Erschienen in:
01.12.2002 | Paper Report
Pathogenic role of anti-myeloperoxidase ANCA
verfasst von:
Martin Aringer
Erschienen in:
Arthritis Research & Therapy
|
Ausgabe 1/2001
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Excerpt
Antineutrophil cytoplasmatic antibodies (ANCA) are present in many patients with systemic vasculitides, with myeloperoxidase (MPO) and proteinase-3 (PR-3) being the main autoantigens in (microscopic) panarteritis nodosa (PAN) and Wegener's granulomatosis (WG), respectively. ANCA are associated with disease activity, but their role in disease pathogenesis has remained obscure. …