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01.09.2010 | Head and Neck

Comprehensive imaging of residual/recurrent nasopharyngeal carcinoma using whole-body MRI at 3 T compared with FDG-PET-CT

verfasst von: Shu-Hang Ng, Sheng-Chieh Chan, Tzu-Chen Yen, Chun-Ta Liao, Joseph Tung-Chieh Chang, Sheung-Fat Ko, Hung-Ming Wang, Chin-Yu Lin, Kai-Ping Chang, Yu-Chun Lin

Erschienen in: European Radiology | Ausgabe 9/2010

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Abstract

Objective

To prospectively compare the diagnostic potential of 3-T whole-body magnetic resonance imaging (WB-MRI) and integrated fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) (FDG-PET-CT), and their combined interpretation for the detection of residual/recurrent nasopharyngeal carcinoma (NPC).

Methods

We enrolled 179 NPC patients at high risk of residual disease or with suspected recurrence. WB-MRI and FDG-PET-CT were obtained with an interval of <10 days.

Results

Fifty-five (30.7%) patients were found to have residual/recurrent tumours. In a patient-based analysis, the sensitivity, specificity and diagnostic capability of WB-MRI were similar to those of FDG-PET-CT (90.9% vs. 87.3%, P = 0.69; 91.1% vs. 90.3%, P > 0.99; 0.929 vs. 0.924, P = 0.83, respectively). Combined interpretation of WB-MRI with FDG-PET-CT increased the sensitivity to 94.5%. A slight improvement in the diagnostic capability was obtained using a combined interpretation of WB-MRI and FDG-PET-CT over WB-MRI alone (0.952 vs. 0.929, P = 0.22) and FDG-PET-CT alone (0.952 vs. 0.924, P = 0.11).

Conclusions

Three-Tesla WB-MRI achieved a similar diagnostic capability to FDG-PET-CT for the detection of residual/recurrent NPC. Both techniques have different advantages, and their combined interpretation can yield a slightly higher diagnostic capability. In clinical practice, 3-T WB-MRI can offer an accurate and comprehensive assessment of residual/recurrent NPC.

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Titel: Comprehensive imaging of residual/recurrent nasopharyngeal carcinoma using whole-body MRI at 3 T compared with FDG-PET-CT
verfasst von: Shu-Hang Ng
Sheng-Chieh Chan
Tzu-Chen Yen
Chun-Ta Liao
Joseph Tung-Chieh Chang
Sheung-Fat Ko
Hung-Ming Wang
Chin-Yu Lin
Kai-Ping Chang
Yu-Chun Lin
Publikationsdatum: 01.09.2010
Verlag: Springer-Verlag
Erschienen in: European Radiology / Ausgabe 9/2010
Print ISSN: 0938-7994
Elektronische ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-010-1784-9

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Comprehensive imaging of residual/recurrent nasopharyngeal carcinoma using whole-body MRI at 3 T compared with FDG-PET-CT