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European Journal of Nuclear Medicine and Molecular Imaging

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01.06.2011 | Original Article

PET/CT and 3-T whole-body MRI in the detection of malignancy in treated oropharyngeal and hypopharyngeal carcinoma

verfasst von: Shu-Hang Ng, Sheng-Chieh Chan, Tzu-Chen Yen, Chun-Ta Liao, Chin-Yu Lin, Joseph Tung-Chieh Chang, Sheung-Fat Ko, Hung-Ming Wang, Kai-Ping Chang, Kang-Hsing Fan

Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging | Ausgabe 6/2011

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Abstract

Purpose

We performed a prospective comparison of the diagnostic capability of integrated fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) (PET/CT), 3-T whole-body magnetic resonance imaging (WB-MRI) and their combination in detecting malignancy in treated oropharyngeal or hypopharyngeal squamous cell carcinoma (OHSCC).

Methods

Seventy-nine OHSCC patients at a high risk of residual disease or suspected to have recurrence after the completion of chemoradiation were included in the study. All patients underwent PET/CT and WB-MRI within 10 days of each other. Histology and follow-up data were used as the reference standard. The McNemar test was used to compare sensitivity and specificity, while the area under the receiver-operating characteristic curve (AUC) was used for comparison of diagnostic capabilities.

Results

Twenty-nine patients (36.7%) had residual/recurrent tumours or second primary tumours. Overall, there was a trend towards increased sensitivity and diagnostic capability for PET/CT compared with WB-MRI (72.4 vs 55.2%, p = 0.13; 0.826 vs 0.753, p = 0.24, respectively). The diagnostic capability of combined interpretation of PET/CT and WB-MRI was similar to PET/CT alone (0.827 vs 0.826, p = 0.97) but was significantly higher than WB-MRI alone (0.827 vs 0.753, p = 0.04).

Conclusion

PET/CT showed a trend towards higher diagnostic capability than 3-T WB-MRI in detecting residual/recurrent tumours or second primary tumours in OHSCC. The combined use of PET/CT and WB-MRI provided more added value to WB-MRI alone than to PET/CT alone. Additional PET/CT can be useful in patients with questionable MRI findings of malignancy.

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Titel: PET/CT and 3-T whole-body MRI in the detection of malignancy in treated oropharyngeal and hypopharyngeal carcinoma
verfasst von: Shu-Hang Ng
Sheng-Chieh Chan
Tzu-Chen Yen
Chun-Ta Liao
Chin-Yu Lin
Joseph Tung-Chieh Chang
Sheung-Fat Ko
Hung-Ming Wang
Kai-Ping Chang
Kang-Hsing Fan
Publikationsdatum: 01.06.2011
Verlag: Springer-Verlag
Erschienen in: European Journal of Nuclear Medicine and Molecular Imaging / Ausgabe 6/2011
Print ISSN: 1619-7070
Elektronische ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-011-1740-1

Springer Medizin

Abstract

Purpose

Methods

Results

Conclusion

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