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01.12.2012 | Short Communication

Perivascular inflammatory cells in ovine Visna/maedi encephalitis and their possible role in virus infection and lesion progression

verfasst von: Laura Polledo, Jorge González, Julio Benavides, Beatriz Martínez-Fernández, Ma. Carmen Ferreras, Juan F. García Marín

Erschienen in: Journal of NeuroVirology | Ausgabe 6/2012

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Abstract

We examined the distribution in the perivascular spaces of Visna/maedi antigen, T cells (CD3+, CD4+ and CD8+), B cells and macrophages by immunohistochemistry in 22 natural cases of Visna/maedi encephalitis. Sheep showed lymphocytic or histiocytic lesions. In mild lymphocytic lesions, the viral antigen was detected in perivascular cuffs where CD8+ T cells predominated, but in severe lymphocytic lesions, sparse antigen was identified, and CD8+/CD4+ T cells appeared in a similar proportion in multilayer perivascular sleeves. In histiocytic lesions, vessels were surrounded by macrophages with abundant viral antigen, with CD8+/CD4+ T cells and B cells in the periphery. These results could reflect different stages of virus neuroinvasion and clarify the neuropathogenesis of Visna/maedi encephalitis.

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Titel: Perivascular inflammatory cells in ovine Visna/maedi encephalitis and their possible role in virus infection and lesion progression
verfasst von: Laura Polledo
Jorge González
Julio Benavides
Beatriz Martínez-Fernández
Ma. Carmen Ferreras
Juan F. García Marín
Publikationsdatum: 01.12.2012
Verlag: Springer US
Erschienen in: Journal of NeuroVirology / Ausgabe 6/2012
Print ISSN: 1355-0284
Elektronische ISSN: 1538-2443
DOI: https://doi.org/10.1007/s13365-012-0131-0

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