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Journal of Cancer Research and Clinical Oncology

Erschienen in:

13.04.2016 | Original Article – Clinical Oncology

Parotid melanoma of unknown primary

verfasst von: Jeffrey F. Scott, Cheryl L. Thompson, Ritva Vyas, Kord Honda, Chad Zender, Rod Rezaee, Pierre Lavertu, Henry Koon, Kevin D. Cooper, Meg R. Gerstenblith

Erschienen in: Journal of Cancer Research and Clinical Oncology | Ausgabe 7/2016

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Abstract

Purpose

Rarely, melanoma is discovered in the parotid gland without an identifiable primary site. It is not known how patients with parotid melanoma of unknown primary (PMUP) compare to those with a known primary (PMKP). As such, we describe the largest series of patients with PMUP to date and compare them to patients with PMKP.

Methods

We analyzed cases from three sources: (1) the University Hospitals Case Medical Center pathology database (n = 45), (2) the Surveillance, Epidemiology, and End Results 18 database (n = 33), and (3) a comprehensive literature search (n = 32).

Results

PMUP patients were predominately male and presented at a mean age of 56 years. When compared to PMKP, PMUP cases were more likely to be diagnosed in the parotid parenchyma, present with stage IV disease, and develop distant metastases during follow-up in a shorter amount of time. However, there was no difference in overall survival between patients with PMUP and PMKP presenting with stage-matched disease.

Conclusions

Overall survival is similar for stage-matched patients with parotid melanoma presenting with an unknown and known primary site.

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Titel: Parotid melanoma of unknown primary
verfasst von: Jeffrey F. Scott
Cheryl L. Thompson
Ritva Vyas
Kord Honda
Chad Zender
Rod Rezaee
Pierre Lavertu
Henry Koon
Kevin D. Cooper
Meg R. Gerstenblith
Publikationsdatum: 13.04.2016
Verlag: Springer Berlin Heidelberg
Erschienen in: Journal of Cancer Research and Clinical Oncology / Ausgabe 7/2016
Print ISSN: 0171-5216
Elektronische ISSN: 1432-1335
DOI: https://doi.org/10.1007/s00432-016-2156-x

Springer Medizin

Parotid melanoma of unknown primary