Background
With many new drugs designed against specific targets the use of biomarkers will increasingly allow patients to receive the drug most likely to be effective for their disease. In parallel, there is an increasing awareness that the different administration regimens and side effect profiles associated with particular therapies can impact health-related quality of life (HRQoL) in ways that vary among individuals. Differences also exist among patients with regard to benefit–harm trade-offs and willingness to obtain the best possible care, and individuals may benefit from holistic solutions adapted to their individual profile and preferences. These approaches could be applied to the majority of procedures and pharmacological agents, not just targeted therapies. Using biomarkers to target therapies is regarded by some as a way towards a more efficient and cost-effective healthcare system [
1‐
4]. This is particularly important as across Europe ageing populations and the increasing prevalence of chronic disorders are placing healthcare budgets under pressure. As a result, healthcare systems are increasingly mindful of budget impact and cost-effective usage of expensive innovative agents.
Personalized medicine (PM) is a relatively young field, although there have been a substantial number of recent publications in the area of PM and how it could be facilitated and implemented [
3,
5,
6]. Different stakeholders’ views on PM may reflect different aspects of the overall concept, and a comprehensive overview of what is understood by the term PM (also referred to as ‘stratified medicine’), and exactly what benefits and challenges may be associated with its implementation, is needed.
Therefore, the purpose of this research was to provide an overview of the concept of PM in Europe, with a particular focus on how patient segmentation is currently performed in nine countries with different healthcare systems: Austria, France, Germany, Hungary, Italy, the Netherlands, Spain, Sweden and the UK. In addition, we sought to identify some of the challenges and opportunities of PM in terms of providing the greatest possible value both for individual patients and society.
To meet these goals, we first conducted a targeted literature review of selected health databases and grey literature with the aim of collating qualitative information regarding the definition, process, use, funding, impact on health technology assessment (HTA) evaluation and challenges associated with PM. We decided to perform a qualitative literature review limiting the search to the selected European countries, and the findings were taken into account during the elaboration and validation of interviews. Second, because PM is an evolving field, and to capture an up-to-date picture of how PM is viewed across Europe, we carried out in-depth qualitative interviews with a range of experts with HTA, clinical provisioning, payer, academic, economic and industry experience, while members of patient associations were also interviewed. Finally, we describe some of the challenges that will need to be overcome in order to integrate patients’ preferences into PM decision-making processes.
Methods
Literature review
Searches of the MEDLINE and Embase databases were carried out between October 2014 and February 2015 using terms specific to PM, including ‘personalized medicine’, ‘individualized medicine’, ‘stratified medicine’, ‘segmented medicine’ and ‘targeted therapies’ according to the PRISMA guidelines (see Additional file
1 for full search terms). Electronic database searches were restricted to English language only; dates searched were 2010 to present but limiting the survey to the nine selected European countries. Similarly, grey literature searches were performed for the nine countries of interest – these searches were not limited to the English language and relevant materials were translated where possible.
Literature was selected for inclusion in the review if it addressed topics such as the definition of PM; methods for patient segmentation; current HTA, reimbursement, pricing and funding processes for PM; and the impact of these on patient access (see Additional file
1 for complete list).
The literature search in MEDLINE generated 1009 potentially relevant titles and/or abstracts and was conducted in October 2014. The Embase search generated 8580 potentially relevant titles and/or abstracts and was conducted in February 2015. Due to the large number of results in the Embase search the number of publications from this specific search was reduced by first filtering the initial results based on duplicates and additional search terms (see Additional file
1).
Both the results from the MEDLINE search and the remaining titles and/or abstracts from the Embase search were filtered based on their relevance to the research questions. For all relevant titles and abstracts, full papers were reviewed, and relevant data were extracted for evaluation. In case of doubt regarding the relevance of a title abstract or paper, a second researcher was consulted.
Based on those papers from the MEDLINE search that were most interesting or provided information and/or data that were scarce within the literature results, a citation search was conducted. In addition to the literature searches carried out in MEDLINE and Embase, the initial search terms were also used to search for literature on relevant websites. The identified literature was screened, reviewed and filtered by a second researcher, who also extracted data from the literature deemed relevant.
Finally, the retrieved literature was analysed to identify possible general themes related to PM, such as those concerning the use of (bio)markers or patients’ preferences, which could refer to “traditional” or innovative attitudes in PM, respectively.
Expert interviews
Semi-structured, anonymized interviews were conducted with experts from nine European countries, as well as three experts from European patient organizations, and one representative of the European Federation of Pharmaceutical industries and Associations (EFPIA). Experts were recruited from a BresMed internal contact list, and additional participants were recruited via snowball sampling. Interview recruitment was double blinded: the experts were not aware of the identity of the sponsor or of the Authors, and vice versa, and this procedure was explained to the experts during the administration of the informed consent. Of note, the privacy of experts was protected by excluding any information that could identify the interviewees while the complete anonymization of collected data was adopted before every analyses were carried out and findings discussed.
An interview guide (see Additional file
2) was developed with open and closed questions based on themes identified from the published evidence base and any obvious gap in the collected and reviewed literature. Pilot interviews were conducted in February 2015 to address any unclear or duplicated questions, and interviews with experts were conducted between April and June 2015. Interviewees were briefed about the objectives of the research and gave their informed verbal consent to participate and for the interviews to be recorded. Interviewees were asked about aspects of PM including definitions, patient segmentation, assessment and implementation of PM, the challenges they perceived personalized medicine to be facing, potential solutions, and expectations of the future of PM. The interviewer asked general questions without forcing the expert toward a pre-classified response.
Qualitative analysis was carried out through coding the transcripts using a software program (NVivo 10, QSR International) to identify any trends, differences and similarities specific to the HTA and reimbursement processes, decision making, challenges, and promoting market access across the study countries. For presentation of the results, anonymity of participants was protected by removing names and creating broad interview categories (e.g., clinical expert or economic expert).
Discussion
Current definitions of PM focus either on demographic criteria or on the use of clinical and biological information, including genetic disposition and biomarkers, to improve stratification of patients to receive optimized treatments. The results of the literature review and expert interviews described here show that these approaches – ‘physiology-based PM’ – are receiving a significant level of attention in the literature and in clinical practice. Although the findings of our survey were analysed in a qualitative way, they matched those obtained by Schleidgen and colleagues [
3], who analysed the literature, categorized and quantified the results until they concluded that PM “seeks to improve stratification and timing of health care” by using biological information and biomarkers [
3]. The use of biomarkers in treatment decisions is important, and there is a clear need to improve the systems for making relevant tests for biomarkers or specific genetic characteristics available alongside new medicines. In particular, the assessment of the value of a medical treatment and its associated CD together rather than separately is likely to simplify the assessment of both.
It is worth noting that part of our findings suggest that PM could be a holistic methodology, which is “centered around the needs of individual patient” as stated before [
3]. Indeed, although the holistic vision of PM is confined to a reduced number of published articles [
13,
38], it is plausible that offering more therapeutic options, as it occurred in some diseases over the last few years, means giving a growing weight to patients’ needs during the decision-making process.
What has been recorded during interviews largely matches the findings of literature survey, as briefly presented in the paragraph above. However, some important themes have been identified in the interviews. First, the majority of experts did agree with the physiological definition of PM, which should be based on a test (whatever the assay could be) to improve patients’ stratification and treatment, both in terms of efficacy and tolerability. This definition matches that synthesized by Schleidgen et al., (2013) [
3], which excludes the possibility that patients’ preferences could have an influence on therapeutic management. This is not surprising, and it could depend on several different factors, such as the need to reduce uncertainty and to objectively stratify patients according to their individual probability or risk of experiencing a therapeutic benefit or toxic effects, respectively. Interestingly, further points of discussion about PM were identified by the interviewees. Indeed, some experts referred to the application of PM protocols as possible causes of uncertainty, while a patients’ representative stated that PM could impede some patients to get access to potentially beneficial treatments. Those issues are very similar and they are not completely new for medicine, because the adoption of some screening procedures could result in erroneous values, thus denying therapeutic opportunities to some patients. It is likely that the development of a CD in parallel with the drug may improve the technical characteristics of the test.
The panorama is completed by the impact of PM for patients, the third aspect. Indeed, disclosing and discussing results of tests with the patients will turn into an informed decision making, as one patients’ representative stated. It is interesting to note that although not explicit, every shared decision making is based on the doctor-patient relationship and does include patient’s preferences [
48]. In a wider view, the discussion concerning a pharmacological option for a disease does mean taking patient’s preferences into account. Indeed, Schleidgen and colleagues discussed about the possibility that PM “is not a new concept as medicine has always been individualized” [
3]. Unfortunately, that assumption does not match with the influence of individual needs and beliefs on treatments that was neglected by the majority of experts.
Overall, the present study suggests that there was little mention in the literature or in the interview results of the use of patients’ behaviour, beliefs, values, personal environment and individual preferences in treatment decisions and the related trade-offs. In particular, there was little evidence for formal incorporation of patient preferences, utilities and social/cultural characteristics into the evaluation of new medicines. Few of the interviewees mentioned HRQoL, suggesting that most stratification is based on individual, but not personal, factors.
We believe that to become truly personalized, medicine will need decision making processes that can help define therapeutic solutions adapted to an individual patient’s profile, including not only their clinical characteristics or genetic disposition, but also their environment and individual preferences.
In addition to disease characteristics and the results of diagnostic tests, it will be important to take into account other patient’s characteristics. Medication adherence and disease management can be affected by patients’ personal environment, and by behavioural factors, such as their knowledge, abilities, occupation, social status, cultural background and beliefs [
49]. Patients may also have individual preferences for particular treatment modalities, the avoidance of certain side effects [
50], and the benefit–harm trade-off of interventions, and may differ in the level of priority they give to health compared with other problems.
PM will therefore need to actively involve patients in the choice of the optimal therapeutic solution for them – to achieve this patients will need information about the disease, the effectiveness of each therapy and the corresponding side effect profiles in order to make an informed decision. In this way, the goal of healthcare providers and patients will be to minimize side effects, secure outcomes and benefits, improve efficacy and HRQoL, and optimize the benefit–harm balance for each individual. By matching the characteristics of the selected therapy to a patient’s lifestyle and preferences, common reasons for non-adherence to prescribed treatments may be avoided, potentially increasing the expected therapeutic benefits, as well as optimizing the use of available healthcare resources. In principle, PM should therefore benefit both the individual patient and society. From a healthcare system perspective, the benefits of PM are likely to be improved outcomes and increased cost-effectiveness through selection of the best treatment for each patient.
Personalization of medicine may therefore take a number of forms not including only a laboratory test (i.e., a biomarker) but also individual preferences. For example, androgen-deprivation therapy is an option for the treatment of localized prostate cancer, but can cause impairment of urogenital function [
51] as well as radical prostatectomy [
52,
53]. The benefit–harm ratio for aggressive treatments may therefore be very different between individual patients, depending on their lifestyles and individual preferences – this could lead to very different estimates of patient-relevant outcomes and cost-effectiveness, depending on what patient population is being considered [
54]. In a wider view, the application of PM may also encompass, for example, not only patients’ preferences but also social constraints [
55], risk perception of a disease and, in an informed way, decision making [
56].
A major challenge in the implementation of PM based on patients’ preferences as well as their physiology will be how best to capture preferences in the assessment of new pharmaceutical products and diagnostics. Patients’ lifestyle, occupation and personal preferences may significantly change the value of a particular intervention from individual to individual and for the same individual on the basis of different situations/conditions, thus requiring a systematic classification (taxonomy) of outcomes or quality of life according to patients’ needs. These differences are likely to add to the complexity of HTA processes, particularly in systems that rely on willingness-to-pay thresholds in terms of cost per quality-adjusted life-year to guide decision making. Once drugs are available for use based on both the results of diagnostic tests and patients’ wishes, there will be a need for appropriate information on treatment effectiveness and side effect profiles that can be provided to patients, and for validated tools that healthcare providers can use to collect individual patients’ preferences and their explicit trade-offs in an unbiased manner. However, that approach will likely depend on the availability of large databases on which tools could be elaborated and validated. Demonstrating the benefits of personalization of medicine beyond the use of biomarkers will necessitate substantial evidence generation after a product’s launch, through both pragmatic trials and observational real-world studies. Finally, effective personalization of medicine based on patients’ environment and preferences will require an understanding of how health outcomes are affected by patients’ behaviour at individual and collective levels. Therefore, it is likely that the implementation of such an approach in the HTA processes will require several substantial changes.
The present study has several limitations. The literature search was not exhaustive, because the search terms were not designed to identify publications in areas such as behavioural science. Behavioural concepts such as patient activation may have an important role to play in the development of PM [
57]. In addition, while attempts were made to interview experts with a range of backgrounds, the number of interviewees was limited. In particular, only two experts from Hungary, Italy and Spain, and one from Sweden, were interviewed. Interview responses may therefore not be fully representative of decision makers in all countries. Similarly, the number of patient group representatives was small, and their responses may not sufficiently reflect patients’ perspectives. Finally, all interviewees did not answer some of the questions, although all experts did respond to items in each section of the interview guide.
Acknowledgements
The literature review and expert interviews were conducted by Nadia Van Dalfsen, Ann-Marie Chapman and Ron Akehurst (BresMed Health Solutions Ltd, Sheffield, UK). Editorial assistance in the preparation of this article was provided by Paul Overton (independent medical writer).