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22.06.2020 | Review

Pharmacological management of pain after periodontal surgery: a systematic review with meta-analysis

verfasst von: Leonardo Stephan Caporossi, Cinthia Studzinski dos Santos, Thayanne Brasil Barbosa Calcia, Maximiliano Sergio Cenci, Francisco Wilker Mustafa Gomes Muniz, Giana da Silveira Lima

Erschienen in: Clinical Oral Investigations | Ausgabe 8/2020

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Abstract

Objectives

To assess and compare the pharmacological effect of different drugs on pain relief after periodontal surgery.

Materials and methods

Five databases were searched up to September 2019. The eligible studies comprised randomized clinical trials, involving only adult individuals that received any periodontal surgery and presenting two distinct groups of therapeutic regimens to control postoperative pain. Placebo groups could be included. The risk of bias was assessed with the RoB 2 Cochrane tool and the GRADE system. Meta-analyses were performed using different follow-up and drug comparisons.

Results

Overall, 2398 studies were identified, of which 35 were included. Low risk of bias was determined for the majority of the studies. The meta-analyses showed that the comparison of dexamethasone or non-steroidal anti-inflammatory drugs (NSAID) versus placebo favored the use of both interventions in a follow-up of 1 to 8 h for open flap procedures (OFP). However, no statistical difference was found for the comparison between NSAID and dexamethasone for OFP.

Conclusions

Patients may benefit from several pharmacological schemes for pain relief after periodontal surgeries. However, due to the high heterogeneity among studies, no fixed pharmacological protocol could be proposed.

Clinical relevance

There is not enough evidence to recommend one therapeutic scheme. However, untreated pain is harmful to the patients and it is not advisable.

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Titel: Pharmacological management of pain after periodontal surgery: a systematic review with meta-analysis
verfasst von: Leonardo Stephan Caporossi
Cinthia Studzinski dos Santos
Thayanne Brasil Barbosa Calcia
Maximiliano Sergio Cenci
Francisco Wilker Mustafa Gomes Muniz
Giana da Silveira Lima
Publikationsdatum: 22.06.2020
Verlag: Springer Berlin Heidelberg
Erschienen in: Clinical Oral Investigations / Ausgabe 8/2020
Print ISSN: 1432-6981
Elektronische ISSN: 1436-3771
DOI: https://doi.org/10.1007/s00784-020-03401-6

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Pharmacological management of pain after periodontal surgery: a systematic review with meta-analysis