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Diabetologia
Erschienen in: Diabetologia 7/2006

01.07.2006 | Review

PGC-1α: a potent transcriptional cofactor involved in the pathogenesis of type 2 diabetes

verfasst von: S. Soyal, F. Krempler, H. Oberkofler, W. Patsch

Erschienen in: Diabetologia | Ausgabe 7/2006

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Abstract

Data derived from several recent studies implicate peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) in the pathogenesis of type 2 diabetes. Lacking DNA binding activity itself, PGC-1α is a potent, versatile regulator of gene expression that co-ordinates the activation and repression of transcription via protein-protein interactions with specific, as well as more general, factors contained within the basal transcriptional machinery. PGC-1α is suggested to play a pivotal role in the control of genetic pathways that result in homeostatic glucose utilisation in liver and muscle, beta cell insulin secretion and mitochondrial biogenesis. This review focuses on the role of PGC-1α in glucose metabolism and considers how PGC-1α links cellular glucose metabolism, insulin sensitivity and mitochondrial function, and why defects in PGC-1α expression and regulation may contribute to the pathophysiology of type 2 diabetes in humans.
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Metadaten
Titel
PGC-1α: a potent transcriptional cofactor involved in the pathogenesis of type 2 diabetes
verfasst von
S. Soyal
F. Krempler
H. Oberkofler
W. Patsch
Publikationsdatum
01.07.2006
Verlag
Springer-Verlag
Erschienen in
Diabetologia / Ausgabe 7/2006
Print ISSN: 0012-186X
Elektronische ISSN: 1432-0428
DOI
https://doi.org/10.1007/s00125-006-0268-6

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10.05.2024 Periphere arterielle Verschlusskrankheit Nachrichten

In den USA ist erstmals eine bioresorbierbare Gefäßstütze – auch Scaffold genannt – zur Rekanalisation infrapoplitealer Arterien bei schwerer PAVK zugelassen worden. Das markiert einen Wendepunkt in der Geschichte dieser speziellen Gefäßstützen.

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