jr, Mihas AA. Hepatic hydrothorax: pathophysiology, diagnosis, and management. J Clin Gastroenterol. 2004;38(1):52–8.PubMedCrossRef Garcia N Jr, Mihas AA. Hepatic hydrothorax: pathophysiology, diagnosis, and management. J Clin Gastroenterol. 2004;38(1):52–8.PubMedCrossRef
8.
Zurück zum Zitat Alagiakrishnan K, Patel PJ. Left-sided hepatic hydrothorax with ascites. Int J Clin Pract. 1999;53(3):225–6.PubMed Alagiakrishnan K, Patel PJ. Left-sided hepatic hydrothorax with ascites. Int J Clin Pract. 1999;53(3):225–6.PubMed
9.
Zurück zum Zitat Gurung P, Goldblatt M, Huggins JT, et al. Pleural fluid analysis and radiographic, sonographic, and echocardiographic characteristics of hepatic hydrothorax. Chest. 2011;140(2):448–53.PubMedCrossRef Gurung P, Goldblatt M, Huggins JT, et al. Pleural fluid analysis and radiographic, sonographic, and echocardiographic characteristics of hepatic hydrothorax. Chest. 2011;140(2):448–53.PubMedCrossRef
10.
Zurück zum Zitat Zenda T, Miyamoto S, Murata S, et al. Detection of diaphragmatic defect as the cause of severe hepatic hydrothorax with magnetic resonance imaging. Am J Gastroenterol. 1998;93(11):2288–9.PubMedCrossRef Zenda T, Miyamoto S, Murata S, et al. Detection of diaphragmatic defect as the cause of severe hepatic hydrothorax with magnetic resonance imaging. Am J Gastroenterol. 1998;93(11):2288–9.PubMedCrossRef
11.
Zurück zum Zitat Huang PM, Chang YL, Yang CY, et al. The morphology of diaphragmatic defects in hepatic hydrothorax: thoracoscopic finding. J Thorac Cardiovasc Surg. 2005;130(1):141–5.PubMedCrossRef Huang PM, Chang YL, Yang CY, et al. The morphology of diaphragmatic defects in hepatic hydrothorax: thoracoscopic finding. J Thorac Cardiovasc Surg. 2005;130(1):141–5.PubMedCrossRef
12.
Zurück zum Zitat Lazaridis KN, Frank JW, Krowka MJ, et al. Hepatic hydrothorax: pathogenesis, diagnosis, and management. Am J Med. 1999;107(3):262–7.PubMedCrossRef Lazaridis KN, Frank JW, Krowka MJ, et al. Hepatic hydrothorax: pathogenesis, diagnosis, and management. Am J Med. 1999;107(3):262–7.PubMedCrossRef
14.
Zurück zum Zitat Kaplan LM, Epstein SK, Schwartz SL, et al. Clinical, echocardiographic, and hemodynamic evidence of cardiac tamponade caused by large pleural effusions. Am J Respir Crit Care Med. 1995;151(3 Pt 1):904–8.PubMed Kaplan LM, Epstein SK, Schwartz SL, et al. Clinical, echocardiographic, and hemodynamic evidence of cardiac tamponade caused by large pleural effusions. Am J Respir Crit Care Med. 1995;151(3 Pt 1):904–8.PubMed
15.
Zurück zum Zitat Castellote J, Gornals J, Lopez C, et al. Acute tension hydrothorax: a life-threatening complication of cirrhosis. J Clin Gastroenterol. 2002;34(5):588–9.PubMedCrossRef Castellote J, Gornals J, Lopez C, et al. Acute tension hydrothorax: a life-threatening complication of cirrhosis. J Clin Gastroenterol. 2002;34(5):588–9.PubMedCrossRef
16.
Zurück zum Zitat Xiol X, Castellvi JM, Guardiola J, et al. Spontaneous bacterial empyema in cirrhotic patients: a prospective study. Hepatology. 1996;23(4):719–23.PubMedCrossRef Xiol X, Castellvi JM, Guardiola J, et al. Spontaneous bacterial empyema in cirrhotic patients: a prospective study. Hepatology. 1996;23(4):719–23.PubMedCrossRef
17.
Zurück zum Zitat Foschi FG, Piscaglia F, Pompili M, et al. Real-time contrast-enhanced ultrasound—a new simple tool for detection of peritoneal-pleural communications in hepatic hydrothorax. Ultraschall Med. 2008;29(5):538–42.PubMedCrossRef Foschi FG, Piscaglia F, Pompili M, et al. Real-time contrast-enhanced ultrasound—a new simple tool for detection of peritoneal-pleural communications in hepatic hydrothorax. Ultraschall Med. 2008;29(5):538–42.PubMedCrossRef
18.
Zurück zum Zitat Nakamura A, Kojima Y, Ohmi H, et al. Peritoneal–pleural communications in hepatic hydrothorax demonstrated by thoracoscopy. Chest. 1996;109(2):579–81.PubMedCrossRef Nakamura A, Kojima Y, Ohmi H, et al. Peritoneal–pleural communications in hepatic hydrothorax demonstrated by thoracoscopy. Chest. 1996;109(2):579–81.PubMedCrossRef
19.
Zurück zum Zitat Alonso JC. Pleural effusion in liver disease. Semin Respir Crit Care Med. 2010;31(6):698–705.PubMedCrossRef Alonso JC. Pleural effusion in liver disease. Semin Respir Crit Care Med. 2010;31(6):698–705.PubMedCrossRef
20.
Zurück zum Zitat Castellote J, Xiol X, Cortes-Beut R, et al. Complications of thoracentesis in cirrhotic patients with pleural effusion. Rev Esp Enferm Dig. 2001;93(9):566–75.PubMed Castellote J, Xiol X, Cortes-Beut R, et al. Complications of thoracentesis in cirrhotic patients with pleural effusion. Rev Esp Enferm Dig. 2001;93(9):566–75.PubMed
21.
Zurück zum Zitat McVay PA, Toy PT. Lack of increased bleeding after paracentesis and thoracentesis in patients with mild coagulation abnormalities. Transfusion. 1991;31(2):164–71.PubMedCrossRef McVay PA, Toy PT. Lack of increased bleeding after paracentesis and thoracentesis in patients with mild coagulation abnormalities. Transfusion. 1991;31(2):164–71.PubMedCrossRef
22.
Zurück zum Zitat Xiol X, Castellote J, Cortes-Beut R, et al. Usefulness and complications of thoracentesis in cirrhotic patients. Am J Med. 2001;111(1):67–9.PubMedCrossRef Xiol X, Castellote J, Cortes-Beut R, et al. Usefulness and complications of thoracentesis in cirrhotic patients. Am J Med. 2001;111(1):67–9.PubMedCrossRef
23.
24.
Zurück zum Zitat Xiol X, Castellote J, Baliellas C, et al. Spontaneous bacterial empyema in cirrhotic patients: analysis of eleven cases. Hepatology. 1990;11(3):365–70.PubMedCrossRef Xiol X, Castellote J, Baliellas C, et al. Spontaneous bacterial empyema in cirrhotic patients: analysis of eleven cases. Hepatology. 1990;11(3):365–70.PubMedCrossRef
25.
Zurück zum Zitat Abba AA, Laajam MA, Zargar SA. Spontaneous neutrocytic hepatic hydrothorax without ascites. Respir Med. 1996;90(10):631–4.PubMedCrossRef Abba AA, Laajam MA, Zargar SA. Spontaneous neutrocytic hepatic hydrothorax without ascites. Respir Med. 1996;90(10):631–4.PubMedCrossRef
26.
Zurück zum Zitat Sese E, Xiol X, Castellote J, et al. Low complement levels and opsonic activity in hepatic hydrothorax: its relationship with spontaneous bacterial empyema. J Clin Gastroenterol. 2003;36(1):75–7.PubMedCrossRef Sese E, Xiol X, Castellote J, et al. Low complement levels and opsonic activity in hepatic hydrothorax: its relationship with spontaneous bacterial empyema. J Clin Gastroenterol. 2003;36(1):75–7.PubMedCrossRef
27.
Zurück zum Zitat Chen CH, Shih CM, Chou JW, et al. Outcome predictors of cirrhotic patients with spontaneous bacterial empyema. Liver Int. 2011;31(3):417–24.PubMedCrossRef Chen CH, Shih CM, Chou JW, et al. Outcome predictors of cirrhotic patients with spontaneous bacterial empyema. Liver Int. 2011;31(3):417–24.PubMedCrossRef
28.
29.
Zurück zum Zitat Gines P, Cardenas A, Arroyo V, et al. Management of cirrhosis and ascites. N Engl J Med. 2004;350(16):1646–54.PubMedCrossRef Gines P, Cardenas A, Arroyo V, et al. Management of cirrhosis and ascites. N Engl J Med. 2004;350(16):1646–54.PubMedCrossRef
30.
Zurück zum Zitat Runyon BA. Management of adult patients with ascites due to cirrhosis: an update. Hepatology. 2009;49(6):2087–107.PubMedCrossRef Runyon BA. Management of adult patients with ascites due to cirrhosis: an update. Hepatology. 2009;49(6):2087–107.PubMedCrossRef
31.
Zurück zum Zitat Kiafar C, Gilani N. Hepatic hydrothorax: current concepts of pathophysiology and treatment options. Ann Hepatol. 2008;7(4):313–20.PubMed Kiafar C, Gilani N. Hepatic hydrothorax: current concepts of pathophysiology and treatment options. Ann Hepatol. 2008;7(4):313–20.PubMed
32.
Zurück zum Zitat Tsiaousi ET, Hatzitolios AI, Trygonis SK, et al. Malnutrition in end stage liver disease: recommendations and nutritional support. J Gastroenterol Hepatol. 2008;23(4):527–33.PubMedCrossRef Tsiaousi ET, Hatzitolios AI, Trygonis SK, et al. Malnutrition in end stage liver disease: recommendations and nutritional support. J Gastroenterol Hepatol. 2008;23(4):527–33.PubMedCrossRef
33.
Zurück zum Zitat Sherman SC. Reexpansion pulmonary edema: a case report and review of the current literature. J Emerg Med. 2003;24(1):23–7.PubMedCrossRef Sherman SC. Reexpansion pulmonary edema: a case report and review of the current literature. J Emerg Med. 2003;24(1):23–7.PubMedCrossRef
34.
Zurück zum Zitat Orman ES, Lok AS. Outcomes of patients with chest tube insertion for hepatic hydrothorax. Hepatol Int. 2009;3(4):582–6.PubMedCrossRef Orman ES, Lok AS. Outcomes of patients with chest tube insertion for hepatic hydrothorax. Hepatol Int. 2009;3(4):582–6.PubMedCrossRef
35.
Zurück zum Zitat Sanyal AJ, Genning C, Reddy KR, et al. The North American study for the treatment of refractory ascites. Gastroenterology. 2003;124(3):634–41.PubMedCrossRef Sanyal AJ, Genning C, Reddy KR, et al. The North American study for the treatment of refractory ascites. Gastroenterology. 2003;124(3):634–41.PubMedCrossRef
36.
Zurück zum Zitat Gordon FD, Anastopoulos HT, Crenshaw W, et al. The successful treatment of symptomatic, refractory hepatic hydrothorax with transjugular intrahepatic portosystemic shunt. Hepatology. 1997;25(6):1366–9.PubMedCrossRef Gordon FD, Anastopoulos HT, Crenshaw W, et al. The successful treatment of symptomatic, refractory hepatic hydrothorax with transjugular intrahepatic portosystemic shunt. Hepatology. 1997;25(6):1366–9.PubMedCrossRef
37.
Zurück zum Zitat Siegerstetter V, Deibert P, Ochs A, et al. Treatment of refractory hepatic hydrothorax with transjugular intrahepatic portosystemic shunt: long-term results in 40 patients. Eur J Gastroenterol Hepatol. 2001;13(5):529–34.PubMedCrossRef Siegerstetter V, Deibert P, Ochs A, et al. Treatment of refractory hepatic hydrothorax with transjugular intrahepatic portosystemic shunt: long-term results in 40 patients. Eur J Gastroenterol Hepatol. 2001;13(5):529–34.PubMedCrossRef
38.
Zurück zum Zitat Rossle M, Gerbes AL. TIPS for the treatment of refractory ascites, hepatorenal syndrome and hepatic hydrothorax: a critical update. Gut. 2010;59(7):988–1000.PubMedCrossRef Rossle M, Gerbes AL. TIPS for the treatment of refractory ascites, hepatorenal syndrome and hepatic hydrothorax: a critical update. Gut. 2010;59(7):988–1000.PubMedCrossRef
39.
Zurück zum Zitat Spencer EB, Cohen DT, Darcy MD. Safety and efficacy of transjugular intrahepatic portosystemic shunt creation for the treatment of hepatic hydrothorax. J Vasc Interv Radiol. 2002;13(4):385–90.PubMedCrossRef Spencer EB, Cohen DT, Darcy MD. Safety and efficacy of transjugular intrahepatic portosystemic shunt creation for the treatment of hepatic hydrothorax. J Vasc Interv Radiol. 2002;13(4):385–90.PubMedCrossRef
40.
Zurück zum Zitat Salerno F, Merli M, Cazzaniga M, et al. MELD score is better than Child–Pugh score in predicting 3-month survival of patients undergoing transjugular intrahepatic portosystemic shunt. J Hepatol. 2002;36(4):494–500.PubMedCrossRef Salerno F, Merli M, Cazzaniga M, et al. MELD score is better than Child–Pugh score in predicting 3-month survival of patients undergoing transjugular intrahepatic portosystemic shunt. J Hepatol. 2002;36(4):494–500.PubMedCrossRef
41.
Zurück zum Zitat Wilputte JY, Goffette P, Zech F, et al. The outcome after transjugular intrahepatic portosystemic shunt (TIPS) for hepatic hydrothorax is closely related to liver dysfunction: a long-term study in 28 patients. Acta Gastroenterol Belg. 2007;70(1):6–10.PubMed Wilputte JY, Goffette P, Zech F, et al. The outcome after transjugular intrahepatic portosystemic shunt (TIPS) for hepatic hydrothorax is closely related to liver dysfunction: a long-term study in 28 patients. Acta Gastroenterol Belg. 2007;70(1):6–10.PubMed
42.
Zurück zum Zitat Dhanasekaran R, West JK, Gonzales PC, et al. Transjugular intrahepatic portosystemic shunt for symptomatic refractory hepatic hydrothorax in patients with cirrhosis. Am J Gastroenterol. 2010;105(3):635–41.PubMedCrossRef Dhanasekaran R, West JK, Gonzales PC, et al. Transjugular intrahepatic portosystemic shunt for symptomatic refractory hepatic hydrothorax in patients with cirrhosis. Am J Gastroenterol. 2010;105(3):635–41.PubMedCrossRef
43.
Zurück zum Zitat Mouroux J, Perrin C, Venissac N, et al. Management of pleural effusion of cirrhotic origin. Chest. 1996;109(4):1093–6.PubMedCrossRef Mouroux J, Perrin C, Venissac N, et al. Management of pleural effusion of cirrhotic origin. Chest. 1996;109(4):1093–6.PubMedCrossRef
44.
Zurück zum Zitat Milanez de Campos JR, Filho LO, de Campos Werebe E, et al. Thoracoscopy and talc poudrage in the management of hepatic hydrothorax. Chest. 2000;118(1):13–7.PubMedCrossRef Milanez de Campos JR, Filho LO, de Campos Werebe E, et al. Thoracoscopy and talc poudrage in the management of hepatic hydrothorax. Chest. 2000;118(1):13–7.PubMedCrossRef
45.
Zurück zum Zitat Takayama T, Kurokawa Y, Kaiwa Y, et al. A new technique of thoracoscopic pleurodesis for refractory hepatic hydrothorax. Surg Endosc. 2004;18(1):140–3.PubMedCrossRef Takayama T, Kurokawa Y, Kaiwa Y, et al. A new technique of thoracoscopic pleurodesis for refractory hepatic hydrothorax. Surg Endosc. 2004;18(1):140–3.PubMedCrossRef
46.
Zurück zum Zitat Ferrante D, Arguedas MR, Cerfolio RJ, et al. Video-assisted thoracoscopic surgery with talc pleurodesis in the management of symptomatic hepatic hydrothorax. Am J Gastroenterol. 2002;97(12):3172–5.PubMedCrossRef Ferrante D, Arguedas MR, Cerfolio RJ, et al. Video-assisted thoracoscopic surgery with talc pleurodesis in the management of symptomatic hepatic hydrothorax. Am J Gastroenterol. 2002;97(12):3172–5.PubMedCrossRef
47.
Zurück zum Zitat Northup PG, Harmon RC, Pruett TL, et al. Mechanical pleurodesis aided by peritoneal drainage: procedure for hepatic hydrothorax. Ann Thorac Surg. 2009;87(1):245–50.PubMedCrossRef Northup PG, Harmon RC, Pruett TL, et al. Mechanical pleurodesis aided by peritoneal drainage: procedure for hepatic hydrothorax. Ann Thorac Surg. 2009;87(1):245–50.PubMedCrossRef
48.
Zurück zum Zitat Drouhin F, Fischer D, Law Koune JD, et al. Treatment of hydrothorax in liver cirrhosis with chemical pleurodesis associated with continuous positive airway pressure ventilation. Preliminary results. Gastroenterol Clin Biol. 1991;15(3):271–2.PubMed Drouhin F, Fischer D, Law Koune JD, et al. Treatment of hydrothorax in liver cirrhosis with chemical pleurodesis associated with continuous positive airway pressure ventilation. Preliminary results. Gastroenterol Clin Biol. 1991;15(3):271–2.PubMed
49.
Zurück zum Zitat Lee WJ, Kim HJ, Park JH, et al. Chemical pleurodesis for the management of refractory hepatic hydrothorax in patients with decompensated liver cirrhosis. Korean J Hepatol. 2011;17(4):292–8.PubMedCrossRef Lee WJ, Kim HJ, Park JH, et al. Chemical pleurodesis for the management of refractory hepatic hydrothorax in patients with decompensated liver cirrhosis. Korean J Hepatol. 2011;17(4):292–8.PubMedCrossRef
50.
Zurück zum Zitat Medford AR, Bennett JA, Free CM, et al. Current status of medical pleuroscopy. Clin Chest Med. 2010;31(1):165–72. (Table of Contents).PubMedCrossRef Medford AR, Bennett JA, Free CM, et al. Current status of medical pleuroscopy. Clin Chest Med. 2010;31(1):165–72. (Table of Contents).PubMedCrossRef
51.
Zurück zum Zitat Shaw P, Agarwal R. Pleurodesis for malignant pleural effusions. Cochrane Database Syst Rev. 2004;1:CD002916.PubMed Shaw P, Agarwal R. Pleurodesis for malignant pleural effusions. Cochrane Database Syst Rev. 2004;1:CD002916.PubMed
52.
Zurück zum Zitat Lin DJ, Zhang M, Gao GX, et al. Thoracoscopy for diagnosis and management of refractory hepatic hydrothorax. Chin Med J (Engl). 2006;119(5):430–4. Lin DJ, Zhang M, Gao GX, et al. Thoracoscopy for diagnosis and management of refractory hepatic hydrothorax. Chin Med J (Engl). 2006;119(5):430–4.
53.
Zurück zum Zitat Xiol X, Tremosa G, Castellote J, et al. Liver transplantation in patients with hepatic hydrothorax. Transpl Int. 2005;18(6):672–5.PubMedCrossRef Xiol X, Tremosa G, Castellote J, et al. Liver transplantation in patients with hepatic hydrothorax. Transpl Int. 2005;18(6):672–5.PubMedCrossRef
54.
Zurück zum Zitat Serste T, Moreno C, Francoz C, et al. The impact of preoperative hepatic hydrothorax on the outcome of adult liver transplantation. Eur J Gastroenterol Hepatol. 2010;22(2):207–12.PubMedCrossRef Serste T, Moreno C, Francoz C, et al. The impact of preoperative hepatic hydrothorax on the outcome of adult liver transplantation. Eur J Gastroenterol Hepatol. 2010;22(2):207–12.PubMedCrossRef
Metadaten
Titel
Paradigms in the management of hepatic hydrothorax: past, present, and future
verfasst von
Sachin Kumar
Shiv Kumar Sarin
Publikationsdatum
01.03.2013
Verlag
Springer-Verlag
Erschienen in
Hepatology International / Ausgabe 1/2013
Print ISSN: 1936-0533
Elektronische ISSN: 1936-0541
DOI
https://doi.org/10.1007/s12072-012-9398-8

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