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Rheumatology International

Erschienen in:

01.02.2011 | Review

Pathophysiology and antioxidant status of patients with fibromyalgia

verfasst von: Riffat Iqbal, M. S. Mughal, Najma Arshad, Muhammad Arshad

Erschienen in: Rheumatology International | Ausgabe 2/2011

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Abstract

Fibromyalgia syndrome (FMS) is characterized by systemic pain of unknown etiology and is often accompanied by various psychological symptoms. Research on different parameters in fibromyalgia (FM) indicates that multifactors are involved in its pathophysiology; such as genetic factors, substance P, serotonin, hypothalamic pituitary adrenal axis (HPA), muscles metabolic dysfunction, reactive oxygen species (ROS) and reactive nitrogen species (RNS). Oxidative stress has also been implicated in the pathophysiology of FM; therefore, supplementation with antioxidants may be important in modulation of the effects of ROS in patients with FM.

Goldenberg DL (1997) Fibromyalgia, chronic fatigue syndrome, and myofascial pain syndrome. Curr Opin Rheumatol 9:135–143. doi:10.1097/00002281-199703000-00010 CrossRefPubMed

Wolfe F, Anderson J, Harkness D, Bennett RM, Caro XJ, Goldenberg DL, Russell IJ, Yunus MB (1997) Health status and disease severity in fibromyalgia: results of a six-center longitudinal study. Arthritis Rheum 40:1571–1579. doi:10.1002/art.1780400905 CrossRefPubMed

Hudson JI, Goldenberg DL, Pope HG, Keck PE, Schlesinger L (1992) Comorbidity of fibromyalgia with medical and psychiatric disorders. Am J Med 92:363–367. doi:10.1016/0002-9343(92)90265-D CrossRefPubMed

Houdenhove BV, Luyten P (2006) Stress depression and fibromyalgia. Acta Neurol Belg 149–156

Olson J (2004) Mapping genes for fibromyalgia. NIAMS spotlight on research, fibromyalgia: summaries of research. National institute of arthritis and musculoskeletal and skin diseases

Griep EN, Boersma JW, De Kloet ER (1993) Altered reactivity of the hypothalamic-pituitary-adrenal axis in the primary fibromyalgia syndrome. J Rheumatol 20:469–474PubMed

Crofford LJ, Pillemer SR, Kalogeras KT (1994) Hypothalamic-pituitary-adrenal axis perturbations in patients with fibromyalgia. Arthritis Rheum 11:1583–1592. doi:10.1002/art.1780371105 CrossRef

Ross R, Jones K, Eldredge D (2004) Clinical and biochemical features of atypical and melancholic depression subtypes in fibromyalgia patients. Program and abstracts of the American College of Rheumatology (ACR) 71st annual meeting

Russell IJ, Michalek JE, Vipraio GA, Fletcher EM, Javors MA, Bowden CA (1992) latelet 3H-imipramine uptake receptor density and serum serotonin levels in patients with fibromyalgia/fibrositis syndrome. J Rheumatol 19:104–109PubMed

10.

Yunus MB, Dailey JW, Aldag JC, Masi AT, Jobe PC (1992) Plasma tryptophan and other amino acids in primary fibromyalgia. A controlled study. J Rheumatol 19:90–94PubMed

11.

Larson AA, Giovengo SL, Russell IJ, Michalek JE (2000) Changes in the concentrations of amino acids in the cerebrospinal fluid that correlate with pain in patients with fibromyalgia: implications for nitric oxide pathways. Pain 87:201–211. doi:10.1016/S0304-3959(00)00284-0 CrossRefPubMed

12.

Vaeroy H, Helle R, Forre O (1998) Elevated CSF levels of substance P and high incidence of Raynaud phenomenon in patients with fibromyalgia. New features for diagnosis. Pain 32:21–26. doi:10.1016/0304-3959(88)90019-X CrossRef

13.

Rauch SL, Shin LM, Phelps EA (2006) Neurocircuitry models of posttraumatic stress disorder and extinction: human neuroimaging research—past, present, and future. Biol Psychiatry 60:376–382. doi:10.1016/j.biopsych.2006.06.004 CrossRefPubMed

14.

Harris RH, Sundgren PC, Pang Y (2007) Variation in glutamate and glutamine levels within the insula are associated with improvements in clinical and experimental pain in fibromyalgia. Program and abstracts of the American College of Rheumatology (ACR) 71st annual meeting. Boston, Massachusetts

15.

Buskila D, Neumann L, Vaisberg G, Alkalay D, Wolfe F (1997) Increased rates of fibromyalgia following cervical spine injury. A controlled study of 161 cases of traumatic injury. Arthritis Rheum 40(3):446–452. doi:10.1002/art.1780400310 CrossRefPubMed

16.

Jeschonneck M, Graohmann G, Hein G, Sprott H (2002) Abnormal microcirculation and temperature in skin above tender points in patients with fibromyalgia. Rheumatology 39:917–921. doi:10.1093/rheumatology/39.8.917 CrossRef

17.

Lund N, Bengtsson A, Thorborg P (1986) Muscle oxygen tissue pressure in primary fibromyalgia. Scand J Rheumatol 15:165–173. doi:10.3109/03009748609102084 CrossRefPubMed

18.

Titova DC, Oeser A, Chung CP, et al (2007) Oxidative stress in fibromyalgia: relationship to symptoms. Program and abstracts of the American college of Rheumatology (ACR) 71st annual meeting

19.

Bilici M, Efe H, Koroglu MA, Uydu HA, Bekaroglu M, Deger O (2001) Antioxidative enzyme activities and lipid peroxidation in major depression: alterations by antidepressant treatments. J Affect Disord 64:43–51. doi:10.1016/S0165-0327(00)00199-3 CrossRefPubMed

20.

Eisinger J, Gandolfo C, Zakarian H, Ayavou T (1997) Reactive oxygen species, antioxidant status and fibromyalgia. J Musculoskeletal Pain 5:5–15. doi:10.1300/J094v05n04_02 CrossRef

21.

Bagis S, Tamer L, Sahin G, Bilgin R, Guler H, Ercan B, Erdogan C (2005) Free radicals and antioxidants in primary fibromyalgia: an oxidative stress disorder. Rheumatol Int 25:188–190. doi:10.1007/s00296-003-0427-8 CrossRefPubMed

22.

Ozgocmen S, Ozyurt H, Sogut S, Akyol O, Ardicoglu O, Yidizhan H (2005) Antioxidant status, lipid peroxidation and nitric oxide in fibromyalgia: etiologic and therapeutic concerns. Rheumatol Int

23.

Sendur OF, Turan Y, Tastaban E, Yenisey C, Serter M (2008) Serum antioxidants and nitric oxide levels in fibromyalgia: a controlled study. Rheumatol Int

24.

Wu G, Fang YZ, Yang S, Lupton JR, Turner ND (2004) Glutathione metabolism and its implications for health. J Nutr 134(3):489–492PubMed

25.

Altindag O, Celik H (2006) Total antioxidant capacity and the severity of the pain in patients with fibromyalgia. Redox Rep 11:131–135. doi:10.1179/135100006X116628 CrossRefPubMed

26.

Cipollone JVF, Falasca K, Mezzetti A, Pizzigallo E, Bucciarelli T, Laurentis SD, Affaitati G, Cesare DD, Giamberardino AD (2003) Relationship between musculoskeletal symptoms and blood markers of oxidative stress in patients with chronic fatigue syndrome. Neurosci Lett 335:151–154. doi:10.1016/S0304-3940(02)01058-3 CrossRefPubMed

27.

Richard EH, Kahn K (2007) Current advances in understanding the pathophysiology of Fibromyalgia. American college of Rheumatology. 71st annual meeting

28.

Manuel YKB, Moorkens G, Vertommen J, Noé M, Neve J, De Leeuw I (2000) Magnesium status and parameters of the oxidant–antioxidant balance in patients with chronic fatigue: effects of supplementation with magnesium. J Am Coll Nutr 19:374–382

29.

Ozgocmen S, Sogut S, Ardicoglu O, Fadillioglu E, Pekkutucu I, Akyol O (2004) Serum nitric oxide, catalase, superoxide dismutase, and malondialdehyde status in patients with ankylosing spondylitis. Rheumatol Int 24:80–83. doi:10.1007/s00296-003-0335-y CrossRefPubMed

30.

Jackson MJ, O’Farrell S (1993) Free radicals and muscle damage. Br Med Bull 49(3):630–641PubMed

31.

Okumus M, Gokoglu F, Kocaoglu S, Ceceli E, Yorgancioglu ZR (2006) Muscle performance in patients with fibromyalgia. Singapore Med J 47:752–756PubMed

32.

Buchwald D, Garrity D (1994) Comparison of patients with chronic fatigue syndrome, fibromyalgia, and multiple chemical sensitivities. Arch Intern Med 26:2049–2053. doi:10.1001/archinte.154.18.2049 CrossRef

33.

Singh A, Naidu PS, Gupta S, Kulkarni SK (2002) Effect of natural and synthetic antioxidants in a mouse model of chronic fatigue syndrome. J Med Food 5(4):211–220. doi:10.1089/109662002763003366 CrossRefPubMed

34.

Zaidi SM, Al-Qirim TM, Banu N (2005) Effects of antioxidant vitamins on glutathione depletion and lipid peroxidation induced by restraint stress in the rat liver. Drugs R D 6(3):157–165. doi:10.2165/00126839-200506030-00004 CrossRefPubMed

35.

Vijayaraghavan R, Suribabu CS, Sekar B, Oommen PK, Kavithalakshmi SN, Madhusudhanan N, Panneerselvam C (2005) Protective role of vitamin E on the oxidative stress in Hansen’s disease (Leprosy) patients. Eur J Clin Nutr 59(10):1121–1128. doi:10.1038/sj.ejcn.1602221 CrossRefPubMed

36.

Cao G, Booth SL, Sadowski JA, Prior RL (1998) Increases in human plasma antioxidant capacity after consumption of controlled diets high in fruit and vegetables. Am J Clin Nutr 68:1081–1087PubMed

37.

Merchant RE, Carmack CA, Wise CM (2000) Nutritional supplementation with Chlorella pyrenoidosa for patients with fibromyalgia syndrome: a pilot study. Phytother Res 14:167–173. doi:10.1002/(SICI)1099-1573(200005)14:3<167:AID-PTR560>3.0.CO;2-R CrossRefPubMed

38.

Deshpande RA, Adhikary P, Tipnis H (1974) Stored grain pest control agent from Nigella sativa and pogostemon heyneanus. Bull Grain Tech 12:232–234

39.

Nair SC, Salomi MJ, Panikkar B, Panikkar KR (1991) Modulatory effects of Crocus sativus and Nigella sativa extracts on cisplatin-induced toxicity in mice. Jethenopharm col 31:75–83

40.

Badary OA, Taha RA, Gamel El Din AM, Abdel Wahab MH (2002) The in vitro antioxidant and pro-oxidant action of thymoquinone and tert butylhydroquinone. Egypt J Biochem Mol Biol 20:1–16

41.

Riaz M, Syed M, Chaudhary FM (1996) Chemistry of the medicinal plants of the genus Nigella. Hamdard Med 39:40–45

42.

Hanafy MSM, Hatem ME (1991) Studies on the antimicrobial activity of Nigella sativa seed. J Ethnopharmacol 34:275–278. doi:10.1016/0378-8741(91)90047-H CrossRefPubMed

43.

Burits M, Bucar F (2000) Antioxidant activity of Nigella sativa essential oil. Phytother Res 14:323–328. doi:10.1002/1099-1573(200008)14:5<323:AID-PTR621>3.0.CO;2-Q CrossRefPubMed

Titel: Pathophysiology and antioxidant status of patients with fibromyalgia
verfasst von: Riffat Iqbal
M. S. Mughal
Najma Arshad
Muhammad Arshad
Publikationsdatum: 01.02.2011
Verlag: Springer-Verlag
Erschienen in: Rheumatology International / Ausgabe 2/2011
Print ISSN: 0172-8172
Elektronische ISSN: 1437-160X
DOI: https://doi.org/10.1007/s00296-010-1470-x

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