Erschienen in:
20.05.2023 | Letter to the Editor
Pediatric onset primary progressive multiple sclerosis with predominant cognitive presentation: a longitudinal MRI and cognitive follow-up
verfasst von:
Gabriel de Deus Vieira, Mariana Moreira Soares de Sá, Ana Carolina Amaral de Andrade, Carla Renata Aparecida Vieira Stella, Alfredo Damasceno
Erschienen in:
Neurological Sciences
|
Ausgabe 10/2023
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Excerpt
Primary Progressive Multiple Sclerosis (PPMS) occurs in 10–15% of patients with MS, with a progressive evolution of symptoms, usually not having well-defined relapses, and often leading to a diagnosis delay by months or even years [
1]. Most cases start by age 40 with rare cognitive manifestations in their initial presentation. Among the clinical manifestations, spastic paraparesis is the most common (80%), followed by cerebellar ataxia (15%). In addition, cases of pediatric PPMS are even less common (2.3 to 7% of all patients with pediatric MS) [
2]. Here, we report a rare case of pediatric-onset PPMS with an atypical presentation of cognitive and neuropsychiatric symptoms, describing a magnetic resonance imaging (MRI) and cognitive evaluation follow-up. …
