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01.09.2014 | Original Communication

Patterns of regional gray matter and white matter atrophy in cortical multiple sclerosis

verfasst von: Laura Parisi, Maria A. Rocca, Flavia Mattioli, Gianna C. Riccitelli, Ruggero Capra, Chiara Stampatori, Fabio Bellomi, Massimo Filippi

Erschienen in: Journal of Neurology | Ausgabe 9/2014

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Abstract

We investigated the patterns of regional distribution of focal lesions, white matter (WM) and gray matter (GM) atrophy in patients with cortical (cort) MS in comparison to classical (c) MS patients. Nine cort-MS, nine c-MS and nine age-matched healthy controls (HC) underwent a brain MRI exam, including FLAIR and high-resolution T1-weighted scans. MS patients underwent neurological and neuropsychological assessment. Between-group differences of GM and WM volumes and their correlations with neuropsychological performances were assessed with voxel-based morphometry. FLAIR and T1 lesion probability maps (LPMs) were also obtained. Performance at neuropsychological tests was worse in cort-MS than in c-MS patients. Compared to HC, MS patients had a distributed pattern of GM and WM atrophy. No GM/WM area was more atrophic in c-MS vs cort-MS patients. Compared to c-MS, cort-MS patients experienced GM atrophy of frontal–temporal–parietal areas and cingulate cortex and WM atrophy of the cingulum bundle, bilateral cerebral peduncles, right inferior longitudinal fasciculus and left superior longitudinal fasciculus. FLAIR and T1 LPMs did not differ between c-MS vs cort-MS patients. A higher susceptibility to neurodegenerative processes in key brain regions known to be related to cognitive functions is likely to underlie the clinical manifestations of cort-MS.

Herderschee D, Stam J, Derix MM (1987) Aphemia as a first symptom of multiple sclerosis. J Neurol Neurosurg Psychiatry 50:499–500PubMedCentralCrossRefPubMed

Achiron A, Ziv I, Djaldetti R, Goldberg H, Kuritzky A, Melamed E (1992) Aphasia in multiple sclerosis: clinical and radiologic correlations. Neurology 42:2195–2197CrossRefPubMed

Skegg K (1993) Multiple sclerosis presenting as a pure psychiatric disorder. Psychol Med 23:909–914CrossRefPubMed

Zarei M, Chandran S, Compston A, Hodges J (2003) Cognitive presentation of multiple sclerosis: evidence for a cortical variant. J Neurol Neurosurg Psychiatry 74:872–877PubMedCentralCrossRefPubMed

Zarei M (2006) Clinical characteristics of cortical multiple sclerosis. J Neurol Sci 245:53–58CrossRefPubMed

Benedict RH, Carone DA, Bakshi R (2004) Correlating brain atrophy with cognitive dysfunction, mood disturbances, and personality disorder in multiple sclerosis. J Neuroimaging 14:36S–45SCrossRefPubMed

Morgen K, Sammer G, Courtney SM, Wolters T, Melchior H, Blecker CR, Oschmann P et al (2006) Evidence for a direct association between cortical atrophy and cognitive impairment in relapsing–remitting MS. Neuroimage 30:891–898CrossRefPubMed

Riccitelli G, Rocca MA, Pagani E, Rodegher ME, Rossi P, Falini A, Comi G et al (2011) Cognitive impairment in multiple sclerosis is associated to different patterns of gray matter atrophy according to clinical phenotype. Hum Brain Mapp 32:1535–1543CrossRefPubMed

Orme JE (1961) The Coloured Progressive Matrices as a measure of intellectual subnormality. Br J Med Psychol 34:291–292CrossRefPubMed

10.

De Renzi E, Vignolo LA (1962) The token test: a sensitive test to detect receptive disturbances in aphasics. Brain 85:665–678CrossRef

11.

Novelli GPC, Capitani E, Laiacona M, Cappa SF, Vallar G (1986) Tre test clinici di memoria verbale a lungo termine. Taratura su soggetti normali. Archivio di Psicologia Neurologia e Psichiatria 2:278–296

12.

Spinnler HTG (1987) Standardizzazione e taratura italiana di test psicometrici. Ital J Neurol Sci 8:7–120

13.

Orsini AGD, Capitani E, Laiacona M, Papagno C, Vallar G (1987) Verbal and spatial immediate memory span: normative data from 1355 adults and 112 children. Ital J Neurol Sci 8:539–548CrossRefPubMed

14.

Amato MP, Portaccio E, Goretti B, Zipoli V, Ricchiuti L, De Caro MF, Patti F et al (2006) The Rao’s Brief Repeatable Battery and Stroop Test: normative values with age, education and gender corrections in an Italian population. Mult Scler 12:787–793CrossRefPubMed

15.

Montgomery SA, Asberg M (1979) A new depression scale designed to be sensitive to change. Br J Psychiatry 134:382–389CrossRefPubMed

16.

Chard DT, Jackson JS, Miller DH, Wheeler-Kingshott CA (2010) Reducing the impact of white matter lesions on automated measures of brain gray and white matter volumes. J Magn Reson Imaging 32:223–228CrossRefPubMed

17.

Smith SM, Zhang Y, Jenkinson M, Chen J, Matthews PM, Federico A, De Stefano N (2002) Accurate, robust, and automated longitudinal and cross-sectional brain change analysis. Neuroimage 17:479–489CrossRefPubMed

18.

Tzourio-Mazoyer N, Landeau B, Papathanassiou D, Crivello F, Etard O, Delcroix N, Mazoyer B et al (2002) Automated anatomical labeling of activations in SPM using a macroscopic anatomical parcellation of the MNI MRI single-subject brain. Neuroimage 15:273–289CrossRefPubMed

19.

Mori S, Wakana S, Van Zijl PCM, Nagae-Poetscher LM (2005) MRI atlas of human white matter. Elsevier, Amsterdam

20.

Metzler-Baddeley C, Jones DK, Steventon J, Westacott L, Aggleton JP, O’Sullivan MJ (2012) Cingulum microstructure predicts cognitive control in older age and mild cognitive impairment. J Neurosci: Off J Soc Neurosci 32:17612–17619CrossRef

21.

Villain N, Desgranges B, Viader F, de la Sayette V, Mezenge F, Landeau B, Baron JC et al (2008) Relationships between hippocampal atrophy, white matter disruption, and gray matter hypometabolism in Alzheimer’s disease. J Neurosci: Off J Soc Neurosci 28:6174–6181CrossRef

22.

Villain N, Fouquet M, Baron JC, Mezenge F, Landeau B, de La Sayette V, Viader F et al (2010) Sequential relationships between grey matter and white matter atrophy and brain metabolic abnormalities in early Alzheimer’s disease. Brain 133:3301–3314PubMedCentralCrossRefPubMed

23.

Zhang S, Li CS (2014) Functional clustering of the human inferior parietal lobule by whole-brain connectivity mapping of resting-state functional magnetic resonance imaging signals. Brain Connect 4:53–69PubMedCentralPubMed

24.

Davachi L, Maril A, Wagner AD (2001) When keeping in mind supports later bringing to mind: neural markers of phonological rehearsal predict subsequent remembering. J Cogn Neurosci 13:1059–1070CrossRefPubMed

25.

Stoeckel C, Gough PM, Watkins KE, Devlin JT (2009) Supramarginal gyrus involvement in visual word recognition. Cortex 45:1091–1096PubMedCentralCrossRefPubMed

26.

Westerhausen R, Kompus K, Hugdahl K (2014) Mapping hemispheric symmetries, relative asymmetries, and absolute asymmetries underlying the auditory laterality effect. Neuroimage 84:962–970CrossRefPubMed

27.

Nagels A, Kauschke C, Schrauf J, Whitney C, Straube B, Kircher T (2013) Neural substrates of figurative language during natural speech perception: an fMRI study. Front Behav Neurosci 7:121PubMedCentralPubMed

28.

Tanaka S, Honda M, Sadato N (2005) Modality-specific cognitive function of medial and lateral human Brodmann area 6. J Neurosci: Off J Soc Neurosci 25:496–501CrossRef

29.

Nachev P, Kennard C, Husain M (2008) Functional role of the supplementary and pre-supplementary motor areas. Nat Rev Neurosci 9:856–869CrossRefPubMed

30.

Fox CJ, Iaria G, Barton JJ (2008) Disconnection in prosopagnosia and face processing. Cortex 44:996–1009CrossRefPubMed

31.

ffytche DH, Catani M (2005) Beyond localization: from hodology to function. Philos Trans R Soc Lond B Biol Sci 360:767–779PubMedCentralCrossRefPubMed

32.

Peters BD, Szeszko PR, Radua J, Ikuta T, Gruner P, DeRosse P, Zhang JP et al (2012) White matter development in adolescence: diffusion tensor imaging and meta-analytic results. Schizophr Bull 38:1308–1317PubMedCentralCrossRefPubMed

33.

Lebel C, Beaulieu C (2009) Lateralization of the arcuate fasciculus from childhood to adulthood and its relation to cognitive abilities in children. Hum Brain Mapp 30:3563–3573CrossRefPubMed

34.

Robertson IH (2013) A noradrenergic theory of cognitive reserve: implications for Alzheimer’s disease. Neurobiol Aging 34:298–308CrossRefPubMed

35.

Stricker NH, Schweinsburg BC, Delano-Wood L, Wierenga CE, Bangen KJ, Haaland KY, Frank LR et al (2009) Decreased white matter integrity in late-myelinating fiber pathways in Alzheimer’s disease supports retrogenesis. Neuroimage 45:10–16PubMedCentralCrossRefPubMed

Titel: Patterns of regional gray matter and white matter atrophy in cortical multiple sclerosis
verfasst von: Laura Parisi
Maria A. Rocca
Flavia Mattioli
Gianna C. Riccitelli
Ruggero Capra
Chiara Stampatori
Fabio Bellomi
Massimo Filippi
Publikationsdatum: 01.09.2014
Verlag: Springer Berlin Heidelberg
Erschienen in: Journal of Neurology / Ausgabe 9/2014
Print ISSN: 0340-5354
Elektronische ISSN: 1432-1459
DOI: https://doi.org/10.1007/s00415-014-7409-5

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