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Child's Nervous System
Erschienen in: Child's Nervous System 6/2019

05.04.2019 | Review Article

Perinatal (fetal and neonatal) choroid plexus tumors: a review

verfasst von: John R. Crawford, Hart Isaacs Jr

Erschienen in: Child's Nervous System | Ausgabe 6/2019

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Abstract

Introduction

The object of this review is to describe the choroid plexus tumors (CPTs) occurring in the fetus and neonate with regard to clinical presentation, location, pathology, treatment, and outcome.

Materials and methods

Case histories and clinical outcomes were reviewed from 93 cases of fetal and neonatal tumors obtained from the literature and our own institutional experience from 1980 to 2016.

Results

Choroid plexus papilloma (CPP) is the most common tumor followed by choroid plexus carcinoma (CPC) and atypical choroid plexus papilloma (ACPP). Hydrocephalus and macrocephaly are the presenting features for all three tumors. The lateral ventricles are the main site of tumor origin followed by the third and fourth ventricles, respectively. CPTs of the fetus are detected most often near the end of the third trimester of pregnancy by fetal ultrasound. The extent of surgical resection plays an important role in the treatment and outcome. In spite of excellent survival, which is especially true in the case of CPP, surgical resection may carry significant risks in an immature baby. Given the neonatal low blood volume and increased vascularity of the tumors, there is potential risk for hemorrhage. Although advances in neurosurgical techniques have led to a greater degree of complete surgical resections, survival for the perinatal CPC group remains low even with multimodality therapies.

Conclusion

Perinatal CPTs have variable overall survivals depending on degree of surgical resection and tumor biology. An increased understanding of the molecular features of these tumors may lead to improved therapies and ultimately survival.
Literatur
1.
Adra AM, Mejides AA, Salman FA (1994) Prenatal sonographic diagnosis of a third ventricle choroid plexus papilloma. Prenat Diagn 14:865–867CrossRefPubMed
2.
3.
Aljared T, Farmer J, Tampieri D (2016) Feasibility and value of preoperative embolization of a congenital choroid plexus tumour in the premature infant: an illustrative case report with technical details. Interv Neuroradiol 22(6):732–735CrossRefPubMedPubMedCentral
4.
Anselem O, Mezzetta L, Grangé G, Zerah M, Benard C, Marcou V, Fallet-Bianco C, Adamsbaum C, Tsatsaris V (2011) Fetal tumors of the choroid plexus: is differential diagnosis between papilloma and carcinoma possible? Ultrasound Obstetr Gynecol 38:229–232CrossRef
5.
Barber MA, Eguiluz I, Plasencia W, Medina M, Valle L (2009) Intracranial fetal hemorrhage due to choroid plexus papilloma. Inter Gynecol Obstetr 105:172–173CrossRef
6.
Bekiesinska Figatowska M, Jurkiewicz E, Duczkowski M et al (2011) Congenital CNS tumors diagnosed on prenatal MRI. Neuroradiol J 24:477–481CrossRefPubMed
7.
Britz GW, Kim DK, Loeser JD (1996) Hydrocephalus secondary to diffuse villous hyperplasia of the choroid plexus. Case report and review of the literature. J Neurosurg 85:689–691CrossRefPubMed
8.
Broad RW, Allen PB (1984) Third ventricle choroid plexus carcinoma. Canad J Neurol Sci 11:461–465CrossRefPubMed
9.
Burger PC, Scheithauer BW (2007) Tumors of the central nervous system. Atlas of tumor pathology, 4th series, fascicle 7. Armed forces Institute of Pathology, Washington, D.C.
10.
Carlotti CG, Salhia B, Weitzman S, Greenberg M, Dirks PB, Mason W, Becker LE, Rutka JT (2002) Evaluation of proliferative index and cell cycle protein expression in choroid plexus tumors in children. Acta Neuropathol 103:1–10CrossRefPubMed
11.
Cassart M, Bosson N, Garel C, Eurin D, Avni F (2008) Fetal intracranial tumors: a review of 27 cases. Eur Radiol 18:2060–2066CrossRefPubMed
12.
Cavalheiro S, Moron AF, Hisaba W, Dastoli P, Silva NS (2003) Fetal brain tumors. Child Nerv Syst 19:529–536CrossRef
13.
Chow PP, Horgan JG, Burns PN, Weltin G, Taylor KJ (1986) Choroid plexus papilloma: detection by real-time and Doppler sonography. AJNR Am J Neuroradiol 7:168–170PubMed
14.
Chow E, Reardon DA, Shah AB (1999) Pediatric choroid plexus neoplasms. Inter J Radiat Oncol Biol Phys 44:249–254CrossRef
15.
Cohen ZR, Achiron R, Feldman Z (2002) Prenatal sonographic diagnosis of lateral ventricle choroid plexus papilloma in an in vitro fertilization-induced pregnancy. Pediatr Neurosurg 37:267–270CrossRefPubMed
16.
Costa JM, Ley L, Claramunt E et al (1997) Choroid plexus papillomas of the III ventricle in infants. Report of three cases. Child Nerv Syst 13(5):244–249CrossRef
17.
D’Ambrosio AL, O’Toole JE, Connolly ES et al (2003) Villous hypertrophy versus choroid plexus papilloma: a case report demonstrating a diagnostic role for the proliferation index. Pediatr Neurosurg 39:91–96CrossRefPubMed
18.
de Oliveira RS, Deriggi DJ, Furlanetti LL et al (2015) The impact of surgical resection of giant supratentorial brain tumor in pediatric patients: safety and neurological outcome evaluated in 23 consecutive cases. Child Nerv Syst 31:67–75CrossRef
19.
Di Rocco C, Iannelli A (1997) Poor outcome of bilateral congenital choroid plexus papillomas with extreme hydrocephalus. Eur Neurol 37:33–37CrossRefPubMed
20.
Ditz C, Nowak G, Koch C et al (2013) Atypical choroid plexus papilloma in a newborn: prenatal diagnosis, preoperative tumor embolization, and resection. J Neurol Surg Part A: Central Europe Neurosurg 74:59–63
21.
Donnenfeld AE, Packer RJ, Zackai EH, Chee CM, Sellinger B, Emanuel BS (1989) Clinical, cytogenetic, and pedigree findings in 18 cases of Aicardi syndrome. Am J Med Genet 32:461–467CrossRefPubMed
22.
Duffner PK, Kun LE, Burger PC, Horowitz ME, Cohen ME, Sanford RA, Krischer JP, Mulhern RK, James HE, Rekate HL, Friedman HS (1995) Postoperative chemotherapy and delayed radiation in infants and very young children with choroid plexus carcinomas. The Pediatric Oncology Group. Pediatr Neurosurg 22:189–196CrossRefPubMed
23.
Erman T, Gocer AI, Erdogan S et al (2003) Choroid plexus papilloma of bilateral lateral ventricle. Acta Neurochir 145:139–143CrossRefPubMed
24.
25.
Gertz HJ, Unger M, Lobeck H (1990) Histological and immunocytochemical findings in a case of fetal choroid plexus papilloma. Zentralbl Allg Pathol 136:719–722PubMed
26.
Gianella Borradori A, Zeltzer PM, Bode B et al (1992) Choroid plexus tumors in childhood. Response to chemotherapy, and immunophenotypic profile using a panel of monoclonal antibodies. Cancer 69:809–816CrossRefPubMed
27.
Gopal P, Debski R, Parker JC (2008) Choroid plexus carcinoma. Arch Pathol Lab Med 132:1350–1354PubMed
28.
Gozali AE, Britt B, Shane L et al (2012) Choroid plexus tumors; management, outcome, and association with the Li-Fraumeni syndrome: Children’s Hospital Los Angeles (CHLA) experience, 1991-2010. Pediatr Blood Cancer 58:905–909CrossRefPubMed
29.
Gupta P, Sodhi KS, Mohindra S et al (2013) Choroid plexus papilloma of the third ventricle: a rare infantile brain tumor. J Pediatr Neurosci 8:247–249CrossRefPubMedPubMedCentral
30.
Hartge DR, Axt Fliedner R, Weichert J (2010) Prenatal diagnosis and successful postnatal therapy of an atypical choroi plexus papilloma-case report and review of literature. J Clin Ultrasound 38:377–383PubMed
31.
Honda E, Hayashi T, Kuramoto S (1984) A case of choroid plexus papilloma in the lateral ventricle, complicated by a neuroepithelial cyst in the posterior fossa in a newborn infant. Kurume Med J 31:115–124CrossRefPubMed
32.
Isaacs H Jr (2002) I. Perinatal brain tumors: a review of 250 cases. Pediatr Neurol 27:249–261CrossRefPubMed
33.
Isaacs H Jr (2002) II. Perinatal brain tumors: a review of 250 cases. Pediatr Neurol 27:333–342CrossRefPubMed
34.
35.
Isaacs H Jr (2013) Brain tumors. In: Isaacs H Jr (ed) Tumors of the fetus and infant: an atlas. Springer-Verlag, New York, pp 163–195CrossRef
36.
Isaacs H Jr (1997) Brain tumors. In: Isaacs H Jr (ed) Tumors of the fetus and newborn: vol. 35 in the series major problems in pathology. W.B. Saunders Co, Philadelphia, pp 223–228
37.
Jeibmann A, Hasselblatt M, Gerss J, Wrede B, Egensperger R, Beschorner R, Hans VHJ, Rickert CH, Wolff JE, Paulus W (2006) Prognostic implications of atypical histologic features in choroid plexus papilloma. J Neuropathol Exp Neurol 65:1069–1073CrossRefPubMed
38.
Joó GJ, Reiniger L, Papp C, Csaba Á, Komáromy H, Rigó J Jr (2014) Intrauterine diagnosis and pathology of fetal choroid plexus carcinoma-a case study. Pathol Res Pract 210:1156–1159CrossRefPubMed
39.
Jooma R, Grant DN (1983) Third ventricle choroid plexus papillomas. Child Brain 10:242–250
40.
41.
Kennedy EC, Cloney MB, Anderson RC et al (2015) Superior parietal lobule approach for choroid plexus papillomas without preoperative embolization in very young patients. J Neurosurg Pediatr 16:101–106CrossRefPubMed
42.
Kleihues P, Cavenee WK (1997) Pathology and genetics of tumors of the nervous system, vol 17. International Agency for Research on Cancer, World Health Organization, Lyon, pp 245–247
43.
Kumabe T, Tominaga T, Kondo T et al (1996) Intraoperative radiation therapy and chemotherapy for huge choroid plexus carcinoma in an infant--case report. Neurol Med Chir 36:179–184CrossRef
44.
Kumar R, Achari G, Benerji D et al (2002) Choroid plexus papillomas of the cerebellopontine angle. Neurol India 50:352–358PubMed
45.
Levy ML, Goldfarb A, Hyder DJ et al (2001) Choroid plexus tumors in children: significance of stromal invasion. Neurosurg 48:303–309
46.
Lippa C, Abroms IF, Davidson R, DeGirolami U (1989) Congenital choroid plexus papilloma of the fourth ventricle. J Child Neurol 4:127–130CrossRefPubMed
47.
Louis DN, Perry A, Reifenberger G, von Deimling A, Figarella-Branger D, Cavenee WK, Ohgaki H, Wiestler OD, Kleihues P, Ellison DW (2016) The 2016 World Health Organization classification of tumors of the central nervous system: a summary. Acta Neuropathol 131(6):803–820CrossRef
48.
Mallick S, Benson R, Melgandi W, Rath GK (2017) Effect of surgery, adjuvant therapy, and other prognostic factors on choroid plexus carcinoma: a systematic review and individual patient data analysis. Int J Radiat Oncol Biol Phys 99(5):1199–1206CrossRefPubMed
49.
Manoranjan B, Provias JP (2011) Congenital brain tumors: diagnostic pitfalls and therapeutic interventions. J Child Neurol 26:599–614CrossRefPubMed
50.
McCune AB, Cohen BA, Gartner JC (1990) Congenital choroid plexus papilloma and giant nevomelanocytic nevus: report of a case. J Am Acad Dermatol 22:849–851CrossRefPubMed
51.
Merino DM, Shlien A, Villani A, Pienkowska M, Mack S, Ramaswamy V, Shih D, Tatevossian R, Novokmet A, Choufani S, Dvir R, Ben-Arush M, Harris BT, Hwang EI, Lulla R, Pfister SM, Achatz MI, Jabado N, Finlay JL, Weksberg R, Bouffet E, Hawkins C, Taylor MD, Tabori U, Ellison DW, Gilbertson RJ, Malkin D (2015) Molecular characterization of choroid plexus tumors reveals novel clinically relevant subgroups. Clin Cancer Res 21(1):184–192CrossRefPubMed
52.
Murata M, Morokuma S, Tsukimori K et al (2009) Rapid growing cystic variant of choroid plexus papilloma in a fetal cerebral hemisphere. Ultrasound Obstet Gynecol 33:116–118CrossRefPubMed
53.
Nejat F, Kazmi SS, Ardakani SB (2008) Congenital brain tumors in a series of seven patients. Pediatr Neurosurg 44:1–8CrossRefPubMed
54.
Newbould MJ, Kelsey AM, Arango JC et al (1995) The choroid plexus carcinomas of childhood : histopathology, immunocytochemistry, and clinicopathological correlations. Histopathol 28:137–143CrossRef
55.
Noguchi A, Shiokawa Y, Kobayashi K et al (2004) Choroid plexus papilloma of the third ventricle in the fetus. Case illustration. J Neurosurg 100(2 Suppl Pediatr):224–224PubMed
56.
Oi S, Kokunai T, Matsumoto S (1990) Congenital brain tumors in Japan (ISPN cooperative study): specific clinical features in neonates. Child Nerv Syst 6:86–91CrossRef
57.
Ortega Aznar A, Romero Vidal FJ, de la Torre J (2001) Neonatal tumors of the CNS: a report of 9 cases and a review. Clin Neuropathol 20:181–189PubMed
58.
Packer RJ, Perilongo G, Johnson D et al (1992) Choroid plexus carcinoma of childhood. Cancer 69:580–585CrossRefPubMed
59.
Pascual Castroviejo I, Roche MC, Villarejo F et al (1982) Choroid plexus papillomas of the fourth ventricle. Report of 3 cases. Childs Brain 9:373–380PubMed
60.
Pascual Castroviejo I, Villarejo F, Perez Higueras A (1983) Childhood choroid plexus neoplasms. A study of 14 cases less than 2 years old. Eur J Pediatr 140:51–56CrossRefPubMed
61.
Passariello A, Tufano M, Spennato P et al (2015) The role of chemotherapy and surgical removal in the treatment of choroid plexus carcinomas and atypical papillomas. Child Nerv Syst 31:1079–1088CrossRef
62.
Pietrini D, Chiano F, Tempara A et al (2004) Massive blood loss during removalof congenital choroid plexus tumors. J Neurosurg Anesthesiol 16:260–263CrossRefPubMed
63.
Radkowski MA, Naidich TP, Tomita T, Byrd SE, McLone DG (1988) Neonatal brain tumors: CT and MR findings. J Comput Assist Tomogr 12:10–20CrossRefPubMed
64.
Reddy D, Gunnarsson T, Scheinemann K et al (2011) Combined staged endoscopic and microsurgical approach of a third ventricular choroid plexus papilloma in an infant. Minim Invasive Neurosurg 54:264–267CrossRefPubMed
65.
66.
Romano F, Bratta FG, Caruso G et al (1996) Prenatal diagnosis of choroid plexus papillomas of the lateral ventricle. A report of two cases. Prenat Diagn 16:567–571CrossRefPubMed
67.
Siegfried A, Moron C, Munzer C et al (2017) A French retrospective study on clinical outcome in 102 choroid plexus tumors in children. J Neuro-Oncol 135:151–160CrossRef
68.
Stafrace S, Molloy J (2008) Extraventricular choroid plexus papilloma in a neonate. Pediatr Radiol 38:593–593CrossRefPubMed
69.
Taggard DA, Menezes AH (2000) Three choroid plexus papillomas in a patient with Aicardi syndrome. A case report. Pediatr Neurosurg 33:219–223CrossRefPubMed
70.
Thomas C, Ruland V, Kordes U, Hartung S, Capper D, Pietsch T, Gerß J, Wolff JEA, Paulus W, Hasselblatt M (2015) Pediatric atypical choroid plexus papilloma reconsidered: increased mitotic activity is prognostic only in older children. Acta Neuropathol 129:925–927CrossRefPubMed
71.
Thomas C, Sill M, Ruland V, Witten A, Hartung S, Kordes U, Jeibmann A, Beschorner R, Keyvani K, Bergmann M, Mittelbronn M, Pietsch T, Felsberg J, Monoranu CM, Varlet P, Hauser P, Olar A, Grundy RG, Wolff JE, Korshunov A, Jones DT, Bewerunge-Hudler M, Hovestadt V, von Deimling A, Pfister SM, Paulus W, Capper D, Hasselblatt M (2016) Methylation profiling of choroid plexus tumors reveals 3 clinically distinct subgroups. Neuro-Oncology 18(6):790–796CrossRefPubMedPubMedCentral
72.
Tomita T, Naidich TP (1987) Successful resection of choroid plexus papillomas diagnosed at birth: report of two cases. Neurosurg 20:774–779CrossRef
73.
Tomita T, McLone DG, Flannery AM (1988) Choroid plexus papillomas of neonates, infants and children. Pediatr Neurosci 14:23–30CrossRefPubMed
74.
Uchiyama CM, Carey CM, Cherny WB et al (1997) Choroid plexus papilloma and cysts in the Aicardi syndrome: case reports. Pediatr Neurosurg 27:100–104CrossRefPubMed
75.
Vassallo M, Maruotti GM, Giuseppe MM et al (2012) Choroid plexus carcinoma: prenatal characterization by 3-dimensional sonography and magnetic resonance imaging, perinatal management, and natural history. J Ultrasound Med 31:337–339CrossRefPubMed
76.
77.
Volpe JJ (2008) Brain tumors and vein malformations. In: Volpe JJ (ed) Neurology of the newborn, 5th edn. WB Saunders Co, Philadelphia, pp 989–1005
78.
Warren DT, Hendson G, Cochrane DD (2009) Bilateral choroid plexus hyperplasia: a case report and management strategies. Child Nerv Syst 25:1617–1622CrossRef
79.
Welch K, Strand R, Bresnan M (1983) Congenital hydrocephalus due to villous hypertrophy of the telencephalic choroid plexuses. Case report. J Neurosurg 59:172–175CrossRefPubMed
80.
Wind J, Bell RS, Bank WO et al (2010) Treatment of third ventricular choroid plexus papilloma in an infant with embolization alone. J Neurosurg Pediatr 6:579–582CrossRefPubMed
81.
82.
Wrede B, Liu P, Wolff JE (2007) Chemotherapy improves the survival of patients with choroid plexus carcinoma: a meta-analysis of individual cases with choroid plexus tumors. J Neuro-Oncol 85(3):345–351CrossRef
83.
Wrede B, Hasselblatt M, Peters O, Thall PF, Kutluk T, Moghrabi A, Mahajan A, Rutkowski S, Diez B, Wang X, Pietsch T, Kortmann RD, Paulus W, Jeibmann A, Wolff JEA (2009) Atypical choroid plexus papilloma: clinical experience in the CPT-SIOP-2000 study. J Neuro-Oncol 95(3):383–392CrossRef
84.
Zaky W, Finlay JL (2018) Pediatric choroid plexus carcinoma: biologically and clinically in need of new perspectives. Pediatr Blood Cancer 65(7):e27031CrossRefPubMed
85.
Zaky W, Dhall G, Khatua S, Brown RJ, Ginn KF, Gardner SL, Yildiz VO, Yankelevich M, Finlay JL (2015) Choroid plexus carcinoma in children: the Head Start experience. Pediatr Blood Cancer 62(5):784–789CrossRefPubMed
Metadaten
Titel
Perinatal (fetal and neonatal) choroid plexus tumors: a review
verfasst von
John R. Crawford
Hart Isaacs Jr
Publikationsdatum
05.04.2019
Verlag
Springer Berlin Heidelberg
Erschienen in
Child's Nervous System / Ausgabe 6/2019
Print ISSN: 0256-7040
Elektronische ISSN: 1433-0350
DOI
https://doi.org/10.1007/s00381-019-04135-x

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